+

PT1970446E - Factor de reprogramação nuclear - Google Patents

Factor de reprogramação nuclear Download PDF

Info

Publication number
PT1970446E
PT1970446E PT06834636T PT06834636T PT1970446E PT 1970446 E PT1970446 E PT 1970446E PT 06834636 T PT06834636 T PT 06834636T PT 06834636 T PT06834636 T PT 06834636T PT 1970446 E PT1970446 E PT 1970446E
Authority
PT
Portugal
Prior art keywords
cell
reprogramming factor
nuclear reprogramming
family gene
gene
Prior art date
Application number
PT06834636T
Other languages
English (en)
Inventor
Shinya Yamanaka
Original Assignee
Univ Kyoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38162968&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1970446(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Kyoto filed Critical Univ Kyoto
Publication of PT1970446E publication Critical patent/PT1970446E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/605—Nanog
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/606—Transcription factors c-Myc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
PT06834636T 2005-12-13 2006-12-06 Factor de reprogramação nuclear PT1970446E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005359537 2005-12-13

Publications (1)

Publication Number Publication Date
PT1970446E true PT1970446E (pt) 2011-09-01

Family

ID=38162968

Family Applications (1)

Application Number Title Priority Date Filing Date
PT06834636T PT1970446E (pt) 2005-12-13 2006-12-06 Factor de reprogramação nuclear

Country Status (17)

Country Link
US (1) US8048999B2 (pt)
EP (6) EP2208786B1 (pt)
JP (8) JP5098028B2 (pt)
KR (1) KR101420740B1 (pt)
CN (4) CN101864392B (pt)
AU (1) AU2006325975B2 (pt)
BR (1) BRPI0619794B8 (pt)
CA (1) CA2632142C (pt)
DK (1) DK1970446T3 (pt)
EA (2) EA014166B1 (pt)
ES (1) ES2367525T3 (pt)
IL (1) IL191903A (pt)
MX (2) MX352337B (pt)
NZ (1) NZ569530A (pt)
PT (1) PT1970446E (pt)
WO (1) WO2007069666A1 (pt)
ZA (1) ZA200804673B (pt)

Families Citing this family (624)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
ES2701704T3 (es) 2004-04-07 2019-02-25 Ncardia Ag Sistemas de ensayo tisulares funcionales no invasivos in vitro
EP1745144B1 (en) 2004-05-11 2010-12-01 Axiogenesis Ag Assay for drug discovery based on in vitro differentiated cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
EP1984487B1 (en) * 2005-08-03 2022-10-12 Astellas Institute for Regenerative Medicine Improved methods of reprogramming animal somatic cells
US9012219B2 (en) * 2005-08-23 2015-04-21 The Trustees Of The University Of Pennsylvania RNA preparations comprising purified modified RNA for reprogramming cells
PT1970446E (pt) 2005-12-13 2011-09-01 Univ Kyoto Factor de reprogramação nuclear
US10647960B2 (en) * 2005-12-13 2020-05-12 The Trustees Of The University Of Pennsylvania Transcriptome transfer produces cellular phenotype conversion
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
DK2602326T3 (en) 2005-12-13 2018-12-10 Univ Pennsylvania Methods for transfecting nucleic acids into living cells
US20090227032A1 (en) * 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US9157066B2 (en) 2005-12-13 2015-10-13 The Trustees Of The University Of Pennsylvania Transcriptome transfer produces cellular phenotype conversion
CA2644856A1 (en) 2006-03-06 2007-09-13 Agency For Science, Technology And Research Human embryonic stem cell methods and podxl expression
CN101679950A (zh) * 2007-02-22 2010-03-24 国立大学法人东京大学 利用胚泡互补的器官再生法
EP3399025B1 (en) * 2007-03-23 2025-05-07 Wisconsin Alumni Research Foundation Somatic cell reprogramming
MX348010B (es) * 2007-04-07 2017-05-23 Whitehead Inst Biomedical Res Reprogramacion de celulas somaticas.
AU2016216711B2 (en) * 2007-04-07 2018-01-25 Whitehead Institute For Biomedical Research Reprogramming of somatic cells
JP2010528613A (ja) * 2007-05-29 2010-08-26 クリストファー ビー． リード， 多能細胞集団を産生する方法およびその使用
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US9213999B2 (en) * 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
US9096832B2 (en) 2007-07-31 2015-08-04 Lifescan, Inc. Differentiation of human embryonic stem cells
US20120282229A1 (en) * 2007-08-01 2012-11-08 Christian Kannemeier Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
CA2698091C (en) * 2007-08-31 2018-07-03 Brett Chevalier Wnt pathway stimulation in reprogramming somatic cells
WO2009057831A1 (ja) * 2007-10-31 2009-05-07 Kyoto University 核初期化方法
CA3123528A1 (en) 2007-11-27 2009-06-04 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
US20110033931A1 (en) * 2007-11-29 2011-02-10 Children's Hospital Of Orange County De-differentiation of human cells
JP5626619B2 (ja) * 2008-12-08 2014-11-19 国立大学法人京都大学 効率的な核初期化方法
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
JP5558097B2 (ja) 2007-12-10 2014-07-23 国立大学法人京都大学 効率的な核初期化方法
WO2009076529A1 (en) 2007-12-11 2009-06-18 Research Development Foundation Small molecules for neuronal differentiation of embryonic stem cells
EP2072618A1 (en) * 2007-12-14 2009-06-24 Johannes Gutenberg-Universität Mainz Use of RNA for reprogramming somatic cells
KR101481164B1 (ko) * 2008-01-30 2015-01-09 주식회사 미래셀바이오 체세포 유래 다능성 줄기세포의 제조 방법
WO2009096049A1 (ja) * 2008-02-01 2009-08-06 Kyoto University 人工多能性幹細胞由来分化細胞
KR101597731B1 (ko) 2008-02-21 2016-02-26 센토코 오르토 바이오테크 인코포레이티드 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
