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WO2018181135A1 - Procédé de production d'un agent améliorant l'efficacité d'apprentissage et composition de produit alimentaire améliorant l'efficacité d'apprentissage, et technologie associée - Google Patents

Procédé de production d'un agent améliorant l'efficacité d'apprentissage et composition de produit alimentaire améliorant l'efficacité d'apprentissage, et technologie associée Download PDF

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Publication number
WO2018181135A1
WO2018181135A1 PCT/JP2018/012048 JP2018012048W WO2018181135A1 WO 2018181135 A1 WO2018181135 A1 WO 2018181135A1 JP 2018012048 W JP2018012048 W JP 2018012048W WO 2018181135 A1 WO2018181135 A1 WO 2018181135A1
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Prior art keywords
improving
learning effect
learning
extract
learning effectiveness
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PCT/JP2018/012048
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English (en)
Japanese (ja)
Inventor
隆彦 藤川
英夫 竹腰
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株式会社サン・クロレラ
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Application filed by 株式会社サン・クロレラ filed Critical 株式会社サン・クロレラ
Priority to JP2019509775A priority Critical patent/JP7127782B2/ja
Publication of WO2018181135A1 publication Critical patent/WO2018181135A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Definitions

  • the present invention relates to a learning effect improving agent comprising a natural ingredient as an active ingredient, a method for producing a food composition for improving learning effect, and related techniques.
  • Japanese Patent Application Laid-Open No. 9-227394 discloses an composition for oral administration comprising an elephant, a trash and an eucommia as an invention which aims to provide an effective drug for improving a reduction in the efficiency of intellectual work caused by stress.
  • the invention is disclosed.
  • the risk avoidance learning effect is a learning test using a step-through passive avoidance learning device consisting of a light box and a dark box, that is, an action based on the instinct that the mouse prefers a dark place. It is an effect of learning to avoid the danger by giving physical pain by electric shock and trying to stop in the light box without entering the dark box.
  • Japanese Patent Laid-Open No. 2002-3391 is effective in preventing and treating stressful gastric ulcer, acute enterocolitis, alopecia areata, insomnia, and irritability, and improves well-being (emotional, willingness) and short-term memory ability. It has the effect of balancing the amount of activity, and is effective in the prevention and treatment of dwarfism, Parkinson's disease and hyperattention behavioral disorder (ADHD), especially in the case of stress-induced gastric ulcers through the increase effect of in vivo prolactin
  • ADHD hyperattention behavioral disorder
  • the administration of the composition for oral administration according to the invention described in the publication has an effect of reducing the influence of physical or psychological stress itself, and physical or psychological stress is As a result of reducing the influence of those stresses in a loaded state, it is recognized that the reduction of the spontaneous exercise amount and the risk avoidance learning effect are prevented.
  • the same gazette shows that the same effect is exerted to some extent, even if only the Ezocogi extract is administered, although it does not reach the composition for oral administration described in the gazette.
  • the administration of Ezocogi extract alone has an effect of reducing the influence of physical or psychological stress load to some extent, and the influence of such stress in a state where physical or psychological stress is loaded.
  • the administration of Ezocogi extract alone has an effect of reducing the influence of physical or psychological stress load to some extent, and the influence of such stress in a state where physical or psychological stress is loaded.
  • the present invention relates to a learning effect improving agent capable of improving a learning effect in a normal state in which physical or psychological stress is not substantially applied, a method for producing a learning effect improving food composition, a learning effect improving agent, and a learning effect improvement.
  • An object of the present invention is to provide a food composition for use, use of a hot water extract of sorghum root for producing a learning effect improving agent, and a method for improving learning effect.
  • Method for producing learning effect improving agent and learning effect improving food composition of the present invention learning effect improving agent and food composition for improving learning effect, use of hot water extract of sorghum root for producing learning effect improving agent
  • the learning effect improving method can be expressed as follows, for example.
  • (1-1) A method for producing a learning effect improving agent characterized by extracting hot elephant roots with hot water and containing the obtained extract as an active ingredient.
  • the learning effect improving agent produced by this production method has an effect of improving the learning effect in a normal state in which physical or psychological stress is not substantially applied.
  • the above extract is obtained by hot water extraction of crushed shrimp root, concentrating the extract under reduced pressure, and spray drying the resulting concentrated extract with a spray dryer.
