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WO2018186108A1 - Dispositif de mesure d'informations biologiques - Google Patents

Dispositif de mesure d'informations biologiques Download PDF

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Publication number
WO2018186108A1
WO2018186108A1 PCT/JP2018/009370 JP2018009370W WO2018186108A1 WO 2018186108 A1 WO2018186108 A1 WO 2018186108A1 JP 2018009370 W JP2018009370 W JP 2018009370W WO 2018186108 A1 WO2018186108 A1 WO 2018186108A1
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WO
WIPO (PCT)
Prior art keywords
light
pulse wave
measurement
volume pulse
signal
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PCT/JP2018/009370
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English (en)
Japanese (ja)
Inventor
添田　薫
良 下北
Original Assignee
アルプス電気株式会社
ジーニアルライト株式会社
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Application filed by アルプス電気株式会社, ジーニアルライト株式会社 filed Critical アルプス電気株式会社
Publication of WO2018186108A1 publication Critical patent/WO2018186108A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow

Definitions

  • the present invention relates to a living body related information measuring apparatus and a sensor mounting unit for estimating living body related information of a subject, particularly information related to a volume pulse wave.
  • the living body related information measuring device described in Patent Document 1 is a living body related information measuring device that is worn on a user's body and measures the user's biological information, and detects the user's pulse wave and outputs a pulse wave signal.
  • a pulse wave detection unit that detects a user's body motion and outputs a body motion signal
  • a state evaluation unit that evaluates the degree of stability of the user's motion state based on the body motion signal
  • a state evaluation A detection interval setting unit that sets a pulse wave detection interval based on the evaluation result of the unit.
  • an apparatus biologically related information measurement apparatus that estimates information on the volume pulse wave of a subject using return light obtained by irradiating the subject with light, such as disclosed in Patent Document 1
  • a blood vessel If the return light that has been transmitted through and reflected from the blood vessel can be received as it is, the information on the change in blood flow that flows through the blood vessel can be returned and accurately captured as the change in the amount of light. it can.
  • the change in the amount of return light detected by the light receiving element due to various factors has information other than the change in blood flow.
  • the return light received by the light receiving element is converted into an electric signal by the photoelectric conversion element, and a process for generating a signal related to the volume pulse wave from the electric signal or a signal based on the electric signal is performed. Also in the processing of the electrical signal after the photoelectric conversion, various disturbance signals may be superimposed, and when such a disturbance signal is superimposed, the reliability of information regarding the finally estimated volume pulse wave is lowered.
  • the present invention has an object to provide a living body related information measuring apparatus that has a light emitting element and a light receiving element and estimates a volume pulse wave based on a light reception result.
  • the present invention provided to solve the above-described problems is a light-emitting element that emits measurement light having a predetermined wavelength, a light-receiving element that receives return light through the subject, and the light-receiving element.
  • a volume pulse wave measurement unit that estimates a volume pulse wave of blood flowing through the blood vessel of the subject based on a light reception result by the element, and causes the measurement light to be emitted in a pulse form from the light emitting element at each time of a predetermined time interval
  • a pulse wave composed of a determination unit that determines that the light received by the element is the return light of the measurement light, and an electric signal based on the light that is determined by the determination unit to be the return light of the measurement light
  • a frequency filter that generates a signal related to the volume pulse wave by removing signal components in a frequency band other than the frequency band corresponding to the heartbeat of the subject from the signal, and estimates information related to the volume pulse wave This is a living body related information measuring device.
  • the measurement light emitted from the light emitting element returns to the light receiving element via the inside of the subject as light.
  • the return light not only information relating to blood flow but also various information can be superimposed on the return light.
  • One factor that reduces the accuracy of the amount of light received by the light receiving element is that light other than the light derived from the measurement light emitted from the light emitting element is misidentified as returning light.
  • a measuring unit is provided to determine the light received in the time zone in which the pulsed measurement light is emitted (the time zone from the rise time to the fall time of the measurement light) as return light, The possibility of misrecognizing light other than light originating from as return light is reduced.