WO2009104794A1 (ja) * 2008-02-22 2009-08-27 国立大学法人 東京大学 遺伝子改変による致死性表現型を持つ動物の繁殖用ファウンダー動物作製法
JP2009215191A (ja) 2008-03-07 2009-09-24 Keio Gijuku 神経損傷治療剤及び神経損傷治療方法
EP2100954A1 (en) * 2008-03-10 2009-09-16 Assistance Publique - Hopitaux de Paris Method for generating primate cardiac progenitor cells for clinical use from primate embryonic stem cells, and their applications
AU2015201026B2 (en) * 2008-03-17 2017-03-16 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
SG10201808863UA (en) * 2008-03-17 2018-11-29 Scripps Research Inst Combined chemical and genetic approaches for generation of induced pluripotent stem cells
WO2009114949A1 (en) * 2008-03-20 2009-09-24 UNIVERSITé LAVAL Methods for deprogramming somatic cells and uses thereof
WO2009118928A1 (en) 2008-03-26 2009-10-01 Kyoto University Efficient production and use of highly cardiogenic progenitors and cardiomyocytes from embryonic and induced pluripotent stem cells
WO2009119105A1 (ja) * 2008-03-28 2009-10-01 国立大学法人東京大学 ＧＰＩｂα＋ＧＰＶ＋ＧＰＶＩ＋血小板のインビトロ調製法
US20110117645A1 (en) * 2008-03-31 2011-05-19 Oriental Yeast Co., Ltd. Method for proliferation of pluripotent stem cells
WO2009122747A1 (ja) * 2008-04-01 2009-10-08 国立大学法人東京大学 ｉＰＳ細胞からの血小板の調製方法
WO2009146098A2 (en) * 2008-04-02 2009-12-03 President And Fellows Of Harvard College Stem cells and uses thereof
EP2276838A4 (en) * 2008-04-07 2012-02-01 Nupotential Inc RE-PROGRAMMING A CELL BY INDUCING A PLURIPOTENTIC GENE THROUGH RNA INTERFERENCE
US20100021437A1 (en) * 2008-04-07 2010-01-28 The McLean Hospital Corporation Whitehead Institute for Biomedical Research Neural stem cells derived from induced pluripotent stem cells
US8623648B2 (en) * 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
WO2009131262A1 (en) * 2008-04-25 2009-10-29 Mirae Biotech Co., Ltd. Method of manufacturing induced pluripotent stem cell originated from human somatic cell
ES2722198T3 (es) 2008-05-02 2019-08-08 Univ Kyoto Método de reprogramación nuclear
US9102920B2 (en) * 2008-05-06 2015-08-11 Agency For Science, Technology And Research Method of effecting de-differentiation of a cell
US20090280096A1 (en) * 2008-05-09 2009-11-12 Atsushi Kubo Pancreatic endocrine progenitor cells derived from pluripotent stem cells
WO2009142717A2 (en) * 2008-05-19 2009-11-26 President And Fellows Of Harvard College Methods and products for dedifferentiation of cells
EP2128245A1 (en) * 2008-05-27 2009-12-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Generation of induced pluripotent stem (iPS) cells
JP2011160661A (ja) * 2008-06-02 2011-08-25 Kyowa Hakko Kirin Co Ltd 血球細胞の初期化法
KR101648019B1 (ko) * 2008-06-04 2016-08-16 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 비-바이러스 접근법을 사용한 ｉＰＳ 세포의 생산 방법
SG191673A1 (en) * 2008-06-13 2013-07-31 Whitehead Biomedical Inst Programming and reprogramming of cells
AU2015202237B2 (en) * 2008-06-13 2017-09-28 Whitehead Institute For Biomedical Research Programming and reprogramming of cells
WO2010008486A2 (en) * 2008-06-24 2010-01-21 Parkinsons Institute Pluripotent cell lines and methods of use thereof
JP2011525794A (ja) * 2008-06-26 2011-09-29 国立大学法人大阪大学 ｉＰＳ細胞の製造方法および製造キット
WO2009157610A1 (en) * 2008-06-26 2009-12-30 Pusan National University Industry-University Cooperation Foundation Selenium dedifferentiated cell, preparation method and usage thereof
KR101606943B1 (ko) 2008-06-27 2016-03-28 고쿠리츠 다이가쿠 호진 교토 다이가쿠 유도된 다능성 줄기 세포의 효율적인 확립 방법
CA2729121C (en) 2008-06-30 2019-04-09 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
EP3075850B1 (en) 2008-07-16 2019-02-06 ID Pharma Co., Ltd. Method for production of reprogrammed cell using chromosomally unintegrated virus vector
CA2697621C (en) * 2008-07-30 2017-01-17 Kyoto University Method of efficiently establishing induced pluripotent stem cells
CA2732401C (en) * 2008-07-31 2014-08-05 Gifu University Efficient method for establishing induced pluripotent stem cells
WO2010016253A1 (en) 2008-08-05 2010-02-11 Keio University Method for selecting secondary neurosphere derived from differentiated cell-derived pluripotent stem cell, clone selected by the method and use of the clone
US10047346B2 (en) * 2008-08-08 2018-08-14 Mayo Foundation For Medical Education And Research Method of treating heart tissue using induced pluripotent stem cells
EP2331696A1 (en) * 2008-08-12 2011-06-15 Cellular Dynamics International, Inc. Methods for the production of ips cells
JP2012500801A (ja) * 2008-08-21 2012-01-12 リヒター ゲデオン ニルバーノシャン ミーケデーレスベニュタールシャシャーグ Ｃｎｓ疾患の治療法
JP5688800B2 (ja) * 2008-08-22 2015-03-25 国立大学法人 東京大学 ｉＰＳ細胞とＢＬＡＳＴＯＣＹＳＴＣＯＭＰＬＥＭＥＮＴＡＴＩＯＮを利用した臓器再生法
WO2010028249A1 (en) * 2008-09-04 2010-03-11 Abt Holding Company Use of stem cells to prevent neuronal dieback
EP2333050A4 (en) 2008-09-04 2013-07-03 Riken IPS CELLS FROM B-CELLS AND ITS APPLICATION
US8945922B2 (en) * 2008-09-08 2015-02-03 Riken Generating a mature NKT cell from a reprogrammed somatic cell with a T-cell antigen receptor α-chain region rearranged to uniform Va-Ja in a NKT-cell specific way
JP2012501680A (ja) * 2008-09-12 2012-01-26 スカラブ ジェノミクス リミティド ライアビリティ カンパニー クリーンゲノムバクトフェクション
CN101492676B (zh) * 2008-09-16 2011-02-16 中国科学院广州生物医药与健康研究院 用脑膜细胞生成诱导的多能性干细胞的方法及其用途
