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WO2002031162A3 - Regulation of human phospholipase a2-like enzyme - Google Patents

Regulation of human phospholipase a2-like enzyme Download PDF

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Publication number
WO2002031162A3
WO2002031162A3 PCT/EP2001/011642 EP0111642W WO0231162A3 WO 2002031162 A3 WO2002031162 A3 WO 2002031162A3 EP 0111642 W EP0111642 W EP 0111642W WO 0231162 A3 WO0231162 A3 WO 0231162A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme
human phospholipase
regulation
reagents
phospholipase
Prior art date
Application number
PCT/EP2001/011642
Other languages
French (fr)
Other versions
WO2002031162A2 (en
Inventor
Zhimin Zhu
Original Assignee
Bayer Ag
Zhimin Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Zhimin Zhu filed Critical Bayer Ag
Priority to AU2002212318A priority Critical patent/AU2002212318A1/en
Publication of WO2002031162A2 publication Critical patent/WO2002031162A2/en
Publication of WO2002031162A3 publication Critical patent/WO2002031162A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human phospholipase A2-like enzyme and reagents which bind to human phospholipase A2-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, asthma, cancer, inflammation, CNS disorders, cardiovascular disorders, chronic obstructive pulmonary disease, diabetes, and obesity.
PCT/EP2001/011642 2000-10-10 2001-10-09 Regulation of human phospholipase a2-like enzyme WO2002031162A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002212318A AU2002212318A1 (en) 2000-10-10 2001-10-09 Regulation of human phospholipase a2-like enzyme

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US23843400P 2000-10-10 2000-10-10
US60/238,434 2000-10-10
US25805100P 2000-12-27 2000-12-27
US60/258,051 2000-12-27
US31598201P 2001-08-31 2001-08-31
US60/315,982 2001-08-31

Publications (2)

Publication Number Publication Date
WO2002031162A2 WO2002031162A2 (en) 2002-04-18
WO2002031162A3 true WO2002031162A3 (en) 2003-01-23

Family

ID=27399097

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011642 WO2002031162A2 (en) 2000-10-10 2001-10-09 Regulation of human phospholipase a2-like enzyme

Country Status (2)

Country Link
AU (1) AU2002212318A1 (en)
WO (1) WO2002031162A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002031125A2 (en) * 2000-10-10 2002-04-18 Bayer Aktiengesellschaft Human phospholipase a2-like enzyme
US7422887B2 (en) 2002-01-17 2008-09-09 Mitsubishi Tanabe Pharma Corporation Phospholipase A2 and gene thereof
CN104328095B (en) * 2014-09-26 2017-12-29 江南大学 Phospholipase A2 and its application of a kind of optimal pH in acid range

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025178A (en) * 1997-03-28 2000-02-15 Eli Lilly And Company Human phospholipase A2 and related nucleic acid compounds
WO2002004490A2 (en) * 2000-07-07 2002-01-17 Incyte Genomics, Inc. Lipid metabolism molecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025178A (en) * 1997-03-28 2000-02-15 Eli Lilly And Company Human phospholipase A2 and related nucleic acid compounds
WO2002004490A2 (en) * 2000-07-07 2002-01-17 Incyte Genomics, Inc. Lipid metabolism molecules

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EMBL; 18 April 1997 (1997-04-18), ADAMS M D ET AL.: "EST112698 Cerebellum II Homo sapiens cDNA 5' end similar to similar to phospholipase A2", XP002212888, Database accession no. AA297121 *
DATABASE EMBL [online] EMBL; 18 July 1996 (1996-07-18), HILLIER L ET AL.: "ze14h11.r1 Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone IMAGE:359013 5' similar to PIR:A39329 A39329 phospholipase A2 ;, mRNA sequence.", XP002212889, Database accession no. W92213 *
DATABASE EMBL [online] EMBL; 2 November 1998 (1998-11-02), PICKARD R T ET AL.: "Homo sapiens cytosolic phospholipase A2 beta (cPLA2 beta) mRNA, complete cds.", XP002212886, Database accession no. AF065215 *
DATABASE EMBL [online] EMBL; 21 December 1999 (1999-12-21), WATERSTON R H: "Homo sapiens chromosome 15 clone RP11-35K2, WORKING DRAFT SEQUENCE, 12 unordered pieces", XP002212890, Database accession no. AC018670 *
DATABASE EMBL [online] EMBL; 25 May 1999 (1999-05-25), SONG C ET AL.: "Homo sapiens cytosolic phospholipase A2 beta mRNA, complete cds.", XP002212887, Database accession no. AF121908 *
DATABASE EMBL [online] EMBL; 8 October 2001 (2001-10-08), NCI-MGC: "603075985F1 NIH_MGC_119 Homo sapiens cDNA clone IMAGE:5167964 5', mRNA sequence.", XP002212891, Database accession no. BI826278 *
MURAKAMI M ET AL.: "Regulatory functions of phospholipase A-2.", CRITICAL REVIEWS IN IMMUNOLOGY, vol. 17, no. 3-4, 1997, pages 225 - 283, XP008008029, ISSN: 1040-8401 *
PICKARD R T ET AL.: "Molecular cloning of two new human paralogs of 85-KDa cytosolic phospholipase A2", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 13, 26 March 1999 (1999-03-26), pages 8823 - 8831, XP002143988 *
SONG C ET AL.: "Molecular characterization of cytosolic phospholipase A2-beta.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 24, 11 June 1999 (1999-06-11), pages 17063 - 17067, XP002212884 *

Also Published As

Publication number Publication date
AU2002212318A1 (en) 2002-04-22
WO2002031162A2 (en) 2002-04-18

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