+

WO2008126783A1 - ジペプチドの製造法 - Google Patents

ジペプチドの製造法 Download PDF

Info

Publication number
WO2008126783A1
WO2008126783A1 PCT/JP2008/056758 JP2008056758W WO2008126783A1 WO 2008126783 A1 WO2008126783 A1 WO 2008126783A1 JP 2008056758 W JP2008056758 W JP 2008056758W WO 2008126783 A1 WO2008126783 A1 WO 2008126783A1
Authority
WO
WIPO (PCT)
Prior art keywords
dipeptide
protein
activity
acid sequence
amino acid
Prior art date
Application number
PCT/JP2008/056758
Other languages
English (en)
French (fr)
Inventor
Mikiro Hayashi
Kazuhiko Tabata
Makoto Yagasaki
Yoshiyuki Yonetani
Original Assignee
Kyowa Hakko Bio Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co., Ltd. filed Critical Kyowa Hakko Bio Co., Ltd.
Priority to EP08739864.0A priority Critical patent/EP2143786B1/en
Priority to US12/594,903 priority patent/US8673590B2/en
Priority to CN200880019211.2A priority patent/CN101715484B/zh
Priority to JP2009509317A priority patent/JP5319521B2/ja
Priority to ES08739864.0T priority patent/ES2526490T3/es
Publication of WO2008126783A1 publication Critical patent/WO2008126783A1/ja

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

 本発明によれば、ジペプチド合成活性を有する蛋白質を生産する能力を有し、かつ以下の[1]~[3]のいずれかに記載の菌体内のジペプチドを菌体外へ輸送する活性(以下、ジペプチド輸送活性という)を有する蛋白質の活性が親株よりも高い微生物、および該微生物を用いたジペプチドの製造法が提供される。 [1]配列番号6~10のいずれかで表されるアミノ酸配列を有する蛋白質 [2]配列番号6~10のいずれかで表されるアミノ酸配列において、1以上のアミノ酸が欠失、置換または付加されたアミノ酸配列からなり、かつジペプチド輸送活性を有する蛋白質 [3]配列番号6~10のいずれかで表されるアミノ酸配列と80%以上の相同性があるアミノ酸配列を有し、かつジペプチド輸送活性を有する蛋白質
PCT/JP2008/056758 2007-04-06 2008-04-04 ジペプチドの製造法 WO2008126783A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08739864.0A EP2143786B1 (en) 2007-04-06 2008-04-04 Method for producing dipeptide
US12/594,903 US8673590B2 (en) 2007-04-06 2008-04-04 Method for producing dipeptide
CN200880019211.2A CN101715484B (zh) 2007-04-06 2008-04-04 二肽的制造方法
JP2009509317A JP5319521B2 (ja) 2007-04-06 2008-04-04 ジペプチドの製造法
ES08739864.0T ES2526490T3 (es) 2007-04-06 2008-04-04 Método para producir un dipéptido

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007099956 2007-04-06
JP2007-099956 2007-04-06

Publications (1)

Publication Number Publication Date
WO2008126783A1 true WO2008126783A1 (ja) 2008-10-23

Family

ID=39863882

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056758 WO2008126783A1 (ja) 2007-04-06 2008-04-04 ジペプチドの製造法

Country Status (6)

Country Link
US (1) US8673590B2 (ja)
EP (1) EP2143786B1 (ja)
JP (1) JP5319521B2 (ja)
CN (1) CN101715484B (ja)
ES (1) ES2526490T3 (ja)
WO (1) WO2008126783A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106480009A (zh) * 2016-12-25 2017-03-08 河北周酶生物科技有限公司 一种固定化氨基酸酯酰转移酶及在制备丙谷二肽中的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150299660A1 (en) * 2012-11-15 2015-10-22 International Stem Cell Corporation Differentiation of human fibroblast cells
CN107354207B (zh) * 2017-07-11 2019-12-10 大连晶泰生物技术有限公司 基于双链探针的液相杂交捕获试剂盒、洗涤试剂盒及其应用
KR102251946B1 (ko) * 2019-10-31 2021-05-17 대상 주식회사 yeeO 유전자 불활성에 의해 방향족 아미노산 생산능력이 향상된 균주
CN116622795B (zh) * 2023-07-20 2023-10-13 凯莱英生命科学技术(天津)有限公司 L-氨基酸连接酶的制备方法及其在二肽合成上的应用

