WO2006005470A3 - Agents diagnostiques et therapeutiques pour des maladies associees au recepteur couple a la proteine g lie au mas (mrge) - Google Patents
Agents diagnostiques et therapeutiques pour des maladies associees au recepteur couple a la proteine g lie au mas (mrge) Download PDFInfo
- Publication number
- WO2006005470A3 WO2006005470A3 PCT/EP2005/007176 EP2005007176W WO2006005470A3 WO 2006005470 A3 WO2006005470 A3 WO 2006005470A3 EP 2005007176 W EP2005007176 W EP 2005007176W WO 2006005470 A3 WO2006005470 A3 WO 2006005470A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diseases
- mrge
- therapeutics
- diagnostics
- diseases associated
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 5
- 101150041973 Mrgpre gene Proteins 0.000 title abstract 3
- 102000018299 Mas-related G protein-coupled receptor E Human genes 0.000 title 1
- 108050007407 Mas-related G protein-coupled receptor E Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 208000012931 Urologic disease Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 208000014951 hematologic disease Diseases 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 208000030159 metabolic disease Diseases 0.000 abstract 2
- 210000003205 muscle Anatomy 0.000 abstract 2
- 208000023504 respiratory system disease Diseases 0.000 abstract 2
- 208000014001 urinary system disease Diseases 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention a trait à un MrgE humain associé aux maladies cardio-vasculaires, aux maladies respiratoires, aux maladies gastro-entérologiques, au cancer, aux maladies métaboliques, à l'inflammation, aux maladies hématologiques, aux maladies du squelette musculaire, aux maladies neurologiques et aux maladies urologiques. L'invention a également trait à des dosages pour l'identification de composés utiles dans le traitement ou la prévention de maladies cardio-vasculaires, de maladies respiratoires, de maladies gastro-entérologiques, du cancer, de maladies métaboliques, de l'inflammation, de maladies hématologiques, de maladies du squelette musculaire, de maladies neurologiques et de maladies urologiques. L'invention a trait en outre à des composés de liaison et/ou d'activation ou d'inhibition de l'activité du MrgE ainsi qu'à des compositions pharmaceutiques comportant de tels composés.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04016641.5 | 2004-07-15 | ||
| EP04016641 | 2004-07-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2006005470A2 WO2006005470A2 (fr) | 2006-01-19 |
| WO2006005470A3 true WO2006005470A3 (fr) | 2006-07-20 |
Family
ID=35106893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2005/007176 WO2006005470A2 (fr) | 2004-07-15 | 2005-07-02 | Agents diagnostiques et therapeutiques pour des maladies associees au recepteur couple a la proteine g lie au mas (mrge) |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2006005470A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0502497A (pt) * | 2005-06-28 | 2007-02-06 | Univ Minas Gerais | uso de agonistas e antagonistas do receptor acoplado a proteìna g, mas, como moduladores de atividade apoptótica para o estudo, a prevenção e o tratamento de doenças |
| GB0819446D0 (en) * | 2008-10-23 | 2008-12-03 | Univ Hull | Treatment of inflammatory disorders |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001048015A2 (fr) * | 1999-12-28 | 2001-07-05 | Pharmacia & Upjohn Company | Nouveaux recepteurs couples a une proteine g |
| WO2001062797A2 (fr) * | 2000-02-23 | 2001-08-30 | Pharmacia & Upjohn Company | Nouveaux recepteurs couples a la proteine g |
| WO2001083555A2 (fr) * | 2000-05-04 | 2001-11-08 | California Institute Of Technology | Molecules de signalisation de la douleur |
| US20030162252A1 (en) * | 2000-06-30 | 2003-08-28 | Masanori Miwa | Novel g protein-coupled receptor protein and dna thereof |
-
2005
- 2005-07-02 WO PCT/EP2005/007176 patent/WO2006005470A2/fr active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001048015A2 (fr) * | 1999-12-28 | 2001-07-05 | Pharmacia & Upjohn Company | Nouveaux recepteurs couples a une proteine g |
| WO2001062797A2 (fr) * | 2000-02-23 | 2001-08-30 | Pharmacia & Upjohn Company | Nouveaux recepteurs couples a la proteine g |
| WO2001083555A2 (fr) * | 2000-05-04 | 2001-11-08 | California Institute Of Technology | Molecules de signalisation de la douleur |
| US20030162252A1 (en) * | 2000-06-30 | 2003-08-28 | Masanori Miwa | Novel g protein-coupled receptor protein and dna thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006005470A2 (fr) | 2006-01-19 |
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