WO2006013014A3 - Diagnostics et therapeutiques pour maladies liees a une proteine similaire a un antigene membranaire specifique de la prostate (psmal) - Google Patents
Diagnostics et therapeutiques pour maladies liees a une proteine similaire a un antigene membranaire specifique de la prostate (psmal) Download PDFInfo
- Publication number
- WO2006013014A3 WO2006013014A3 PCT/EP2005/007953 EP2005007953W WO2006013014A3 WO 2006013014 A3 WO2006013014 A3 WO 2006013014A3 EP 2005007953 W EP2005007953 W EP 2005007953W WO 2006013014 A3 WO2006013014 A3 WO 2006013014A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diseases
- psmal
- therapeutics
- diagnostics
- prostate
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 7
- 101000931359 Homo sapiens Putative N-acetylated-alpha-linked acidic dipeptidase Proteins 0.000 title abstract 3
- 102100020995 Putative N-acetylated-alpha-linked acidic dipeptidase Human genes 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 208000012931 Urologic disease Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000002124 endocrine Effects 0.000 abstract 2
- 208000014951 hematologic disease Diseases 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 208000030159 metabolic disease Diseases 0.000 abstract 2
- 210000003205 muscle Anatomy 0.000 abstract 2
- 208000023504 respiratory system disease Diseases 0.000 abstract 2
- 208000014001 urinary system disease Diseases 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention concerne une protéine similaire à un antigène membranaire spécifique de la prostate (PSMAL) humaine associée aux maladies cardio-vasculaires, au cancer, aux maladies endocriniennes, aux maladies du métabolisme, aux maladies gastroentérologiques, aux inflammations, aux maladies hématologiques, aux maladies respiratoires, aux maladies du squelette et des muscles, aux maladies neurologiques, aux maladies urologiques. Cette invention a aussi pour objet des dosages destinés à l'identification de composés utilisés dans le traitement ou la prévention de maladies cardio-vasculaires, de cancer, de maladies endocriniennes, de maladies du métabolisme, de maladies gastroentérologiques, d'inflammations, de maladies hématologiques, de maladies respiratoires, de maladies du squelette et des muscles, de maladies neurologiques, de maladies urologiques. Ladite invention a également trait à des composés qui se lient et/ou activent ou inhibent l'activité de PSMAL, ainsi que des compositions pharmaceutiques contenant de tels composés.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04018441.8 | 2004-08-04 | ||
| EP04018441 | 2004-08-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2006013014A2 WO2006013014A2 (fr) | 2006-02-09 |
| WO2006013014A3 true WO2006013014A3 (fr) | 2006-03-30 |
Family
ID=35344658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2005/007953 WO2006013014A2 (fr) | 2004-08-04 | 2005-07-21 | Diagnostics et therapeutiques pour maladies liees a une proteine similaire a un antigene membranaire specifique de la prostate (psmal) |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2006013014A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1448588A4 (fr) | 2001-10-23 | 2006-10-25 | Psma Dev Company L L C | Anticorps et multimeres de proteines psma |
| US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061605A1 (fr) * | 1999-04-09 | 2000-10-19 | Sloan-Kettering Institute For Cancer Research | Adn codant pour le gene de type antigene membranaire specifique de la prostate et utilisations de celui-ci |
-
2005
- 2005-07-21 WO PCT/EP2005/007953 patent/WO2006013014A2/fr active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061605A1 (fr) * | 1999-04-09 | 2000-10-19 | Sloan-Kettering Institute For Cancer Research | Adn codant pour le gene de type antigene membranaire specifique de la prostate et utilisations de celui-ci |
Non-Patent Citations (6)
| Title |
|---|
| BZDEGA TOMASZ ET AL: "The cloning and characterization of a second brain enzyme with NAAG peptidase activity", JOURNAL OF NEUROCHEMISTRY, vol. 89, no. 3, May 2004 (2004-05-01), pages 627 - 635, XP002355349, ISSN: 0022-3042 * |
| O'KEEFE D S ET AL: "CLONING AND CHARACTERIZATION OF THE PROSTATE-SPECIFIC MEMBRANE ANTIGEN-LIKE GENE", PROCEEDINGS OF THE 91ST ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. SAN FRANCISCO, CA, APRIL 1 - 5, 2000, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA : AACR, US, vol. VOL. 41, March 2000 (2000-03-01), pages 39, XP001147719 * |
| O'KEEFE D S ET AL: "COMPARATIVE ANALYSIS OF PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) VERSUS A PROSTATE-SPECIFIC MEMBRANE ANTIGEN-LIKE GENE", PROSTATE, WILEY-LISS, NEW YORK, NY, US, vol. 58, no. 2, 1 February 2004 (2004-02-01), pages 200 - 210, XP009056468, ISSN: 0270-4137 * |
| O'KEEFE D S ET AL: "COMPARATIVE ANALYSIS OF THE PSMA AND PSMA-LIKE GENES YIELDS SOME SURPRISING INSIGHTS", PROCEEDINGS OF THE 91ST ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. SAN FRANCISCO, CA, APRIL 1 - 5, 2000, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA : AACR, US, vol. VOL. 41, March 2000 (2000-03-01), pages 393, XP001147721 * |
| SMITH M W ET AL: "Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 63, 15 February 2003 (2003-02-15), pages 859 - 864, XP002978060, ISSN: 0008-5472 * |
| TSAI S J: "Strategies to increase central N-acetyl aspartylglutamate: A potential treatment for schizophrenia and bipolar disorders", SCHIZOPHRENIA RESEARCH, ELSEVIER, vol. 76, no. 2-3, 15 July 2005 (2005-07-15), pages 359 - 360, XP004931653, ISSN: 0920-9964 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006013014A2 (fr) | 2006-02-09 |
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