SG160248A1 (en) * 2008-09-18 2010-04-29 Agency Science Tech & Res Use of novel monoclonal antibodies targeting human embryonic stem cells to characterize and kill induced pluripotent stem cells
US8703413B2 (en) 2008-09-22 2014-04-22 Children's Medical Center Corporation Detection of human somatic cell reprogramming
KR101746864B1 (ko) * 2008-10-24 2017-06-14 주식회사 쿠라레 세포 보존 방법 및 세포 수송 방법
WO2010050626A1 (en) * 2008-10-30 2010-05-06 Kyoto University Method for producing induced pluripotent stem cells
BRPI0919883A2 (pt) 2008-10-31 2015-08-11 Centocor Ortho Biotech Inc Diferenciação de células-tronco embrionárias humanas para a linhagem endócrina pancreática
KR101712085B1 (ko) 2008-10-31 2017-03-03 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 계통으로의 분화
JP5608645B2 (ja) 2008-11-05 2014-10-15 学校法人慶應義塾 神経幹細胞製造方法
CA2744234C (en) 2008-11-20 2018-11-06 Centocor Ortho Biotech Inc. Pluripotent stem cell culture on micro-carriers
WO2010059778A1 (en) 2008-11-20 2010-05-27 Centocor Ortho Biotech Inc. Methods and compositions for cell attachment and cultivation on planar substrates
EP2881461A1 (en) * 2008-11-21 2015-06-10 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Reprogramming cells toward a pluripotent state
CA2688804A1 (en) 2008-12-17 2010-06-17 The Uab Research Foundation Polycistronic vector for human induced pluripotent stem cell production
CN102317442B (zh) * 2008-12-17 2014-08-13 斯克里普斯研究所 干细胞的产生和保持
EP2377926A4 (en) * 2008-12-18 2011-12-14 New Ind Res Organization CHONDROCYTE-CELL AND MANUFACTURING METHOD THEREFOR
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
US10328103B2 (en) 2009-01-03 2019-06-25 Ray C. Wasielewski Medical treatment composition comprising mammalian dental pulp stem cells
WO2010090007A1 (en) 2009-02-03 2010-08-12 Keio University Culture method of embryoid bodies and/or neural stem cells derived from human differentiated cell-derived pluripotent stem cells
WO2010093655A2 (en) * 2009-02-10 2010-08-19 University Of Dayton Enhanced method for producing stem-like cells from somatic cells
WO2010098419A1 (en) 2009-02-27 2010-09-02 Kyoto University Novel nuclear reprogramming substance
EP2408904B1 (en) 2009-03-20 2017-10-18 Mesoblast, Inc. Production of reprogrammed pluripotent cells
JP5637354B2 (ja) * 2009-03-30 2014-12-10 独立行政法人産業技術総合研究所 精製転写因子の調製法と細胞導入技術
WO2010119819A1 (ja) 2009-04-17 2010-10-21 国立大学法人東北大学 ヒト肺組織幹細胞の調製方法及びヒト肺胞上皮細胞への分化誘導方法
CN101613717B (zh) * 2009-04-17 2012-01-11 中国科学院广州生物医药与健康研究院 用猪成纤维细胞生成诱导的多能性干细胞的方法
CN101580816B (zh) * 2009-04-23 2012-02-29 中国科学院广州生物医药与健康研究院 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法
JP2010268789A (ja) 2009-04-24 2010-12-02 Kumamoto Univ 細胞医薬の製造方法
EP2253700A1 (en) 2009-05-13 2010-11-24 Helmholtz-Zentrum für Infektionsforschung GmbH A method for producing test systems from donors suffering from adverse effects of medicaments and /or medical treatments, and uses of said systems
US8957037B2 (en) 2009-05-18 2015-02-17 Curna, Inc. Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
WO2010137746A1 (en) 2009-05-29 2010-12-02 Kyoto University Method for producing induced pluripotent stem cells and method for culturing the same
US9005975B2 (en) * 2009-05-29 2015-04-14 Kyoto University Method for selecting clone of induced pluripotent stem cells
US9365866B2 (en) 2009-06-03 2016-06-14 National Institute Of Advanced Industrial Science And Technology Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
US9550975B2 (en) * 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
US9399758B2 (en) 2009-07-15 2016-07-26 Mari Dezawa SSEA3(+) pluripotent stem cell that can be isolated from body tissue
WO2011011300A2 (en) 2009-07-20 2011-01-27 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells
CN102471744B (zh) * 2009-07-21 2015-06-10 国立大学法人京都大学 图像处理装置、培养观察装置及图像处理方法
SG10201608797WA (en) * 2009-08-07 2016-12-29 Univ Kyoto Method of efficiently establishing induced pluripotent stem cells
JP5751548B2 (ja) 2009-08-07 2015-07-22 国立大学法人京都大学 イヌｉＰＳ細胞及びその製造方法
CN101993495B (zh) * 2009-08-12 2013-07-24 上海近岸科技有限公司 一种蛋白质混合物及其制备方法
ES2590036T3 (es) 2009-08-12 2016-11-17 Kyoto University Método para inducir la diferenciación de células madre pluripotentes en células precursoras neurales
US20120282318A1 (en) 2009-08-19 2012-11-08 Koyoto University Sheet for corneal transplants
CN102576027B (zh) 2009-08-22 2014-10-01 里兰斯坦福初级大学理事会 成像并评估胚胎、卵母细胞和干细胞
US20110052549A1 (en) * 2009-08-27 2011-03-03 The Regents Of The University Of California Cell culture device to differentiate stem cells in a specific orientation
US8748179B2 (en) 2009-08-31 2014-06-10 Osaka University Method for efficient production of induced pluripotent stem cells utilizing cells derived from oral mucosa
US8741649B2 (en) 2009-09-04 2014-06-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for enhancing genome stability and telomere elongation in embryonic stem cells
GB0915523D0 (en) * 2009-09-07 2009-10-07 Genome Res Ltd Cells and methods for obtaining them
US8741644B2 (en) 2009-09-08 2014-06-03 Kyoto University Method for producing mast cells from pluripotent stem cells
WO2011032025A2 (en) * 2009-09-10 2011-03-17 The Salk Institute For Biological Studies Adipose-derived induced pluripotent stem cells
JP5791191B2 (ja) * 2009-09-15 2015-10-07 国立大学法人 東京大学 分化細胞の新規製造法
