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WO2002004610A3 - Regulation of human dipeptidyl-peptidase iv-like enzyme - Google Patents

Regulation of human dipeptidyl-peptidase iv-like enzyme Download PDF

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Publication number
WO2002004610A3
WO2002004610A3 PCT/EP2001/007730 EP0107730W WO0204610A3 WO 2002004610 A3 WO2002004610 A3 WO 2002004610A3 EP 0107730 W EP0107730 W EP 0107730W WO 0204610 A3 WO0204610 A3 WO 0204610A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidase
enzyme
human dipeptidyl
regulation
reagents
Prior art date
Application number
PCT/EP2001/007730
Other languages
French (fr)
Other versions
WO2002004610A2 (en
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to AU2001269123A priority Critical patent/AU2001269123A1/en
Publication of WO2002004610A2 publication Critical patent/WO2002004610A2/en
Publication of WO2002004610A3 publication Critical patent/WO2002004610A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Reagents which regulate human dipeptidyl-peptidase IV-like enzyme and reagents which bind to human dipeptidyl-peptidase IV-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, tumors and peripheral and central nervous system disorders including pain and neurodegenerative disorders.
PCT/EP2001/007730 2000-07-10 2001-07-06 Regulation of human dipeptidyl-peptidase iv-like enzyme WO2002004610A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001269123A AU2001269123A1 (en) 2000-07-10 2001-07-06 Regulation of human dipeptidyl-peptidase iv-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21707500P 2000-07-10 2000-07-10
US60/217,075 2000-07-10

Publications (2)

Publication Number Publication Date
WO2002004610A2 WO2002004610A2 (en) 2002-01-17
WO2002004610A3 true WO2002004610A3 (en) 2002-07-11

Family

ID=22809580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007730 WO2002004610A2 (en) 2000-07-10 2001-07-06 Regulation of human dipeptidyl-peptidase iv-like enzyme

Country Status (2)

Country Link
AU (1) AU2001269123A1 (en)
WO (1) WO2002004610A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470700B2 (en) 2003-08-13 2008-12-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7550590B2 (en) 2003-03-25 2009-06-23 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7897633B2 (en) 2004-02-05 2011-03-01 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8906901B2 (en) 2005-09-14 2014-12-09 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101172158A (en) 2001-05-11 2008-05-07 得克萨斯州立大学董事会 Anti-CD26 Monoclonal Antibodies as Treatment for Diseases Associated with CD26-Expressing Cells
DE10150203A1 (en) 2001-10-12 2003-04-17 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitor in treatment of cancer
WO2004017989A1 (en) 2002-08-09 2004-03-04 Prosidion Ltd. Methods for improving islet signaling in diabetes mellitus and for its prevention
DE202004021723U1 (en) 2003-05-05 2010-07-15 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
ATE464889T1 (en) 2003-05-05 2010-05-15 Probiodrug Ag MEDICAL USE OF GLUTAMINYL AND GLUTAMATIC CYCLASE INHIBITORS
EP1625122A1 (en) 2003-05-14 2006-02-15 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
KR101121882B1 (en) 2003-10-15 2012-04-12 프로비오드룩 아게 Use of effectors of glutaminyl and glutamate cyclases
NZ546887A (en) 2003-11-03 2009-04-30 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
CN101360723A (en) 2005-09-16 2009-02-04 武田药品工业株式会社 Process for preparing pyrimidinedione derivatives
EP1971614A1 (en) 2005-11-14 2008-09-24 Probiodrug AG Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase iv inhibitors
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
MX2008013130A (en) 2006-04-12 2008-11-19 Probiodrug Ag Enzyme inhibitors.
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CUNNINGHAM D F ET AL: "Proline specific peptidases", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1343, no. 2, 5 December 1997 (1997-12-05), pages 160 - 186, XP004278373, ISSN: 0167-4838 *
DATABASE EMBL 1 November 1995 (1995-11-01), YOKOTANI,N., DOI,K., WENTHOLD,R.J., WADA,K.,: "DIPEPTIDYL PEPTIDASE IV LIKE PROTEIN (DIPEPTIDYL AMINOPEPTIDASE- RELATED PROTEIN)(DIPEPTIDYLPEPTIDASE VI) (DPPX).", XP002193823 *
DATABASE EMBL 23 May 2000 (2000-05-23), OHARA O., NAGASE T., KIKUNO R.: "Homo sapiens mRNA for KIAA1492 protein, partial cds.", XP002193822 *
DATABASE EMBL 25 May 1995 (1995-05-25), HILLIER L. ET AL.: "yg99h11.r1 Soares infant brain 1NIB Homo sapiens cDNA clone IMAGE:41862 5'", XP002193821 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XVII. THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 7, no. 6, 2000, pages 143 - 150, XP000943428, ISSN: 1340-2838 *
YOKOTANI N ET AL: "NON-CONSERVATION OF A CATALYTIC RESIDUE IN A DIPEPTIDYL AMINOPEPTIDASE IV-RELATED PROTEIN ENCODED BY A GENE ON HUMAN CHROMOSOME 7", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 2, no. 7, July 1993 (1993-07-01), pages 1037 - 1039, XP001026522, ISSN: 0964-6906 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550590B2 (en) 2003-03-25 2009-06-23 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7470700B2 (en) 2003-08-13 2008-12-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7579357B2 (en) 2003-08-13 2009-08-25 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7897633B2 (en) 2004-02-05 2011-03-01 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8906901B2 (en) 2005-09-14 2014-12-09 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors

Also Published As

Publication number Publication date
WO2002004610A2 (en) 2002-01-17
AU2001269123A1 (en) 2002-01-21

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