Citations (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618596A (en) 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
JPS56144092A (en) 1980-04-14 1981-11-10 Ajinomoto Co Inc Preparation of l-methionine by fermentation
JPS5813599A (ja) 1981-07-08 1983-01-26 シエ−リング・アクチエンゲゼルシヤフト プラスミド、その製法、e・コリ−突然変異体、l−プロリンの製法及び新規菌株物の製法
JPS58110600A (ja) 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
JPS6394985A (ja) 1986-10-09 1988-04-26 Kyowa Hakko Kogyo Co Ltd L−チロシンの製造法
JPS63233798A (ja) 1986-10-09 1988-09-29 Kyowa Hakko Kogyo Co Ltd 5′−グアニル酸の製造法
JPS63248394A (ja) 1987-04-06 1988-10-14 Kyowa Hakko Kogyo Co Ltd 核酸関連物質の製造法
JPH02113887A (ja) 1988-10-21 1990-04-26 Ajinomoto Co Inc プロリンイミノペプチダーゼをコードする遺伝子を有する組換えdna及び該組換えdnaを有する細胞を用いるプロリンイミノペプチダーゼの製造法
WO1996027669A1 (fr) 1995-03-07 1996-09-12 Kyowa Hakko Kogyo Co., Ltd. Procede de production de trans-4-hydroxy-l-proline
WO1997015673A1 (de) 1995-10-26 1997-05-01 Consortium für elektrochemische Industrie GmbH Verfahren zur herstellung von o-acetylserin, l-cystein und l-cystein-verwandten produkten
JPH09121860A (ja) 1995-10-31 1997-05-13 Rikagaku Kenkyusho プロリンイミノペプチダーゼ
WO1997023597A2 (de) 1995-12-22 1997-07-03 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern
WO1998012343A1 (fr) 1996-09-17 1998-03-26 Kyowa Hakko Kogyo Co., Ltd. Procedes de production de nucleotides de sucre et de glucides complexes
JP2000116390A (ja) 1998-10-13 2000-04-25 Ajinomoto Co Inc 大腸菌にl―ホモセリンに対する耐性を付与するタンパク質をコ―ドするdna及びl―アミノ酸の製造方法
JP2000189177A (ja) 1998-12-23 2000-07-11 Ajinomoto Co Inc 新規遺伝子及びアミノ酸の製造法
WO2003010307A1 (en) 2001-07-26 2003-02-06 Ajinomoto Co., Inc. Peptide synthase gene, peptide synthase and process for producing dipeptide
JP2003511086A (ja) 1999-10-14 2003-03-25 コンゾルテイウム フユール エレクトロケミツシエ インヅストリー ゲゼルシヤフト ミツト ベシユレンクテル ハフツング L−システイン又はl−システイン誘導体を発酵により製造する方法
JP2003164297A (ja) 2001-11-30 2003-06-10 Ajinomoto Co Inc 新規変異型グルタミンシンテターゼ、およびアミノ酸の生産方法
US20030113899A1 (en) 2001-07-25 2003-06-19 Ajinomoto Co., Inc. Method for producing L-arginine
WO2004058960A1 (ja) 2002-12-26 2004-07-15 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2005045006A1 (ja) 2003-11-05 2005-05-19 Kyowa Hakko Kogyo Co., Ltd. ジペプチドを生産する微生物および該微生物を用いたジペプチドの製造法
WO2005052153A1 (ja) 2003-11-27 2005-06-09 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2005052177A1 (ja) 2003-11-28 2005-06-09 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
JP2005237379A (ja) 2004-01-30 2005-09-08 Ajinomoto Co Inc L−アミノ酸生産菌及びl−アミノ酸の製造法
JP2005287333A (ja) 2004-03-31 2005-10-20 Ajinomoto Co Inc L−システイン生産菌及びl−システインの製造法
WO2005103260A1 (ja) 2004-04-21 2005-11-03 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2006001382A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
WO2006001381A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
WO2006001379A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629142B2 (en) 2004-01-30 2009-12-08 Ajinomoto Co., Inc. L-amino acid-producing microorganism and method for producing L-amino acid