AU2014240253B2 (en) * 2009-09-15 2017-08-03 The University Of Tokyo Novel Method for Producing Differentiated Cells
EP2480657B1 (en) 2009-09-24 2018-01-17 Kyoto University Method of efficiently establishing induced pluripotent stem cells
WO2011040887A1 (en) * 2009-09-30 2011-04-07 Agency For Science, Technology And Research A nuclear receptor and mutant thereof and the use of the same in the reprogramming of cells
CA3091210C (en) * 2009-10-16 2023-04-04 The Scripps Research Institute Induction of pluripotent cells
US9340772B2 (en) 2009-10-29 2016-05-17 Mcmaster University Generating induced pluripotent stem cells and progenitor cells from fibroblasts
EP3633025B1 (en) 2009-11-12 2022-09-14 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
GB0919773D0 (en) 2009-11-12 2009-12-30 Univ Nottingham Induced pluripotent stem cell
WO2011058064A1 (en) 2009-11-13 2011-05-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Reprogrammation of eukaryotic cells with engineered microvesicles
SG10201407645YA (en) 2009-11-19 2015-01-29 Agency Science Tech & Res Methods of Enhancing Pluripotentcy
US20120244619A1 (en) 2009-12-09 2012-09-27 Kyoto University Composition for promoting differentiation of pluripotent stem cells into cardiac muscle cells which comprises nitrovin
US20130115622A1 (en) 2009-12-14 2013-05-09 Kyoto University Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis
SG10201408552YA (en) 2009-12-23 2015-02-27 Janssen Biotech Inc Differentiation of human embryonic stem cells
JP2011135864A (ja) * 2009-12-30 2011-07-14 Korea Univ Research & Business Foundation Ｏｃｔ４及びＢｍｉ１、またはその上位調節子を用いて体細胞から胚幹細胞類似細胞への逆分化を誘導する組成物及びこれを用いた胚幹細胞類似細胞の製造方法
AU2011204143B2 (en) 2010-01-06 2014-09-18 National University Corporation Tottori University Mouse artificial chromosome vector
JP5827220B2 (ja) 2010-01-22 2015-12-02 国立大学法人京都大学 人工多能性幹細胞の樹立効率改善方法
ES2667058T3 (es) 2010-02-03 2018-05-09 Tetsuya Ishikawa Célula madre hepática inducida y procedimiento para su producción, y aplicaciones de la célula
JP5765746B2 (ja) 2010-02-16 2015-08-19 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
EP2537930A4 (en) 2010-02-18 2013-10-02 Univ Osaka METHOD FOR THE PRODUCTION OF INDUCED PLURIPOTENTAL STEM CELLS
SG183535A1 (en) 2010-03-01 2012-10-30 Janssen Biotech Inc Methods for purifying cells derived from pluripotent stem cells
EP2926821B1 (en) 2010-03-05 2019-12-25 Tissue Genesis, LLC Compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells
JP2013521760A (ja) * 2010-03-10 2013-06-13 国立大学法人京都大学 人工多能性幹細胞の選別方法
ES2624780T3 (es) * 2010-03-31 2017-07-17 The Scripps Research Institute Reprogramación de células
WO2011129446A1 (ja) 2010-04-16 2011-10-20 学校法人慶應義塾 人工多能性幹細胞の製造方法
CA2796616A1 (en) 2010-04-21 2011-10-27 Research Development Foundation Methods and compositions related to dopaminergic neuronal cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
CN102242146B (zh) * 2010-05-10 2015-11-25 高丽大学校产学协力团 组合物和用其产生诱导全能干细胞的方法
EP2569419B1 (en) 2010-05-12 2019-03-20 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
JP5920725B2 (ja) 2010-05-25 2016-05-18 国立研究開発法人国立がん研究センター 生体外で自己複製可能な誘導前がん幹細胞又は誘導悪性幹細胞、これらの製造方法、及び、これらの細胞の応用
EP2580320B1 (en) 2010-06-14 2018-08-01 The Scripps Research Institute Reprogramming of cells to a new fate
EP2582795B1 (en) 2010-06-15 2017-04-12 Kyoto University Method for selecting human induced pluripotent stem cells
AU2011268056B2 (en) * 2010-06-18 2014-04-24 Cellular Dynamics International, Inc. Cardiomyocyte medium with dialyzed serum
US9476041B2 (en) 2010-07-12 2016-10-25 National University Corporation Tottori University Method for producing novel hipsc by means of siRNA introduction
US9121011B2 (en) 2010-07-21 2015-09-01 Kyoto University Method for inducing differentiation of human pluripotent stem cell into intermediate mesoderm cell
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
JP5892661B2 (ja) 2010-08-13 2016-03-23 国立大学法人京都大学 多能性幹細胞から生殖細胞への分化誘導方法
EP2609425A1 (en) 2010-08-23 2013-07-03 President and Fellows of Harvard College Optogenetic probes for measuring membrane potential
CN103209968B (zh) 2010-08-26 2015-08-05 国立大学法人京都大学 多能干细胞心肌细胞分化促进剂
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
WO2012029770A1 (ja) 2010-08-30 2012-03-08 ディナベック株式会社 多能性幹細胞を誘導するための組成物およびその使用
SG10201506852VA (en) 2010-08-31 2015-10-29 Janssen Biotech Inc Differentiation of human embryonic stem cells
CA2809305C (en) 2010-08-31 2019-06-11 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
PL2611909T3 (pl) 2010-08-31 2018-05-30 Janssen Biotech, Inc Zróżnicowanie ludzkich embrionalnych komórek macierzystych
EP2611437B1 (en) 2010-09-02 2017-03-29 Kyoto University Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis
JP5794588B2 (ja) 2010-09-14 2015-10-14 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
WO2012037456A1 (en) 2010-09-17 2012-03-22 President And Fellows Of Harvard College Functional genomics assay for characterizing pluripotent stem cell utility and safety
PL4108671T3 (pl) 2010-10-01 2025-02-24 Modernatx, Inc. Zmodyfikowane nukleozydy, nukleotydy i kwasy nukleinowe oraz ich zastosowania
CA2814713A1 (en) * 2010-10-14 2012-04-19 University Of Central Florida Research Foundation, Inc. Cardiac induced pluripotent stem cells and methods of use in repair and regeneration of myocardium