  • a pulse wave signal having information related to the pulse wave is obtained by arranging in time series the electric signals obtained by photoelectrically converting the return light received in the time zone set by the determination unit in this way. Since this pulse wave signal is an aggregate of a plurality of pulse-shaped electric signals, these electric signals are digitized, and digital-analog conversion is performed on the obtained digital data signal to thereby relate to the volume pulse wave.
  • a continuous electrical signal (analog signal) with information is obtained.
  • the analog signal includes noise (stray light and the like) superimposed in the state of return light before photoelectric conversion, noise superimposed in the process until the analog signal is formed, and the like. Therefore, by performing a frequency filter process that removes signal components in a frequency band other than the frequency band corresponding to the heart rate range of the subject from the analog signal, it is possible to generate a highly accurate signal related to the volume pulse wave. .
  • the removal frequency band of the frequency filter is appropriately set according to the frequency band of the heart rate range of the subject. As a specific example, when the subject is a person, it is possible to remove signal components in a frequency band of less than 0.6 Hz and a frequency band of more than 3.3 Hz.
  • the signal relating to the volume pulse wave generated in the frequency filter includes information relating to overlapping notches of the volume pulse wave. If the signal related to the volume pulse wave contains information related to the overlapping notch, the signal related to the volume pulse wave can be used to confirm the boundary time between the systole and the diastole of the heart. It becomes possible to grasp information more accurately.
  • the measurement apparatus includes a contact adjustment mechanism that adjusts a contact state with the subject.
  • the contact state with respect to the subject that is, the mounting state of the measuring apparatus changes during measurement
  • the amount of return light received by the light receiving element may change greatly.
  • Such a change in the amount of light adversely affects the reliability of the signal related to the volume pulse wave. Therefore, it is possible to improve the accuracy of the signal related to the volume pulse wave by suppressing the fluctuation of the contact state (the mounting state of the measurement device) with respect to the subject by the contact device including the contact adjustment mechanism.
  • the contact adjustment mechanism includes a mechanism that elastically presses the casing from the opposite side of the casing that holds the light receiving element and the light emitting element to the side of the subject. It is preferable.
  • the measurement apparatus includes a light shielding mechanism that prevents light other than the measurement light emitted from the light emitting element from entering the light receiving element.
  • a light shielding mechanism that prevents light other than the measurement light emitted from the light emitting element from entering the light receiving element.
  • the plethysmogram obtained by the living body related information measuring device can appropriately have information on overlapping notches. Therefore, the open / closed state of the aortic valve of the heart can be appropriately estimated by specifying the overlapping notch from the obtained signal regarding the volume pulse wave.
  • a measuring apparatus that estimates a volume pulse wave that is accurate and, in a preferred aspect, is accurate enough to confirm an overlapping notch based on a result of receiving a return light of measuring light emitted from a light emitting element.
  • FIG. 2 is a cross-sectional view taken along line A′-A ′ of FIG. It is a block diagram which illustrates the composition of the sensor module in the embodiment of the present invention.
  • XYZ coordinates are shown as reference coordinates
  • the XY plane is a plane orthogonal to the Z1-Z2 direction.
  • the state viewed along the Z1-Z2 direction with the Z1 direction as the upward direction and the Z2 direction as the downward direction may be referred to as a plan view.
  • the same members are denoted by the same reference numerals, and the description of the members once described is omitted as appropriate.
  • FIGS. 1A and 1B are perspective views showing a schematic configuration of a living body related information measuring apparatus 10 according to the present embodiment.
  • 1A is a perspective view seen from the substrate 20 side
  • FIG. 1B is a perspective view seen from the light receiving and emitting surface 10a side opposite to the substrate 20.
  • FIG. FIG. 2 is a plan view showing an arrangement example of the first light emitting unit 11, the second light emitting unit 12, and the light receiving unit 13 in the living body related information measuring apparatus 10.
