WO2008126783A1 - ジペプチドの製造法 - Google Patents
ジペプチドの製造法 Download PDFInfo
- Publication number
- WO2008126783A1 WO2008126783A1 PCT/JP2008/056758 JP2008056758W WO2008126783A1 WO 2008126783 A1 WO2008126783 A1 WO 2008126783A1 JP 2008056758 W JP2008056758 W JP 2008056758W WO 2008126783 A1 WO2008126783 A1 WO 2008126783A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dipeptide
- protein
- activity
- acid sequence
- amino acid
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title abstract 7
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08739864.0A EP2143786B1 (en) | 2007-04-06 | 2008-04-04 | Method for producing dipeptide |
US12/594,903 US8673590B2 (en) | 2007-04-06 | 2008-04-04 | Method for producing dipeptide |
CN200880019211.2A CN101715484B (zh) | 2007-04-06 | 2008-04-04 | 二肽的制造方法 |
JP2009509317A JP5319521B2 (ja) | 2007-04-06 | 2008-04-04 | ジペプチドの製造法 |
ES08739864.0T ES2526490T3 (es) | 2007-04-06 | 2008-04-04 | Método para producir un dipéptido |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007099956 | 2007-04-06 | ||
JP2007-099956 | 2007-04-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008126783A1 true WO2008126783A1 (ja) | 2008-10-23 |
Family
ID=39863882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/056758 WO2008126783A1 (ja) | 2007-04-06 | 2008-04-04 | ジペプチドの製造法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8673590B2 (ja) |
EP (1) | EP2143786B1 (ja) |
JP (1) | JP5319521B2 (ja) |
CN (1) | CN101715484B (ja) |
ES (1) | ES2526490T3 (ja) |
WO (1) | WO2008126783A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106480009A (zh) * | 2016-12-25 | 2017-03-08 | 河北周酶生物科技有限公司 | 一种固定化氨基酸酯酰转移酶及在制备丙谷二肽中的应用 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150299660A1 (en) * | 2012-11-15 | 2015-10-22 | International Stem Cell Corporation | Differentiation of human fibroblast cells |
CN107354207B (zh) * | 2017-07-11 | 2019-12-10 | 大连晶泰生物技术有限公司 | 基于双链探针的液相杂交捕获试剂盒、洗涤试剂盒及其应用 |
KR102251946B1 (ko) * | 2019-10-31 | 2021-05-17 | 대상 주식회사 | yeeO 유전자 불활성에 의해 방향족 아미노산 생산능력이 향상된 균주 |
CN116622795B (zh) * | 2023-07-20 | 2023-10-13 | 凯莱英生命科学技术(天津)有限公司 | L-氨基酸连接酶的制备方法及其在二肽合成上的应用 |
Citations (29)
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JPS5618596A (en) | 1979-07-23 | 1981-02-21 | Ajinomoto Co Inc | Production of l-lysine through fermentation process |
JPS56144092A (en) | 1980-04-14 | 1981-11-10 | Ajinomoto Co Inc | Preparation of l-methionine by fermentation |
JPS5813599A (ja) | 1981-07-08 | 1983-01-26 | シエ−リング・アクチエンゲゼルシヤフト | プラスミド、その製法、e・コリ−突然変異体、l−プロリンの製法及び新規菌株物の製法 |
JPS58110600A (ja) | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
JPS6394985A (ja) | 1986-10-09 | 1988-04-26 | Kyowa Hakko Kogyo Co Ltd | L−チロシンの製造法 |
JPS63233798A (ja) | 1986-10-09 | 1988-09-29 | Kyowa Hakko Kogyo Co Ltd | 5′−グアニル酸の製造法 |
JPS63248394A (ja) | 1987-04-06 | 1988-10-14 | Kyowa Hakko Kogyo Co Ltd | 核酸関連物質の製造法 |
JPH02113887A (ja) | 1988-10-21 | 1990-04-26 | Ajinomoto Co Inc | プロリンイミノペプチダーゼをコードする遺伝子を有する組換えdna及び該組換えdnaを有する細胞を用いるプロリンイミノペプチダーゼの製造法 |
WO1996027669A1 (fr) | 1995-03-07 | 1996-09-12 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production de trans-4-hydroxy-l-proline |
WO1997015673A1 (de) | 1995-10-26 | 1997-05-01 | Consortium für elektrochemische Industrie GmbH | Verfahren zur herstellung von o-acetylserin, l-cystein und l-cystein-verwandten produkten |
JPH09121860A (ja) | 1995-10-31 | 1997-05-13 | Rikagaku Kenkyusho | プロリンイミノペプチダーゼ |
WO1997023597A2 (de) | 1995-12-22 | 1997-07-03 | Forschungszentrum Jülich GmbH | Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern |
