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WO2002003789A3 - Transgenic mice containing targeted gpcr gene disruptions - Google Patents

Transgenic mice containing targeted gpcr gene disruptions Download PDF

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Publication number
WO2002003789A3
WO2002003789A3 PCT/US2001/021498 US0121498W WO0203789A3 WO 2002003789 A3 WO2002003789 A3 WO 2002003789A3 US 0121498 W US0121498 W US 0121498W WO 0203789 A3 WO0203789 A3 WO 0203789A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
mice containing
gpcr gene
gene disruptions
containing targeted
Prior art date
Application number
PCT/US2001/021498
Other languages
French (fr)
Other versions
WO2002003789A2 (en
Inventor
Keith D Allen
Thomas J Brennan
Original Assignee
Deltagen Inc
Keith D Allen
Thomas J Brennan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Keith D Allen, Thomas J Brennan filed Critical Deltagen Inc
Priority to AU2001271902A priority Critical patent/AU2001271902A1/en
Publication of WO2002003789A2 publication Critical patent/WO2002003789A2/en
Publication of WO2002003789A3 publication Critical patent/WO2002003789A3/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Animal Husbandry (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Plant Pathology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a target GPCR gene. Such transgenic mice are useful as models for desease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
PCT/US2001/021498 2000-07-06 2001-07-06 Transgenic mice containing targeted gpcr gene disruptions WO2002003789A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001271902A AU2001271902A1 (en) 2000-07-06 2001-07-06 Transgenic mice containing targeted gpcr gene disruptions

Applications Claiming Priority (44)

Application Number Priority Date Filing Date Title
US21627100P 2000-07-06 2000-07-06
US21625200P 2000-07-06 2000-07-06
US21610800P 2000-07-06 2000-07-06
US21647300P 2000-07-06 2000-07-06
US21625400P 2000-07-06 2000-07-06
US21625300P 2000-07-06 2000-07-06
US21625900P 2000-07-06 2000-07-06
US21626000P 2000-07-06 2000-07-06
US21625000P 2000-07-06 2000-07-06
US21647500P 2000-07-06 2000-07-06
US60/216,260 2000-07-06
US60/216,253 2000-07-06
US60/216,475 2000-07-06
US60/216,108 2000-07-06
US60/216,250 2000-07-06
US60/216,259 2000-07-06
US60/216,271 2000-07-06
US60/216,473 2000-07-06
US60/216,252 2000-07-06
US60/216,254 2000-07-06
US21940300P 2000-07-19 2000-07-19
US60/219,403 2000-07-19
US22148400P 2000-07-27 2000-07-27
US22147400P 2000-07-27 2000-07-27
US22149700P 2000-07-27 2000-07-27
US22147300P 2000-07-27 2000-07-27
US22149000P 2000-07-27 2000-07-27
US60/221,490 2000-07-27
US60/221,474 2000-07-27
US60/221,473 2000-07-27
US60/221,484 2000-07-27
US60/221,497 2000-07-27
US22362500P 2000-08-07 2000-08-07
US60/223,625 2000-08-07
US25181500P 2000-12-06 2000-12-06
US60/251,815 2000-12-06
US26213801P 2001-01-16 2001-01-16
US26213701P 2001-01-16 2001-01-16
US60/262,137 2001-01-16
US60/262,138 2001-01-16
US28026401P 2001-03-29 2001-03-29
US60/280,264 2001-03-29
US30092901P 2001-06-26 2001-06-26
US60/300,929 2001-06-26

Publications (2)

Publication Number Publication Date
WO2002003789A2 WO2002003789A2 (en) 2002-01-17
WO2002003789A3 true WO2002003789A3 (en) 2003-02-27

Family

ID=27586645

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021498 WO2002003789A2 (en) 2000-07-06 2001-07-06 Transgenic mice containing targeted gpcr gene disruptions

Country Status (2)

Country Link
AU (1) AU2001271902A1 (en)
WO (1) WO2002003789A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030096299A1 (en) * 2001-07-09 2003-05-22 Valerie Wittamer Natural ligand of G protein coupled receptor ChemR23 and uses thereof
US7419658B2 (en) 2001-07-09 2008-09-02 Euroscreen S.A. Isolated ligand of ChemerinR
US7470772B2 (en) 2001-07-09 2008-12-30 Euroscreen S.A. Antibody that specifically binds to Chemerin receptor ligand precursor
US7858755B2 (en) 2001-07-09 2010-12-28 Euroscreen S.A. Monoclonal antibodies that bind Chemerin polypeptide
US20050037946A1 (en) * 2003-01-13 2005-02-17 Millennium Pharmaceuticals, Inc. Methods and compositions for treating cardiovascular disease using 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 or 2419
WO2005106490A1 (en) * 2004-04-30 2005-11-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with chemokine-like receptor 1 (cmklr1)
WO2016137841A1 (en) * 2015-02-26 2016-09-01 William Paterson University Of New Jersey Transgenic mice

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047316A1 (en) * 1996-06-10 1997-12-18 Millennium Pharmaceuticals, Inc. Screening methods for compounds useful in the regulation of body weight
WO1998053071A1 (en) * 1997-05-23 1998-11-26 Biogen, Inc. Modulators of tissue regeneration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047316A1 (en) * 1996-06-10 1997-12-18 Millennium Pharmaceuticals, Inc. Screening methods for compounds useful in the regulation of body weight
WO1998053071A1 (en) * 1997-05-23 1998-11-26 Biogen, Inc. Modulators of tissue regeneration

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
METHNER AXEL ET AL: "A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 233, no. 2, 1997, pages 336 - 342, XP002204803, ISSN: 0006-291X *
RANE M ET AL: "Activation of mitogen-activated protein kinases by formyl peptide receptors is regulated by the cytoplasmic tail", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 273, no. 33, 14 August 1998 (1998-08-14), pages 20916 - 20923, XP002204804 *

Also Published As

Publication number Publication date
AU2001271902A1 (en) 2002-01-21
WO2002003789A2 (en) 2002-01-17

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