  • FIG. 3 is a cross-sectional view taken along line A-A ′ of FIG.
  • the living body related information measuring device 10 is a device that is attached so as to be in close contact with a subject, for example, the skin of a human body, and measures information related to volume pulse waves as living body information.
  • the living body related information measuring device 10 includes a sensor module 10m shown in FIG.
  • the sensor module 10 m includes two light emitting units 11 and 12 and a light receiving unit 13 provided on the upper surface 20 a (FIG. 3) of the substrate 20.
  • each of the two light emitting units 11 and 12 emits light I11 and I12 having a predetermined wavelength by turning on the light emitting elements 11a and 12a, respectively, and emits (emits) light toward the subject as measurement light.
  • the return light I13 emitted from the two light emitting units 11 and 12 and passing through the subject is received by the light receiving element 13a.
  • the return light that has passed through includes light that has passed through the inside of the subject, for example, inside a blood vessel, light that has diffused inside, and light that has been reflected or diffused on the surface.
  • the measurement lights I11 and I12 are emitted and the return light I13 is received by the light emitting / receiving surface 10a facing the substrate 20 in the Z1-Z2 direction.
  • the living body related information measuring device 10 is mounted so that the light emitting / receiving surface 10a is in close contact with the subject.
  • the details of the sensor module 10m having the two light emitting units 11 and 12 and the light receiving unit 13 will be described later.
  • the first light emitting unit 11, the light receiving unit 13, and the second light emitting unit 12 are sequentially arranged from the Y2 side to the Y1 side along the Y1-Y2 direction.
  • the center distance between the plane center C11 of the first light emitting unit 11 and the plane center C13 of the light receiving unit 13 is the first distance L1, and the plane center C12 of the second light emitting unit 12 and the plane center C13 of the light receiving unit 13 are the same.
  • the center distance is set to the second distance L2.
  • the first distance L1 and the second distance L2 are most preferably the same distance, but the two distances L1 and L2 preferably satisfy the following expression (1). 0.7 ⁇ L2 / L1 ⁇ 1.3 (1)
  • the distances L1 and L2 are preferably in the range of 4 mm to 11 mm.
  • the measurement light emitted from each of the two light emitting elements 11a and 12a reaches each measurement site of the subject.
  • Variation in depth can be suppressed to a certain range, and measurement variation of biological information based on measurement light from these light emitting elements 11a and 12a (specifically, variation in shape of measured volume pulse wave) can be suppressed. .
  • the living body related information measuring apparatus 10 includes a housing 30 that holds the first light emitting unit 11, the second light emitting unit 12, and the light receiving unit 13.
  • the housing 30 is provided on the upper surface 20a (the surface facing the Z1 direction) of the substrate 20 by the adhesive layer 21.
  • the housing 30 has a first emission opening 31 provided in the emission path of the measurement light I11 from the first light emitting unit 11 and a second emission provided in the emission path of the measurement light I12 from the second light emission part 12.
  • the light emitting opening 32 and the light receiving opening 33 provided in the light receiving path of the return light I13 in the light receiving unit 13 are provided.
  • the first light emitting unit 11 is arranged in the first emission opening 31, the second light emitting unit 12 is arranged in the second emission opening 32, and the light receiving unit 13 is arranged in the light receiving opening 33. .
  • the outgoing light from the first light emitting unit 11 travels into the first emission opening 31, and the outgoing light from the second light emitting unit 12 travels into the second emission opening 32.
  • the housing 30 is formed of a light shielding material, for example, metal or resin.
  • a light-shielding material By configuring the housing 30 with a light-shielding material, it is possible to prevent light emitted from the first light emitting unit 11 and the second light emitting unit 12 from directly entering the light receiving unit 13 without passing through the subject. Therefore, it becomes easy to accurately extract information necessary for measurement of biological information, and highly accurate measurement is possible.
