+

WO2002003788A3 - Transgenic mice containing targeted phosphatase gene disruptions - Google Patents

Transgenic mice containing targeted phosphatase gene disruptions Download PDF

Info

Publication number
WO2002003788A3
WO2002003788A3 PCT/US2001/021434 US0121434W WO0203788A3 WO 2002003788 A3 WO2002003788 A3 WO 2002003788A3 US 0121434 W US0121434 W US 0121434W WO 0203788 A3 WO0203788 A3 WO 0203788A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
phosphatase gene
mice containing
gene disruptions
containing targeted
Prior art date
Application number
PCT/US2001/021434
Other languages
French (fr)
Other versions
WO2002003788A2 (en
Inventor
Keith D Allen
Original Assignee
Deltagen Inc
Keith D Allen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Keith D Allen filed Critical Deltagen Inc
Priority to AU2001271880A priority Critical patent/AU2001271880A1/en
Publication of WO2002003788A2 publication Critical patent/WO2002003788A2/en
Publication of WO2002003788A3 publication Critical patent/WO2002003788A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a phosphatase gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
PCT/US2001/021434 2000-07-06 2001-07-06 Transgenic mice containing targeted phosphatase gene disruptions WO2002003788A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001271880A AU2001271880A1 (en) 2000-07-06 2001-07-06 Transgenic mice containing targeted phosphatase gene disruptions

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US21647600P 2000-07-06 2000-07-06
US21610400P 2000-07-06 2000-07-06
US60/216,104 2000-07-06
US60/216,476 2000-07-06
US22148900P 2000-07-27 2000-07-27
US60/221,489 2000-07-27
US22338600P 2000-08-07 2000-08-07
US60/223,386 2000-08-07
US30098301P 2001-06-26 2001-06-26
US60/300,983 2001-06-26

Publications (2)

Publication Number Publication Date
WO2002003788A2 WO2002003788A2 (en) 2002-01-17
WO2002003788A3 true WO2002003788A3 (en) 2003-07-10

Family

ID=27539727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021434 WO2002003788A2 (en) 2000-07-06 2001-07-06 Transgenic mice containing targeted phosphatase gene disruptions

Country Status (2)

Country Link
AU (1) AU2001271880A1 (en)
WO (1) WO2002003788A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020116729A1 (en) * 2000-12-06 2002-08-22 Allen Keith D. Transgenic mice containing NTTP1 phosphatase gene disruptions
AU2007309029B2 (en) 2006-10-25 2013-05-09 Aovatechnologies, Inc. Methods of reducing phosphate absorption
BRPI0716317A8 (en) * 2006-10-26 2019-02-05 Aovatechnologies Inc method for reducing phosphate absorption in a human or non-human animal individual and method for reducing phosphate absorption in a human individual

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036910A1 (en) * 1998-12-22 2000-06-29 Albert Einstein College Of Medicine Msh5 ablated mice and uses therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036910A1 (en) * 1998-12-22 2000-06-29 Albert Einstein College Of Medicine Msh5 ablated mice and uses therefor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MACGREGOR GRANT R ET AL: "Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells.", DEVELOPMENT (CAMBRIDGE), vol. 121, no. 5, 1995, pages 1487 - 1496, XP008008483, ISSN: 0950-1991 *
MANES T ET AL: "GENETIC COMPLEXITY, STRUCTURE, AND CHARACTERIZATION OF HIGHLY ACTIVE BOVINE INTESTINAL ALKALINE PHOSPHATASES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 36, 4 September 1998 (1998-09-04), pages 23353 - 23360, XP001029065, ISSN: 0021-9258 *
MANES T ET AL: "GENOMIC STRUCTURE AND COMPARISON OF MOUSE TISSUE-SPECIFIC ALKALINE PHOSPHATASE GENES", GENOMICS, vol. 8, no. 3, 1990, pages 541 - 554, XP001062172, ISSN: 0888-7543 *
NARISAWA SONOKO ET AL: "Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.", DEVELOPMENTAL DYNAMICS, vol. 208, no. 3, 1997, pages 432 - 446, XP008008484, ISSN: 1058-8388 *

Also Published As

Publication number Publication date
AU2001271880A1 (en) 2002-01-21
WO2002003788A2 (en) 2002-01-17

Similar Documents

Publication Publication Date Title
WO2002079440A3 (en) Transgenic mice containing gpcr5-1 gene disruptions
WO2002046390A3 (en) Transgenic mice containing rptpb tyrosine phosphatase gene disruptions
WO2002079424A3 (en) TRANSGENIC MICE CONTAINING β3GALT2 GENE DISRUPTIONS
WO2002079438A3 (en) Ogri gene disruptions, compositions and methods relating thereto
WO2003026395A3 (en) Mo54 gene disruptions, compositions and methods related thereto
WO2002048345A3 (en) Transgenic mice containing glutamate receptor (grik5) gene disruptions
WO2001067855A3 (en) Transgenic mice containing targeted gene disruptions
WO2002003789A3 (en) Transgenic mice containing targeted gpcr gene disruptions
WO2002040662A3 (en) Transgenic mice containing targeted gene disruptions
WO2002081658A8 (en) Transgenic mice containing cacnb4 calcium ion channel gene disruptions
WO2002001950A3 (en) Transgenic mice containing targeted gene disruptions
WO2002003788A3 (en) Transgenic mice containing targeted phosphatase gene disruptions
WO2002048342A3 (en) Knockout mice for trp6 gene
WO2002003793A3 (en) Transgenic mice containing targeted gene disruptions
WO2002079433A3 (en) Transgenic mice containing tmem3 beta-1,3-n-acetylglucosaminyltransferase gene disruptions
WO2002037957A3 (en) Transgenic mice containing perk protein kinase gene disruptions
WO2003026403A3 (en) Ctsz disruptions, compositions and methods relating thereto
WO2002003787A3 (en) Transgenic mice containing targeted gene disruptions
WO2002048346A3 (en) Transgenic mice containing bsmap gene disruptions
WO2002045500A3 (en) Transgenic mice containing ptp36 tyrosine phosphatase disruptions
WO2002079412A3 (en) Transgenic mice containing usp3-like deubiquitinating enzyme gene disruptions
WO2002003791A3 (en) Transgenic mice containing targeted gene disruptions
WO2002045497A3 (en) Transgenic mice containing dusp8 phosphatase gene disruptions
WO2002045492A3 (en) Transgenic mice containing polycystin-related gene disruptions
WO2002045493A3 (en) Transgenic mice containing phosphatase target gene disruptions

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载