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WO1999033866A3 - Aus gelee royale isoliertes antiviral wirksames oligopeptid - Google Patents

Aus gelee royale isoliertes antiviral wirksames oligopeptid Download PDF

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Publication number
WO1999033866A3
WO1999033866A3 PCT/EP1998/007811 EP9807811W WO9933866A3 WO 1999033866 A3 WO1999033866 A3 WO 1999033866A3 EP 9807811 W EP9807811 W EP 9807811W WO 9933866 A3 WO9933866 A3 WO 9933866A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligopeptides
antiviral
molecules
isolated
royal jelly
Prior art date
Application number
PCT/EP1998/007811
Other languages
English (en)
French (fr)
Other versions
WO1999033866A2 (de
Inventor
Eberhard Bengsch
Antonius Kettrup
Juergen Polster
Original Assignee
Gsf Forschungszentrum Umwelt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gsf Forschungszentrum Umwelt filed Critical Gsf Forschungszentrum Umwelt
Priority to EP98965731A priority Critical patent/EP1042364A2/de
Priority to BR9814506-1A priority patent/BR9814506A/pt
Publication of WO1999033866A2 publication Critical patent/WO1999033866A2/de
Publication of WO1999033866A3 publication Critical patent/WO1999033866A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die Erfindung betrifft eine Familie von Oligopeptiden mit völlig neuartiger Struktur, die in selektiv gewonnenen Gelées royales bestimmten pflanzlichen Ursprungs auftritt und mit ausgeprägten antiviralen Wirkungen korreliert ist. Die Pilotstruktur ist ein Molekül mit 52 Aminosäuren. Satellitenartig dazu existieren zahlreiche analoge fast-identische Moleküle. Die Substanzen haben ein breites antivirales Wirkungsspektrum, Retrovieren inbegriffen und sind selbst in hohen Dosen human-untoxisch. Überraschend ist ebenfalls ihre extreme Resistenz gegen alle gesteuerten Proteasen und anderen Enzyme. Die Moleküle sind hochgradig verknäult und unangreifbar. Trotz der Verknäulung sind sie geometrisch hoch flexibel und können mehrere Konformere bilden. Im nativen Zustand liegt eine gut wasserlösliche Form vor. Aus der chemischen Synthese resultiert eine wasserunlösliche Form, die jedoch in ein lösliches, der nativen Form nahestehende, bioaktives Konformeres umgewandelt werden kann. Die neuen Oligopeptide vereinen somit erstmalig und in optimaler Weise alle Eigenschaften, die von einer potentiell antiviralen Wirkstoffklasse gefordert werden müssen.
PCT/EP1998/007811 1997-12-27 1998-12-02 Aus gelee royale isoliertes antiviral wirksames oligopeptid WO1999033866A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98965731A EP1042364A2 (de) 1997-12-27 1998-12-02 Aus gelee royale isoliertes antiviral wirksames oligopeptid
BR9814506-1A BR9814506A (pt) 1997-12-27 1998-12-02 Oligopetìdios

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19757932.9 1997-12-27
DE1997157932 DE19757932C2 (de) 1997-12-27 1997-12-27 Oligopeptide

Publications (2)

Publication Number Publication Date
WO1999033866A2 WO1999033866A2 (de) 1999-07-08
WO1999033866A3 true WO1999033866A3 (de) 1999-09-10

Family

ID=7853425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/007811 WO1999033866A2 (de) 1997-12-27 1998-12-02 Aus gelee royale isoliertes antiviral wirksames oligopeptid

Country Status (4)

Country Link
EP (1) EP1042364A2 (de)
BR (1) BR9814506A (de)
DE (1) DE19757932C2 (de)
WO (1) WO1999033866A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10344561B4 (de) * 2003-09-25 2011-12-22 Eberhard Bengsch Verwendung eines Tetra-, Penta- und Octapeptids aus Gelée Royale
JP2008208088A (ja) * 2007-02-27 2008-09-11 Ehime Univ 口内炎処置用組成物
US20200399330A1 (en) * 2018-09-06 2020-12-24 Salem Ismaell Salem EL-FIKY Anti-leukemic, anti-hiv, and sialidase activities of royal-jelly proteins

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1048323A (zh) * 1989-06-28 1991-01-09 北京朝阳三益日用化学厂 防治艾滋病、性病洗液的制备方法
WO1991001742A1 (en) * 1989-07-28 1991-02-21 Ruffles, Graham, Keith Biologically active compositions
WO1994007512A1 (de) * 1992-09-30 1994-04-14 GSF - Forschungszentrum für Umwelt und Gesundheit GmbH Gelee-royale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1048323A (zh) * 1989-06-28 1991-01-09 北京朝阳三益日用化学厂 防治艾滋病、性病洗液的制备方法
WO1991001742A1 (en) * 1989-07-28 1991-02-21 Ruffles, Graham, Keith Biologically active compositions
WO1994007512A1 (de) * 1992-09-30 1994-04-14 GSF - Forschungszentrum für Umwelt und Gesundheit GmbH Gelee-royale

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE EPODOC EPO; XP002107788 *

Also Published As

Publication number Publication date
DE19757932C2 (de) 2000-01-05
DE19757932A1 (de) 1999-07-08
WO1999033866A2 (de) 1999-07-08
EP1042364A2 (de) 2000-10-11
BR9814506A (pt) 2000-10-10

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