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WO2005073729A3 - Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y11 (p2y11) - Google Patents

Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y11 (p2y11) Download PDF

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Publication number
WO2005073729A3
WO2005073729A3 PCT/EP2005/000470 EP2005000470W WO2005073729A3 WO 2005073729 A3 WO2005073729 A3 WO 2005073729A3 EP 2005000470 W EP2005000470 W EP 2005000470W WO 2005073729 A3 WO2005073729 A3 WO 2005073729A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
therapeutics
diagnostics
protein
diseases associated
Prior art date
Application number
PCT/EP2005/000470
Other languages
French (fr)
Other versions
WO2005073729A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts, Holger Summer filed Critical Bayer Healthcare Ag
Publication of WO2005073729A2 publication Critical patent/WO2005073729A2/en
Publication of WO2005073729A3 publication Critical patent/WO2005073729A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a human P2Y11 which is associated with the dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, cardiovascular diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, cardiovascular diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of P2Y11 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/000470 2004-01-31 2005-01-19 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y11 (p2y11) WO2005073729A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04002140.4 2004-01-31
EP04002140 2004-01-31

Publications (2)

Publication Number Publication Date
WO2005073729A2 WO2005073729A2 (en) 2005-08-11
WO2005073729A3 true WO2005073729A3 (en) 2005-12-08

Family

ID=34814232

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/000470 WO2005073729A2 (en) 2004-01-31 2005-01-19 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y11 (p2y11)

Country Status (1)

Country Link
WO (1) WO2005073729A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136336A1 (en) * 2006-05-19 2007-11-29 Forskarpatent I Syd Ab Diagnosis of increased risk of acute myocardial infarction
DE102006037920A1 (en) * 2006-08-11 2008-02-14 Rheinische Friedrich-Wilhelms Universität Special carbonylbisimino compounds for the treatment of immune diseases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOEYNAEMS J M: "overview of P2Y receptors as therapeutic targets", DRUG DEVELOPMENT RESEARCH, vol. 52, 2001, pages 187 - 189, XP002325018 *
COMMUNI D ET AL: "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenyl cyclase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 51, 19 December 1997 (1997-12-19), pages 31969 - 31973, XP002083513, ISSN: 0021-9258 *
COMMUNI^A D ET AL: "Rapid up-regulation of P2Y messengers during granulocytic differentiation of HL-60 cells", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 475, no. 1, 9 June 2000 (2000-06-09), pages 39 - 42, XP004337229, ISSN: 0014-5793 *
JANSSENS R ET AL: "Effects of extracellular nucleotides and nucleosides on prostate carcinoma cells", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 132, no. 2, January 2001 (2001-01-01), pages 536 - 546, XP002973033, ISSN: 0007-1188 *
WANG L: "P2 receptor expression profiles in human vascular smooth muscle and endothelial cells", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 40, 2002, pages 841 - 853, XP008019699 *
WEYDEN L: "pharmacological characterisation of the p2y11 receptors in stabily transfected haematological cell lines", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 213, 2000, pages 75 - 81, XP002325019 *

Also Published As

Publication number Publication date
WO2005073729A2 (en) 2005-08-11

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