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WO2000023066A3 - Irrigation solution and method for inhibition of pain and inflammation - Google Patents

Irrigation solution and method for inhibition of pain and inflammation Download PDF

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Publication number
WO2000023066A3
WO2000023066A3 PCT/US1999/024672 US9924672W WO0023066A3 WO 2000023066 A3 WO2000023066 A3 WO 2000023066A3 US 9924672 W US9924672 W US 9924672W WO 0023066 A3 WO0023066 A3 WO 0023066A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonist
pain
tetrahydro
solution
inflammation
Prior art date
Application number
PCT/US1999/024672
Other languages
French (fr)
Other versions
WO2000023066A2 (en
Inventor
Gregory A Demopulos
Pamela P Dalmer
Jeffrey M Herz
Original Assignee
Omeros Med Sys Inc
Gregory A Demopulos
Palmer Pamela P
Jeffrey M Herz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP99956629A priority Critical patent/EP1227807B1/en
Priority to DE69924536T priority patent/DE69924536T2/en
Priority to AT99956629T priority patent/ATE291907T1/en
Priority to AU13192/00A priority patent/AU1319200A/en
Application filed by Omeros Med Sys Inc, Gregory A Demopulos, Palmer Pamela P, Jeffrey M Herz filed Critical Omeros Med Sys Inc
Publication of WO2000023066A2 publication Critical patent/WO2000023066A2/en
Priority to US09/839,633 priority patent/US7091181B2/en
Priority to US09/839,633 priority patent/US20020028798A1/en
Publication of WO2000023066A3 publication Critical patent/WO2000023066A3/en
Priority to US10/138,193 priority patent/US20030087962A1/en
Priority to US10/138,192 priority patent/US7973068B2/en
Priority to HK03100488.6A priority patent/HK1048259B/en
Priority to US11/410,406 priority patent/US20060205657A1/en
Priority to US11/409,919 priority patent/US20060229588A1/en
Priority to US11/410,407 priority patent/US20060205658A1/en
Priority to US12/384,781 priority patent/US9254271B2/en
Priority to US13/047,386 priority patent/US8450309B2/en
Priority to US14/933,633 priority patent/US20160067219A1/en
Priority to US14/937,002 priority patent/US20160120846A1/en
Priority to US14/984,031 priority patent/US20160184272A1/en
Priority to US15/392,335 priority patent/US20170246150A1/en
Priority to US15/404,600 priority patent/US20170182007A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at leat one alpha 2-receptor agonist from the group consisting of clonidine; dexmedetomidine; oxymetazonline; (R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluoro-methanesulfoanilide; 2-[(5-methylbenz-1-ox-4-azin-6-yl)imino]imidazoline; AGN 191103; AGN 192172; 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine (UK14304); 5,6,7,8-tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amine (BHT920); 6-ethyl-5,6,7,8-tetrahydro-4H-oxaazolo[4,5-d]azepin-2-amine; and 5,6-dihydroxyl-1,2,3,4-tetrahydro-1-naphyl-imidazoline, and optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration like a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a DOLLAR (g)m-opioid agonist. The solution is applied by continous irrigation of a wound during a surgical procedure for preemptive inhibition of pain.
PCT/US1999/024672 1994-12-12 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation WO2000023066A2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
EP99956629A EP1227807B1 (en) 1998-10-20 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation
DE69924536T DE69924536T2 (en) 1998-10-20 1999-10-20 RINSE SOLUTION AND METHODS FOR INHIBITING PAIN AND INFLAMMATION
AT99956629T ATE291907T1 (en) 1998-10-20 1999-10-20 FLUSHING SOLUTION AND METHODS FOR INHIBITING PAIN AND INFLAMMATION
AU13192/00A AU1319200A (en) 1998-10-20 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation
US09/839,633 US7091181B2 (en) 1994-12-12 2001-04-20 Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US09/839,633 US20020028798A1 (en) 1995-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US10/138,193 US20030087962A1 (en) 1998-10-20 2002-05-01 Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US10/138,192 US7973068B2 (en) 1998-10-20 2002-05-01 Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
HK03100488.6A HK1048259B (en) 1998-10-20 2003-01-20 Irrigation solution and method for inhibition of pain and inflammation
US11/410,406 US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,407 US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US12/384,781 US9254271B2 (en) 1998-10-20 2009-04-08 Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US13/047,386 US8450309B2 (en) 1998-10-20 2011-03-14 Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US14/933,633 US20160067219A1 (en) 1998-10-20 2015-11-05 Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation
US14/937,002 US20160120846A1 (en) 1998-10-20 2015-11-10 Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation
US14/984,031 US20160184272A1 (en) 1998-10-20 2015-12-30 Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US15/392,335 US20170246150A1 (en) 1998-10-20 2016-12-28 Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US15/404,600 US20170182007A1 (en) 1998-10-20 2017-01-12 Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10502998P 1998-10-20 1998-10-20
US60/105,029 1998-10-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024625 Continuation-In-Part WO2000023072A1 (en) 1994-12-12 1999-10-20 Irrigation solution containing mapk inhibitors and their use for treating pain and inflammation

