WO2005114209A3 - Diagnostics and therapeutics for diseases associated with g protein-dependent receptor kinase 2 (grk2) - Google Patents
Diagnostics and therapeutics for diseases associated with g protein-dependent receptor kinase 2 (grk2) Download PDFInfo
- Publication number
- WO2005114209A3 WO2005114209A3 PCT/EP2005/004895 EP2005004895W WO2005114209A3 WO 2005114209 A3 WO2005114209 A3 WO 2005114209A3 EP 2005004895 W EP2005004895 W EP 2005004895W WO 2005114209 A3 WO2005114209 A3 WO 2005114209A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diseases
- grk2
- therapeutics
- diagnostics
- protein
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 5
- 101100015811 Caenorhabditis elegans grk-2 gene Proteins 0.000 title 1
- 108091005682 Receptor kinases Proteins 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 2
- 101000751445 Homo sapiens Beta-adrenergic receptor kinase 1 Proteins 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 208000012931 Urologic disease Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000002124 endocrine Effects 0.000 abstract 2
- 208000014951 hematologic disease Diseases 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 208000030159 metabolic disease Diseases 0.000 abstract 2
- 208000023504 respiratory system disease Diseases 0.000 abstract 2
- 208000014001 urinary system disease Diseases 0.000 abstract 2
- 102100021738 Beta-adrenergic receptor kinase 1 Human genes 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000053346 human GRK2 Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention provides a human GRK2 which is associated with hematological diseases, infections, cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, respiratory diseases, inflammation, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, infections, cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases gastroenterological diseases, respiratory diseases, inflammation, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GRK2 as well as pharmaceutical compositions comprising such compounds.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04012024.8 | 2004-05-21 | ||
| EP04012024 | 2004-05-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2005114209A2 WO2005114209A2 (en) | 2005-12-01 |
| WO2005114209A3 true WO2005114209A3 (en) | 2006-05-11 |
Family
ID=35063034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2005/004895 WO2005114209A2 (en) | 2004-05-21 | 2005-05-06 | Diagnostics and therapeutics for diseases associated with g protein-dependent receptor kinase 2 (grk2) |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2005114209A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230035892A1 (en) * | 2019-09-03 | 2023-02-02 | Flagship Pioneering Innovations V, Inc. | Methods and compositions for treating cancer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002035923A1 (en) * | 2000-10-31 | 2002-05-10 | Duke University | Hypertension |
| WO2004014296A2 (en) * | 2002-08-13 | 2004-02-19 | U.S. Department Of Veterans Affairs | Method of detecting and preventing alzheimer’s disease, particularly at prodromal and early stages |
-
2005
- 2005-05-06 WO PCT/EP2005/004895 patent/WO2005114209A2/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002035923A1 (en) * | 2000-10-31 | 2002-05-10 | Duke University | Hypertension |
| WO2004014296A2 (en) * | 2002-08-13 | 2004-02-19 | U.S. Department Of Veterans Affairs | Method of detecting and preventing alzheimer’s disease, particularly at prodromal and early stages |
Non-Patent Citations (2)
| Title |
|---|
| LOMBARDI M S ET AL: "Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 FEB 2001, vol. 166, no. 3, 1 February 2001 (2001-02-01), pages 1635 - 1640, XP009055729, ISSN: 0022-1767 * |
| VROON ANNE ET AL: "Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis.", JOURNAL OF NEUROIMMUNOLOGY. APR 2003, vol. 137, no. 1-2, April 2003 (2003-04-01), pages 79 - 86, XP009055706, ISSN: 0165-5728 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005114209A2 (en) | 2005-12-01 |
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