  • (1-6) A method for producing a food composition for improving learning effects, comprising extracting hot elephant roots with hot water and containing the obtained extract as an active ingredient.
  • the learning effect improving food composition produced by this production method has an effect of improving the learning effect in a normal state in which physical or psychological stress is not substantially applied.
  • the above extract is obtained by hot water extraction of crushed shrimp root, concentrating the extract under reduced pressure, and spray drying the resulting concentrated extract with a spray dryer.
  • a learning effect improving agent characterized by containing a hot water extract of potato elephant root as an active ingredient.
  • This learning effect improving agent has an effect of improving the learning effect in a normal state in which physical or psychological stress is not substantially applied.
  • the above extract is obtained by hot water extraction of crushed shrimp roots, concentrating the extract under reduced pressure, and spray drying the resulting concentrated extract with a spray dryer.
  • the learning effect improving agent according to any one of (2-1) to (2-4) above.
  • a food composition for improving learning effect comprising a hot water extract of Ezo-kogi root as an active ingredient.
  • This learning effect improving food composition has an effect of improving the learning effect in a normal state in which physical or psychological stress is not substantially applied.
  • the above extract is obtained by hot water extraction of crushed shrimp root, concentrating the extract under reduced pressure, and spray drying the resulting concentrated extract with a spray dryer.
  • the food composition for improving learning effect according to any one of (2-6) to (2-9) above.
  • (3-3) Use according to (3-1) or (3-2) above, wherein the learning effect improving agent is for improving operant learning effect.
  • (3-4) The use according to (3-1) or (3-2) above, wherein the learning effect improving agent is for improving an operant learning effect through visual identification of a figure.
  • (4-1) A learning effect improving method characterized by applying a hot water extract of Ezogigi root to a person who needs improvement of the learning effect.
  • This method has the effect of improving the learning effect in a normal state in which no physical or psychological stress is practically applied.
  • the learning effect improving agent and the learning effect improving food composition of the present invention have an effect of improving the learning effect in a normal state in which physical or psychological stress is not substantially loaded.
  • Ezo-kogi refers to a plant belonging to the family Urugiaceae, and its scientific name is Acanthopanax senticosus Harms.
  • an extract of root of Ekogigi which is an active ingredient of the learning effect improving agent and the food composition for improving learning effect in the present invention, can be obtained as follows.
  • a dry powder of the extract can be obtained by spray drying with a spray dryer.
  • the vacuum concentration can be performed up to a certain concentration (for example, a predetermined concentration).
  • the learning effect improving agent and the learning effect improving food composition of the present invention have an effect on learning effect improvement (learning memory function improving effect) in a no-load state in which physical or psychological stress is not substantially loaded.
  • the learning effect improving agent and the learning effect improving food composition of the present invention are preferably used for improving the operant learning effect, and more preferably used for improving the operant learning effect through visual identification of figures.
  • the learning effect improving agent and the food composition for improving learning effect comprising, as an active ingredient, an extract obtained by hot water extraction of Ezoukogi root in the present invention, for example, for those who need the learning effect improvement as described above, It is preferably applied by oral administration.
  • various excipients in forming various forms, various excipients, binders, disintegrants, lubricants, coating agents, coloring agents, flavoring agents, flavoring agents, plasticizers, and the like can be used as appropriate.
  • excipients examples include sugars (lactose, sucrose, glucose, mannitol), starch (potato, wheat, corn), minerals (calcium carbonate, calcium sulfate, sodium bicarbonate, sodium chloride), crystalline cellulose, plant powder ( Licorice powder, gentian powder) and the like.
  • binders examples include starch paste, gum arabic, gelatin, sodium alginate, meth / recellulose (MC), ethylcellulose (EC), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), hydroxypropylcellulose (HPC). , Carboxymethylcellulose (CMC) and the like.
  • disintegrants examples include starch, agar, gelatin powder, crystalline cellulose, CMC / Na, CMC / Ca, calcium carbonate, sodium bicarbonate, sodium alginate and the like.
  • lubricants examples include magnesium stearate, talc, hydrogenated vegetable oil, macrogol, silicone oil and the like.
  • coating agents include sugar coating (sucrose, HPC, shellac), glue (gelatin, glycerin, sorbitol), film coating [hydroxypropyl methylcellulose (HPMC), EC, HPC, PVP], enteric coating [hydroxyprovir Methyl cellulose phthalate (HPMCP), cellulose acetate phthalate (CAP)] and the like.
  • colorants include water-soluble food dyes and lake dyes.
  • examples of the corrigent include lactose, sucrose, glucose, mannitol) and the like.
