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WO2000023062A3 - Irrigation solution and method for inhibition of pain and inflammation - Google Patents

Irrigation solution and method for inhibition of pain and inflammation Download PDF

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Publication number
WO2000023062A3
WO2000023062A3 PCT/US1999/024558 US9924558W WO0023062A3 WO 2000023062 A3 WO2000023062 A3 WO 2000023062A3 US 9924558 W US9924558 W US 9924558W WO 0023062 A3 WO0023062 A3 WO 0023062A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonist
pain
solution
inflammation
agonist
Prior art date
Application number
PCT/US1999/024558
Other languages
French (fr)
Other versions
WO2000023062A2 (en
Inventor
Gregory A Demopulos
Pamela P Palmer
Jeffrey M Herz
Original Assignee
Omeros Med Sys Inc
Gregory A Demopulos
Pamela P Palmer
Jeffrey M Herz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Med Sys Inc, Gregory A Demopulos, Pamela P Palmer, Jeffrey M Herz filed Critical Omeros Med Sys Inc
Priority to AU12149/00A priority Critical patent/AU1214900A/en
Priority to EP99970596A priority patent/EP1434573A2/en
Publication of WO2000023062A2 publication Critical patent/WO2000023062A2/en
Publication of WO2000023062A3 publication Critical patent/WO2000023062A3/en
Priority to US09/839,633 priority patent/US20020028798A1/en
Priority to US09/839,633 priority patent/US7091181B2/en
Priority to US11/410,406 priority patent/US20060205657A1/en
Priority to US11/410,407 priority patent/US20060205658A1/en
Priority to US11/409,919 priority patent/US20060229588A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one neuronal nicotinic acetylcholine receptor agonist and, optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a neuronal nicotinic acetylcholine receptor agonist, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a ν-opioid agonist.
PCT/US1999/024558 1994-12-12 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation WO2000023062A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU12149/00A AU1214900A (en) 1998-10-20 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation
EP99970596A EP1434573A2 (en) 1998-10-20 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation
US09/839,633 US20020028798A1 (en) 1995-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US09/839,633 US7091181B2 (en) 1994-12-12 2001-04-20 Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US11/410,406 US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,407 US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10504498P 1998-10-20 1998-10-20
US60/105,044 1998-10-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024557 Continuation-In-Part WO2000023061A2 (en) 1994-12-12 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation

Related Child Applications (5)

Application Number Title Priority Date Filing Date
PCT/US1999/024625 Continuation-In-Part WO2000023072A1 (en) 1994-12-12 1999-10-20 Irrigation solution containing mapk inhibitors and their use for treating pain and inflammation
US09/839,633 Continuation-In-Part US20020028798A1 (en) 1994-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 Continuation-In-Part US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,406 Continuation-In-Part US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,407 Continuation-In-Part US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation

Publications (2)

Publication Number Publication Date
WO2000023062A2 WO2000023062A2 (en) 2000-04-27
WO2000023062A3 true WO2000023062A3 (en) 2000-07-27

Family

ID=22303751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024558 WO2000023062A2 (en) 1994-12-12 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation

Country Status (3)

Country Link
EP (1) EP1434573A2 (en)
AU (1) AU1214900A (en)
WO (1) WO2000023062A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2313900T3 (en) 1999-07-28 2009-03-16 The Board Of Trustees Of The Leland Stanford Junior University NICOTINE IN ANGIOGENESIS AND THERAPEUTIC VASCULOGENESIS.
US7838539B2 (en) 1999-07-28 2010-11-23 The Board Of Trustees Of The Leland Stanford Junior University Nicotine receptor agonists in stem cell and progenitor cell recruitment
BR0012787A (en) * 1999-07-28 2002-07-30 Univ Leland Stanford Junior Nicotine receptor agonists in stem cell and progenitor cell recruitment
US8188043B2 (en) 1999-07-28 2012-05-29 The Board Of Trustees Of The Leland Stanford Jr. University Nicotine in therapeutic angiogenesis and vasculogenesis
CA2341952A1 (en) 2001-03-23 2002-09-23 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases
US8557804B2 (en) 2002-03-25 2013-10-15 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
US8039459B2 (en) 2004-07-15 2011-10-18 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
CN101327325A (en) 2002-07-30 2008-12-24 奥默罗斯公司 Ophthalmologic irrigation solutions and method
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
CA2676357A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI809304B (en) 2014-12-01 2023-07-21 奥默羅斯公司 Anti-inflammatory and mydriatic intracameral solutions for inhibition of postoperative ocular inflammatory conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820583A (en) * 1995-12-12 1998-10-13 Omeros Medical Systems, Inc. Surgical irrigation solution and method for inhibition of pain and inflammation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820583A (en) * 1995-12-12 1998-10-13 Omeros Medical Systems, Inc. Surgical irrigation solution and method for inhibition of pain and inflammation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BONDAREV V I ET AL: "[Disorders of immunoreactivity in acute cholecystitis in middle-aged and elderly patients and their correction in preventing postoperative complications]. Narusheniia immunoreaktivnosti pri ostrom kholetsistite u bol'nykh pozhilogo i starcheskogo vozrasta i ikh korrektsiia v profilatike posleoperats", KLINICHESKAIA KHIRURGIIA, (1990) (9) 27-9., XP002137213 *
CHIARI A, EISENACH J C: "ANTINOCICEPTIVE EFFECTS OF RJR 2403, A SELECTIVE NICOTINIC AGONIST, IN MALE AND FEMALE RATS.", FASEB JOURNAL, vol. 12, no. 4 PART 1, SUPP. [S], 17 March 1998 (1998-03-17), pages 920, XP000906769 *
DECKER ET AL: "Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice", EUROPEAN JOURNAL OF PHARMACOLOGY,NL,AMSTERDAM, vol. 346, no. 1, 3 April 1998 (1998-04-03), pages 23 - 33-33, XP002110643, ISSN: 0014-2999 *
DONNELLY-ROBERTS ET AL: "ABT-594: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,US,AMERICAN SOCIETY FOR PHARMACOLOGY AND, vol. 285, no. 2, May 1998 (1998-05-01), pages 777 - 786-786, XP002105019, ISSN: 0022-3565 *
HOLLADAY ET AL: "Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 40, no. 26, 19 December 1997 (1997-12-19), pages 4169 - 4194-4194, XP002124847, ISSN: 0022-2623 *
ZHANG, XIAO. GONG, ZE-HUI. FASTH, KARL JOHAN. LANGSTROM, BENGT. NORDBER AGNETA: "INTERACTION OF THE NICOTINIC AGONIST (R,S)-3-PYRIDYL-1-METHYL-2-(3-PYRIDYL)-AZETIDINE (MPA) WITH NICOTINIC ACETYLCHOLINE RECEPTOR SUBTYPES EXPRESSED IN CELL LINES AND RAT CORTEX.", NEUROCHEM. INT., vol. 32, no. 5-6, 1998, pages 435 - 441, XP000905243 *

Also Published As

Publication number Publication date
EP1434573A2 (en) 2004-07-07
AU1214900A (en) 2000-05-08
WO2000023062A2 (en) 2000-04-27

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