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WO2002002797A3 - Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme - Google Patents

Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme Download PDF

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Publication number
WO2002002797A3
WO2002002797A3 PCT/EP2001/007632 EP0107632W WO0202797A3 WO 2002002797 A3 WO2002002797 A3 WO 2002002797A3 EP 0107632 W EP0107632 W EP 0107632W WO 0202797 A3 WO0202797 A3 WO 0202797A3
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WO
WIPO (PCT)
Prior art keywords
beta
human
enzyme
hydroxysteroid dehydrogenase
regulation
Prior art date
Application number
PCT/EP2001/007632
Other languages
French (fr)
Other versions
WO2002002797A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to EP01954005A priority Critical patent/EP1309697A2/en
Priority to AU2001276378A priority patent/AU2001276378A1/en
Priority to JP2002508037A priority patent/JP2004502432A/en
Publication of WO2002002797A2 publication Critical patent/WO2002002797A2/en
Publication of WO2002002797A3 publication Critical patent/WO2002002797A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01146—11-Beta-hydroxysteroid dehydrogenase (1.1.1.146)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Reagents which regulate human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme and reagents which bind to human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to CNS disorders, osteoporosis, liver disease, obesity, blood pressure or fetal development abnormalities, and diabetes.
PCT/EP2001/007632 2000-07-05 2001-07-04 Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme WO2002002797A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01954005A EP1309697A2 (en) 2000-07-05 2001-07-04 Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme
AU2001276378A AU2001276378A1 (en) 2000-07-05 2001-07-04 Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme
JP2002508037A JP2004502432A (en) 2000-07-05 2001-07-04 Regulation of human 11β-hydroxysteroid dehydrogenase 1-like enzyme

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21635000P 2000-07-05 2000-07-05
US60/216,350 2000-07-05
US23129500P 2000-09-08 2000-09-08
US60/231,295 2000-09-08

Publications (2)

Publication Number Publication Date
WO2002002797A2 WO2002002797A2 (en) 2002-01-10
WO2002002797A3 true WO2002002797A3 (en) 2003-02-27

Family

ID=26910926

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007632 WO2002002797A2 (en) 2000-07-05 2001-07-04 Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme

Country Status (4)

Country Link
EP (1) EP1309697A2 (en)
JP (1) JP2004502432A (en)
AU (1) AU2001276378A1 (en)
WO (1) WO2002002797A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160452A1 (en) * 2000-11-30 2002-10-31 Meyers Rachel E. 25206, a novel human short-chain dehydrogenase/reductase family member and uses thereof
GB0107383D0 (en) * 2001-03-23 2001-05-16 Univ Edinburgh Lipid profile modulation
EP1597267A4 (en) * 2003-02-21 2007-04-18 Merck & Co Inc Pharmacodynamic assay for inhibitors of 11-beta-hydroxysteroid dehydrogenase activity in animal tissues
WO2004080535A2 (en) * 2003-03-12 2004-09-23 Millennium Pharmaceuticals, Inc. Methods and compositions for treating aids and hiv-related disorders using 9145, 1725, 311, 837, 58305, 156, 14175, 50352, 32678, 5560, 7240, 8865, 12396, 12397, 13644, 19938, 2077, 1735, 1786, 10220, 17822, 33945, 43748, 47161, 81982, or 46777
JP2006522750A (en) * 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ Combination therapy using 11β-hydroxysteroid dehydrogenase type 1 inhibitors and antihypertensive agents to treat metabolic syndrome and related diseases and disorders
EP1862181A3 (en) * 2003-04-11 2010-09-15 High Point Pharmaceuticals, LLC New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof
US7501405B2 (en) 2003-04-11 2009-03-10 High Point Pharmaceuticals, Llc Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders
WO2005119525A1 (en) * 2004-06-04 2005-12-15 Pfizer Products Inc. 11βHSD1 CRYSTAL STRUCTURES FOR STRUCTURE BASED DRUG DESIGN
WO2006059507A1 (en) * 2004-11-30 2006-06-08 Sankyo Company, Limited 11β-HSD1 ANTISENSE COMPOUND
WO2007058346A1 (en) 2005-11-21 2007-05-24 Shionogi & Co., Ltd. HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE I
ES2535317T3 (en) 2007-05-18 2015-05-08 Shionogi & Co., Ltd. Nitrogen-containing heterocyclic derivative that has 11 beta-hydroxysteroid dehydrogenase inhibitor activity
KR20110088575A (en) 2008-11-21 2011-08-03 하이 포인트 파마슈티칼스, 엘엘씨 Adamantyl Benzamide Compound
WO2012015715A1 (en) 2010-07-27 2012-02-02 High Point Pharmaceuticals, Llc Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta hsd1 modulators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965372A (en) * 1995-08-24 1999-10-12 Baker Medical Research Institute Genetic sequences encoding glucocorticoid dehydrogenases and uses thereof
WO2001090090A1 (en) * 2000-05-22 2001-11-29 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965372A (en) * 1995-08-24 1999-10-12 Baker Medical Research Institute Genetic sequences encoding glucocorticoid dehydrogenases and uses thereof
WO2001090090A1 (en) * 2000-05-22 2001-11-29 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 11 November 1999 (1999-11-11), XP002217921, Database accession no. AW163684 *
HULT M ET AL: "Selective inhibition of human type 1 11beta-hydroxysteroid dehydrogenase by synthetic steroids and xenobiotics", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 441, no. 1, 11 December 1998 (1998-12-11), pages 25 - 28, XP004258864, ISSN: 0014-5793 *
KROZOWSKI ZYGMUNT: "The 11beta-hydroxysteroid dehydrogenases: Functions and physiological effects.", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 151, no. 1-2, 25 May 1999 (1999-05-25), pages 121 - 127, XP002217920, ISSN: 0303-7207 *
STEWART P M ET AL: "11BETA-HYDROXYSTEROID DEHYDROGENASE", VITAMINS AND HORMONES, ACADEMIC PRESS, NEW YORK, NY,, US, vol. 57, 1999, pages 249 - 324, XP001004592, ISSN: 0083-6729 *

Also Published As

Publication number Publication date
JP2004502432A (en) 2004-01-29
EP1309697A2 (en) 2003-05-14
WO2002002797A2 (en) 2002-01-10
AU2001276378A1 (en) 2002-01-14

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