WO2000023061A3 - Irrigation solution and method for inhibition of pain and inflammation - Google Patents
Irrigation solution and method for inhibition of pain and inflammation Download PDFInfo
- Publication number
- WO2000023061A3 WO2000023061A3 PCT/US1999/024557 US9924557W WO0023061A3 WO 2000023061 A3 WO2000023061 A3 WO 2000023061A3 US 9924557 W US9924557 W US 9924557W WO 0023061 A3 WO0023061 A3 WO 0023061A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antagonist
- pain
- solution
- inflammation
- inhibitor
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title abstract 4
- 230000004054 inflammatory process Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 229940113601 irrigation solution Drugs 0.000 title 1
- 239000005557 antagonist Substances 0.000 abstract 3
- 206010052428 Wound Diseases 0.000 abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229940111134 coxibs Drugs 0.000 abstract 2
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000001356 surgical procedure Methods 0.000 abstract 2
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- 229940122204 Cyclooxygenase inhibitor Drugs 0.000 abstract 1
- 102000016924 KATP Channels Human genes 0.000 abstract 1
- 108010053914 KATP Channels Proteins 0.000 abstract 1
- 102000000033 Purinergic Receptors Human genes 0.000 abstract 1
- 108010080192 Purinergic Receptors Proteins 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 239000000480 calcium channel blocker Substances 0.000 abstract 1
- BPKIGYQJPYCAOW-FFJTTWKXSA-I calcium;potassium;disodium;(2s)-2-hydroxypropanoate;dichloride;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].C[C@H](O)C([O-])=O BPKIGYQJPYCAOW-FFJTTWKXSA-I 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000007918 intramuscular administration Methods 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 230000002262 irrigation Effects 0.000 abstract 1
- 238000003973 irrigation Methods 0.000 abstract 1
- 239000002742 neurokinin 1 receptor antagonist Substances 0.000 abstract 1
- 239000002746 neurokinin 2 receptor antagonist Substances 0.000 abstract 1
- 239000003402 opiate agonist Substances 0.000 abstract 1
- 239000004036 potassium channel stimulating agent Substances 0.000 abstract 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 abstract 1
- 239000003215 serotonin 5-HT2 receptor antagonist Substances 0.000 abstract 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 abstract 1
- 239000000952 serotonin receptor agonist Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one COX-2 inhibitor and, optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a COX-2 inhibitor, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a ν-opioid agonist.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU12148/00A AU1214800A (en) | 1998-10-21 | 1999-10-20 | Irrigation solution and method for inhibition of pain and inflammation |
| US09/839,633 US20020028798A1 (en) | 1995-12-12 | 2001-04-20 | Irrigation solution and method for inhibition of pain and inflammation |
| US09/839,633 US7091181B2 (en) | 1994-12-12 | 2001-04-20 | Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors |
| US11/410,406 US20060205657A1 (en) | 1994-12-12 | 2006-04-24 | Irrigation solution and method for inhibition of pain and inflammation |
| US11/410,407 US20060205658A1 (en) | 1994-12-12 | 2006-04-24 | Irrigation solution and method for inhibition of pain and inflammation |
| US11/409,919 US20060229588A1 (en) | 1994-12-12 | 2006-04-24 | Irrigation solution and method for inhibition of pain and inflammation |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10516698P | 1998-10-21 | 1998-10-21 | |
| US60/105,166 | 1998-10-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/072,913 Continuation-In-Part US6261279B1 (en) | 1994-12-12 | 1998-05-04 | Surgical irrigation solution and method for inhibition of pain and inflammation |
Related Child Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1999/024558 Continuation-In-Part WO2000023062A2 (en) | 1994-12-12 | 1999-10-20 | Irrigation solution and method for inhibition of pain and inflammation |
| US09/839,633 Continuation-In-Part US20020028798A1 (en) | 1994-12-12 | 2001-04-20 | Irrigation solution and method for inhibition of pain and inflammation |
| US11/409,919 Continuation-In-Part US20060229588A1 (en) | 1994-12-12 | 2006-04-24 | Irrigation solution and method for inhibition of pain and inflammation |
| US11/410,406 Continuation-In-Part US20060205657A1 (en) | 1994-12-12 | 2006-04-24 | Irrigation solution and method for inhibition of pain and inflammation |
