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WO2002045498A3 - Souris transgenique presentant des disruptions geniques ciblees de proteine canal - Google Patents

Souris transgenique presentant des disruptions geniques ciblees de proteine canal Download PDF

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Publication number
WO2002045498A3
WO2002045498A3 PCT/US2001/046870 US0146870W WO0245498A3 WO 2002045498 A3 WO2002045498 A3 WO 2002045498A3 US 0146870 W US0146870 W US 0146870W WO 0245498 A3 WO0245498 A3 WO 0245498A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
target gene
channel protein
protein target
mice containing
Prior art date
Application number
PCT/US2001/046870
Other languages
English (en)
Other versions
WO2002045498A2 (fr
Inventor
Keith D Allen
Thomas J Brennan
Original Assignee
Deltagen Inc
Keith D Allen
Thomas J Brennan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Keith D Allen, Thomas J Brennan filed Critical Deltagen Inc
Priority to AU2002239540A priority Critical patent/AU2002239540A1/en
Publication of WO2002045498A2 publication Critical patent/WO2002045498A2/fr
Publication of WO2002045498A3 publication Critical patent/WO2002045498A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des animaux transgéniques ainsi que des compositions et des méthodes concernant la caractérisation de la fonction génique. L'invention concerne spécifiquement une souris transgénique présentant des mutations dans un gène cible. Cette souris transgénique peut servir de modèle de maladie, permet d'identifier des agents qui modulent l'expression et la fonction géniques, et est utilisée pour des traitements potentiels de différents états maladifs et pathologiques.
PCT/US2001/046870 2000-12-08 2001-12-05 Souris transgenique presentant des disruptions geniques ciblees de proteine canal WO2002045498A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002239540A AU2002239540A1 (en) 2000-12-08 2001-12-05 Transgenic mice containing channel protein target gene disruptions

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US25430200P 2000-12-08 2000-12-08
US60/254,302 2000-12-08
US25522800P 2000-12-11 2000-12-11
US60/255,228 2000-12-11
US25619700P 2000-12-13 2000-12-13
US25619100P 2000-12-13 2000-12-13
US60/256,197 2000-12-13
US60/256,191 2000-12-13

Publications (2)

Publication Number Publication Date
WO2002045498A2 WO2002045498A2 (fr) 2002-06-13
WO2002045498A3 true WO2002045498A3 (fr) 2004-02-26

Family

ID=27500501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046870 WO2002045498A2 (fr) 2000-12-08 2001-12-05 Souris transgenique presentant des disruptions geniques ciblees de proteine canal

Country Status (2)

Country Link
AU (1) AU2002239540A1 (fr)
WO (1) WO2002045498A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7117033B2 (en) 2000-05-08 2006-10-03 Brainsgate, Ltd. Stimulation for acute conditions
US20030180712A1 (en) 2002-03-20 2003-09-25 Biostratum Ab Inhibition of the beta3 subunit of L-type Ca2+ channels
US7561919B2 (en) 2002-11-14 2009-07-14 Brainsgate Ltd. SPG stimulation via the greater palatine canal
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
WO2006059069A2 (fr) * 2004-11-30 2006-06-08 Paradigm Therapeutics Limited Canal ionique
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
EP3093043B1 (fr) 2015-05-13 2018-11-14 Brainsgate Ltd. Implant et système de distribution pour stimulateur neural

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HUGNOT J-P ET AL: "KV8.1, A NEW NEURONAL POTASSIUM CHANNEL SUBUNIT WITH SPECIFIC INHIBITORY PROPERTIES TOWARDS SHAB AND SHAW CHANNELS", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 15, no. 13, 1 July 1996 (1996-07-01), pages 3322 - 3331, XP001096415, ISSN: 0261-4189 *
KLOCKE, R. ET AL.: "Chromosomal mapping in the mouse of eight K+ channel genes representing the four shaker-like subfamilies Shaker, Shab, Shaw and Shal", GENOMICS, vol. 18, no. 3, December 1993 (1993-12-01), pages 568 - 574, XP008015612 *
MIGUEL SALINAS ET AL: "New modulatory alpha subunits for mamalian Shab K+ channels", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 39, 26 September 1997 (1997-09-26), pages 24371 - 24379, XP002103779, ISSN: 0021-9258 *
PAK MD ET AL: "A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 11, no. 3, March 1991 (1991-03-01), pages 869 - 880, XP002120174, ISSN: 0270-6474 *
ZARITSKY JJ, ECKMAN DM, WELLMAN GC, NELSON MT, SCHWARZ T.L.: "Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation.", CIRCULATION RESEARCH, vol. 87, no. 2, 21 July 2000 (2000-07-21), pages 160 - 166, XP002957453 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation

Also Published As

Publication number Publication date
AU2002239540A1 (en) 2002-06-18
WO2002045498A2 (fr) 2002-06-13

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