WO2003012389A3 - Method for analysing macromolecules, analysis device and a method for producing an analysis device - Google Patents
Method for analysing macromolecules, analysis device and a method for producing an analysis device Download PDFInfo
- Publication number
- WO2003012389A3 WO2003012389A3 PCT/EP2002/007644 EP0207644W WO03012389A3 WO 2003012389 A3 WO2003012389 A3 WO 2003012389A3 EP 0207644 W EP0207644 W EP 0207644W WO 03012389 A3 WO03012389 A3 WO 03012389A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drop
- macromolecules
- liquid
- spots
- microarray
- Prior art date
Links
- 229920002521 macromolecule Polymers 0.000 title abstract 9
- 238000004458 analytical method Methods 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 abstract 7
- 238000002493 microarray Methods 0.000 abstract 4
- 239000007787 solid Substances 0.000 abstract 3
- 230000005540 biological transmission Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00533—Sheets essentially rectangular
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
- B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
- B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0493—Specific techniques used
- B01L2400/0496—Travelling waves, e.g. in combination with electrical or acoustic forces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002328867A AU2002328867A1 (en) | 2001-07-24 | 2002-07-09 | Method for analysing macromolecules, analysis device and a method for producing an analysis device |
EP02764659A EP1412533A2 (en) | 2001-07-24 | 2002-07-09 | Method for analysing macromolecules, analysis device and a method for producing an analysis device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10136008.8 | 2001-07-24 | ||
DE10136008A DE10136008B4 (en) | 2001-07-24 | 2001-07-24 | Method for analyzing macromolecules and method for producing an analysis device |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003012389A2 WO2003012389A2 (en) | 2003-02-13 |
WO2003012389A3 true WO2003012389A3 (en) | 2003-07-17 |
Family
ID=7692898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/007644 WO2003012389A2 (en) | 2001-07-24 | 2002-07-09 | Method for analysing macromolecules, analysis device and a method for producing an analysis device |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1412533A2 (en) |
AU (1) | AU2002328867A1 (en) |
DE (1) | DE10136008B4 (en) |
WO (1) | WO2003012389A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10328624A1 (en) * | 2003-06-25 | 2005-01-20 | Advalytix Ag | A hybridizing process, for the study of biological material, the spots of an array on a microscope slide are in contact with a hybridizing solution in a set height level for the reaction time |
DE102004037348A1 (en) * | 2004-08-02 | 2006-03-16 | Infineon Technologies Ag | Fluid transport device, sensor assembly, fluid mixing device and method of manufacturing a fluid transport device |
DE102004051394B4 (en) * | 2004-10-21 | 2006-08-17 | Advalytix Ag | Method for moving small amounts of liquid in microchannels and microchannel system |
EP1833598B1 (en) | 2005-01-05 | 2008-10-08 | Olympus Life Science Research Europa GmbH | Method and device for dosing and mixing small amounts of liquid |
DE102005000835B3 (en) | 2005-01-05 | 2006-09-07 | Advalytix Ag | Method and device for dosing small quantities of liquid |
DE102005056639A1 (en) * | 2005-11-28 | 2007-06-06 | Advalytix Ag | Method, device and kit for the study of macromolecules in a sample |
DE102006056694B4 (en) * | 2006-11-30 | 2010-08-05 | Advalytix Ag | Method for carrying out an enzymatic reaction |
WO2008080531A2 (en) * | 2007-01-05 | 2008-07-10 | Advalytix Ag | Method, device, and kit for analyzing a liquid sample |
EP2194381B1 (en) * | 2008-12-03 | 2015-12-02 | Roche Diagnostics GmbH | Testing element with combined control and calibration zone |
JP2015512766A (en) * | 2012-01-31 | 2015-04-30 | ザ・ペン・ステート・リサーチ・ファンデーション | Microfluidic manipulation and particle classification using variable stationary surface acoustic waves |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994027719A1 (en) * | 1993-05-27 | 1994-12-08 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5674742A (en) * | 1992-08-31 | 1997-10-07 | The Regents Of The University Of California | Microfabricated reactor |
US6010316A (en) * | 1996-01-16 | 2000-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Acoustic micropump |
DE19836110A1 (en) * | 1998-08-10 | 2000-02-24 | Biotul Bio Instr Gmbh | Mixer effective close to liquid-biosensor interface employs parallel or transverse acoustic wave propagation between optical measurements, to agitate under controlled conditions of frequency and power, avoiding disruption |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
JPH0927590A (en) * | 1995-07-10 | 1997-01-28 | Nippon Inter Electronics Corp | Composite semiconductor device |
DE19827900A1 (en) * | 1997-10-21 | 1999-04-22 | Roche Diagnostics Gmbh | Process for coating surfaces |
DE59915204D1 (en) * | 1998-08-28 | 2010-10-28 | Febit Holding Gmbh | PROCESS FOR THE PRODUCTION OF BIOCHEMICAL REACTION CARRIER |
FR2783179B1 (en) * | 1998-09-16 | 2000-10-06 | Commissariat Energie Atomique | CHEMICAL OR BIOLOGICAL ANALYSIS DEVICE COMPRISING A PLURALITY OF ANALYSIS SITES ON A MEDIUM, AND ITS MANUFACTURING METHOD |
-
2001
- 2001-07-24 DE DE10136008A patent/DE10136008B4/en not_active Expired - Fee Related
-
2002
- 2002-07-09 AU AU2002328867A patent/AU2002328867A1/en not_active Abandoned
- 2002-07-09 EP EP02764659A patent/EP1412533A2/en not_active Withdrawn
- 2002-07-09 WO PCT/EP2002/007644 patent/WO2003012389A2/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5674742A (en) * | 1992-08-31 | 1997-10-07 | The Regents Of The University Of California | Microfabricated reactor |
WO1994027719A1 (en) * | 1993-05-27 | 1994-12-08 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US6010316A (en) * | 1996-01-16 | 2000-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Acoustic micropump |
DE19836110A1 (en) * | 1998-08-10 | 2000-02-24 | Biotul Bio Instr Gmbh | Mixer effective close to liquid-biosensor interface employs parallel or transverse acoustic wave propagation between optical measurements, to agitate under controlled conditions of frequency and power, avoiding disruption |
Non-Patent Citations (2)
Title |
---|
WANG J: "SURVEY AND SUMMARY FROM DNA BIOSENSORS TO GENE CHIPS", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 28, no. 16, 2000, pages 3011 - 3016, XP001127052, ISSN: 0305-1048 * |
WIXFORTH A., SCRIBA J.: "Nanopumpen für das Chiplabor", GIT LABOR-FACHZEITSCHRIFT, vol. 05, 2002, pages 594, XP009009065 * |
Also Published As
Publication number | Publication date |
---|---|
DE10136008A1 (en) | 2003-02-20 |
AU2002328867A1 (en) | 2003-02-17 |
EP1412533A2 (en) | 2004-04-28 |
DE10136008B4 (en) | 2005-03-31 |
WO2003012389A2 (en) | 2003-02-13 |
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