Related Child Applications (5)

Application Number Title Priority Date Filing Date
PCT/US1999/026330 Continuation-In-Part WO2000025745A2 (en) 1994-12-12 1999-11-05 Irrigation solution and method for inhibition of pain and inflammation
US09/839,633 Continuation-In-Part US20020028798A1 (en) 1994-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 Continuation-In-Part US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,406 Continuation-In-Part US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,407 Continuation-In-Part US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation

Publications (2)

Publication Number Publication Date
WO2000023066A2 WO2000023066A2 (en) 2000-04-27
WO2000023066A3 true WO2000023066A3 (en) 2001-08-23

Family

ID=22303668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024672 WO2000023066A2 (en) 1994-12-12 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation

Country Status (7)

Country Link
EP (1) EP1227807B1 (en)
AT (1) ATE291907T1 (en)
AU (1) AU1319200A (en)
DE (1) DE69924536T2 (en)
ES (1) ES2239466T3 (en)
HK (1) HK1048259B (en)
WO (1) WO2000023066A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294553B1 (en) * 2000-02-15 2001-09-25 Allergan Sales, Inc. Method for treating ocular pain
US7345065B2 (en) * 2002-05-21 2008-03-18 Allergan, Inc. Methods and compositions for alleviating pain
CN101327325A (en) 2002-07-30 2008-12-24 奥默罗斯公司 Ophthalmologic irrigation solutions and method
CA2676357A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
WO2011117377A2 (en) 2010-03-26 2011-09-29 Galderma Research & Development Improved methods and compositions for safe and effective treatment of erythema
AU2012324543B2 (en) 2011-10-19 2017-08-10 Galderma S.A. Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors
SG11201403094TA (en) 2011-12-11 2014-10-30 Recro Pharma Inc Intranasal dexmedetomidine compositions and methods of use thereof
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
WO2015054058A1 (en) 2013-10-07 2015-04-16 Teikoku Pharma Usa, Inc. Dexmedetomidine Transdermal Delivery Devices and Methods for Using the Same
ES2856189T3 (en) 2013-10-07 2021-09-27 Teikoku Pharma Usa Inc Methods and compositions for the treatment of attention deficit hyperactivity disorder, anxiety and insomnia using transdermal compositions of dexmedetomidine
CA2924236C (en) 2013-10-07 2020-01-07 Teikoku Pharma Usa, Inc. Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
TWI809304B (en) 2014-12-01 2023-07-21 奥默羅斯公司 Anti-inflammatory and mydriatic intracameral solutions for inhibition of postoperative ocular inflammatory conditions

