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WO1996019578A3 - METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN ahpCF OPERON - Google Patents

METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN ahpCF OPERON Download PDF

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Publication number
WO1996019578A3
WO1996019578A3 PCT/NZ1995/000133 NZ9500133W WO9619578A3 WO 1996019578 A3 WO1996019578 A3 WO 1996019578A3 NZ 9500133 W NZ9500133 W NZ 9500133W WO 9619578 A3 WO9619578 A3 WO 9619578A3
Authority
WO
WIPO (PCT)
Prior art keywords
operon
inh
ahpcf
compositions
detecting
Prior art date
Application number
PCT/NZ1995/000133
Other languages
French (fr)
Other versions
WO1996019578A2 (en
WO1996019578A9 (en
Inventor
Desmond Michael Collins
Theresa Wilson
Original Assignee
Pastoral Agric Res Inst Nz Ltd
Desmond Michael Collins
Theresa Wilson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pastoral Agric Res Inst Nz Ltd, Desmond Michael Collins, Theresa Wilson filed Critical Pastoral Agric Res Inst Nz Ltd
Priority to EP95941938A priority Critical patent/EP0805863A2/en
Priority to AU43185/96A priority patent/AU708456B2/en
Publication of WO1996019578A2 publication Critical patent/WO1996019578A2/en
Publication of WO1996019578A3 publication Critical patent/WO1996019578A3/en
Publication of WO1996019578A9 publication Critical patent/WO1996019578A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The embodiments of the invention are based upon the identification and characterization of an operon that determines mycobacterial resistance to the antibiotic isoniazid (INH) and its analogs. This operon, termed ahpCF, encodes polypeptides, AhpC and AhpF, which likely combine to form an active alkyl hydroperoxide reductase enzyme that may either be a direct target for INH or act to confer INH resistance. The sequence of the mutant ahpCF operon is provided, showing that INH resistance can be conferred by a mutation in the promoter region. Also provided are polynucleotides and polypeptides that are useful in diagnosis and treatment.
PCT/NZ1995/000133 1994-12-20 1995-12-20 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN ahpCF OPERON WO1996019578A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP95941938A EP0805863A2 (en) 1994-12-20 1995-12-20 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN ahpCF OPERON
AU43185/96A AU708456B2 (en) 1994-12-20 1995-12-20 Methods and compositions for detecting and treating mycobacterial infections using an ahpCF operon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ27022294 1994-12-20
NZ270222 1994-12-20

Publications (3)

Publication Number Publication Date
WO1996019578A2 WO1996019578A2 (en) 1996-06-27
WO1996019578A3 true WO1996019578A3 (en) 1996-08-29
WO1996019578A9 WO1996019578A9 (en) 1996-10-03

Family

ID=19925097

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NZ1995/000133 WO1996019578A2 (en) 1994-12-20 1995-12-20 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN ahpCF OPERON

Country Status (4)

Country Link
EP (1) EP0805863A2 (en)
AU (1) AU708456B2 (en)
CA (1) CA2210378A1 (en)
WO (1) WO1996019578A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2275177A1 (en) * 1996-12-12 1998-06-18 Leopold Flohe Tryparedoxin peroxidase
NO994317L (en) * 1999-09-06 2001-03-07 Veso As V Tore B Tjaberg Diagnostic Method
US7288261B2 (en) * 2000-07-10 2007-10-30 Colorado State University Research Foundation Mid-life vaccine and methods for boosting anti-mycobacterial immunity
WO2002061063A1 (en) * 2001-01-30 2002-08-08 Universite Catholique De Louvain Crystal structure of peroxiredoxin 5 and its use for design of structural homologues
EP1484413A1 (en) * 2003-06-03 2004-12-08 Leopold Prof. Dr. Flohé Assay for identifying inhibitors of Mycobacterium anti-oxidant defense system
US7892566B2 (en) * 2005-08-09 2011-02-22 Hav Vaccines Limited Immunogenic constructs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026312A1 (en) * 1993-05-13 1994-11-24 Jacobs William R Jr METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN inhA GENE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026312A1 (en) * 1993-05-13 1994-11-24 Jacobs William R Jr METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN inhA GENE

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DERETIC, V. ET AL.: "Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid.", MOLECULAR MICROBIOLOGY, (1995 SEP) 17 (5) 889-900, XP000572779 *
ROSNER, J.: "Susceptibilities of oxyR regulon mutants of Escherichi coli and Salmonella typhimurium to isoniazid", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 37, October 1993 (1993-10-01), pages 2251 - 2253, XP000573870 *
SHERMAN, D. ET AL.: "Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1995 JUL 3) 92 (14) 6625-9, XP002006471 *
YAMAGUCHI, R. ET AL.: "Cloning and expression of the gene for the Avi-3 antigen of Mycobacterium avium and mapping of its epitopes", INFECTION AND IMMUNITY, vol. 60, March 1992 (1992-03-01), WASHINGTON US, pages 1210 - 1216, XP002006470 *

Also Published As

Publication number Publication date
AU708456B2 (en) 1999-08-05
WO1996019578A2 (en) 1996-06-27
CA2210378A1 (en) 1996-06-27
EP0805863A2 (en) 1997-11-12
AU4318596A (en) 1996-07-10

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