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WO2002003788A3 - Souris transgeniques contenant des disruptions ciblees du gene de la phosphatase - Google Patents

Souris transgeniques contenant des disruptions ciblees du gene de la phosphatase Download PDF

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Publication number
WO2002003788A3
WO2002003788A3 PCT/US2001/021434 US0121434W WO0203788A3 WO 2002003788 A3 WO2002003788 A3 WO 2002003788A3 US 0121434 W US0121434 W US 0121434W WO 0203788 A3 WO0203788 A3 WO 0203788A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
phosphatase gene
mice containing
gene disruptions
containing targeted
Prior art date
Application number
PCT/US2001/021434
Other languages
English (en)
Other versions
WO2002003788A2 (fr
Inventor
Keith D Allen
Original Assignee
Deltagen Inc
Keith D Allen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Keith D Allen filed Critical Deltagen Inc
Priority to AU2001271880A priority Critical patent/AU2001271880A1/en
Publication of WO2002003788A2 publication Critical patent/WO2002003788A2/fr
Publication of WO2002003788A3 publication Critical patent/WO2002003788A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des animaux transgéniques ainsi que des compositions et des procédés concernant l'interprétation d'une fonction génique. Plus particulièrement, la présente invention concerne des souris transgéniques présentant des mutations du gène de la phosphatase. Ces souris transgéniques servent de modèles pour des maladies et elles permettent d'identifier des agents modulant l'expression génique et la fonction génique. Ces souris servent également pour les traitements potentiels de divers états pathologiques et de diverses affections pathologiques.
PCT/US2001/021434 2000-07-06 2001-07-06 Souris transgeniques contenant des disruptions ciblees du gene de la phosphatase WO2002003788A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001271880A AU2001271880A1 (en) 2000-07-06 2001-07-06 Transgenic mice containing targeted phosphatase gene disruptions

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US21647600P 2000-07-06 2000-07-06
US21610400P 2000-07-06 2000-07-06
US60/216,104 2000-07-06
US60/216,476 2000-07-06
US22148900P 2000-07-27 2000-07-27
US60/221,489 2000-07-27
US22338600P 2000-08-07 2000-08-07
US60/223,386 2000-08-07
US30098301P 2001-06-26 2001-06-26
US60/300,983 2001-06-26

Publications (2)

Publication Number Publication Date
WO2002003788A2 WO2002003788A2 (fr) 2002-01-17
WO2002003788A3 true WO2002003788A3 (fr) 2003-07-10

Family

ID=27539727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021434 WO2002003788A2 (fr) 2000-07-06 2001-07-06 Souris transgeniques contenant des disruptions ciblees du gene de la phosphatase

Country Status (2)

Country Link
AU (1) AU2001271880A1 (fr)
WO (1) WO2002003788A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020116729A1 (en) * 2000-12-06 2002-08-22 Allen Keith D. Transgenic mice containing NTTP1 phosphatase gene disruptions
AU2007309029B2 (en) 2006-10-25 2013-05-09 Aovatechnologies, Inc. Methods of reducing phosphate absorption
BRPI0716317A8 (pt) * 2006-10-26 2019-02-05 Aovatechnologies Inc método para reduzir a absorção de fosfato em um indivíduo animal humano ou não-humano e método para reduzir a absorção de fosfato em um indivíduo humano

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036910A1 (fr) * 1998-12-22 2000-06-29 Albert Einstein College Of Medicine Souris dont le gene msh5 a ete modifie et utilisations de ces dernieres

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036910A1 (fr) * 1998-12-22 2000-06-29 Albert Einstein College Of Medicine Souris dont le gene msh5 a ete modifie et utilisations de ces dernieres

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MACGREGOR GRANT R ET AL: "Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells.", DEVELOPMENT (CAMBRIDGE), vol. 121, no. 5, 1995, pages 1487 - 1496, XP008008483, ISSN: 0950-1991 *
MANES T ET AL: "GENETIC COMPLEXITY, STRUCTURE, AND CHARACTERIZATION OF HIGHLY ACTIVE BOVINE INTESTINAL ALKALINE PHOSPHATASES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 36, 4 September 1998 (1998-09-04), pages 23353 - 23360, XP001029065, ISSN: 0021-9258 *
MANES T ET AL: "GENOMIC STRUCTURE AND COMPARISON OF MOUSE TISSUE-SPECIFIC ALKALINE PHOSPHATASE GENES", GENOMICS, vol. 8, no. 3, 1990, pages 541 - 554, XP001062172, ISSN: 0888-7543 *
NARISAWA SONOKO ET AL: "Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.", DEVELOPMENTAL DYNAMICS, vol. 208, no. 3, 1997, pages 432 - 446, XP008008484, ISSN: 1058-8388 *

Also Published As

Publication number Publication date
AU2001271880A1 (en) 2002-01-21
WO2002003788A2 (fr) 2002-01-17

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