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WO1996019578A3 - PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT D'INFECTIONS MYCOBACTERIENNES A L'AIDE D'UN OPERON ahpCF - Google Patents

PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT D'INFECTIONS MYCOBACTERIENNES A L'AIDE D'UN OPERON ahpCF Download PDF

Info

Publication number
WO1996019578A3
WO1996019578A3 PCT/NZ1995/000133 NZ9500133W WO9619578A3 WO 1996019578 A3 WO1996019578 A3 WO 1996019578A3 NZ 9500133 W NZ9500133 W NZ 9500133W WO 9619578 A3 WO9619578 A3 WO 9619578A3
Authority
WO
WIPO (PCT)
Prior art keywords
operon
inh
ahpcf
compositions
detecting
Prior art date
Application number
PCT/NZ1995/000133
Other languages
English (en)
Other versions
WO1996019578A2 (fr
WO1996019578A9 (fr
Inventor
Desmond Michael Collins
Theresa Wilson
Original Assignee
Pastoral Agric Res Inst Nz Ltd
Desmond Michael Collins
Theresa Wilson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pastoral Agric Res Inst Nz Ltd, Desmond Michael Collins, Theresa Wilson filed Critical Pastoral Agric Res Inst Nz Ltd
Priority to EP95941938A priority Critical patent/EP0805863A2/fr
Priority to AU43185/96A priority patent/AU708456B2/en
Publication of WO1996019578A2 publication Critical patent/WO1996019578A2/fr
Publication of WO1996019578A3 publication Critical patent/WO1996019578A3/fr
Publication of WO1996019578A9 publication Critical patent/WO1996019578A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Les modes de réalisation de l'invention sont basés sur l'identification et la caractérisation d'un opéron déterminant la résistance mycobactérienne à l'antibiotique isoniaside (INH) et ses analogues. Cet opéron, appelé ahpCF, code des polypeptides, AhpC et AhpF, lesquels sont susceptibles de se combiner pour former une réductase d'hydropéroxyde d'alkyle active pouvant être soit une cible directe pour l'INH soit agir pour conférer une résistance à l'INH. L'invention concerne également la séquence de l'opéron ahpCF mutant illustrant que la résistance à l'INH peut être conférée par une mutation dans la région promotrice. L'invention concerne également des polynucléotides ainsi que des polypeptides utiles dans le diagnostic et le traitement.
PCT/NZ1995/000133 1994-12-20 1995-12-20 PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT D'INFECTIONS MYCOBACTERIENNES A L'AIDE D'UN OPERON ahpCF WO1996019578A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP95941938A EP0805863A2 (fr) 1994-12-20 1995-12-20 PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT D'INFECTIONS MYCOBACTERIENNES A L'AIDE D'UN OPERON ahpCF
AU43185/96A AU708456B2 (en) 1994-12-20 1995-12-20 Methods and compositions for detecting and treating mycobacterial infections using an ahpCF operon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ27022294 1994-12-20
NZ270222 1994-12-20

Publications (3)

Publication Number Publication Date
WO1996019578A2 WO1996019578A2 (fr) 1996-06-27
WO1996019578A3 true WO1996019578A3 (fr) 1996-08-29
WO1996019578A9 WO1996019578A9 (fr) 1996-10-03

Family

ID=19925097

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NZ1995/000133 WO1996019578A2 (fr) 1994-12-20 1995-12-20 PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT D'INFECTIONS MYCOBACTERIENNES A L'AIDE D'UN OPERON ahpCF

Country Status (4)

Country Link
EP (1) EP0805863A2 (fr)
AU (1) AU708456B2 (fr)
CA (1) CA2210378A1 (fr)
WO (1) WO1996019578A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2275177A1 (fr) * 1996-12-12 1998-06-18 Leopold Flohe Tryparedoxine peroxydase
NO994317L (no) * 1999-09-06 2001-03-07 Veso As V Tore B Tjaberg Diagnosemetode
US7288261B2 (en) * 2000-07-10 2007-10-30 Colorado State University Research Foundation Mid-life vaccine and methods for boosting anti-mycobacterial immunity
WO2002061063A1 (fr) * 2001-01-30 2002-08-08 Universite Catholique De Louvain Structure cristalline de peroxyredoxine 5 et son utilisation pour concevoir des homologues structuraux
EP1484413A1 (fr) * 2003-06-03 2004-12-08 Leopold Prof. Dr. Flohé Essai pour l'identification des inhibiteurs du système antioxydant de Mycobacterium
US7892566B2 (en) * 2005-08-09 2011-02-22 Hav Vaccines Limited Immunogenic constructs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026312A1 (fr) * 1993-05-13 1994-11-24 Jacobs William R Jr PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT DES INFECTIONS MYCOBACTERIENNES AU MOYEN D'UN GENE inhA

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026312A1 (fr) * 1993-05-13 1994-11-24 Jacobs William R Jr PROCEDES ET COMPOSITIONS DE DETECTION ET DE TRAITEMENT DES INFECTIONS MYCOBACTERIENNES AU MOYEN D'UN GENE inhA

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DERETIC, V. ET AL.: "Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid.", MOLECULAR MICROBIOLOGY, (1995 SEP) 17 (5) 889-900, XP000572779 *
ROSNER, J.: "Susceptibilities of oxyR regulon mutants of Escherichi coli and Salmonella typhimurium to isoniazid", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 37, October 1993 (1993-10-01), pages 2251 - 2253, XP000573870 *
SHERMAN, D. ET AL.: "Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1995 JUL 3) 92 (14) 6625-9, XP002006471 *
YAMAGUCHI, R. ET AL.: "Cloning and expression of the gene for the Avi-3 antigen of Mycobacterium avium and mapping of its epitopes", INFECTION AND IMMUNITY, vol. 60, March 1992 (1992-03-01), WASHINGTON US, pages 1210 - 1216, XP002006470 *

Also Published As

Publication number Publication date
AU708456B2 (en) 1999-08-05
WO1996019578A2 (fr) 1996-06-27
CA2210378A1 (fr) 1996-06-27
EP0805863A2 (fr) 1997-11-12
AU4318596A (en) 1996-07-10

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