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2040510A1 (en) * 1970-08-14 1972-02-17 Thomae Gmbh Dr K 2-amino-4,5,7,8-tetrahydro-6h-thiazolo-or oxazolo(5,4-d) - azepines - as hypotensive, antiphlogistic, sedative and bechic agents
EP0160191A1 (en) * 1984-03-27 1985-11-06 Dentsply Limited Kit for treating mammals
EP0166937A2 (en) * 1984-06-06 1986-01-08 Abbott Laboratories Adrenergic compounds
EP0424059A1 (en) * 1989-10-17 1991-04-24 Orion-Yhtymà„ Oy Use of sustituted imidazoles for the manufacture of an analgesic
WO1992014453A1 (en) * 1991-02-26 1992-09-03 Arc 1, Inc. Compositions and methods of treatment of sympathetically maintained pain
EP0538469A1 (en) * 1990-02-07 1993-04-28 Nippon Shinyaku Company, Limited Sulfonanilide derivative and medicine
US5212196A (en) * 1986-10-21 1993-05-18 Alcon Laboratories, Inc. Control of post-surgical intraocular pressure using clonidine derivatives
WO1995010280A1 (en) * 1993-10-13 1995-04-20 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
WO1995016449A1 (en) * 1993-12-17 1995-06-22 The Procter & Gamble Company 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists
WO1997021445A1 (en) * 1995-12-12 1997-06-19 Omeros Medical Systems, Inc. Vascular irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis
US5800385A (en) * 1994-12-12 1998-09-01 Omeros Medical Systems, Inc. Vascular irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis
WO1998038997A1 (en) * 1997-03-03 1998-09-11 Darwin Discovery Limited Use of levobupivacaine in combination with opiods or alfa2-agonists for providing anaesthesia or analgesia
WO1999024023A2 (en) * 1997-11-11 1999-05-20 Grünenthal GmbH FORMULATION OF A COMBINATION COMPRISED OF OPIOID AND α - ADRENERGIC AGONISTS AND THE APPLICATION THEREOF
WO2000038684A1 (en) * 1998-12-30 2000-07-06 Allergan Sales, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives for the treatment of pain

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2040510A1 (en) * 1970-08-14 1972-02-17 Thomae Gmbh Dr K 2-amino-4,5,7,8-tetrahydro-6h-thiazolo-or oxazolo(5,4-d) - azepines - as hypotensive, antiphlogistic, sedative and bechic agents
EP0160191A1 (en) * 1984-03-27 1985-11-06 Dentsply Limited Kit for treating mammals
EP0166937A2 (en) * 1984-06-06 1986-01-08 Abbott Laboratories Adrenergic compounds
US5212196A (en) * 1986-10-21 1993-05-18 Alcon Laboratories, Inc. Control of post-surgical intraocular pressure using clonidine derivatives
EP0424059A1 (en) * 1989-10-17 1991-04-24 Orion-Yhtymà„ Oy Use of sustituted imidazoles for the manufacture of an analgesic
EP0538469A1 (en) * 1990-02-07 1993-04-28 Nippon Shinyaku Company, Limited Sulfonanilide derivative and medicine
WO1992014453A1 (en) * 1991-02-26 1992-09-03 Arc 1, Inc. Compositions and methods of treatment of sympathetically maintained pain
WO1995010280A1 (en) * 1993-10-13 1995-04-20 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
WO1995016449A1 (en) * 1993-12-17 1995-06-22 The Procter & Gamble Company 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists
US5800385A (en) * 1994-12-12 1998-09-01 Omeros Medical Systems, Inc. Vascular irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis
WO1997021445A1 (en) * 1995-12-12 1997-06-19 Omeros Medical Systems, Inc. Vascular irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis
WO1998038997A1 (en) * 1997-03-03 1998-09-11 Darwin Discovery Limited Use of levobupivacaine in combination with opiods or alfa2-agonists for providing anaesthesia or analgesia
WO1999024023A2 (en) * 1997-11-11 1999-05-20 Grünenthal GmbH FORMULATION OF A COMBINATION COMPRISED OF OPIOID AND α - ADRENERGIC AGONISTS AND THE APPLICATION THEREOF
WO2000038684A1 (en) * 1998-12-30 2000-07-06 Allergan Sales, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives for the treatment of pain