Patent Citations (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618596A (en) 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
JPS56144092A (en) 1980-04-14 1981-11-10 Ajinomoto Co Inc Preparation of l-methionine by fermentation
JPS5813599A (ja) 1981-07-08 1983-01-26 シエ−リング・アクチエンゲゼルシヤフト プラスミド、その製法、e・コリ−突然変異体、l−プロリンの製法及び新規菌株物の製法
JPS58110600A (ja) 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
JPS6394985A (ja) 1986-10-09 1988-04-26 Kyowa Hakko Kogyo Co Ltd L−チロシンの製造法
JPS63233798A (ja) 1986-10-09 1988-09-29 Kyowa Hakko Kogyo Co Ltd 5′−グアニル酸の製造法
JPS63248394A (ja) 1987-04-06 1988-10-14 Kyowa Hakko Kogyo Co Ltd 核酸関連物質の製造法
JPH02113887A (ja) 1988-10-21 1990-04-26 Ajinomoto Co Inc プロリンイミノペプチダーゼをコードする遺伝子を有する組換えdna及び該組換えdnaを有する細胞を用いるプロリンイミノペプチダーゼの製造法
WO1996027669A1 (fr) 1995-03-07 1996-09-12 Kyowa Hakko Kogyo Co., Ltd. Procede de production de trans-4-hydroxy-l-proline
WO1997015673A1 (de) 1995-10-26 1997-05-01 Consortium für elektrochemische Industrie GmbH Verfahren zur herstellung von o-acetylserin, l-cystein und l-cystein-verwandten produkten
JPH09121860A (ja) 1995-10-31 1997-05-13 Rikagaku Kenkyusho プロリンイミノペプチダーゼ
WO1997023597A2 (de) 1995-12-22 1997-07-03 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern
WO1998012343A1 (fr) 1996-09-17 1998-03-26 Kyowa Hakko Kogyo Co., Ltd. Procedes de production de nucleotides de sucre et de glucides complexes
JP2000116390A (ja) 1998-10-13 2000-04-25 Ajinomoto Co Inc 大腸菌にl―ホモセリンに対する耐性を付与するタンパク質をコ―ドするdna及びl―アミノ酸の製造方法
JP2000189177A (ja) 1998-12-23 2000-07-11 Ajinomoto Co Inc 新規遺伝子及びアミノ酸の製造法
JP2003511086A (ja) 1999-10-14 2003-03-25 コンゾルテイウム フユール エレクトロケミツシエ インヅストリー ゲゼルシヤフト ミツト ベシユレンクテル ハフツング L−システイン又はl−システイン誘導体を発酵により製造する方法
US20030113899A1 (en) 2001-07-25 2003-06-19 Ajinomoto Co., Inc. Method for producing L-arginine
WO2003010307A1 (en) 2001-07-26 2003-02-06 Ajinomoto Co., Inc. Peptide synthase gene, peptide synthase and process for producing dipeptide
WO2003010187A1 (fr) 2001-07-26 2003-02-06 Ajinomoto Co., Inc. Procede de production de dipeptides, l-aminoacide amide hydrolase s'utilisant dans ce contexte et procede de production de l-aminoacide amide hydrolase
WO2003010189A1 (en) 2001-07-26 2003-02-06 Ajinomoto Co., Inc. Process for producing dipeptide, peptide synthase to be used therein and process for producing peptide synthase
JP2003164297A (ja) 2001-11-30 2003-06-10 Ajinomoto Co Inc 新規変異型グルタミンシンテターゼ、およびアミノ酸の生産方法
WO2004058960A1 (ja) 2002-12-26 2004-07-15 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2005045006A1 (ja) 2003-11-05 2005-05-19 Kyowa Hakko Kogyo Co., Ltd. ジペプチドを生産する微生物および該微生物を用いたジペプチドの製造法
WO2005052153A1 (ja) 2003-11-27 2005-06-09 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2005052177A1 (ja) 2003-11-28 2005-06-09 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
JP2005237379A (ja) 2004-01-30 2005-09-08 Ajinomoto Co Inc L−アミノ酸生産菌及びl−アミノ酸の製造法
JP2005287333A (ja) 2004-03-31 2005-10-20 Ajinomoto Co Inc L−システイン生産菌及びl−システインの製造法
WO2005103260A1 (ja) 2004-04-21 2005-11-03 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2006001382A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
WO2006001381A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
WO2006001379A1 (ja) 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法

Non-Patent Citations (67)

