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WO2008136393A1 - ラクタム化合物の結晶形およびその製造方法 - Google Patents

ラクタム化合物の結晶形およびその製造方法 Download PDF

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Publication number
WO2008136393A1
WO2008136393A1 PCT/JP2008/058037 JP2008058037W WO2008136393A1 WO 2008136393 A1 WO2008136393 A1 WO 2008136393A1 JP 2008058037 W JP2008058037 W JP 2008058037W WO 2008136393 A1 WO2008136393 A1 WO 2008136393A1
Authority
WO
WIPO (PCT)
Prior art keywords
crystal
agent
lactam compound
production
glucose transport
Prior art date
Application number
PCT/JP2008/058037
Other languages
English (en)
French (fr)
Inventor
Shinichiro Takahashi
Yukako Sakio
Keiko Hamajima
Tatsuya Ishikawa
Junko Koizumi
Haruya Sato
Kunio Ono
Kouji Haga
Yuuji Ikegaya
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2007/059540 external-priority patent/WO2008139574A1/ja
Priority claimed from PCT/JP2007/059544 external-priority patent/WO2008139575A1/ja
Priority claimed from PCT/JP2007/059545 external-priority patent/WO2008139576A1/ja
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of WO2008136393A1 publication Critical patent/WO2008136393A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

　本発明は、優れた糖輸送増強作用剤、血糖降下剤などの医薬に適した保存安定性、取扱い容易性などを有するラクタム化合物の結晶を提供する。本発明の式（Ｉ）で表される化合物またはその製薬学的に許容される塩の結晶は、糖輸送増強作用剤、血糖降下剤などの医薬として有用である。
PCT/JP2008/058037 2007-04-27 2008-04-25 ラクタム化合物の結晶形およびその製造方法 WO2008136393A1 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
PCT/JP2007/059540 WO2008139574A1 (ja) 2007-04-27 2007-04-27 ラクタム化合物の結晶形およびその製造方法
PCT/JP2007/059544 WO2008139575A1 (ja) 2007-04-27 2007-04-27 経口投与用製剤
JPPCT/JP2007/059544 2007-04-27
JPPCT/JP2007/059540 2007-04-27
JPPCT/JP2007/059545 2007-04-27
PCT/JP2007/059545 WO2008139576A1 (ja) 2007-04-27 2007-04-27 ラクタム化合物の製造方法及びその製造中間体

Publications (1)

Publication Number Publication Date
WO2008136393A1 true WO2008136393A1 (ja) 2008-11-13

Family

ID=39943501

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/JP2008/058037 WO2008136393A1 (ja) 2007-04-27 2008-04-25 ラクタム化合物の結晶形およびその製造方法
PCT/JP2008/058036 WO2008136392A1 (ja) 2007-04-27 2008-04-25 経口投与用製剤
PCT/JP2008/058038 WO2008136394A1 (ja) 2007-04-27 2008-04-25 ラクタム化合物の製造方法及びその製造中間体

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/JP2008/058036 WO2008136392A1 (ja) 2007-04-27 2008-04-25 経口投与用製剤
PCT/JP2008/058038 WO2008136394A1 (ja) 2007-04-27 2008-04-25 ラクタム化合物の製造方法及びその製造中間体

Country Status (1)

Country Link
WO (3) WO2008136393A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012180282A (ja) * 2009-07-02 2012-09-20 Ajinomoto Co Inc ラクタム化合物の製造方法およびその製造中間体
JP2012180283A (ja) * 2009-07-02 2012-09-20 Ajinomoto Co Inc ラクタム化合物の製造方法およびその製造中間体
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
EP2568988B1 (en) * 2010-05-11 2016-07-13 Janssen Pharmaceutica, N.V. Pharmaceutical formulations comprising 1-(beta-d-glucopyranosyl)-2-thienylmethylbenzene derivatives as inhibitors of sglt
EP3238723B1 (en) * 2014-12-22 2020-02-05 EA Pharma Co., Ltd. Drug for treating disorders of corneal epithelium
JP6498158B2 (ja) * 2016-07-11 2019-04-10 ニプロ株式会社 口腔内崩壊錠

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044180A1 (fr) * 2000-12-01 2002-06-06 Ajinomoto Co.,Inc. Composes de lactame et leur utilisation medicale
JP2003055372A (ja) * 2000-05-15 2003-02-26 Takeda Chem Ind Ltd 結晶の製造法
WO2004069259A1 (ja) * 2003-02-07 2004-08-19 Ajinomoto Co., Inc. 糖尿病治療剤
JP2005502648A (ja) * 2001-08-06 2005-01-27 レコーダチ アイルランド リミテッド 塩酸レルカニジピンの溶媒和物及び塩酸レルカニジピンの新しい結晶性形状
WO2005042536A1 (ja) * 2003-10-31 2005-05-12 Ajinomoto Co., Inc. 複素環を有する新規縮合多環式化合物及びその医薬用途
WO2006039639A1 (en) * 2004-10-01 2006-04-13 Bristol-Myers Squibb Company Crystalline forms and process for preparing spiro-hydantoin compounds
WO2006118341A1 (ja) * 2005-04-28 2006-11-09 Ajinomoto Co., Inc. 新規ラクタム化合物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ295956B6 (cs) * 1997-12-22 2005-12-14 Schering Corporation Farmaceutický prostředek obsahující molekulární disperzi
KR100882156B1 (ko) * 2003-08-08 2009-02-06 아지노모토 가부시키가이샤 나테글리니드 함유 제제
US20090208584A1 (en) * 2005-06-09 2009-08-20 Tomohiro Yoshinari Solid preparation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003055372A (ja) * 2000-05-15 2003-02-26 Takeda Chem Ind Ltd 結晶の製造法
WO2002044180A1 (fr) * 2000-12-01 2002-06-06 Ajinomoto Co.,Inc. Composes de lactame et leur utilisation medicale
JP2005502648A (ja) * 2001-08-06 2005-01-27 レコーダチ アイルランド リミテッド 塩酸レルカニジピンの溶媒和物及び塩酸レルカニジピンの新しい結晶性形状
WO2004069259A1 (ja) * 2003-02-07 2004-08-19 Ajinomoto Co., Inc. 糖尿病治療剤
WO2005042536A1 (ja) * 2003-10-31 2005-05-12 Ajinomoto Co., Inc. 複素環を有する新規縮合多環式化合物及びその医薬用途
WO2006039639A1 (en) * 2004-10-01 2006-04-13 Bristol-Myers Squibb Company Crystalline forms and process for preparing spiro-hydantoin compounds
WO2006118341A1 (ja) * 2005-04-28 2006-11-09 Ajinomoto Co., Inc. 新規ラクタム化合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CSJ: THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Guide Book", 15 June 1984, MARUZEN CO., LTD., pages: 130 - 131 *
OGATA A.: "Kagaku Jikken Sosaho", vol. 27TH ED., 20 November 1963, NANKODO CO., LTD., pages: 376 - 399 *
OKANO T.: "Shin.Yakuzaigaku Soron, revisted 3rd ed.", 10 April 1987, NANKODO CO., LTD., pages: 110 - 111 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

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Publication number Publication date
WO2008136394A1 (ja) 2008-11-13
WO2008136392A1 (ja) 2008-11-13

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