  • the casing 30 is made of a metal material, it can function as a heat radiating member that releases heat generated in the two light emitting units 11 and 12 and the light receiving unit 13 to the outside.
  • the housing 30 when the housing 30 is made of a resin material, the elasticity can be arranged along the shape of the skin as the subject, thereby improving the adhesion.
  • three translucent members 41, 42, and 43 are provided so as to cover the upper portions of the first emission opening 31, the second emission opening 32, and the light receiving opening 33, respectively. It has been.
  • the light emitted from the first light emitting unit 11 is emitted as measurement light from the inside of the first emission opening 31 through the translucent member 41 and is emitted to the outside on the upper side of the living body related information measuring device 10, and the second light emission.
  • the light emitted from the unit 12 passes through the translucent member 42 from the second emission opening 32 as measurement light and is emitted to the outside on the upper side of the living body related information measuring device 10.
  • the return light through which the measurement light passes through the subject passes through the translucent member 43, reaches the light receiving opening 33, and is received by the light receiving unit 13.
  • the translucent members 41, 42 and 43 for example, PET (polyethylene terephthalate) is used.
  • PET polyethylene terephthalate
  • the three translucent members 41, 42, 43 are fixed to the housing 30 by adhesion, and the upper end surfaces 41a, 42a, 43a form the same surface as the light emitting / receiving surface 10a together with the upper surface 30a of the housing 30. .
  • casing 30 and the translucent member 41,42,43 can be closely_contact
  • FIG. 4 is a block diagram illustrating the configuration of the sensor module 10m.
  • the sensor module 10 m includes a pair of light emitting units 11 and 12, a light receiving unit 13, a control unit 14, and an input / output interface unit 15.
  • the 1st light emission part 11 is provided with the 1st light emission element 11a
  • the 2nd light emission part 12 is provided with the 2nd light emission element 12a.
  • the emission wavelengths of the first light-emitting element 11a and the second light-emitting element 12a are not limited, but are preferably 500 nm or more and 1000 nm or less from the viewpoint of appropriately securing the amount of return light.
  • the first light-emitting element 11a and the second light-emitting element 12a emit light containing near-infrared light of 600 nm to 804 nm, preferably 758 nm to 762 nm, as measurement light.
  • the first light emitting element 11a and the second light emitting element 12a are light emitting diode elements or laser elements.
  • Each of the first light emitting unit 11 and the second light emitting unit 12 further includes a light emitting element that emits light having a wavelength region different from the emission wavelength of the first light emitting element 11a and the second light emitting element 12a as measurement light. May be. Specific examples of such an emission wavelength include near infrared light having a wavelength of 806 nm to 995 nm.
  • the light-receiving unit 13 is emitted from the first light-emitting unit 11 or the second light-emitting unit 12 and receives near-infrared light as return light that passes through the blood flowing through the blood vessel in the subject, in particular, the blood vessel, and converts it into an electrical signal. It has a light receiving element 13a.
  • the light receiving element 13a is, for example, a photodiode.
  • the light receiving element 13a has a sensitivity of outputting an electrical signal corresponding to the amount of received light.
  • the two light emitting units 11 and 12 and the light receiving unit 13 are integrally configured as a light receiving and emitting unit.
  • the sensor module 10m may be a package of the two light emitting units 11 and 12, the light receiving unit 13, the control unit 14, and the input / output interface unit 15.
  • the first light emitting unit 11 has a drive circuit 11b that drives the first light emitting element 11a
  • the second light emitting unit 12 has a drive circuit 12b that drives the second light emitting element 12a
  • the light receiving unit 13 includes an amplification circuit 13b that amplifies a light reception signal output from the light receiving element 13a.
  • the control unit 14 is composed of a microcomputer. As the light emission control unit, the control unit 14 transmits a timing signal to each of the drive circuit 11b of the light emission unit 11 and the drive circuit 12b of the second light emission unit 12, and the first light emission unit 11 and the second light emission unit 12 are predetermined. Control to emit near-infrared light at the timing of. More specifically, the control unit 14 causes the first light emitting unit 11 and the second light emitting unit 12 to simultaneously emit light for a short time of about 200 to 600 microseconds at 10 millisecond intervals, for example. By controlling in this way, pulsed measurement light is continuously emitted from the first light emitting element 11a and the second light emitting element 12a.