  • flavoring agents include aromatic essential oils) and light blocking agents (titanium oxide).
  • examples of the plasticizer include phthalic acid esters, vegetable oils, polyethylene glycol) and the like.
  • the human dose requiring improvement of the learning effect of the learning effect improving agent and the learning effect improving food composition in the present invention is, for example, 500 mg in the dry powder content of the extract of Ezogi root as an active ingredient. / Day or more is preferable.
  • the test was conducted on the learning effect improving effect of the extract obtained by hot water extraction of the root of Ezoukogi.
  • the extract obtained by hot water extraction from the crushed pieces obtained by crushing 19.9 parts by weight of Ezokogi root was concentrated under reduced pressure to obtain 7.1 parts by weight of concentrated extract.
  • This concentrated extract is spray-dried with a spray dryer, and 1 part by weight of a dry powder of the extract (hereinafter, also simply referred to as “Ezo-kogi root extract”) obtained by hot water extraction of Ezo-kogi root with a water content of 4% by weight or less. Obtained.
  • each window is provided with a screen capable of displaying a required image.
  • a touch screen for detecting that the rat's (test animal) snout touched was provided.
  • a feeding port lamp that can be turned on is provided at the feeding port.
  • the monitor power of the touch screen is turned off in advance and 10 pellets of MF feed (Oriental Yeast Co., Ltd.) are placed in the feeding port with the feeding port lamp always on, and ingested during free search. I let you. This is for associating the fact that the feed opening lamp is lit and the presence of feed pellets.
  • Fig. 1 shows a flowchart of the basic trial procedure.
  • the training for learning the procedure for selecting an image consists of four stages 1 to 4, and the trial interval (ITI) is 15 seconds.
  • the screen changes to a gray image, and at the same time, feed pellets (MF feed from Oriental Yeast Co., Ltd.) ) 1 grain (45 mg) was fed. At the same time, a buzzer sound of 1 second was presented and the feeding port lamp was lit for 3 seconds.
  • feed pellets MF feed from Oriental Yeast Co., Ltd.
  • test animal selects a window with no image displayed by mouth-and-mouth contact, it is common to change the screen to a gray image, but the subsequent response varies from stage to stage.
  • the images used as visual stimuli in the selection training are obtained by arranging white (contrast 100%) graphics on a black (contrast 0%) background, and there are 35 types of images (that is, graphics).
  • the purpose of this training is not to learn the shape of the figure itself in the image used for visual stimulation, but to determine the presence or absence of visual stimulation and associate it with rewards.
  • the purpose of this stage was to learn trigger behavior.
  • Trigger action is an action in which a rat (test animal) puts a snout into a feeding mouth, whereby an image is displayed on a window. By learning this behavior, it is possible to smoothly proceed with subsequent image classification tasks. Furthermore, by taking a predetermined trigger behavior, the image is obtained by aligning the position and posture of the rat (test animal) at the start of the trial. The discrimination process should be unified.
  • the feeding mouth lamp was turned on simultaneously with the start of the trial, and the feeding mouth lamp was turned off at the same time as the rat (test animal) took a trigger action to put the snout into the feeding mouth.
  • a click sound was generated by an electromagnetic valve, and an image was presented on the window.
  • the trigger behavior was detected by an infrared sensor installed in the feeding port.
  • stage 3 In addition to the same trial as in stage 3, if the rat (test animal) selected a window without an image by mistake, the house light was turned on for 5 seconds to inform the light and dark environment in the chamber. And a 5 second delay in trial interval (ITI) was imposed.
  • ITI trial interval
  • Stages 1 to 3 when 30 trials were completed within 60 minutes, it was determined that learning of the rat (test animal) was established, and the next stage was entered.
  • stage 4 the selection training was completed when the number of times of selection of the window on which the image was presented was 23 or more out of 30 trials and the completion within 20 minutes could be achieved continuously for two sessions.
  • MF feed Oriental Yeast Co., Ltd.
  • Ezokogi root extract was freely ingested.
  • the two-image discrimination task is a total of 6 sessions, 1 session per day, in a state where there is virtually no physical or psychological stress, and the ratio of the number of collect touches to the number of mistouches in each session [number of collect touches / number of mistouches ], The results of session 2-6 with the result of session 1 being 100 and the average value were calculated and compared.
  • one of two types of figures capable of visual discrimination is displayed on one of both windows in the operant chamber.
  • the other figure was simultaneously presented in the other window.
  • the star shape was a reward graphic (target)
  • the bubble shape was a non-reward graphic (non-target)
  • the target and non-target were randomly presented in the left and right windows for each trial.
  • the Ezocogi group showed an increasing tendency compared to the control group.
  • the Ezoukogi group showed a significant increase compared to the control group.