WO1998012343A1 (fr) | 1996-09-17 | 1998-03-26 | Kyowa Hakko Kogyo Co., Ltd. | Procedes de production de nucleotides de sucre et de glucides complexes |
JP2000116390A (ja) | 1998-10-13 | 2000-04-25 | Ajinomoto Co Inc | 大腸菌にl―ホモセリンに対する耐性を付与するタンパク質をコ―ドするdna及びl―アミノ酸の製造方法 |
JP2000189177A (ja) | 1998-12-23 | 2000-07-11 | Ajinomoto Co Inc | 新規遺伝子及びアミノ酸の製造法 |
WO2003010307A1 (en) | 2001-07-26 | 2003-02-06 | Ajinomoto Co., Inc. | Peptide synthase gene, peptide synthase and process for producing dipeptide |
JP2003511086A (ja) | 1999-10-14 | 2003-03-25 | コンゾルテイウム フユール エレクトロケミツシエ インヅストリー ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | L−システイン又はl−システイン誘導体を発酵により製造する方法 |
JP2003164297A (ja) | 2001-11-30 | 2003-06-10 | Ajinomoto Co Inc | 新規変異型グルタミンシンテターゼ、およびアミノ酸の生産方法 |
US20030113899A1 (en) | 2001-07-25 | 2003-06-19 | Ajinomoto Co., Inc. | Method for producing L-arginine |
WO2004058960A1 (ja) | 2002-12-26 | 2004-07-15 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
WO2005045006A1 (ja) | 2003-11-05 | 2005-05-19 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドを生産する微生物および該微生物を用いたジペプチドの製造法 |
WO2005052153A1 (ja) | 2003-11-27 | 2005-06-09 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
WO2005052177A1 (ja) | 2003-11-28 | 2005-06-09 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
JP2005237379A (ja) | 2004-01-30 | 2005-09-08 | Ajinomoto Co Inc | L−アミノ酸生産菌及びl−アミノ酸の製造法 |
JP2005287333A (ja) | 2004-03-31 | 2005-10-20 | Ajinomoto Co Inc | L−システイン生産菌及びl−システインの製造法 |
WO2005103260A1 (ja) | 2004-04-21 | 2005-11-03 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
WO2006001382A1 (ja) | 2004-06-25 | 2006-01-05 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドまたはジペプチド誘導体の製造法 |
WO2006001381A1 (ja) | 2004-06-25 | 2006-01-05 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドまたはジペプチド誘導体の製造法 |
WO2006001379A1 (ja) | 2004-06-25 | 2006-01-05 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7629142B2 (en) | 2004-01-30 | 2009-12-08 | Ajinomoto Co., Inc. | L-amino acid-producing microorganism and method for producing L-amino acid |
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2008
- 2008-04-04 EP EP08739864.0A patent/EP2143786B1/en active Active
- 2008-04-04 CN CN200880019211.2A patent/CN101715484B/zh active Active
- 2008-04-04 JP JP2009509317A patent/JP5319521B2/ja active Active
- 2008-04-04 US US12/594,903 patent/US8673590B2/en active Active
- 2008-04-04 WO PCT/JP2008/056758 patent/WO2008126783A1/ja active Application Filing
- 2008-04-04 ES ES08739864.0T patent/ES2526490T3/es active Active
Patent Citations (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5618596A (en) | 1979-07-23 | 1981-02-21 | Ajinomoto Co Inc | Production of l-lysine through fermentation process |
JPS56144092A (en) | 1980-04-14 | 1981-11-10 | Ajinomoto Co Inc | Preparation of l-methionine by fermentation |
JPS5813599A (ja) | 1981-07-08 | 1983-01-26 | シエ−リング・アクチエンゲゼルシヤフト | プラスミド、その製法、e・コリ−突然変異体、l−プロリンの製法及び新規菌株物の製法 |
JPS58110600A (ja) | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
JPS6394985A (ja) | 1986-10-09 | 1988-04-26 | Kyowa Hakko Kogyo Co Ltd | L−チロシンの製造法 |
JPS63233798A (ja) | 1986-10-09 | 1988-09-29 | Kyowa Hakko Kogyo Co Ltd | 5′−グアニル酸の製造法 |
JPS63248394A (ja) | 1987-04-06 | 1988-10-14 | Kyowa Hakko Kogyo Co Ltd | 核酸関連物質の製造法 |
JPH02113887A (ja) | 1988-10-21 | 1990-04-26 | Ajinomoto Co Inc | プロリンイミノペプチダーゼをコードする遺伝子を有する組換えdna及び該組換えdnaを有する細胞を用いるプロリンイミノペプチダーゼの製造法 |