  • the control unit 14 controls the measurement light at each time when the measurement light is emitted from the first light emitting element 11a and the second light emitting element 12a at a predetermined time interval (for example, every 10 milliseconds) under the control of the light emission control unit.
  • a determination unit that determines that the light received by the light receiving element 13a in the time period from the rising time to the falling time (for example, the time period from 200 microseconds to 600 microseconds) is the return light of the measurement light.
  • FIG. 5 is a flowchart showing the operation of the determination unit.
  • the timing signal which the light emission control part which the control part 14 has transmits to each of the drive circuit 11b of the light emission part 11 and the drive circuit 12b of the 2nd light emission part 12 is confirmed (step S101).
  • each rise time of the measurement light is grasped, and it is determined whether or not the confirmed time is the rise time (step S102).
  • the light received by the light receiving element 13a is determined as the return light of the measurement light, and after the amplification output from the amplifier circuit 13b of the light receiving unit 13 Is received in a memory (not shown) as a signal for generating a volume pulse signal (step S103). If the rise time has not been reached, the process returns to step S101 for checking the timing signal.
  • step S104 the timing signal is confirmed again (step S104), the respective falling times of the measurement light are grasped, and the confirmed time is the falling time or the time when the falling time has elapsed. It is determined whether or not (step S105).
  • the confirmed time is the falling time or the time when the falling time has elapsed
  • the amplified light reception signal output from the amplification circuit 13b of the light receiving unit 13 is used as a signal for generating a volume pulse wave signal.
  • step S106 After capturing the data in the memory, one pulsed light reception signal corresponding to one pulse signal of the measurement light is obtained (step S106), and the process returns to step S101 where the timing signal is confirmed with respect to the rise time. If the fall time has not been reached, the process returns to step S105 where the timing signal is confirmed with respect to the fall time.
  • a plurality of pulsed light receiving signals are obtained corresponding to the continuous pulsed measurement light. Since the plurality of pulsed light receiving signals have information on time and the amount of light received by the light receiving element, a digital signal having information on pulse waves can be obtained by digitizing a group of pulsed light receiving signals. This digital signal is converted from digital to analog to generate an analog signal. For conversion to an analog signal, a conventionally known method such as linear interpolation may be used. This digital-analog conversion is also performed by the control unit 14.
  • the control unit 14 removes a signal component in a frequency band other than the frequency band corresponding to the heart rate of the subject from the analog signal, and generates a signal related to the volume pulse wave.
  • the frequency band to be removed is appropriately set according to the heart rate range of the subject. Taking a case where the subject is a person as a specific example, the heart rate range of a person is generally 40 to 200 times per minute, and if this is set to a frequency range, 0.6 Hz to 3.3 Hz. Therefore, signal components in this frequency band are extracted, and signal components in other frequency bands (frequency bands consisting of less than 0.6 Hz and more than 3.3 Hz) are removed.
  • the frequency filter By having such a frequency filter, low-frequency noise and high-frequency noise are appropriately removed, and a signal related to the volume pulse wave can be generated with high accuracy.
  • a low frequency noise source in the analog signal the relative position between the external light source and the sensor module 10m changes due to the movement of the subject, or the mounting state of the sensor module 10m changes.
  • the amount of received light changes.
  • the high frequency noise source include noise generated from the control unit 14, noise from an electronic device carried by the subject, noise generated in processing such as digital-analog conversion, and the like.
  • a digital signal obtained from a group of pulsed light reception signals is processed by a frequency filter on an analog signal obtained by digital-analog conversion.
  • the present invention is not limited to this. You may process with a frequency filter with respect to a digital signal.