Non-Patent Citations (31)

* Cited by examiner, † Cited by third party
Title
ASANO, Y. ET AL.: "Pial arteriolar constriction to systemic and local administration of dexmedetomidine", ANESTHESIOLOGY, vol. 83, 1995, pages A153, XP000974716 *
BONNET F. ET AL: "Alpha 2 adrenergic agonists in pain management.", MEDICAL SCIENCE MONITOR, (1997) 3/SUPPL. 1 (10-16)., XP000974728 *
BONNET F. ET AL: "Alpha 2 adrenergic agonists in pain management.", MEDICAL SCIENCE MONITOR, (1997) 3/SUPPL. 1 (10-16)., XP000974733 *
BRITISH JOURNAL OF OPHTHALMOLOGY, vol. 78, no. 2, 1994, pages 95 - 98, ISSN: 0007-1161 *
CHANG J ET AL: "THE ANTIINFLAMMATORY ACTION OF GUANABENZ IS MEDIATED THROUGH 5 LIPOXYGENASE AND CYCLOOXYGENASE INHIBITION.", EUR J PHARMACOL, (1987) 142 (2), 197-206., XP000978100 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, TARVER CYNTHIA P ET AL: "A comparison of cocaine vs. lidocaine with oxymetazoline for use in nasal procedures.", XP002157663, Database accession no. PREV199497036633 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1994, CORBETT MELANIE C ET AL: "Intraocular adrenaline maintains mydriasis during cataract surgery.", XP002146559, Database accession no. PREV199497231668 *
FLACKE J.W.: "Alpha2-adrenergic agonists in cardiovascular anesthesia.", JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, (1992) 6/3 (344-359)., XP000978118 *
GAUMANN D M ET AL: "Hyperpolarizing afterpotentials in C fibers and local anesthetic effects of clonidine and lidocaine.", PHARMACOLOGY (BASEL), vol. 48, no. 1, 1994, pages 21 - 29, XP000910638, ISSN: 0031-7012 *
GILLART T ET AL: "Effects of local clonidine for prolongation of akinesia after peribulbar block.", ANESTHESIOLOGY (HAGERSTOWN), vol. 81, no. 3A, 1994, Annual Meeting of the American Society of Anesthesiologists;San Francisco, California, USA; October 15-19, 1994, pages A941, XP000910641, ISSN: 0003-3022 *
ISHIYAMA TADAHIKO ET AL: "Mechanisms of dexmedetomidine-induced cerebrovascular effects in canine in vivo experiments.", ANESTHESIA & ANALGESIA, vol. 81, no. 6, 1995, pages 1208 - 1215, XP000974672, ISSN: 0003-2999 *
KANTO J.: "The place of alpha-2-agonists in anaesthesiology of today.", ACTA ANAESTHESIOLOGICA SCANDINAVICA, (1997) 41/1 I (4-5)., XP000910684 *
KULKARNI, S. K. ET AL: "Anti- inflammatory actions of clonidine, guanfacine and B-HT 920 against various inflammagen -induced acute paw edema in rats", ARCH. INT. PHARMACODYN. THER. (1986), 279(2), 324-34, XP000978110 *
KYNCL, JOHN J. ET AL: "Novel adrenergic compounds. I. Receptor interactions of Abbott-54741 [(5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline] an.alpha.-adrenergic agonist", J. CARDIOVASC. PHARMACOL. (1989), 13(3), 382-91, XP000974773 *
LYDIATT W.M. ET AL: "A prospective double-blind evaluation of cocaine, phenylephrine with xylocaine and oxymetazoline with xylocaine for topical intranasal use.", AMERICAN JOURNAL OF RHINOLOGY, (1989) 3/2 (105-112). CODEN: AJRHE5, XP000974795 *
MACKENZIE T.A. ET AL: "Local anesthetic update.", ANESTHESIA PROGRESS, (1993) 40/2 (29-34)., XP000978106 *