WO1996027669A1 (fr) | 1995-03-07 | 1996-09-12 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production de trans-4-hydroxy-l-proline |
WO1997015673A1 (de) | 1995-10-26 | 1997-05-01 | Consortium für elektrochemische Industrie GmbH | Verfahren zur herstellung von o-acetylserin, l-cystein und l-cystein-verwandten produkten |
JPH09121860A (ja) | 1995-10-31 | 1997-05-13 | Rikagaku Kenkyusho | プロリンイミノペプチダーゼ |
WO1997023597A2 (de) | 1995-12-22 | 1997-07-03 | Forschungszentrum Jülich GmbH | Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern |
WO1998012343A1 (fr) | 1996-09-17 | 1998-03-26 | Kyowa Hakko Kogyo Co., Ltd. | Procedes de production de nucleotides de sucre et de glucides complexes |
JP2000116390A (ja) | 1998-10-13 | 2000-04-25 | Ajinomoto Co Inc | 大腸菌にl―ホモセリンに対する耐性を付与するタンパク質をコ―ドするdna及びl―アミノ酸の製造方法 |
JP2000189177A (ja) | 1998-12-23 | 2000-07-11 | Ajinomoto Co Inc | 新規遺伝子及びアミノ酸の製造法 |
JP2003511086A (ja) | 1999-10-14 | 2003-03-25 | コンゾルテイウム フユール エレクトロケミツシエ インヅストリー ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | L−システイン又はl−システイン誘導体を発酵により製造する方法 |
US20030113899A1 (en) | 2001-07-25 | 2003-06-19 | Ajinomoto Co., Inc. | Method for producing L-arginine |
WO2003010307A1 (en) | 2001-07-26 | 2003-02-06 | Ajinomoto Co., Inc. | Peptide synthase gene, peptide synthase and process for producing dipeptide |
WO2003010187A1 (fr) | 2001-07-26 | 2003-02-06 | Ajinomoto Co., Inc. | Procede de production de dipeptides, l-aminoacide amide hydrolase s'utilisant dans ce contexte et procede de production de l-aminoacide amide hydrolase |
WO2003010189A1 (en) | 2001-07-26 | 2003-02-06 | Ajinomoto Co., Inc. | Process for producing dipeptide, peptide synthase to be used therein and process for producing peptide synthase |
JP2003164297A (ja) | 2001-11-30 | 2003-06-10 | Ajinomoto Co Inc | 新規変異型グルタミンシンテターゼ、およびアミノ酸の生産方法 |
WO2004058960A1 (ja) | 2002-12-26 | 2004-07-15 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
WO2005045006A1 (ja) | 2003-11-05 | 2005-05-19 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドを生産する微生物および該微生物を用いたジペプチドの製造法 |
WO2005052153A1 (ja) | 2003-11-27 | 2005-06-09 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
WO2005052177A1 (ja) | 2003-11-28 | 2005-06-09 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
JP2005237379A (ja) | 2004-01-30 | 2005-09-08 | Ajinomoto Co Inc | L−アミノ酸生産菌及びl−アミノ酸の製造法 |
JP2005287333A (ja) | 2004-03-31 | 2005-10-20 | Ajinomoto Co Inc | L−システイン生産菌及びl−システインの製造法 |
WO2005103260A1 (ja) | 2004-04-21 | 2005-11-03 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
WO2006001382A1 (ja) | 2004-06-25 | 2006-01-05 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドまたはジペプチド誘導体の製造法 |
WO2006001381A1 (ja) | 2004-06-25 | 2006-01-05 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドまたはジペプチド誘導体の製造法 |
WO2006001379A1 (ja) | 2004-06-25 | 2006-01-05 | Kyowa Hakko Kogyo Co., Ltd. | ジペプチドの製造法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106480009A (zh) * | 2016-12-25 | 2017-03-08 | 河北周酶生物科技有限公司 | 一种固定化氨基酸酯酰转移酶及在制备丙谷二肽中的应用 |
CN106480009B (zh) * | 2016-12-25 | 2020-12-11 | 河北周酶生物科技有限公司 | 一种固定化氨基酸酯酰转移酶及在制备丙谷二肽中的应用 |
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US20100129867A1 (en) | 2010-05-27 |
EP2143786B1 (en) | 2014-12-10 |
US8673590B2 (en) | 2014-03-18 |
EP2143786A4 (en) | 2010-06-16 |
CN101715484B (zh) | 2014-02-19 |
JPWO2008126783A1 (ja) | 2010-07-22 |
ES2526490T3 (es) | 2015-01-12 |
CN101715484A (zh) | 2010-05-26 |
EP2143786A1 (en) | 2010-01-13 |
JP5319521B2 (ja) | 2013-10-16 |
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