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WO2008126783A1 - ジペプチドの製造法 - Google Patents

ジペプチドの製造法 Download PDF

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Publication number
WO2008126783A1
WO2008126783A1 PCT/JP2008/056758 JP2008056758W WO2008126783A1 WO 2008126783 A1 WO2008126783 A1 WO 2008126783A1 JP 2008056758 W JP2008056758 W JP 2008056758W WO 2008126783 A1 WO2008126783 A1 WO 2008126783A1
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WO
WIPO (PCT)
Prior art keywords
dipeptide
protein
activity
acid sequence
amino acid
Prior art date
Application number
PCT/JP2008/056758
Other languages
English (en)
French (fr)
Inventor
Mikiro Hayashi
Kazuhiko Tabata
Makoto Yagasaki
Yoshiyuki Yonetani
Original Assignee
Kyowa Hakko Bio Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co., Ltd. filed Critical Kyowa Hakko Bio Co., Ltd.
Priority to EP08739864.0A priority Critical patent/EP2143786B1/en
Priority to US12/594,903 priority patent/US8673590B2/en
Priority to CN200880019211.2A priority patent/CN101715484B/zh
Priority to JP2009509317A priority patent/JP5319521B2/ja
Priority to ES08739864.0T priority patent/ES2526490T3/es
Publication of WO2008126783A1 publication Critical patent/WO2008126783A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

　本発明によれば、ジペプチド合成活性を有する蛋白質を生産する能力を有し、かつ以下の［１］～［３］のいずれかに記載の菌体内のジペプチドを菌体外へ輸送する活性（以下、ジペプチド輸送活性という）を有する蛋白質の活性が親株よりも高い微生物、および該微生物を用いたジペプチドの製造法が提供される。 ［１］配列番号６～１０のいずれかで表されるアミノ酸配列を有する蛋白質 ［２］配列番号６～１０のいずれかで表されるアミノ酸配列において、１以上のアミノ酸が欠失、置換または付加されたアミノ酸配列からなり、かつジペプチド輸送活性を有する蛋白質 ［３］配列番号６～１０のいずれかで表されるアミノ酸配列と８０％以上の相同性があるアミノ酸配列を有し、かつジペプチド輸送活性を有する蛋白質
PCT/JP2008/056758 2007-04-06 2008-04-04 ジペプチドの製造法 WO2008126783A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08739864.0A EP2143786B1 (en) 2007-04-06 2008-04-04 Method for producing dipeptide
US12/594,903 US8673590B2 (en) 2007-04-06 2008-04-04 Method for producing dipeptide
CN200880019211.2A CN101715484B (zh) 2007-04-06 2008-04-04 二肽的制造方法
JP2009509317A JP5319521B2 (ja) 2007-04-06 2008-04-04 ジペプチドの製造法
ES08739864.0T ES2526490T3 (es) 2007-04-06 2008-04-04 Método para producir un dipéptido

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007099956 2007-04-06
JP2007-099956 2007-04-06

Publications (1)

Publication Number Publication Date
WO2008126783A1 true WO2008126783A1 (ja) 2008-10-23

Family

ID=39863882

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056758 WO2008126783A1 (ja) 2007-04-06 2008-04-04 ジペプチドの製造法

Country Status (6)

Country Link
US (1) US8673590B2 (ja)
EP (1) EP2143786B1 (ja)
JP (1) JP5319521B2 (ja)
CN (1) CN101715484B (ja)
ES (1) ES2526490T3 (ja)
WO (1) WO2008126783A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN106480009A (zh) * 2016-12-25 2017-03-08 河北周酶生物科技有限公司 一种固定化氨基酸酯酰转移酶及在制备丙谷二肽中的应用

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US20150299660A1 (en) * 2012-11-15 2015-10-22 International Stem Cell Corporation Differentiation of human fibroblast cells
CN107354207B (zh) * 2017-07-11 2019-12-10 大连晶泰生物技术有限公司 基于双链探针的液相杂交捕获试剂盒、洗涤试剂盒及其应用
KR102251946B1 (ko) * 2019-10-31 2021-05-17 대상 주식회사 yeeO 유전자 불활성에 의해 방향족 아미노산 생산능력이 향상된 균주
CN116622795B (zh) * 2023-07-20 2023-10-13 凯莱英生命科学技术(天津)有限公司 L-氨基酸连接酶的制备方法及其在二肽合成上的应用

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JP2005237379A (ja) 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2005287333A (ja) 2004-03-31 2005-10-20 Ajinomoto Co Inc Ｌ−システイン生産菌及びｌ−システインの製造法
WO2005103260A1 (ja) 2004-04-21 2005-11-03 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2006001382A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
WO2006001381A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
WO2006001379A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法

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WO2005045006A1 (ja) 2003-11-05 2005-05-19 Kyowa Hakko Kogyo Co., Ltd. ジペプチドを生産する微生物および該微生物を用いたジペプチドの製造法
WO2005052153A1 (ja) 2003-11-27 2005-06-09 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2005052177A1 (ja) 2003-11-28 2005-06-09 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
JP2005237379A (ja) 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2005287333A (ja) 2004-03-31 2005-10-20 Ajinomoto Co Inc Ｌ−システイン生産菌及びｌ−システインの製造法
WO2005103260A1 (ja) 2004-04-21 2005-11-03 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2006001382A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
WO2006001381A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
WO2006001379A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106480009A (zh) * 2016-12-25 2017-03-08 河北周酶生物科技有限公司 一种固定化氨基酸酯酰转移酶及在制备丙谷二肽中的应用
CN106480009B (zh) * 2016-12-25 2020-12-11 河北周酶生物科技有限公司 一种固定化氨基酸酯酰转移酶及在制备丙谷二肽中的应用

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CN101715484B (zh) 2014-02-19
JPWO2008126783A1 (ja) 2010-07-22
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CN101715484A (zh) 2010-05-26
EP2143786A1 (en) 2010-01-13
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