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WO2008150001A1 - アディポクラスタ－ - Google Patents

アディポクラスタ－ Download PDF

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Publication number
WO2008150001A1
WO2008150001A1 PCT/JP2008/060501 JP2008060501W WO2008150001A1 WO 2008150001 A1 WO2008150001 A1 WO 2008150001A1 JP 2008060501 W JP2008060501 W JP 2008060501W WO 2008150001 A1 WO2008150001 A1 WO 2008150001A1
Authority
WO
WIPO (PCT)
Prior art keywords
cell
adipose tissue
preparation
neural stem
stem cell
Prior art date
Application number
PCT/JP2008/060501
Other languages
English (en)
French (fr)
Inventor
Takashi Nagase
Toshiyuki Kikuchi
Yuko Fujita
Shoko Murase
Original Assignee
Biomaster, Inc.
National Hospital Organization
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomaster, Inc., National Hospital Organization filed Critical Biomaster, Inc.
Priority to JP2009517921A priority Critical patent/JP5388297B2/ja
Publication of WO2008150001A1 publication Critical patent/WO2008150001A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

神経幹細胞調製物を調製するにおいて、クローン性の要件が必要かどうかについて検討することが課題のひとつであり、そして、神経幹細胞を簡便に調製する方法を提供することもまた課題のひとつである。本発明は、Musashi陽性脂肪組織由来細胞含有細胞の生産方法であって、脂肪組織由来細胞を提供する工程；および該脂肪組織由来細胞を、アグリゲーションが生じるに十分な期間浮遊培養する工程を包含する、方法を提供することによって上記課題を解決した。
PCT/JP2008/060501 2007-06-08 2008-06-06 アディポクラスタ－ WO2008150001A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009517921A JP5388297B2 (ja) 2007-06-08 2008-06-06 アディポクラスター

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-153424 2007-06-08
JP2007153424 2007-06-08

Publications (1)

Publication Number Publication Date
WO2008150001A1 true WO2008150001A1 (ja) 2008-12-11

Family

ID=40093805

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060501 WO2008150001A1 (ja) 2007-06-08 2008-06-06 アディポクラスタ－

Country Status (2)

Country Link
JP (1) JP5388297B2 (ja)
WO (1) WO2008150001A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015033558A1 (ja) * 2013-09-04 2015-03-12 株式会社大塚製薬工場 多能性幹細胞の調製方法
JP2015511487A (ja) * 2012-03-13 2015-04-20 インスティテュート オブ ジェネティックス アンド ディベロップメンタル バイオロジー，チャイニーズ アカデミー オブ サイエンシズ ３次元培養による細胞の再プログラミング
WO2016013352A1 (ja) * 2014-07-23 2016-01-28 学校法人日本大学 脱分化脂肪細胞の製造方法
JP2019503474A (ja) * 2015-11-06 2019-02-07 ヴェンタナ メディカル システムズ， インク． 代表診断法
CN115501393A (zh) * 2022-09-21 2022-12-23 中国人民解放军总医院第一医学中心 用于修复神经缺损的水凝胶及其制备方法和用途
CN115697347A (zh) * 2020-07-08 2023-02-03 北京荣祥再生医学研究所有限公司 一种调节musashi1在细胞中表达水平的方法
WO2023159019A1 (en) * 2022-02-15 2023-08-24 The General Hospital Corporation Neural progenitor cell compositions and methods of using the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537849A (ja) * 1999-03-10 2002-11-12 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 脂肪由来の幹細胞および格子
WO2003008592A1 (fr) * 2001-07-19 2003-01-30 Yasuhiko Tabata Cellules embryonnaires polyfonctionnelles provenant de tissus adipeux
WO2003045137A1 (fr) * 2001-11-29 2003-06-05 Japan Science And Technology Agency Procede de construction d'un modele simien de lesion spinale et son utilisation
WO2008018190A1 (fr) * 2006-08-09 2008-02-14 Biomaster, Inc. Cellules de la crête neurale dérivées de tissu adipeux

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537849A (ja) * 1999-03-10 2002-11-12 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 脂肪由来の幹細胞および格子
WO2003008592A1 (fr) * 2001-07-19 2003-01-30 Yasuhiko Tabata Cellules embryonnaires polyfonctionnelles provenant de tissus adipeux
WO2003045137A1 (fr) * 2001-11-29 2003-06-05 Japan Science And Technology Agency Procede de construction d'un modele simien de lesion spinale et son utilisation
WO2008018190A1 (fr) * 2006-08-09 2008-02-14 Biomaster, Inc. Cellules de la crête neurale dérivées de tissu adipeux

Non-Patent Citations (16)