WO2012054896A1 (en) 2010-10-22 2012-04-26 Biotime Inc. Methods of modifying transcriptional regulatory networks in stem cells
WO2012057052A1 (ja) * 2010-10-25 2012-05-03 公立大学法人横浜市立大学 幹細胞の安定的維持、複製を制御するためのペプチジルプロリルイソメラーゼＰｉｎ１の利用
US9376665B2 (en) 2010-11-02 2016-06-28 National University Corporation Kumamoto University Method for producing intestinal cells
EP2635678A4 (en) * 2010-11-04 2014-04-23 Univ Kyoto METHOD FOR EFFICIENT MANUFACTURE OF INDUCED PLURIPOTENTER STEM CELLS
EP2635707B1 (en) 2010-11-05 2019-03-27 Kyoto University Method of examining polycystic kidney disease and method of screening for therapeutic agent of the disease
WO2012063817A1 (ja) * 2010-11-09 2012-05-18 独立行政法人産業技術総合研究所 末梢血単球由来多能性幹細胞作製方法
JP6090855B2 (ja) 2010-11-17 2017-03-08 国立大学法人京都大学 心筋細胞および／または心筋前駆細胞増殖剤ならびに心筋細胞および／または心筋前駆細胞の増殖方法
US10813950B2 (en) 2010-12-02 2020-10-27 Riken Immunotherapy using allo-NKT cells, cells for immunotherapy in which alpha chain of t-cell receptor (TCR) gene has been rearranged to uniform Vα-Jα, and banking of NKT cells derived from said cells
WO2012074117A1 (ja) 2010-12-03 2012-06-07 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
US9404082B2 (en) 2010-12-03 2016-08-02 Kyoto University Method for production of eosinophil from pluripotent stem cell
JP5888852B2 (ja) * 2010-12-08 2016-03-22 学校法人近畿大学 免疫不全動物を用いた細胞の製法
CA2822638C (en) 2010-12-22 2021-02-16 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of ipscs
US9850466B2 (en) 2011-01-19 2017-12-26 The Regents Of The University Of California Somatic cells with innate potential for pluripotency
WO2012098260A1 (en) 2011-01-21 2012-07-26 Axiogenesis Ag A non-viral system for the generation of induced pluripotent stem (ips) cells
WO2012112458A2 (en) * 2011-02-14 2012-08-23 The Regents Of The University Of California Compositions and methods for increasing reprogramming efficiency
CA2827945C (en) 2011-02-23 2021-10-12 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting aneuploidy in human embryos
WO2012115276A1 (en) 2011-02-23 2012-08-30 Kyoto University Method for producing dendritic cells from pluripotent stem cells
GB201103600D0 (en) 2011-03-01 2011-04-13 Isis Innovation Dendritic cells
EP2691522B1 (en) 2011-03-30 2020-11-25 Transine Therapeutics Limited Functional nucleic acid molecule and use thereof
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
WO2012133811A1 (ja) 2011-03-31 2012-10-04 独立行政法人理化学研究所 未分化状態の制御剤およびその用途
EP2691513A4 (en) 2011-03-31 2014-09-03 Iheart Japan Corp NEW CARDIOMYOCYTE MARKER
EP2694642B8 (en) 2011-04-08 2018-10-17 Institut National de la Sante et de la Recherche Medicale (INSERM) Method for rejuvenating cells
EP2695894B1 (en) 2011-04-08 2017-11-01 Osaka University Modified laminin and use thereof
WO2012141181A1 (ja) * 2011-04-11 2012-10-18 国立大学法人京都大学 核初期化物質
CN103492555A (zh) 2011-04-20 2014-01-01 国立大学法人大阪大学 角膜上皮分化取向性iPS细胞
US9932560B2 (en) 2011-05-13 2018-04-03 Elixirgen, Llc Use of Zscan4 and Zscan4-dependent genes for direct reprogramming of somatic cells
WO2012168434A1 (en) 2011-06-08 2012-12-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Partial reprogramming of somatic cells to induced tissue stem (its) cells
GB201110331D0 (en) 2011-06-16 2011-08-03 Isis Innovation Method of cryopreserving pluripotent stem cells
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US20130029416A1 (en) 2011-07-22 2013-01-31 Tayaramma Thatava Differentiating induced pluripotent stem cells into glucose-responsive, insulin-secreting progeny
JP6234924B2 (ja) 2011-07-22 2017-11-22 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィックＣｅｎｔｒｅ Ｎａｔｉｏｎａｌ Ｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｓｃｉｅｎｔｉｆｉｑｕｅ 多能性幹細胞を得るための細胞抽出物の使用
AU2012288249B2 (en) 2011-07-25 2017-06-22 Kyoto University Method for screening induced pluripotent stem cells
WO2013031826A1 (ja) * 2011-08-29 2013-03-07 国立大学法人京都大学 核初期化物質
US9145547B2 (en) 2011-08-30 2015-09-29 Riken Nuclear reprogrammed cells generated by introduction of a histone H2aa or TH2A gene, a histone H2ba or TH2B gene, or a phosphorylation-mimic of histone chaperon Npm2 gene, an Oct family gene and a klf family gene into a mammalian somatic cell
JP6028236B2 (ja) 2011-09-12 2016-11-16 国立大学法人 熊本大学 物質のスクリーニング方法
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9480695B2 (en) 2011-09-29 2016-11-01 The University Of Tokyo Methods for inducing orexin neurons and agent for treating narcolepsy or eating disorder
EP2762560A4 (en) * 2011-09-29 2015-05-20 Univ Tokyo PROCESS FOR INDUCING OREXINE NEURONES
KR102014061B1 (ko) 2011-10-03 2019-08-28 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도
EP2770051B1 (en) 2011-10-21 2017-09-27 ARKRAY, Inc. Method for culturing pluripotency-maintained singly dispersed cells by means of laminar flow
GB2496375A (en) 2011-10-28 2013-05-15 Kymab Ltd A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
WO2013078433A1 (en) 2011-11-23 2013-05-30 University Of Hawaii Auto-processing domains for polypeptide expression
WO2013077423A1 (ja) 2011-11-25 2013-05-30 国立大学法人京都大学 多能性幹細胞の培養方法
TW201335372A (zh) 2011-11-30 2013-09-01 Nat Cancer Ct 誘導惡性幹細胞
GB201122047D0 (en) 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals
MX382822B (es) 2011-12-05 2025-03-13 Factor Bioscience Inc Metodos y productos para transfeccion de celulas.