  • An analog signal may be generated by performing digital-analog conversion on the obtained noise-removed digital signal.
  • FIG. 6A shows an analog signal generated by digital-analog conversion of the amplified received light signal output from the amplification circuit 13b of the light receiving unit 13, and is positioned as a conventional technique.
  • the plurality of volume pulse waves shown in the display range of FIG. 6A are non-uniform in shape, and it is difficult to grasp the overlapping notch DN from each volume pulse wave.
  • FIG. 6B illustrates a process of a determination unit performed on the amplified light reception signal output from the amplification circuit 13b of the light reception unit 13, and digital signals obtained from a plurality of obtained pulse signals are digital-analog.
  • the plurality of volume pulse waves shown in the display range of FIG. 6B have substantially similar shape characteristics, and the position of the overlapping notch DN can be specified for any signal.
  • FIG. 6C is a diagram for explaining the characteristics of the volume pulse wave.
  • the plethysmogram rises sharply with the opening of the aortic valve (ascending leg AS), and an overlapping notch DN is formed in which the signal intensity varies greatly when the aortic valve is closed. After that, it will gradually descend. It is possible to estimate the open / close state of the aorta of the heart from the waveform of the volume pulse wave. As shown in FIG. 6 (c), the systolic and diastolic phases of the heart can be determined from the opening and closing times of the aorta, and the systolic and diastolic pressures can be measured based on these times.
  • the mean arterial pressure can be calculated.
  • the stroke volume can be estimated from the rise of the volume pulse waveform from the systolic force, the compliance of the artery, the area of the systole, and the like. This stroke volume is calculated from the hatched region R1 in FIG. These are very useful in anesthesia management because they can be measured continuously in real time.
  • the control part 14 estimates the information relevant to a volume pulse wave as a volume pulse wave measurement part. At that time, the shape characteristic of the volume pulse wave including the overlapping notch DN as described above may be specified.
  • FIG. 7 is a flowchart of an information processing method according to an embodiment of the present invention. As shown in FIG. 7, first, a process for obtaining a signal related to volume pulse wave using the living body related information measuring apparatus 10 according to the present embodiment is performed (step S111). In this step, the above-described determination unit processing and frequency filter processing are performed.
  • a step of identifying the overlapping notch DN from the signal relating to the volume pulse wave thus obtained is performed (step S112).
  • a minute waveform called a precursor phase wave is generated before the ascending leg AS described above
  • a shock wave that is a peak portion of the volume pulse wave is generated immediately after the ascending leg AS
  • a double notch DN It is known that a peak lower than that of a shock wave called a tidal wave is generated up to and a double pulse is generated in the diastole after the overlapping notch DN.
  • the position of the overlapping notch DN can be specified. Specifically, the position of the overlapping notch DN can be specified by performing primary differentiation or secondary differentiation on the volume pulse wave.
  • a process of estimating the open / closed state of the aortic valve of the subject's heart from the overlapping notch DN is performed (step S113).
  • the period from the initial rise of the ascending leg AS to the overlapping notch DN corresponds to the systole of the heart, and the period from the overlapping notch DN to immediately before the ascending leg AS of the next plethysmogram starts is dilated. It corresponds to the period.
  • Information on the open / closed state of the aortic valve of the heart can be obtained from the relationship between the systolic area (region R1 in FIG. 6C) and the diastole area.
  • the control unit 14 may perform all of the information processing method described above for the living body related information measuring apparatus 10, or the living body related information measuring apparatus 10 performs only the step of acquiring the volume pulse wave (step S ⁇ b> 111),
  • the signal related to the volume pulse wave obtained in step S111 is transmitted to an external device (for example, a smartphone) by the communication device included in the living body related information measuring apparatus 10, and the remaining steps (step S112 and step S113) are performed in the external device. May be.
  • control unit 14 uses a built-in analog-digital conversion circuit as a living body related information measurement unit, and uses digital signal information that can process the amplified received light signal output from the amplification circuit 13b of the light receiving unit 13. And information (biological information) on blood passing through the blood vessel of the subject may be estimated based on the converted signal information.
