+

WO2002036731A3 - Human lysosomal acid lipase - Google Patents

Human lysosomal acid lipase Download PDF

Info

Publication number
WO2002036731A3
WO2002036731A3 PCT/EP2001/012518 EP0112518W WO0236731A3 WO 2002036731 A3 WO2002036731 A3 WO 2002036731A3 EP 0112518 W EP0112518 W EP 0112518W WO 0236731 A3 WO0236731 A3 WO 0236731A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid lipase
lysosomal acid
human lysosomal
reagents
copd
Prior art date
Application number
PCT/EP2001/012518
Other languages
French (fr)
Other versions
WO2002036731A2 (en
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to AU2002226319A priority Critical patent/AU2002226319A1/en
Publication of WO2002036731A2 publication Critical patent/WO2002036731A2/en
Publication of WO2002036731A3 publication Critical patent/WO2002036731A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human lysosomal acid lipase and reagents which bind to human lysosomal acid lipase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, obesity, COPD, diabetes, peripheral and central nervous system disorders and cardiovascular disorders.
PCT/EP2001/012518 2000-10-31 2001-10-30 Human lysosomal acid lipase WO2002036731A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002226319A AU2002226319A1 (en) 2000-10-31 2001-10-30 Human lysosomal acid lipase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24417000P 2000-10-31 2000-10-31
US60/244,170 2000-10-31
US29351601P 2001-05-29 2001-05-29
US60/293,516 2001-05-29

Publications (2)

Publication Number Publication Date
WO2002036731A2 WO2002036731A2 (en) 2002-05-10
WO2002036731A3 true WO2002036731A3 (en) 2003-03-13

Family

ID=26936360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/012518 WO2002036731A2 (en) 2000-10-31 2001-10-30 Human lysosomal acid lipase

Country Status (2)

Country Link
AU (1) AU2002226319A1 (en)
WO (1) WO2002036731A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1414963A2 (en) * 2000-12-08 2004-05-06 Incyte Genomics, Inc. Lipid-associated molecules
US6638738B2 (en) * 2001-03-20 2003-10-28 Applera Corporation Isolated human lipase proteins, nucleic acid molecules encoding human lipase proteins, and uses thereof
KR20140130443A (en) * 2012-03-02 2014-11-10 시나게바 바이오파르마, 코포레이션 Truncated lysosomal acid lipase
WO2014000058A1 (en) * 2012-06-29 2014-01-03 Garvan Institute Of Medical Research Method of treating glucose metabolism disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000077239A2 (en) * 1999-06-14 2000-12-21 Millennium Pharmaceuticals, Inc. Novel genes encoding proteins having diagnostic, preventive, therapeutic, and other uses
WO2001079446A2 (en) * 2000-04-14 2001-10-25 Hyseq, Inc. Materials and methods relating to lipid metabolism

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000077239A2 (en) * 1999-06-14 2000-12-21 Millennium Pharmaceuticals, Inc. Novel genes encoding proteins having diagnostic, preventive, therapeutic, and other uses
WO2001079446A2 (en) * 2000-04-14 2001-10-25 Hyseq, Inc. Materials and methods relating to lipid metabolism

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANDERSON R ET AL: "Cloning and expression of cDNA encoding human lysosomal acid lipase/cholestreryl ester hydrolase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 266, no. 33, 25 November 1991 (1991-11-25), pages 22479 - 22484, XP002192752, ISSN: 0021-9258 *
DATABASE EMBL [online] 26 October 2000 (2000-10-26), NIH-MGC: "601780142F1 NCI_CGAP Mus musculus cDNA clone IMAGE:4008131 5', mRNA sequence", XP002213529, Database accession no. BF135102 *
ROUSSEL A ET AL: "Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 24, 11 June 1999 (1999-06-11), pages 16995 - 17002, XP002192751, ISSN: 0021-9258 *
SHERIFF S ET AL: "CHARACTERIZATION OF LYSOSOMAL ACID LIPASE BY SITE-DIRECTED MUTAGENESIS AND HETEROLOGOUS EXPRESSION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 270, no. 46, 17 November 1995 (1995-11-17), pages 27766 - 27772, XP000986290, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2002226319A1 (en) 2002-05-15
WO2002036731A2 (en) 2002-05-10

Similar Documents

Publication Publication Date Title
WO2002004610A3 (en) Regulation of human dipeptidyl-peptidase iv-like enzyme
WO2002036754A3 (en) Nucleotide and polypeptide sequence of human lysosomal acid lipase
WO2002006453A3 (en) Regulation of human desc1-like serine protease
WO2002061092A3 (en) Regulation of human lysyl oxidase
WO2002036731A3 (en) Human lysosomal acid lipase
WO2002072824A3 (en) Human transient receptor potential channel protein.
WO2002036629A3 (en) Regulation of human serotonin receptor precursor
WO2002036613A3 (en) Regulation of human patched-like protein
WO2002032938A3 (en) Regulation of human pgc-1-like protein
WO2002046403A3 (en) Regulation of human patched-like protein
WO2002000855A3 (en) Regulation of human s-acyl fatty acid synthase thioesterase-like enzyme
WO2002032958A3 (en) Polynucleotide and polypeptide sequences of human dendritic cell immunoreceptors
WO2002038747A3 (en) Human adenylate cyclase
WO2002048358A3 (en) Regulation of human chemokine-like receptor
WO2002046402A3 (en) Regulation of human patched-like protein
WO2002097074A3 (en) Human protein phosphatase 2c-like enzyme
WO2002055681A3 (en) Regulation of human tau-tubulin kinase
WO2002051989A3 (en) Human 4-nitrophenylphosphatase
WO2002024878A3 (en) Human e3 ubiquitin protein ligase-like enzyme
WO2002031125A3 (en) Human phospholipase a2-like enzyme
WO2003025174A3 (en) Regulation of human mrp1-like protein
WO2002057461A3 (en) Regulation of human adam-ts-like zinc metalloprotease
WO2003014148A3 (en) Human fatty acid-coa ligase
WO2002072825A3 (en) Human mrp5-like protein
WO2002055710A3 (en) Regulation of human purple acid phosphatase

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载