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013094771A1 (en) 2011-12-19 2013-06-27 Kyoto University Method for inducing differentiation of human pluripotent stem cells into intermediate mesoderm cells
SG10201608914WA (en) 2011-12-22 2016-12-29 Janssen Biotech Inc Differentiation of human embryonic stem cells into single hormonal insulin positive cells
JP5935224B2 (ja) 2011-12-27 2016-06-15 国立大学法人大阪大学 ｉＰＳ細胞の腫瘍化を抑制することが可能な分化誘導方法
EP2804944A1 (en) 2012-01-15 2014-11-26 Yeda Research and Development Co. Ltd. Induction of dedifferentiation of mesenchymal stromal cells
US9587220B2 (en) 2012-01-27 2017-03-07 Kyoto University Method for inducing cardiac differentiation of pluripotent stem cell
AU2013230020B2 (en) 2012-03-07 2018-08-09 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
US9764063B2 (en) 2012-03-15 2017-09-19 Iheart Japan Corporation Method for producing mixed cell population of cardiomyocytes and vascular cells from induced pluripotent stem cell
EP2829605B1 (en) 2012-03-21 2019-05-08 Kyoto University Method for screening therapeutic and/or prophylactic agents for alzheimer's disease
WO2013139429A1 (en) 2012-03-21 2013-09-26 Merck Patent Gmbh Induced neural stem cells
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
HK1206636A1 (zh) 2012-04-02 2016-01-15 Modernatx, Inc. 用於制备肿瘤相关蛋白和多肽的修饰的多核苷酸
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
WO2013151186A1 (ja) 2012-04-06 2013-10-10 国立大学法人京都大学 エリスロポエチン産生細胞の誘導方法
US10195229B2 (en) * 2012-04-19 2019-02-05 Elsa R. Flores Generation of human induced pluripotent stem cells using nucleic acid sequences that inhibit Δ-NP63 and DGCR8
ES2725827T3 (es) 2012-05-23 2019-09-27 Univ Kyoto Método altamente eficiente para establecer una célula madre pluripotencial artificial
FI3597749T3 (fi) 2012-05-25 2023-10-09 Univ California Menetelmiä ja koostumuksia rna-ohjattua kohde-dna-modifikaatiota varten ja rna-ohjattua transkription modulaatiota varten
WO2013181549A2 (en) 2012-05-31 2013-12-05 Auxogyn, Inc. In vitro embryo blastocyst prediction methods
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY
EP3957714A1 (en) 2012-06-08 2022-02-23 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells
WO2014011813A1 (en) 2012-07-11 2014-01-16 Tissuetech, Inc. Compositions containing hc-ha/ptx3 complexes and methods of use thereof
WO2014014119A1 (en) 2012-07-17 2014-01-23 Kyoto University Novel cardiomyocyte marker
CN113151179A (zh) 2012-07-31 2021-07-23 阿格克斯治疗有限公司 Hla g修饰的细胞及方法
EP2882445B1 (en) 2012-08-13 2019-04-24 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
WO2014057997A1 (ja) 2012-10-09 2014-04-17 Hayashi Nakanobu 初期化ペプチド及びその用途
JP2014082956A (ja) 2012-10-19 2014-05-12 Somar Corp 細胞培養基材、およびそれを用いた細胞培養方法並びに多能性幹細胞の分化誘導方法
US10077429B2 (en) 2012-10-23 2018-09-18 Kyoto University Method of efficiently establishing induced pluripotent stem cells
CA2889232C (en) 2012-10-30 2018-05-15 Daiichi Sankyo Company, Limited Mait-like cells and their preparation method
BR122019025681B1 (pt) 2012-11-01 2023-04-18 Factor Bioscience Inc Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
SMT202200337T1 (it) 2012-11-26 2022-09-14 Modernatx Inc Rna modificato al livello del terminale
GB201222693D0 (en) * 2012-12-17 2013-01-30 Babraham Inst Novel method
JP6308134B2 (ja) 2012-12-27 2018-04-11 ソニー株式会社 細胞分析システム、細胞分析プログラム及び細胞分析方法
JP6312215B2 (ja) 2012-12-28 2018-04-18 国立大学法人京都大学 人工多能性幹細胞、心筋細胞又はその前駆細胞の製造方法
KR20150103203A (ko) 2012-12-31 2015-09-09 얀센 바이오테크 인코포레이티드 췌장 내분비 세포 내로의 분화를 위한 인간 만능 세포의 현탁 및 클러스터링
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
RU2768963C2 (ru) 2012-12-31 2022-03-25 Янссен Байотек, Инк. Культивация эмбриональных стволовых клеток человека в воздушно-жидкостной зоне взаимодействия с целью их дифференцировки в панкреатические эндокринные клетки
MX2015008578A (es) 2012-12-31 2015-09-07 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9.