* Cited by examiner, † Cited by third party
Title
"Amino Acid Fermentation", 1986, JAPAN SCIENTIFIC SOCIETIES PRESS
"Biotechnology", vol. 6
"Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
"Immunology methods manual", ACADEMIC PRESS
"Methods for General and Molecular Bacteriolgy", 2001, ASM PRESS, article "Molecular Cloning Second Edition"
"Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Nucleic Acids Research", vol. 10, 1982, pages: 6487
"PCR Protocols", 1990, ACADEMIC PRESS
"Proc. Natl. Acad. Sci. USA", vol. 79, 1982, pages: 6409
"Products of Primary Metabolism", 1996, VCH VERLAGSGESELLSCHAFT MBH
ADVANCES IN BIOCHEMICAL ENGINEERING/BIOTECHNOLOGY, vol. 79, 2003, pages 1 - 35
AGRIC. BIOL. CHEM., vol. 36, 1972, pages 1675 - 1684
AGRIC. BIOL. CHEM., vol. 37, 1973, pages 2013 - 2023
AGRIC. BIOL. CHEM., vol. 39, 1975, pages 1149 - 1153
AGRIC. BIOL. CHEM., vol. 39, 1975, pages 153 - 160
AGRIC. BIOL. CHEM., vol. 39, 1987, pages 371 - 377
AGRIC. BIOL. CHEM., vol. 41, 1977, pages 109 - 116
AGRIC. BIOL. CHEM., vol. 42, 1978, pages 1773 - 1778
AGRIC. BIOL. CHEM., vol. 43, 1979, pages 105 - 111
AGRIC. BIOL. CHEM., vol. 48, 1984, pages 669
AGRIC. BIOL. CHEM., vol. 51, 1987, pages 2089 - 2094
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
APPL. ENVIRON. MICRIBIOL., vol. 38, 1979, pages 181 - 190
APPL. ENVIRON. MICROBIOL., vol. 64, 1998, pages 4736
APPL. MICROBIOL. BIOTECHNOL., vol. 35, 1991, pages 594 - 599
APPL. MICROBIOL. BIOTECHNOL., vol. 39, 1993, pages 318 - 323
APPL. MICROBIOL. BIOTECHNOL., vol. 53, 2000, pages 674 - 679
ARCH. BIOCHEM. BIOPHYS., vol. 336, 1996, pages 35
DELGADO M.A. ET AL.: "YojI of Escherichia coli functions as a microcin J25 efflux pump", J. BACTERIOL., vol. 187, no. 10, May 2005 (2005-05-01), pages 3465 - 3470, XP002579093 *
FASTA, METHODS ENZYMOL., vol. 183, 1990, pages 63
FEBS LETT., vol. 398, 1996, pages 101
FEMS MICROBIOL. LETT., vol. 78, 1999, pages 191
GENE, vol. 127, 1993, pages 117 - 120
GENE, vol. 33, 1985, pages 103
GENE, vol. 34, 1985, pages 315
J. ANTIMICROB. CHEMOTHER., vol. 51, 2003, pages 545 - 56
J. APPL. MICROBIOL., vol. 90, 2001, pages 449
J. BACTERIOL., vol. 110, 1972, pages 761 - 763
J. BACTERIOL., vol. 174, 1992, pages 7919
J. BACTERIOL., vol. 174, 1994, pages 7919
J. BACTERIOL., vol. 183, 2001, pages 5803 - 5812
J. BACTERIOL., vol. 187, 2005, pages 3465 - 3470
J. BIOCHEM., vol. 116, 1994, pages 818
J. BIOCHEM., vol. 119, 1996, pages 468
J. BIOCHEM., vol. 122, 1997, pages 601
J. GEN. APPL. MICROBIOL., vol. 4, 1958, pages 272 - 283
J. MOL. BIOL., vol. 215, 1990, pages 403
KARLIN; ALTSCHUL, PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
MICROBIOL. LETT., vol. 78, 1999, pages 191
MICROBIOLOGY, vol. 140, 1994, pages 527
MOL. MICROBIOL., vol. 9, 1993, pages 1203
NATURE, vol. 406, 2000, pages 959
NISHINO K. ET AL.: "Analysis of a complete library of putative drug transporter genes in Escherichia coli", J. BACTERIOL., vol. 183, no. 20, October 2001 (2001-10-01), pages 5803 - 5812, XP008125245 *
NUCLEIC ACIDS RES., vol. 16, 1988, pages 6127
NUCLEIC ACIDS RES., vol. 18, 1990, pages 6069
NUCLEIC ACIDS RESEARCH, vol. 13, 1985, pages 4431
PROC. NATL. ACAD. SCI. U S A., vol. 97, 2000, pages 6640
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6641 - 6645
PROC. NATL. ACAD. SCI., USA, vol. 69, 1972, pages 2110
PROC. NATL. ACAD. SCI., USA, vol. 74, 1977, pages 5463
PROC. NATL. ACAD. SCI., USA, vol. 82, 1985, pages 4306
RILEY M. ET AL.: "Escherichia coli K12: a cooperatively developed annotation snapshot-2005", NUCLEIC ACIDS RES., vol. 34, no. 1, 5 January 2006 (2006-01-05), pages 1 - 9, XP002450278 *
SCIENCE, vol. 533, no. 1, 1997, pages 1453 - 1474
SMITH M.W. ET AL.: "Substrate specificity of the periplasmic dipeptide-binding protein from Escherichia coli: experimental basis for the design of peptide prodrugs", MICROBIOLOGY, vol. 145, October 1999 (1999-10-01), pages 2891 - 2901, XP008126108 *
TABATA K. ET AL.: "Dipeptide no Kakushinteki Seiho no Kaihatsu -Amino acid Hakko kara Dipeptide hakko e-", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY 2006 NENDO TAIKAI KOEN YOSHISHU, 5 March 2006 (2006-03-05), pages SHI72, XP003021966 *
TABATA K. ET AL.: "Fermentative production of L-alanyl-L-glutamine by a metabolically engineered Escherichia coli strain expressing L-amino acid alpha-ligase", APPL. ENVIRON. MICROBIOL., vol. 73, no. 20, October 2007 (2007-10-01), pages 6378 - 6385, XP007912741 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106480009A (zh) * 2016-12-25 2017-03-08 河北周酶生物科技有限公司 一种固定化氨基酸酯酰转移酶及在制备丙谷二肽中的应用
CN106480009B (zh) * 2016-12-25 2020-12-11 河北周酶生物科技有限公司 一种固定化氨基酸酯酰转移酶及在制备丙谷二肽中的应用