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Title
BUNNELL B.A. ET AL.: "Common transcriptional gene profile in neurospheres-derived from pATSCs, pBMSCs, and pNSCs", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 343, 2006, pages 762 - 771, XP024924774 *
CRANE J.F. AND TRAINOR P.A.: "Neural crest stem and progenitor cells", ANN. REV. CELL DEVELOP. BIOL., vol. 22, 2006, pages 267 - 286 *
DICKER A. ET AL.: "Functional studies of mesenchymal stem cells derived from adult human adipose tissue", EXP. CELL RES., vol. 308, 2005, pages 283 - 290, XP004997316 *
FERNANDES K.J.L. ET AL.: "A dermal niche for multipotent adult skin-derived precursor cells", NATURE CELL BIOL., vol. 6, no. 11, November 2004 (2004-11-01), pages 1082 - 1093, XP002494290 *
HARRISON J. ET AL.: "Colonization and maintenance of murine embryonic stem cells on poly (alpha-hydroxy esters)", BIOMATERIALS, vol. 25, 2004, pages 4963 - 4970, XP004504183 *
KANG S.K. ET AL.: "Neurogenesis of Rhesus adipose stromal cells", J. CELL SCI., vol. 117, no. 18, 2004, pages 4289 - 4299 *
KOIKE M. ET AL.: "A round-bottom 96-well polystyrene plate coated with 2-methacryloyloxyethyl phosphorylcholine as an effective tool for embryoid body formation", CYTOTECHNOLOGY, vol. 47, 2005, pages 3 - 10, XP019236867 *
NAGASE T. ET AL.: "Adipocluster: Mouse, Rat Hikashibo karano Jinsoku na Shinkei Zenkusaibo Kaishuho no Kaihatsu", DAI 16 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM.YOKOSHU, October 2007 (2007-10-01), pages 96 *
NAGASE T. ET AL.: "Hito Shibo Soshiki Yurai neurosphere Saibo no Mouse Hai eno Ishoku no Kokoromi", DAI 15 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM.YOKOSHU, December 2006 (2006-12-01), pages 108 *
NAGASE T. ET AL.: "Neurospheres from human adipose tissue transplanted into cultured mouse embryos can contribute to craniofacial morphogenesis: A preliminary report", J. CRANIOFACIAL SURGERY, vol. 18, no. 1, January 2007 (2007-01-01), pages 49 - 53, XP003020988 *
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NING H. ET AL.: "Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells", DIFFERENTIATION, vol. 74, 2006, pages 510 - 518, XP026770202, DOI: doi:10.1111/j.1432-0436.2006.00081.x *
SCHAUB G.A. ET AL.: "Hydrophobic attachment of trypanosoma cruzi to the rectal cuticle of Triatoma infestans and its influence on methacyclogenesis-A review", TOKAI J. EXP. CLIN. MED., vol. 23, no. 6, 1999, pages 321 - 327 *
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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015511487A (ja) * 2012-03-13 2015-04-20 インスティテュート オブ ジェネティックス アンド ディベロップメンタル バイオロジー，チャイニーズ アカデミー オブ サイエンシズ ３次元培養による細胞の再プログラミング
US9650602B2 (en) 2012-03-13 2017-05-16 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences Reprogramming cells by three-dimensional cultivation
US11155782B2 (en) 2013-09-04 2021-10-26 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
JPWO2015033558A1 (ja) * 2013-09-04 2017-03-02 株式会社大塚製薬工場 多能性幹細胞の調製方法
US9765296B2 (en) 2013-09-04 2017-09-19 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
JP2018023401A (ja) * 2013-09-04 2018-02-15 株式会社大塚製薬工場 多能性幹細胞の調製方法
WO2015033558A1 (ja) * 2013-09-04 2015-03-12 株式会社大塚製薬工場 多能性幹細胞の調製方法
US10370639B2 (en) 2013-09-04 2019-08-06 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
WO2016013352A1 (ja) * 2014-07-23 2016-01-28 学校法人日本大学 脱分化脂肪細胞の製造方法
JP5991687B2 (ja) * 2014-07-23 2016-09-14 学校法人日本大学 脱分化脂肪細胞の製造方法
JP2019503474A (ja) * 2015-11-06 2019-02-07 ヴェンタナ メディカル システムズ， インク． 代表診断法
JP7094880B2 (ja) 2015-11-06 2022-07-04 ヴェンタナ メディカル システムズ， インク． 代表診断法
US11959838B2 (en) 2015-11-06 2024-04-16 Ventana Medical Systems, Inc. Representative diagnostics
CN115697347A (zh) * 2020-07-08 2023-02-03 北京荣祥再生医学研究所有限公司 一种调节musashi1在细胞中表达水平的方法
CN115697347B (zh) * 2020-07-08 2024-04-19 北京荣祥再生医学研究所有限公司 一种调节musashi1在细胞中表达水平的方法
WO2023159019A1 (en) * 2022-02-15 2023-08-24 The General Hospital Corporation Neural progenitor cell compositions and methods of using the same
CN115501393A (zh) * 2022-09-21 2022-12-23 中国人民解放军总医院第一医学中心 用于修复神经缺损的水凝胶及其制备方法和用途
CN115501393B (zh) * 2022-09-21 2023-10-24 中国人民解放军总医院第一医学中心 用于修复神经缺损的水凝胶及其制备方法和用途

Also Published As

Publication number Publication date
JPWO2008150001A1 (ja) 2010-08-26
JP5388297B2 (ja) 2014-01-15

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