+

WO2003014148A3 - Human fatty acid-coa ligase - Google Patents

Human fatty acid-coa ligase Download PDF

Info

Publication number
WO2003014148A3
WO2003014148A3 PCT/EP2002/008617 EP0208617W WO03014148A3 WO 2003014148 A3 WO2003014148 A3 WO 2003014148A3 EP 0208617 W EP0208617 W EP 0208617W WO 03014148 A3 WO03014148 A3 WO 03014148A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acid
coa ligase
human fatty
reagents
human
Prior art date
Application number
PCT/EP2002/008617
Other languages
French (fr)
Other versions
WO2003014148A2 (en
Inventor
Jiing-Ren Liou
Original Assignee
Bayer Ag
Jiing-Ren Liou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Jiing-Ren Liou filed Critical Bayer Ag
Priority to AU2002355343A priority Critical patent/AU2002355343A1/en
Publication of WO2003014148A2 publication Critical patent/WO2003014148A2/en
Publication of WO2003014148A3 publication Critical patent/WO2003014148A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01002—Butyrate-CoA ligase (6.2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01003—Long-chain-fatty-acid-CoA ligase (6.2.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents that regulate human fatty acid-CoA ligase and reagents which bind to human fatty acid-CoA ligase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity, diabetes or cardiovascular disorder.
PCT/EP2002/008617 2001-08-06 2002-08-02 Human fatty acid-coa ligase WO2003014148A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002355343A AU2002355343A1 (en) 2001-08-06 2002-08-02 Human fatty acid-coa ligase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30979401P 2001-08-06 2001-08-06
US60/309,794 2001-08-06

Publications (2)

Publication Number Publication Date
WO2003014148A2 WO2003014148A2 (en) 2003-02-20
WO2003014148A3 true WO2003014148A3 (en) 2003-08-28

Family

ID=23199696

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008617 WO2003014148A2 (en) 2001-08-06 2002-08-02 Human fatty acid-coa ligase

Country Status (2)

Country Link
AU (1) AU2002355343A1 (en)
WO (1) WO2003014148A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1456400A4 (en) * 2001-12-19 2005-09-14 Exelixis Inc Modulating insulin receptor signaling through targeting facl

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 4 December 1997 (1997-12-04), HILLIER L ET AL.: "zj66f12.s1 Soares fetal liver spleen 1NFLS S1 Homo sapiens cDNA clone 455279 3' similar to TR:G666014 G666014 SA SA GENE PRODUCT, COMPLETE CDS PRECURSOR", XP002230354, Database accession no. AA677577 *
DATABASE EMBL [online] 7 September 2001 (2001-09-07), FUJINO T ET AL.: "Homo sapiens MACS mRNA for medium-chain acyl-CoA synthetase, complete cds.", XP002230355, Database accession no. AB059429 *
FUJINO T ET AL: "MOLECULAR IDENTIFICATION AND CHARACTERIZATION OF TWO MEDIUM-CHAIN ACYL-COA SYNTHETHASES, MACS1 AND THE SA GENE PRODUCT", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 38, 24 July 2001 (2001-07-24), pages 35961 - 35966, XP001094129, ISSN: 0021-9258 *
FUJIWARA K ET AL: "Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 3 AUG 2001, vol. 276, no. 31, 3 August 2001 (2001-08-03), pages 28819 - 28823, XP002230353, ISSN: 0021-9258 *
IWAI N ET AL.: "Human SA gene locus as a candidate locus for essential hypertension", HYPERTENSION, vol. 23, no. 3, March 1994 (1994-03-01), pages 375 - 380, XP001097389 *
VESSEY D A ET AL: "Isolation and sequencing of cDNAs for the XL-I and XL-III forms of bovine liver xenobiotic-metabolizing medium-chain fatty acid:CoA ligase.", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. UNITED STATES 2000, vol. 14, no. 1, 2000, pages 11 - 19, XP009005546, ISSN: 1095-6670 *

Also Published As

Publication number Publication date
AU2002355343A1 (en) 2003-02-24
WO2003014148A2 (en) 2003-02-20

Similar Documents

Publication Publication Date Title
WO2002059621A3 (en) Regulation of transthyretin to treat obesity
WO2002020731A3 (en) Regulation of human protein disulfide isomerase-like enzyme
WO2002061092A3 (en) Regulation of human lysyl oxidase
WO2002070675A3 (en) Regulation of human histone acetyltransferase
WO2003014148A3 (en) Human fatty acid-coa ligase
WO2002036731A3 (en) Human lysosomal acid lipase
WO2002055712A3 (en) Regulation of human alanine aminotransferase
WO2002032938A3 (en) Regulation of human pgc-1-like protein
WO2004031375A3 (en) Regulation of human 3’, 5’ cyclic nucleotide phosphodiesterase pde1c
WO2002000855A3 (en) Regulation of human s-acyl fatty acid synthase thioesterase-like enzyme
WO2002099106A3 (en) Regulation of human secretin -type gpcr
WO2004009803A3 (en) Regulation of human hepsin
WO2002062974A3 (en) Regulation of human elongase hselo1-like protein
WO2002051989A3 (en) Human 4-nitrophenylphosphatase
WO2003052088A3 (en) Regulation of human sialyltransferase
EP1700921A3 (en) Regulation of a human asparagine-hydroxylase
WO2002081705A3 (en) Regulation of human gnat acetyltransferase-like protein
WO2002046403A3 (en) Regulation of human patched-like protein
WO2002062975A3 (en) Regulation of human elongase hselo1-like protein
WO2002072825A3 (en) Human mrp5-like protein
WO2002055710A3 (en) Regulation of human purple acid phosphatase
WO2003000725A3 (en) Regulation of human lipoate-protein ligase b-like enzyme
WO2003052087A3 (en) Regulation of human short chain dehydrogenase/-reductase
WO2003025162A3 (en) Regulation of human prolyl 4-hydroxylase alpha subunit precursor
WO2002088363A3 (en) Regulation of novel human prolyl 4-hydroxylases

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VN YU ZA ZM

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载