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Abstract

L'invention concerne : un procédé pour produire un agent améliorant l'efficacité d'apprentissage et une composition de produit alimentaire améliorant l'efficacité d'apprentissage qui sont capables d'améliorer l'efficacité d'apprentissage dans des situations normales, dans lesquels le stress physique ou psychologique ne constituent pas une entrave importante; un agent améliorant l'efficacité d'apprentissage et une composition de produit alimentaire améliorant l'efficacité d'apprentissage; une utilisation de l'extrait à l'eau chaude de la racine d'Eleutherococcus senticosus pour la production de l'agent améliorant l'efficacité d'apprentissage; et un procédé pour améliorer l'efficacité d'apprentissage. Cet agent améliorant l'efficacité d'apprentissage ou la composition de produit alimentaire améliorant l'efficacité d'apprentissage à utiliser pour améliorer l'efficacité d'apprentissage opérant par reconnaissance de formes visuelles dans des situations sensiblement exemptes de stress physique ou psychologique, est formulé à partir d'une poudre séchée obtenue par pulvérisation de la racine d'Eleutherococcus senticosus et formation de bandes à partir de celle-ci, obtention d'un extrait par extraction à l'eau chaude à partir des bandes, concentration sous vide de l'extrait liquide à une certaine concentration, et obtention d'une poudre séchée de l'extrait par séchage par atomisation, à l'aide d'un dispositif de séchage par atomisation, de l'extrait liquide concentré dont les substances insolubles à l'éthanol ont été éliminées.
PCT/JP2018/012048 2017-03-31 2018-03-26 Procédé de production d'un agent améliorant l'efficacité d'apprentissage et composition de produit alimentaire améliorant l'efficacité d'apprentissage, et technologie associée WO2018181135A1 (fr)

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JP2019509775A JP7127782B2 (ja) 2017-03-31 2018-03-26 学習効果改善剤及び学習効果改善用食品組成物の製法並びにその関連技術

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JP2017-073242 2017-03-31

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003391A (ja) * 2000-06-23 2002-01-09 I-Deal Coms Kk エゾウコギを用いた薬剤並びに組成物及びその抽出方法
JP2008044887A (ja) * 2006-08-16 2008-02-28 Redox:Kk エゾウコギの枝及び／又は葉の抽出物、その製造方法及びその用途
JP2010507651A (ja) * 2006-10-24 2010-03-11 エスケー ケミカルズ カンパニー リミテッド 認知症及び軽度認識障害の治療、及び認知機能の改善に有効であるオレアナン系トリテルペンサポニン化合物
CN102268060A (zh) * 2011-06-07 2011-12-07 苏州派腾生物医药科技有限公司 一种β-常春藤素的制备方法
JP2017007974A (ja) * 2015-06-19 2017-01-12 株式会社サン・クロレラ 心機能調節剤
WO2017030167A1 (fr) * 2015-08-18 2017-02-23 レジリオ株式会社 Agent reconstructeur/activateur de réseau neuronal

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003391A (ja) * 2000-06-23 2002-01-09 I-Deal Coms Kk エゾウコギを用いた薬剤並びに組成物及びその抽出方法
JP2008044887A (ja) * 2006-08-16 2008-02-28 Redox:Kk エゾウコギの枝及び／又は葉の抽出物、その製造方法及びその用途
JP2010507651A (ja) * 2006-10-24 2010-03-11 エスケー ケミカルズ カンパニー リミテッド 認知症及び軽度認識障害の治療、及び認知機能の改善に有効であるオレアナン系トリテルペンサポニン化合物
CN102268060A (zh) * 2011-06-07 2011-12-07 苏州派腾生物医药科技有限公司 一种β-常春藤素的制备方法
JP2017007974A (ja) * 2015-06-19 2017-01-12 株式会社サン・クロレラ 心機能調節剤
WO2017030167A1 (fr) * 2015-08-18 2017-02-23 レジリオ株式会社 Agent reconstructeur/activateur de réseau neuronal

Non-Patent Citations (3)

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Title
HUANG, D. ET AL.: "Eleutheroside B or E enhances learning and memory in experimentally aged rats", NEURAL REGENERATION RESEARCH, vol. 8, no. 12, 2013, pages 1103 - 1112, ISSN: 1673-5374 *
MA, B. ET AL.: "Simultaneous determination of Eleutheroside Band Eleutheroside E in rat plasma by high performance liquid chromatography-electrospray ionization mass spectrometry and its application in a pharmacokinetic study", JOURNAL OF CHROMATOGRAPHY B, vol. 917, no. 918, 2013, pages 84 - 92, XP028522305, ISSN: 1570-0232 *
YAMAUCHI, YU ET AL.: "Reviews on memory enhancement action by Eleutherococcus senticosus leaf extract and active ingredients", 34TH CONFERENCE ABSTRACTS OF THE MEDICAL AND PHARMACEUTICAL SOCIETY FOR WAKAN-YAKU, 26 August 2017 (2017-08-26), pages 81 *

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TW201900037A (zh) 2019-01-01

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