MUNK S A ET AL: "SYNTHESIS AND EVALUATION OF 2-U(5-METHYLBENZ-1-OX-4-AZIN-6-YL)IMIMOIM IDAZOLINE, A POTENT, PERIPHERALLY ACTING ALFA2 ADRENOCEPTOR AGONIST", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 39, no. 18, 1996, pages 3533 - 3538, XP002057462, ISSN: 0022-2623 *
NOORILY ALLEN D ET AL: "Cocaine, lidocaine, tetracaine: Which is best for topical nasal anesthesia?", ANESTHESIA & ANALGESIA, vol. 81, no. 4, 1995, pages 724 - 727, XP000912132, ISSN: 0003-2999 *
NOORILY ALLEN D ET AL: "Intranasal anesthetic effects of lidocaine and tetracaine compared.", OTOLARYNGOLOGY - HEAD AND NECK SURGERY, vol. 113, no. 4, 1995, pages 370 - 374, XP000912198, ISSN: 0194-5998 *
OGREN FREDERICK P ET AL: "Anesthesia for rhinoplasty.", ANESTHESIA FOR FACIAL PLASTIC SURGERY., 1993, Thieme Medical Publishers, Inc.;Georg Thieme Verlag Suite 1501, 381 Park Avenue South, New York, New York 10016, USA; Postfach 104853, D-7000 Stuttgart 10, Germany, pages 51 - 53, XP000974729 *
OTOLARYNGOLOGY - HEAD AND NECK SURGERY, vol. 109, no. 4, 1993, pages 653 - 659, ISSN: 0194-5998 *
PERTOVAARA A.: "antinociception induced by alpha-2-adrenoceptor agonists, with special emphasis on medetomidine studies.", PROGRESS IN NEUROBIOLOGY, vol. 40, no. 6, 1993, pages 691 - 709, XP000974679 *
REINHART DOUGLAS J ET AL: "Postoperative analgesia after peripheral nerve block for podiatric surgery: Clinical efficacy and chemical stability of lidocaine alone versus lidocaine plus clonidine.", ANESTHESIA & ANALGESIA, vol. 83, no. 4, 1996, pages 760 - 765, XP000910632, ISSN: 0003-2999 *
SMITH I. ET AL: "Monitored anesthesia care.", INTERNATIONAL ANESTHESIOLOGY CLINICS, (1994) 32/3 (99-112)., XP000974665 *
TAITTONEN, M. T. ET AL: "Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and hemodynamic state", BR. J. ANAESTH. (1997), 78(4), 400-406, XP000910640 *
TALKE P ET AL: "Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group.", ANESTHESIOLOGY, (1995 MAR) 82 (3) 620-33., XP000910604 *
THORIG, LOUIS ET AL: "Effects of B-HT 920 in the eye and on regional blood flows in anesthetized and conscious rabbits", CURR. EYE RES. (1986), 5(8), 565-73, XP000974794 *
TONG C. ET AL: ".alpha.2-Adrenergic agonists.", ANESTHESIOLOGY CLINICS OF NORTH AMERICA, (1994) 12/1 (49-63)., XP000978108 *
TSCHERNKO EDDA M; KLEPETKO HEIKE; GRUBER EVA; KRITZINGER MEINHARD; KLIMSCHA WALTER; JANDRASITS OLIVER; HAIDER WOLFRAM: "Clonidine added to the anesthetic solution enhances analgesia and improves oxygenation after intercostal nerve block for thoracotomy.", ANESTHESIA & ANALGESIA, vol. 87, no. july, 1998, pages 107 - 111, XP000914192 *
VERMA, ANITA ET AL: ".alpha.2-Adrenoceptor- and D2-dopamine receptor-mediated analgesic response of B-HT 920", J. PHARM. PHARMACOL. (1991), 43(2), 131-3, XP000978104 *
YOON T J ET AL: "Pharmacological evaluation of UK-14,304 analogs at cloned human alpha adrenergic receptors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 5, no. 19, 5 October 1995 (1995-10-05), pages 2255 - 2258, XP004135294, ISSN: 0960-894X *

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