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WO2002004610A3 - Regulation d'une enzyme humaine du type dipeptidyl-peptidase iv - Google Patents

Regulation d'une enzyme humaine du type dipeptidyl-peptidase iv Download PDF

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Publication number
WO2002004610A3
WO2002004610A3 PCT/EP2001/007730 EP0107730W WO0204610A3 WO 2002004610 A3 WO2002004610 A3 WO 2002004610A3 EP 0107730 W EP0107730 W EP 0107730W WO 0204610 A3 WO0204610 A3 WO 0204610A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidase
enzyme
human dipeptidyl
regulation
reagents
Prior art date
Application number
PCT/EP2001/007730
Other languages
English (en)
Other versions
WO2002004610A2 (fr
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to AU2001269123A priority Critical patent/AU2001269123A1/en
Publication of WO2002004610A2 publication Critical patent/WO2002004610A2/fr
Publication of WO2002004610A3 publication Critical patent/WO2002004610A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Selon l'invention, les réactifs permettant de réguler une enzyme humaine du type dipeptidyl-peptidase IV et les réactifs se liant à des produits géniques de l'enzyme humaine dipeptidyl-peptidase IV peuvent jouer un rôle dans la prévention, l'amélioration ou la correction de dysfonctionnements ou de maladies, notamment, mais pas exclusivement, les tumeurs et les troubles des systèmes nerveux périphérique et central, tels que la douleur et les troubles neurodégénératifs.
PCT/EP2001/007730 2000-07-10 2001-07-06 Regulation d'une enzyme humaine du type dipeptidyl-peptidase iv WO2002004610A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001269123A AU2001269123A1 (en) 2000-07-10 2001-07-06 Regulation of human dipeptidyl-peptidase iv-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21707500P 2000-07-10 2000-07-10
US60/217,075 2000-07-10

Publications (2)

Publication Number Publication Date
WO2002004610A2 WO2002004610A2 (fr) 2002-01-17
WO2002004610A3 true WO2002004610A3 (fr) 2002-07-11

Family

ID=22809580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007730 WO2002004610A2 (fr) 2000-07-10 2001-07-06 Regulation d'une enzyme humaine du type dipeptidyl-peptidase iv

Country Status (2)

Country Link
AU (1) AU2001269123A1 (fr)
WO (1) WO2002004610A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470700B2 (en) 2003-08-13 2008-12-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7550590B2 (en) 2003-03-25 2009-06-23 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7897633B2 (en) 2004-02-05 2011-03-01 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8906901B2 (en) 2005-09-14 2014-12-09 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100863624B1 (ko) 2001-05-11 2008-10-15 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 Ｃｄ26을 발현하는 세포와 연관된 질환의 치료제로사용되는 항-ｃｄ26 단클론항체
DE10150203A1 (de) 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
EP1528931B1 (fr) 2002-08-09 2008-05-07 Prosidion Ltd. Inhibiteurs de la dipeptidyl peptidase iv pour diminuer la prise de poids chronique
EA009291B1 (ru) 2003-05-05 2007-12-28 Пробиодруг Аг Применение эффекторов глутаминил- и глутаматциклаз
KR20110059664A (ko) 2003-05-05 2011-06-02 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
EP1625122A1 (fr) 2003-05-14 2006-02-15 Takeda San Diego, Inc. Inhibiteurs de dipeptidyl peptidase
BRPI0415409A (pt) 2003-10-15 2006-12-05 Probiodrug Ag uso de efetuadores de ciclases de glutaminila e glutamato
EP1680120A2 (fr) 2003-11-03 2006-07-19 Probiodrug AG Combinaisons utiles au traitement de troubles neuronaux
JP5122462B2 (ja) 2005-09-16 2013-01-16 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
EP1971614A1 (fr) 2005-11-14 2008-09-24 Probiodrug AG Derives de pyrrolidine a fusion de cyclopropyle, en tant qu'inhibiteurs de dipeptidyle peptidase iv (dp iv)
WO2007112347A1 (fr) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Inhibiteurs de la dipeptidyl peptidase
BRPI0709984A2 (pt) 2006-04-12 2011-08-02 Probiodrug Ag inibidores de enzima
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CUNNINGHAM D F ET AL: "Proline specific peptidases", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1343, no. 2, 5 December 1997 (1997-12-05), pages 160 - 186, XP004278373, ISSN: 0167-4838 *
DATABASE EMBL 1 November 1995 (1995-11-01), YOKOTANI,N., DOI,K., WENTHOLD,R.J., WADA,K.,: "DIPEPTIDYL PEPTIDASE IV LIKE PROTEIN (DIPEPTIDYL AMINOPEPTIDASE- RELATED PROTEIN)(DIPEPTIDYLPEPTIDASE VI) (DPPX).", XP002193823 *
DATABASE EMBL 23 May 2000 (2000-05-23), OHARA O., NAGASE T., KIKUNO R.: "Homo sapiens mRNA for KIAA1492 protein, partial cds.", XP002193822 *
DATABASE EMBL 25 May 1995 (1995-05-25), HILLIER L. ET AL.: "yg99h11.r1 Soares infant brain 1NIB Homo sapiens cDNA clone IMAGE:41862 5'", XP002193821 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XVII. THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 7, no. 6, 2000, pages 143 - 150, XP000943428, ISSN: 1340-2838 *
YOKOTANI N ET AL: "NON-CONSERVATION OF A CATALYTIC RESIDUE IN A DIPEPTIDYL AMINOPEPTIDASE IV-RELATED PROTEIN ENCODED BY A GENE ON HUMAN CHROMOSOME 7", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 2, no. 7, July 1993 (1993-07-01), pages 1037 - 1039, XP001026522, ISSN: 0964-6906 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550590B2 (en) 2003-03-25 2009-06-23 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7470700B2 (en) 2003-08-13 2008-12-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7579357B2 (en) 2003-08-13 2009-08-25 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7897633B2 (en) 2004-02-05 2011-03-01 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8906901B2 (en) 2005-09-14 2014-12-09 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors

Also Published As

Publication number Publication date
WO2002004610A2 (fr) 2002-01-17
AU2001269123A1 (en) 2002-01-21

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