  • the biological information estimated by the control unit 14 includes changes in blood hemoglobin (Hb) in the measurement using the return light through which the near-infrared light emitted from the first light emitting element 11a and the second light emitting element 12a passes through the subject. Change amount), blood oxygen ratio change (oxygen level), and the like.
  • the absorbances of oxygenated hemoglobin and deoxygenated hemoglobin are equal at a wavelength of 805 nm, the absorbance of oxygenated hemoglobin is greater than that of deoxygenated hemoglobin at a wavelength longer than 805 nm, and oxygen at a wavelength shorter than 805 nm.
  • the absorbance of oxyhemoglobin is smaller than the absorbance of deoxygenated hemoglobin. Therefore, when near-infrared light having a wavelength of 804 nm or less emitted from the first light-emitting element 11a and the second light-emitting element 12a is given to the human body as the subject, the absorbance of deoxygenated hemoglobin can be measured preferentially. . Since deoxygenated hemoglobin tends to have a smaller change in absorbance with respect to elapsed time than oxygenated hemoglobin, the pulsation and volume pulse wave of the subject can be measured more accurately.
  • each of the first light emitting unit 11 and the second light emitting unit 12 is further provided with a light emitting element that emits measurement light including near infrared light having an emission wavelength of 806 nm or more and 995 nm or less.
  • Information obtained from blood passing through the blood flow for example, pulsation of blood flow, blood flow rate, flow rate, etc. can be obtained.
  • the blood oxygen ratio It is possible to derive changes (oxygen levels) or related information
  • FIG. 8 is a diagram for explaining the structure of a band as a contact adjusting mechanism and a light shielding mechanism.
  • FIG. 8A is a diagram illustrating a state where the band is attached to the subject.
  • FIG. 8B is a cross-sectional view taken along the line AA in FIG.
  • the subject MB (a human wrist is shown as a specific example in FIG. 8A) in the housing 30 included in the living body related information measuring apparatus 100 is opposed.
  • a band 200 made of an elastic body (specifically, an elastic cloth) is positioned so as to cover the side opposite to the side to be performed.
  • Each of the bands 200 has a structure in which an inner elastic cloth 210 and an outer elastic cloth 220 having light shielding properties are overlapped, and the casing 30 is placed in a space 200 ⁇ / b> C between the inner elastic cloth 210 and the outer elastic cloth 220.
  • the first light emitting unit 11, the second light emitting unit 12, and the light receiving unit 13 incorporated in the housing 30 can face the subject MB through the opening 210A of the inner elastic cloth 210.
  • the outer elastic cloth 220 elastically presses the housing 30 from the side opposite to the side facing the subject MB to the subject MB. If the contact state with respect to the subject MB, that is, the mounting state of the biological related information measuring device 100 changes during measurement, the amount of return light received by the light receiving unit 13 may change greatly. Such a change in the amount of light adversely affects the reliability of the signal related to the volume pulse wave. Specifically, it becomes a low-frequency noise source that destabilizes the baseline.
  • the biological related information measuring device 100 includes the band 200 as a contact adjustment mechanism, fluctuations in the contact state with respect to the subject MB (the wearing state of the biological related information measuring device 100) are suppressed, and the accuracy of the signal related to the volume pulse wave is suppressed. Can be increased.
  • the band 200 is made of a light shielding material, it also has a function as a light shielding mechanism. Therefore, the band 200 can more stably reduce the possibility that the light receiving elements (the first light emitting element 11a and the second light emitting element 12a) of the living body related information measuring device receive light other than the return light other than the measurement light. Can do.
  • the band 200 and the member that constitutes the light shielding mechanism and also the member that constitutes the contact adjustment mechanism are from the viewpoint of simplifying the structure by reducing the number of components of the living body related information measuring apparatus 100 as a whole. preferable.
