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WO2006010489A3 - Diagnostic et traitement de maladies associees a la proteine chkl - Google Patents

Diagnostic et traitement de maladies associees a la proteine chkl Download PDF

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Publication number
WO2006010489A3
WO2006010489A3 PCT/EP2005/007698 EP2005007698W WO2006010489A3 WO 2006010489 A3 WO2006010489 A3 WO 2006010489A3 EP 2005007698 W EP2005007698 W EP 2005007698W WO 2006010489 A3 WO2006010489 A3 WO 2006010489A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
chkl
therapeutics
diagnostics
protein
Prior art date
Application number
PCT/EP2005/007698
Other languages
English (en)
Other versions
WO2006010489A2 (fr
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2006010489A2 publication Critical patent/WO2006010489A2/fr
Publication of WO2006010489A3 publication Critical patent/WO2006010489A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne une protéine humaine CHKL (choline kinase like) associée à des infections, des maladies cardiovasculaires, au cancer, des maladies endocrinologiques, des maladies métaboliques, des maladies gastroentérologiques, à l'inflammation, des maladies hématologiques, des maladies respiratoires, des maladies musculosquelettiques, des maladies neurologiques, des maladies urologiques. L'invention concerne des essais conçus pour l'identification de composés utiles pour le traitement ou la prévention d'infections, des maladies cardiovasculaires, du cancer, des maladies endocrinologiques, des maladies métabolique, des maladies gastroentérologiques, de l'inflammation, des maladies hématologiques, des maladies respiratoires, des maladies musculosquelettiques, des maladies neurologiques, des maladies urologiques. L'invention concerne également des composés qui se lient à l'activité de CHKL et/ou qui activent ou inhibent l'activité de CHKL ainsi que des compositions pharmaceutiques comprenant ces composés.
PCT/EP2005/007698 2004-07-28 2005-07-15 Diagnostic et traitement de maladies associees a la proteine chkl WO2006010489A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04017826 2004-07-28
EP04017826.1 2004-07-28

Publications (2)

Publication Number Publication Date
WO2006010489A2 WO2006010489A2 (fr) 2006-02-02
WO2006010489A3 true WO2006010489A3 (fr) 2006-04-27

Family

ID=35429497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/007698 WO2006010489A2 (fr) 2004-07-28 2005-07-15 Diagnostic et traitement de maladies associees a la proteine chkl

Country Status (1)

Country Link
WO (1) WO2006010489A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001924A1 (fr) * 1977-11-02 1979-05-16 Massachusetts Institute Of Technology Composition pharmaceutique pour l'administration de choline
WO2003023001A2 (fr) * 2001-09-07 2003-03-20 Curagen Corporation Nouvelles proteines et acides nucleiques codant ces proteines
US20030186241A1 (en) * 2002-03-20 2003-10-02 Ken-Shwo Dai Human choline/ethanolamine kinase (HCEK)-related gene variant associated with lung cancers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001924A1 (fr) * 1977-11-02 1979-05-16 Massachusetts Institute Of Technology Composition pharmaceutique pour l'administration de choline
WO2003023001A2 (fr) * 2001-09-07 2003-03-20 Curagen Corporation Nouvelles proteines et acides nucleiques codant ces proteines
US20030186241A1 (en) * 2002-03-20 2003-10-02 Ken-Shwo Dai Human choline/ethanolamine kinase (HCEK)-related gene variant associated with lung cancers

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HERNANDEZ-ALCOCEBA RUBEN ET AL: "In vivo antitumor activity of choline kinase inhibitors: A novel target for anticancer drug discovery", CANCER RESEARCH, vol. 59, no. 13, 1 July 1999 (1999-07-01), pages 3112 - 3118, XP002357883, ISSN: 0008-5472 *
RAMÍREZ DE MOLINA A ET AL: "OVEREXPRESSION OF CHOLINE KINASE IS A FREQUENT FEATURE IN HUMAN TUMOR-DERIVED CELL LINES AND IN LUNG, PROSTATE, AND COLORECTAL HUMAN CANCERS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 296, no. 3, 23 August 2002 (2002-08-23), pages 580 - 583, XP001182226, ISSN: 0006-291X *
SHACKEL NICHOLAS A ET AL: "Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization.", HEPATOLOGY, vol. 38, no. 3, September 2003 (2003-09-01), pages 577 - 588, XP002357884, ISSN: 0270-9139 *
TANAKA A ET AL: "GENOMIC ANALYSIS OF DIFFERENTIALLY EXPRESSED GENES IN LIVER AND BILIARY EPITHELIAL CELLS OF PATIENTS WITH PRIMARY BILIARY CIRRHOSIS", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 17, no. 1, August 2001 (2001-08-01), pages 89 - 98, XP001154074, ISSN: 0896-8411 *

Also Published As

Publication number Publication date
WO2006010489A2 (fr) 2006-02-02

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