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WO2002048325A3 - Regulation of human serine palmitoyltransferase - Google Patents

Regulation of human serine palmitoyltransferase Download PDF

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Publication number
WO2002048325A3
WO2002048325A3 PCT/EP2001/014653 EP0114653W WO0248325A3 WO 2002048325 A3 WO2002048325 A3 WO 2002048325A3 EP 0114653 W EP0114653 W EP 0114653W WO 0248325 A3 WO0248325 A3 WO 0248325A3
Authority
WO
WIPO (PCT)
Prior art keywords
human serine
serine palmitoyltransferase
regulation
reagents
palmitoyltransferase
Prior art date
Application number
PCT/EP2001/014653
Other languages
French (fr)
Other versions
WO2002048325A2 (en
Inventor
Sophia Kossida
Original Assignee
Bayer Ag
Sophia Kossida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Sophia Kossida filed Critical Bayer Ag
Priority to AU2002234568A priority Critical patent/AU2002234568A1/en
Publication of WO2002048325A2 publication Critical patent/WO2002048325A2/en
Publication of WO2002048325A3 publication Critical patent/WO2002048325A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents which regulate human serine palmitoyltransferase and reagents which bind to human serine palmitoyltransferase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, HIV infection, cancer, obesity, and diabetes.
PCT/EP2001/014653 2000-12-15 2001-12-13 Regulation of human serine palmitoyltransferase WO2002048325A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002234568A AU2002234568A1 (en) 2000-12-15 2001-12-13 Regulation of human serine palmitoyltransferase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25544500P 2000-12-15 2000-12-15
US60/255,445 2000-12-15

Publications (2)

Publication Number Publication Date
WO2002048325A2 WO2002048325A2 (en) 2002-06-20
WO2002048325A3 true WO2002048325A3 (en) 2002-11-14

Family

ID=22968361

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/014653 WO2002048325A2 (en) 2000-12-15 2001-12-13 Regulation of human serine palmitoyltransferase

Country Status (2)

Country Link
AU (1) AU2002234568A1 (en)
WO (1) WO2002048325A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005092325A1 (en) * 2004-03-26 2005-10-06 Warner-Lambert Company Llc Use of a serine palmitoyltransferase (spt) inhibitor to treat atherosclerosis and dyslipidemia
JP4849622B2 (en) * 2004-08-11 2012-01-11 中外製薬株式会社 Drugs for treating or preventing HCV infection
MX2007004262A (en) * 2004-10-12 2008-03-04 Forbes Medi Tech Res Inc Compounds and methods of treating insulin resistance and cardiomyopathy.
US8957199B2 (en) 2008-11-26 2015-02-17 Chugai Seiyaku Kabushiki Kaisha Oligoribonucleotide or peptide nucleic acid capable of inhibiting activity of hepatitis C virus
WO2020038973A1 (en) 2018-08-23 2020-02-27 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting sptlc1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024884A2 (en) * 2000-09-19 2002-03-28 Bayer Aktiengesellschaft Regulation of human serine palmitoyltransferase-like enzyme

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024884A2 (en) * 2000-09-19 2002-03-28 Bayer Aktiengesellschaft Regulation of human serine palmitoyltransferase-like enzyme

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 4 October 1997 (1997-10-04), XP002211826, Database accession no. Y08686 *
WEISS ET AL: "Human and murine serine-palmitoyl-CoA transferase. Clonng, expression and characterization of the key enzyme in sphingolipid synthesis", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 249, no. 1, Y08686, October 1997 (1997-10-01), pages 239 - 247, XP002108813, ISSN: 0014-2956 *

Also Published As

Publication number Publication date
AU2002234568A1 (en) 2002-06-24
WO2002048325A2 (en) 2002-06-20

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