Also Published As

Publication number Publication date
US20100129867A1 (en) 2010-05-27
EP2143786B1 (en) 2014-12-10
US8673590B2 (en) 2014-03-18
EP2143786A4 (en) 2010-06-16
CN101715484B (zh) 2014-02-19
JPWO2008126783A1 (ja) 2010-07-22
ES2526490T3 (es) 2015-01-12
CN101715484A (zh) 2010-05-26
EP2143786A1 (en) 2010-01-13
JP5319521B2 (ja) 2013-10-16

Similar Documents

Publication Publication Date Title
WO2008126784A1 (ja) グルタチオンおよびγ-グルタミルシステインの製造法
NZ600690A (en) Fkbp-l and uses thereof
NZ595495A (en) Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
WO2006128764A3 (en) Process for cultivating animal cells comprising the feeding of plant-derived peptones
NZ600540A (en) Ethanol production in non-recombinant hosts
EP2330199A3 (en) Surfactant tolerant cellulase and method for modification thereof
PL2041276T3 (pl) Sposób wytwarzania L-aminokwasów za pomocą mutantów genu gltA kodującego syntazę cytranianową
EP2599869A3 (en) Plants having enhanced yield-related traits and a method for making the same
EA201001435A1 (ru) Клетка, ферментирующая сахар-пентозу
MX2007002380A (es) Produccion de polipeptidos.
WO2007120932A3 (en) Expression of o-glycosylated therapeutic proteins in prokaryotic microorganisms
MX2007009489A (es) Microorganismos que comprenden enzimas expresadas con baja actividad de eliminacion gamma.
NZ597923A (en) Protein glycosylation
NZ588903A (en) A process for concentration of galactosycerebrosidase or porphobuilinogen deaminase
NZ586430A (en) Mutant forms of streptolysin o (slo)
WO2005103228B1 (en) L-amino acid-producing bacterium and a method for producing l-amino acid
WO2008126783A1 (ja) ジペプチドの製造法
WO2002081721A3 (en) Process for the production of l-amino acids using strains of the family enterobacteriaceae that contain an attenuated dgsa gene
WO2009066320A3 (en) Gcsf fusion protein systems suitable for high expression of peptides
MX2013002144A (es) Alimentacion alcalina.
NZ590011A (en) Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof
DE502006008100D1 (de) Verfahren zur produktion von aminosäuren mit mikroorganismen
WO2005094185A3 (en) Recombinant calf-chymosin and a process for producing the same
MX2011001174A (es) Metodo para modificar material de carbohidrato sin almidon utilizando enzimas de peroxidasa.
WO2008126785A1 (ja) 有用物質の製造法

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880019211.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08739864

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2009509317

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 12594903

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008739864

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务,不要输入任何密码和下载