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WO2004071379A3 - Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y10 (p2y10) - Google Patents

Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y10 (p2y10) Download PDF

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Publication number
WO2004071379A3
WO2004071379A3 PCT/EP2004/001057 EP2004001057W WO2004071379A3 WO 2004071379 A3 WO2004071379 A3 WO 2004071379A3 EP 2004001057 W EP2004001057 W EP 2004001057W WO 2004071379 A3 WO2004071379 A3 WO 2004071379A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
therapeutics
diagnostics
protein
diseases associated
Prior art date
Application number
PCT/EP2004/001057
Other languages
French (fr)
Other versions
WO2004071379A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Holger Summer filed Critical Bayer Healthcare Ag
Publication of WO2004071379A2 publication Critical patent/WO2004071379A2/en
Publication of WO2004071379A3 publication Critical patent/WO2004071379A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human P2Y10 which is associated with the hematological diseases, cardiovascular diseases, urology diseases, respiratory diseases, cancer diseases, gastrointestinal diseases and endocrinological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, urology diseases, respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of P2Y10 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/001057 2003-02-17 2004-02-05 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y10 (p2y10) WO2004071379A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03003545.5 2003-02-17
EP03003545 2003-02-17

Publications (2)

Publication Number Publication Date
WO2004071379A2 WO2004071379A2 (en) 2004-08-26
WO2004071379A3 true WO2004071379A3 (en) 2004-12-16

Family

ID=32864944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/001057 WO2004071379A2 (en) 2003-02-17 2004-02-05 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y10 (p2y10)

Country Status (1)

Country Link
WO (1) WO2004071379A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0835933A2 (en) * 1996-10-08 1998-04-15 Smithkline Beecham Corporation A G-protein coupled receptor, HLTEX11
WO2000077256A1 (en) * 1999-06-11 2000-12-21 Human Genome Sciences, Inc. 48 human secreted proteins
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0835933A2 (en) * 1996-10-08 1998-04-15 Smithkline Beecham Corporation A G-protein coupled receptor, HLTEX11
US5834587A (en) * 1996-10-08 1998-11-10 Smithkline Beecham Corporation G-protein coupled receptor, HLTEX 11
WO2000077256A1 (en) * 1999-06-11 2000-12-21 Human Genome Sciences, Inc. 48 human secreted proteins
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides

Also Published As

Publication number Publication date
WO2004071379A2 (en) 2004-08-26

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