| US11/410,407 Continuation-In-Part US20060205658A1 (en) | 1994-12-12 | 2006-04-24 | Irrigation solution and method for inhibition of pain and inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2000023061A2 WO2000023061A2 (en) | 2000-04-27 |
| WO2000023061A3 true WO2000023061A3 (en) | 2000-11-16 |
Family
ID=22304411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1999/024557 WO2000023061A2 (en) | 1994-12-12 | 1999-10-20 | Irrigation solution and method for inhibition of pain and inflammation |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU1214800A (en) |
| WO (1) | WO2000023061A2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004521856A (en) * | 2000-05-15 | 2004-07-22 | メルク フロスト カナダ アンド カンパニー | Combination therapy using a COX-2 selective inhibitor and a thromboxane inhibitor and compositions therefor |
| CN101327325A (en) | 2002-07-30 | 2008-12-24 | 奥默罗斯公司 | Ophthalmologic irrigation solutions and method |
| CA2676357A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
| AU2013201465B2 (en) | 2012-10-24 | 2016-03-03 | Rayner Intraocular Lenses Limited | Stable preservative-free mydriatic and anti-inflammatory solutions for injection |
| TWI809304B (en) | 2014-12-01 | 2023-07-21 | 奥默羅斯公司 | Anti-inflammatory and mydriatic intracameral solutions for inhibition of postoperative ocular inflammatory conditions |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5373022A (en) * | 1991-03-04 | 1994-12-13 | The Warner-Lambert Company | Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms |
| US5820583A (en) * | 1995-12-12 | 1998-10-13 | Omeros Medical Systems, Inc. | Surgical irrigation solution and method for inhibition of pain and inflammation |
-
1999
- 1999-10-20 AU AU12148/00A patent/AU1214800A/en not_active Abandoned
- 1999-10-20 WO PCT/US1999/024557 patent/WO2000023061A2/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5373022A (en) * | 1991-03-04 | 1994-12-13 | The Warner-Lambert Company | Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms |
| US5820583A (en) * | 1995-12-12 | 1998-10-13 | Omeros Medical Systems, Inc. | Surgical irrigation solution and method for inhibition of pain and inflammation |
Non-Patent Citations (10)
| Title |
|---|
| BURITOVA JAROSLAVA; CHAPMAN VICTORIA; HONORE PRISCA; BESSON JEAN-MARIE: "Selective cyclooxygenase-2 inhibition reduces carrageenan oedema and associated spinal c-Fos expression in the rat.", BRAIN RESEARCH, vol. 715, no. 1-2, 1996, pages 217 - 220, XP000905607 * |
| ENGELHARDT G: "Pharmacology of meloxicam, a new non-steroidal anti-inflammatory drug with an improved safety profile through preferential inhibition of COX-2.", BRITISH JOURNAL OF RHEUMATOLOGY, vol. 35, no. suppl. 1, 1996, pages 4 - 12, XP000905630 * |
| HAY CATRIONA; DE BELLEROCHE JACQUELINE: "Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord.", NEUROREPORT, vol. 8, no. 5, 1997, pages 1249 - 1251, XP000905625 * |
| JOSHI G.P.: "Postoperative pain management.", INTERNATIONAL ANESTHESIOLOGY CLINICS, (1994) 32/3 (113-126)., XP000905593 * |
| MEHLISCH D R; HUBBARD R C; ISAKSON P; KARIM A; WEAVER M; MILLS S: "Analgesic efficacy and plasma levels of a highly selective inhibitor of COX-2 (SC-58635;SC) in patients with post-surgical dental pain.", CLINICAL PHARMACOLOGY & THERAPEUTICS, vol. 61, no. 2, 1997, pages 195, XP000905616 * |
| OSIPOVA N A: "[Antinociceptive components of general anesthesia and postoperative analgesia]. Antinotsitseptivnye komponenty obschchei anestezii i posleoperatsionnoi analgezii.", ANESTEZIOLOGIIA I REANIMATOLOGIIA, (1998 SEP-OCT) (5) 11-5. REF: 21, XP000905655 * |
| REYNOLDS J.: "Martindale - The Extra Pharmacopoeia Edition 31", 1996, ROYAL PHARMACEUTICAL SOCIETY, LONDON GB, XP002137139, 224540 * |
| SCHWEIZER A; BROM R; WIESENBERG-BOETTCHER I: "INHIBITION OF INTERLEUKIN-1 IL-1 ENHANCED PAIN REFLEXES IN THE RABBIT BY CGP-28238", AGENTS AND ACTIONS, vol. 32, no. 1-2, 1991, pages 67 - 69, XP000905639 * |
| SEIBERT KAREN; ZHANG YAN; LEAHY KATHLEEN; HAUSER SCOTT; MASFERRER JAIME; PERKINS WILLIAM; LEE LEN; ISAKSON PETER: "Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 91, no. 25, 1994, pages 12013 - 12017, XP000604765 * |
| SOUTER A J ET AL: "CONTROVERSIES IN THE PERIOPERATIVE USE OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS", ANESTHESIA AND ANALGESIA, (DEC 1994) VOL. 79, NO. 6, PP. 1178-1190. ISSN: 0003-2999., UNIV TEXAS, SW MED CTR, DEPT ANESTHESIOL & PAIN MANAGEMENT, 5323 HARRY HINES BLVD, DALLAS, TX, 75235 (Reprint);UNIV TEXAS, SW MED CTR, DEPT ANESTHESIOL & PAIN MANAGEMENT, DALLAS, TX, 75235, XP000905591 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1214800A (en) | 2000-05-08 |
| WO2000023061A2 (en) | 2000-04-27 |
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