  • the return light of the measurement light from the two light emitting elements is received by the light receiving element 13a, but the number of light emitting elements is one. It may be three or more. There may be a plurality of light receiving elements.
  • information from another sensor may be taken in and the operation of the determination unit may be determined.
  • a signal indicating that the measurement should not be continued is input from a sensor related to environmental information such as an outside air temperature / humidity sensor or an atmospheric pressure sensor, or a sensor related to other information related to the subject such as an electrocardiogram sensor, an electroencephalogram sensor, or a motion sensor. In this case, if the light reception signal is not taken in, the volume pulse wave can be estimated more accurately.

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  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

Cette invention concerne un dispositif de mesure d'informations biologiques comprenant : un élément électroluminescent pour émettre une lumière de mesure de longueur d'onde prédéfinie ; un élément récepteur de lumière pour recevoir la lumière de retour de la lumière de mesure ; une unité de mesure d'onde d'impulsion volumique pour estimer une onde d'impulsion volumique sur la base des résultats de réception de lumière par l'élément récepteur de lumière ; une unité de commande d'émission de lumière pour amener l'élément électroluminescent à émettre la lumière de mesure sous la forme d'une impulsion à chaque intervalle de temps prédéfini ; une unité de détermination pour déterminer, comme lumière de retour de la lumière de mesure, la lumière qui est reçue par l'élément récepteur de lumière pendant un laps de temps allant d'un front de montée à un front de descente de la lumière de mesure à chaque fois que la lumière de mesure est émise aux intervalles de temps prédéfinis sous la commande de l'unité de commande d'émission de lumière ; et un filtre de fréquence qui élimine un bruit basse fréquence et un bruit haute fréquence d'un signal d'onde d'impulsion composé d'un signal électrique basé sur la lumière définie comme étant la lumière de retour de la lumière de mesure par l'unité de détermination, et qui génère un signal relatif à l'onde d'impulsion volumique. Le dispositif de mesure d'informations biologiques selon l'invention permet d'estimer une onde d'impulsion volumique sur la base des résultats de réception de lumière.
PCT/JP2018/009370 2017-04-07 2018-03-12 Dispositif de mesure d'informations biologiques WO2018186108A1 (fr)

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JP2017-076741 2017-04-07
JP2017076741A JP2020096648A (ja) 2017-04-07 2017-04-07 生体関連情報測定装置

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03126437A (ja) * 1989-10-11 1991-05-29 Seiko Instr Inc 脈拍計
JPH05504084A (ja) * 1990-02-16 1993-07-01 リンドバーク　ラース―ゲーラン フォトプレチスモグラフィー測定により脈拍数を分析するモニタ
US20130324855A1 (en) * 2012-05-31 2013-12-05 Nellcor Puritan Bennett Llc Methods and systems for power optimization in a medical device
JP2016179124A (ja) * 2015-03-25 2016-10-13 セイコーエプソン株式会社 生体情報測定機器
JP2017012483A (ja) * 2015-07-01 2017-01-19 浜松ホトニクス株式会社 血圧比算出装置、血圧比算出方法、血圧比算出プログラム、及びそのプログラムを記録する記録媒体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03126437A (ja) * 1989-10-11 1991-05-29 Seiko Instr Inc 脈拍計
JPH05504084A (ja) * 1990-02-16 1993-07-01 リンドバーク　ラース―ゲーラン フォトプレチスモグラフィー測定により脈拍数を分析するモニタ
US20130324855A1 (en) * 2012-05-31 2013-12-05 Nellcor Puritan Bennett Llc Methods and systems for power optimization in a medical device
JP2016179124A (ja) * 2015-03-25 2016-10-13 セイコーエプソン株式会社 生体情報測定機器
JP2017012483A (ja) * 2015-07-01 2017-01-19 浜松ホトニクス株式会社 血圧比算出装置、血圧比算出方法、血圧比算出プログラム、及びそのプログラムを記録する記録媒体

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