US20160017441A1 (en) 2013-01-16 2016-01-21 Universal Bio Research Co., Ltd. Method for identifying cells
AU2014212230B2 (en) 2013-02-01 2019-07-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method for generating retinal pigment epithelium (RPE) cells from induced pluripotent stem cells (iPSCs)
CA2900741C (en) 2013-02-01 2022-01-18 Progyny, Inc. Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower developmental potential
WO2014124087A1 (en) 2013-02-06 2014-08-14 University Of Rochester Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders
JP6495658B2 (ja) 2013-02-08 2019-04-03 国立大学法人京都大学 巨核球及び血小板の製造方法
JP6494903B2 (ja) 2013-02-14 2019-04-03 ソニー株式会社 分析システム、分析プログラム及び分析方法
JP6511606B2 (ja) 2013-03-01 2019-05-15 株式会社生命科学インスティテュート 多能性幹細胞を損傷部位に誘導する遊走因子を含む医薬組成物
JP6292415B2 (ja) 2013-03-06 2018-03-14 国立大学法人京都大学 多能性幹細胞の培養システム及び多能性幹細胞の継代方法
US10196609B2 (en) 2013-03-08 2019-02-05 Kyoto University Composition for promoting cardiac differentiation of pluripotent stem cell comprising EGFR inhibitor
AU2014236150B2 (en) 2013-03-14 2019-10-31 The Regents Of The University Of California In vitro production of medial ganglionic eminence precursor cells
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014148646A1 (ja) 2013-03-21 2014-09-25 国立大学法人京都大学 神経分化誘導用の多能性幹細胞
JP6473686B2 (ja) 2013-03-25 2019-02-20 公益財団法人神戸医療産業都市推進機構 細胞の選別方法
GB201306589D0 (en) 2013-04-11 2013-05-29 Abeterno Ltd Live cell imaging
EP2985344B1 (en) 2013-04-12 2018-07-18 Kyoto University Method for inducing alveolar epithelium progenitor cells
EP2998391B1 (en) 2013-05-14 2020-02-19 Kyoto University Efficient myocardial cell induction method
EP3006559B1 (en) 2013-05-31 2019-11-06 iHeart Japan Corporation Layered cell sheet incorporating hydrogel
JP6697380B2 (ja) 2013-06-10 2020-05-20 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 多能性幹細胞の有用性および安全性を特徴付けるための初期発生ゲノムアッセイ
JP6450311B2 (ja) 2013-06-11 2019-01-09 国立大学法人京都大学 腎前駆細胞の製造方法及び腎前駆細胞を含む医薬
US10240126B2 (en) 2013-06-12 2019-03-26 Kyoto University Induced pluripotent stem cell selection method and method for inducing differentiation to blood cells
EP3031905A4 (en) 2013-08-07 2017-04-26 Kyoto University Method for producing pancreatic hormone-producing cell
EP3037534B1 (en) 2013-08-23 2021-02-17 Riken Polypeptide exhibiting fluorescent properties, and utilization of same
WO2015030111A1 (ja) 2013-08-28 2015-03-05 国立大学法人岐阜大学 人工多能性幹細胞の作製方法
EP3040414B1 (en) 2013-08-29 2018-12-12 Norimasa Miura Biomolecular group related to cell anti-aging
EP3042194B1 (en) 2013-09-05 2019-11-27 Tempo Bioscience Inc. Human cellular models with biosensors
CA2923592A1 (en) 2013-09-05 2015-03-12 Kyoto University Method for inducing dopamine-producing neural precursor cells from pluripotent stem cells
EP3045531B1 (en) 2013-09-12 2023-08-30 Kaneka Corporation Method for inducing differentiation of induced pluripotent stem cells and method for selecting induced pluripotent stem cells
EP3045451B1 (en) 2013-09-13 2018-03-28 Kyoto University Compound promoting differentiation of pluripotent stem cells into cardiomyocytes
WO2015046229A1 (ja) 2013-09-24 2015-04-02 ディナベック株式会社 多能性幹細胞の誘導効率を改善する方法
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
BR112016007255A2 (pt) 2013-10-03 2017-09-12 Moderna Therapeutics Inc polinucleotídeos que codificam receptor de lipoproteína de baixa densidade
WO2015066488A2 (en) 2013-11-01 2015-05-07 New England Biolabs, Inc. Method for producing induced pluripotent stem cells
US10100283B2 (en) 2013-11-01 2018-10-16 Kyoto University Efficient chondrocyte induction method
JP6942925B2 (ja) 2013-11-08 2021-09-29 ソニーグループ株式会社 細胞分析システム、細胞分析プログラム及び細胞分析方法
US11767507B2 (en) 2013-11-08 2023-09-26 The Mclean Hospital Corporation Methods for efficient generation of GABAergic interneurons from pluripotent stem cells
US9932607B2 (en) 2013-11-15 2018-04-03 The Board Of Trustees Of The Leland Stanford Junior University Site-specific integration of transgenes into human cells
CN104630136B (zh) * 2013-11-15 2019-10-01 中国科学院广州生物医药与健康研究院 一种制备诱导多能性干细胞的方法以及该方法中所使用的组合物及其应用
WO2015071474A2 (en) 2013-11-18 2015-05-21 Crispr Therapeutics Ag Crispr-cas system materials and methods
JP6536871B2 (ja) 2013-12-02 2019-07-03 国立大学法人京都大学 Ｆｇｆｒ３病の予防および治療剤ならびにそのスクリーニング方法
KR102070967B1 (ko) * 2013-12-10 2020-01-29 한국한의학연구원 사군자탕을 유효성분으로 포함하는, 세포의 유도만능줄기세포로의 리프로그래밍 촉진용 조성물 및 이를 이용한 유도만능줄기세포의 제조방법
KR101871084B1 (ko) 2013-12-11 2018-06-25 화이자 리미티드 망막 색소 상피 세포의 제조 방법
EP3080266B1 (en) 2013-12-12 2021-02-03 The Regents of The University of California Methods and compositions for modifying a single stranded target nucleic acid
