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WO2002036731A3 - Lipase acide lysosomiale de l'homme - Google Patents

Lipase acide lysosomiale de l'homme Download PDF

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Publication number
WO2002036731A3
WO2002036731A3 PCT/EP2001/012518 EP0112518W WO0236731A3 WO 2002036731 A3 WO2002036731 A3 WO 2002036731A3 EP 0112518 W EP0112518 W EP 0112518W WO 0236731 A3 WO0236731 A3 WO 0236731A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid lipase
lysosomal acid
human lysosomal
reagents
copd
Prior art date
Application number
PCT/EP2001/012518
Other languages
English (en)
Other versions
WO2002036731A2 (fr
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to AU2002226319A priority Critical patent/AU2002226319A1/en
Publication of WO2002036731A2 publication Critical patent/WO2002036731A2/fr
Publication of WO2002036731A3 publication Critical patent/WO2002036731A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des réactifs qui assurent la régulation de la lipase acide lysosomiale de l'homme et des réactifs qui se lient aux produits géniques de la lipase acide lysosomiale de l'homme . Ces réactifs peuvent permettre de prévenir, d'améliorer, ou de corriger des troubles ou des maladies comprenant, mais sans s'y limiter, le cancer, l'obésité, la broncho-pneumopathie chronique obstructive, le diabète les troubles du système nerveux central et périphérique et les troubles cardio-vasculaires.
PCT/EP2001/012518 2000-10-31 2001-10-30 Lipase acide lysosomiale de l'homme WO2002036731A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002226319A AU2002226319A1 (en) 2000-10-31 2001-10-30 Human lysosomal acid lipase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24417000P 2000-10-31 2000-10-31
US60/244,170 2000-10-31
US29351601P 2001-05-29 2001-05-29
US60/293,516 2001-05-29

Publications (2)

Publication Number Publication Date
WO2002036731A2 WO2002036731A2 (fr) 2002-05-10
WO2002036731A3 true WO2002036731A3 (fr) 2003-03-13

Family

ID=26936360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/012518 WO2002036731A2 (fr) 2000-10-31 2001-10-30 Lipase acide lysosomiale de l'homme

Country Status (2)

Country Link
AU (1) AU2002226319A1 (fr)
WO (1) WO2002036731A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1414963A2 (fr) * 2000-12-08 2004-05-06 Incyte Genomics, Inc. Molecules associees a des lipides
US6638738B2 (en) * 2001-03-20 2003-10-28 Applera Corporation Isolated human lipase proteins, nucleic acid molecules encoding human lipase proteins, and uses thereof
KR20140130443A (ko) * 2012-03-02 2014-11-10 시나게바 바이오파르마, 코포레이션 절두된 리소좀 산 리파제
WO2014000058A1 (fr) * 2012-06-29 2014-01-03 Garvan Institute Of Medical Research Méthode de traitement de troubles du métabolisme des sucres

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000077239A2 (fr) * 1999-06-14 2000-12-21 Millennium Pharmaceuticals, Inc. Nouveaux genes codant pour des proteines a des fins de diagnostic, de prevention, de therapie et autres
WO2001079446A2 (fr) * 2000-04-14 2001-10-25 Hyseq, Inc. Matieres et procedes relatifs au metabolisme lipidique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000077239A2 (fr) * 1999-06-14 2000-12-21 Millennium Pharmaceuticals, Inc. Nouveaux genes codant pour des proteines a des fins de diagnostic, de prevention, de therapie et autres
WO2001079446A2 (fr) * 2000-04-14 2001-10-25 Hyseq, Inc. Matieres et procedes relatifs au metabolisme lipidique

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANDERSON R ET AL: "Cloning and expression of cDNA encoding human lysosomal acid lipase/cholestreryl ester hydrolase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 266, no. 33, 25 November 1991 (1991-11-25), pages 22479 - 22484, XP002192752, ISSN: 0021-9258 *
DATABASE EMBL [online] 26 October 2000 (2000-10-26), NIH-MGC: "601780142F1 NCI_CGAP Mus musculus cDNA clone IMAGE:4008131 5', mRNA sequence", XP002213529, Database accession no. BF135102 *
ROUSSEL A ET AL: "Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 24, 11 June 1999 (1999-06-11), pages 16995 - 17002, XP002192751, ISSN: 0021-9258 *
SHERIFF S ET AL: "CHARACTERIZATION OF LYSOSOMAL ACID LIPASE BY SITE-DIRECTED MUTAGENESIS AND HETEROLOGOUS EXPRESSION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 270, no. 46, 17 November 1995 (1995-11-17), pages 27766 - 27772, XP000986290, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2002226319A1 (en) 2002-05-15
WO2002036731A2 (fr) 2002-05-10

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