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WO2008136394A1 - ラクタム化合物の製造方法及びその製造中間体 - Google Patents

ラクタム化合物の製造方法及びその製造中間体 Download PDF

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Publication number
WO2008136394A1
WO2008136394A1 PCT/JP2008/058038 JP2008058038W WO2008136394A1 WO 2008136394 A1 WO2008136394 A1 WO 2008136394A1 JP 2008058038 W JP2008058038 W JP 2008058038W WO 2008136394 A1 WO2008136394 A1 WO 2008136394A1
Authority
WO
WIPO (PCT)
Prior art keywords
production
lactam compound
producing
therapeutic agent
production method
Prior art date
Application number
PCT/JP2008/058038
Other languages
English (en)
French (fr)
Inventor
Kouji Haga
Nobuhiro Yamanaka
Tsuyoshi Mita
Shigeo Hirasawa
Akinori Tatara
Junko Yamanaka
Kotaro Okado
Seiji Niwa
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2007/059540 external-priority patent/WO2008139574A1/ja
Priority claimed from PCT/JP2007/059544 external-priority patent/WO2008139575A1/ja
Priority claimed from PCT/JP2007/059545 external-priority patent/WO2008139576A1/ja
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of WO2008136394A1 publication Critical patent/WO2008136394A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

　本発明は、ラクタム化合物の新規な製造法およびその製造中間体に関する。さらに詳しくは、本発明は、穏和で安全な条件で実施できる糖尿病治療薬あるいはその製造中間体としてのラクタム化合物の簡便な製造法、およびそのような製造法に有用な製造中間体に関する。
PCT/JP2008/058038 2007-04-27 2008-04-25 ラクタム化合物の製造方法及びその製造中間体 WO2008136394A1 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
PCT/JP2007/059540 WO2008139574A1 (ja) 2007-04-27 2007-04-27 ラクタム化合物の結晶形およびその製造方法
PCT/JP2007/059544 WO2008139575A1 (ja) 2007-04-27 2007-04-27 経口投与用製剤
JPPCT/JP2007/059544 2007-04-27
JPPCT/JP2007/059540 2007-04-27
JPPCT/JP2007/059545 2007-04-27
PCT/JP2007/059545 WO2008139576A1 (ja) 2007-04-27 2007-04-27 ラクタム化合物の製造方法及びその製造中間体

Publications (1)

Publication Number Publication Date
WO2008136394A1 true WO2008136394A1 (ja) 2008-11-13

Family

ID=39943501

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/JP2008/058037 WO2008136393A1 (ja) 2007-04-27 2008-04-25 ラクタム化合物の結晶形およびその製造方法
PCT/JP2008/058036 WO2008136392A1 (ja) 2007-04-27 2008-04-25 経口投与用製剤
PCT/JP2008/058038 WO2008136394A1 (ja) 2007-04-27 2008-04-25 ラクタム化合物の製造方法及びその製造中間体

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/JP2008/058037 WO2008136393A1 (ja) 2007-04-27 2008-04-25 ラクタム化合物の結晶形およびその製造方法
PCT/JP2008/058036 WO2008136392A1 (ja) 2007-04-27 2008-04-25 経口投与用製剤

Country Status (1)

Country Link
WO (3) WO2008136393A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002075A1 (ja) * 2009-07-02 2011-01-06 味の素株式会社 ラクタム化合物の製造方法およびその製造中間体
WO2011002076A1 (ja) * 2009-07-02 2011-01-06 味の素株式会社 ラクタム化合物の製造方法およびその製造中間体

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2568988B1 (en) * 2010-05-11 2016-07-13 Janssen Pharmaceutica, N.V. Pharmaceutical formulations comprising 1-(beta-d-glucopyranosyl)-2-thienylmethylbenzene derivatives as inhibitors of sglt
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3238723B1 (en) * 2014-12-22 2020-02-05 EA Pharma Co., Ltd. Drug for treating disorders of corneal epithelium
JP6498158B2 (ja) * 2016-07-11 2019-04-10 ニプロ株式会社 口腔内崩壊錠

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044180A1 (fr) * 2000-12-01 2002-06-06 Ajinomoto Co.,Inc. Composes de lactame et leur utilisation medicale

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ295956B6 (cs) * 1997-12-22 2005-12-14 Schering Corporation Farmaceutický prostředek obsahující molekulární disperzi
JP4327424B2 (ja) * 2000-05-15 2009-09-09 武田薬品工業株式会社 結晶の製造法
ITMI20011727A1 (it) * 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi
KR20050097537A (ko) * 2003-02-07 2005-10-07 아지노모토 가부시키가이샤 당뇨병 치료제
KR100882156B1 (ko) * 2003-08-08 2009-02-06 아지노모토 가부시키가이샤 나테글리니드 함유 제제
CA2544310A1 (en) * 2003-10-31 2005-05-12 Ajinomoto Co., Inc. New fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof
TW200616634A (en) * 2004-10-01 2006-06-01 Bristol Myers Squibb Co Crystalline forms and process for preparing spiro-hydantoin compounds
KR20080004632A (ko) * 2005-04-28 2008-01-09 아지노모토 가부시키가이샤 신규 락탐 화합물
US20090208584A1 (en) * 2005-06-09 2009-08-20 Tomohiro Yoshinari Solid preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044180A1 (fr) * 2000-12-01 2002-06-06 Ajinomoto Co.,Inc. Composes de lactame et leur utilisation medicale

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002075A1 (ja) * 2009-07-02 2011-01-06 味の素株式会社 ラクタム化合物の製造方法およびその製造中間体
WO2011002076A1 (ja) * 2009-07-02 2011-01-06 味の素株式会社 ラクタム化合物の製造方法およびその製造中間体

Also Published As

Publication number Publication date
WO2008136393A1 (ja) 2008-11-13
WO2008136392A1 (ja) 2008-11-13

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