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WO1999033866A3 - Oligopeptides - Google Patents

Oligopeptides Download PDF

Info

Publication number
WO1999033866A3
WO1999033866A3 PCT/EP1998/007811 EP9807811W WO9933866A3 WO 1999033866 A3 WO1999033866 A3 WO 1999033866A3 EP 9807811 W EP9807811 W EP 9807811W WO 9933866 A3 WO9933866 A3 WO 9933866A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligopeptides
antiviral
molecules
isolated
royal jelly
Prior art date
Application number
PCT/EP1998/007811
Other languages
German (de)
English (en)
Other versions
WO1999033866A2 (fr
Inventor
Eberhard Bengsch
Antonius Kettrup
Juergen Polster
Original Assignee
Gsf Forschungszentrum Umwelt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gsf Forschungszentrum Umwelt filed Critical Gsf Forschungszentrum Umwelt
Priority to BR9814506-1A priority Critical patent/BR9814506A/pt
Priority to EP98965731A priority patent/EP1042364A2/fr
Publication of WO1999033866A2 publication Critical patent/WO1999033866A2/fr
Publication of WO1999033866A3 publication Critical patent/WO1999033866A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une famille d'oligopeptides possédant une structure entièrement nouvelle qui apparaît dans des gelées royales d'origine végétale définie et obtenues par sélection, et qui a été corrélée avec des effets antiviraux marqués. La structure pilote est une molécule avec 52 aminoacides. De nombreuses molécules analogues pratiquement identiques sont présentes sous forme satellitaire. Les substances possèdent un large spectre d'activité antivirale, y compris contre les rétrovirus, et ne présentent aucun effet toxique chez l'homme, même à de fortes doses. Une autre caractéristique surprenante est leur extrême résistance à toutes les protéases régulées et les autres enzymes. Ces molécules sont extrêmement convolutées et résistantes à l'attaque. En dépit de leur convolution, elles sont géométriquement très souples et peuvent former plusieurs conformères. Il existe à l'état natif une forme aisément soluble dans l'eau. La synthèse chimique donne une forme insoluble dans l'eau pouvant toutefois être transformée aisément en un conformère bioactif soluble similaire à la forme native. Ces nouveaux oligopeptides sont donc les premiers à réunir de manière optimale toutes les propriétés exigées d'une classe de principes actifs potentiellement antiviraux.
PCT/EP1998/007811 1997-12-27 1998-12-02 Oligopeptides WO1999033866A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR9814506-1A BR9814506A (pt) 1997-12-27 1998-12-02 Oligopetìdios
EP98965731A EP1042364A2 (fr) 1997-12-27 1998-12-02 Oligopeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1997157932 DE19757932C2 (de) 1997-12-27 1997-12-27 Oligopeptide
DE19757932.9 1997-12-27

Publications (2)

Publication Number Publication Date
WO1999033866A2 WO1999033866A2 (fr) 1999-07-08
WO1999033866A3 true WO1999033866A3 (fr) 1999-09-10

Family

ID=7853425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/007811 WO1999033866A2 (fr) 1997-12-27 1998-12-02 Oligopeptides

Country Status (4)

Country Link
EP (1) EP1042364A2 (fr)
BR (1) BR9814506A (fr)
DE (1) DE19757932C2 (fr)
WO (1) WO1999033866A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10344561B4 (de) * 2003-09-25 2011-12-22 Eberhard Bengsch Verwendung eines Tetra-, Penta- und Octapeptids aus Gelée Royale
JP2008208088A (ja) * 2007-02-27 2008-09-11 Ehime Univ 口内炎処置用組成物
WO2018188714A2 (fr) * 2018-09-06 2018-10-18 El Fiky Salem Ismaeil Salem Activités anti-leucémiques, anti-vih et sialidase de protéines de gelée royale

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1048323A (zh) * 1989-06-28 1991-01-09 北京朝阳三益日用化学厂 防治艾滋病、性病洗液的制备方法
WO1991001742A1 (fr) * 1989-07-28 1991-02-21 Ruffles, Graham, Keith Compositions biologiquement actives
WO1994007512A1 (fr) * 1992-09-30 1994-04-14 GSF - Forschungszentrum für Umwelt und Gesundheit GmbH Gelee royale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1048323A (zh) * 1989-06-28 1991-01-09 北京朝阳三益日用化学厂 防治艾滋病、性病洗液的制备方法
WO1991001742A1 (fr) * 1989-07-28 1991-02-21 Ruffles, Graham, Keith Compositions biologiquement actives
WO1994007512A1 (fr) * 1992-09-30 1994-04-14 GSF - Forschungszentrum für Umwelt und Gesundheit GmbH Gelee royale

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE EPODOC EPO; XP002107788 *

Also Published As

Publication number Publication date
DE19757932A1 (de) 1999-07-08
WO1999033866A2 (fr) 1999-07-08
DE19757932C2 (de) 2000-01-05
EP1042364A2 (fr) 2000-10-11
BR9814506A (pt) 2000-10-10

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