EP3088415B1 (en) 2013-12-25 2019-11-06 Toagosei Co., Ltd. Method for inducing differentiation of pluripotent stem cells into endodermal cells
EP2896688A1 (en) 2014-01-20 2015-07-22 Centre National de la Recherche Scientifique (CNRS) A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide
FI3690056T3 (fi) 2014-01-31 2023-03-19 Factor Bioscience Inc Menetelmiä ja tuotteita nukleiinihapon valmistamiseksi ja viemiseksi
PT3114214T (pt) 2014-03-04 2024-01-03 Fate Therapeutics Inc Métodos de reprogramação melhorados e plataformas de cultura celular
EP3119879B1 (en) 2014-03-19 2019-12-25 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for inducing human cholangiocyte differentiation
EP3120297B1 (en) 2014-03-20 2020-12-02 Ares Trading S.A. Quantitative measurement of human blastocyst and morula morphology developmental kinetics
EP3121276B1 (en) 2014-03-20 2019-04-17 Kyoto University Cardiomyocyte sorting method
WO2015151307A1 (ja) * 2014-03-31 2015-10-08 味の素株式会社 幹細胞用培地
RU2694311C2 (ru) 2014-05-16 2019-07-11 Янссен Байотек, Инк. Применение малых молекул для увеличения экспрессии mafa в панкреатических эндокринных клетках
CN106536718B (zh) 2014-05-21 2021-04-27 国立大学法人京都大学 胰芽细胞的制造方法及含有胰芽细胞的胰疾病治疗剂
JP6651218B2 (ja) 2014-05-30 2020-02-19 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
WO2015195769A2 (en) 2014-06-18 2015-12-23 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
US10138469B2 (en) 2014-06-23 2018-11-27 Toagosei Co., Ltd. Synthetic peptide and use thereof
JP7012432B2 (ja) 2014-07-14 2022-01-28 中外製薬株式会社 タンパク質のエピトープを同定するための方法
WO2016010148A1 (ja) 2014-07-18 2016-01-21 国立大学法人京都大学 多能性幹細胞から免疫細胞療法用ｔ細胞を誘導する方法
US10570418B2 (en) 2014-09-02 2020-02-25 The Regents Of The University Of California Methods and compositions for RNA-directed target DNA modification
JP6452107B2 (ja) 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
JP6878274B2 (ja) 2014-10-03 2021-05-26 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム
JP6598185B2 (ja) 2014-11-07 2019-10-30 国立大学法人京都大学 軟骨過形成疾患の予防および治療剤ならびにそのスクリーニング方法
CA2968655C (en) 2014-11-25 2021-11-16 President And Fellows Of Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
SI3233129T1 (sl) 2014-12-17 2020-07-31 Fundacion Para La Investigacion Medica Aplicada Konstrukti nukleinske kisline in vektorji genske terapije za uporabo pri zdravljenju Wilsonove bolezni in drugih stanj
HUE055002T2 (hu) 2014-12-17 2021-10-28 Fundacion Para La Investig Medica Aplicada Nukleinsav-konstrukciók és génterápiás vektorok Wilson-kór kezelésében történõ alkalmazásra
US10711249B2 (en) 2014-12-26 2020-07-14 Kyoto University Method for inducing hepatocytes
US10077463B2 (en) 2015-01-15 2018-09-18 President And Fellows Of Harvard College Optical selection of cells
TWI696700B (zh) 2015-01-16 2020-06-21 國立研究開發法人產業技術總合研究所 使用具有匿跡性之ｒｎａ的基因表現系統及含有該ｒｎａ的基因導入、表現載體
EP4406585A3 (en) 2015-02-13 2024-10-23 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
WO2016131137A1 (en) 2015-02-17 2016-08-25 University Health Network Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes
LT3059307T (lt) 2015-02-20 2019-01-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Laminino panaudojimas pliuripotentinių ląstelių diferenciacijai į hepatocitų linijos ląsteles
EP3266864A4 (en) 2015-03-06 2018-08-29 Kyoto University Method for inducing differentiation of alveolar epithelial cells
JP6719449B2 (ja) 2015-03-18 2020-07-08 小野薬品工業株式会社 ナイーブ型多能性幹細胞の製造方法
EP3283510B1 (en) 2015-04-14 2020-08-05 UAB Ferentis Collagen mimetic peptide
EP3296390B1 (en) * 2015-04-14 2023-01-04 Kyoto University Method for producing stem cell clones suitable for induction of differentiation into somatic cells
EP3081638A1 (en) 2015-04-16 2016-10-19 Kyoto University Method for producing pseudo-islets
WO2016175303A1 (ja) 2015-04-28 2016-11-03 東亞合成株式会社 合成ペプチドを用いた心筋細胞の生産方法
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
FR3037338B1 (fr) 2015-06-12 2020-02-28 Philippe Nirde Procede de greffe de cellule cardiaque sur la membrane choriallantoide d'œuf feconde
JP6746945B2 (ja) 2015-06-30 2020-08-26 ソニー株式会社 情報処理装置、情報処理システム及び情報処理方法
WO2017002300A1 (en) 2015-06-30 2017-01-05 Sony Corporation Information processing apparatus, information processing system, and information processing method
CA2990476C (en) 2015-07-10 2021-09-07 Heartseed Inc. Method for producing high-quality ips cells
EP3327118B1 (en) 2015-07-17 2021-12-29 Kyoto University Method for inducing vascular endothelial cells
JP7370529B2 (ja) 2015-08-31 2023-10-30 剛士 田邊 多能性幹細胞製造システム、幹細胞の誘導方法、幹細胞の浮遊培養方法、幹細胞の浮遊培養器、人工多能性幹細胞の作製方法、及び動物細胞から特定の体細胞を作製する方法
DK3344758T3 (da) 2015-09-01 2021-11-01 Ncardia B V Fremgangsmåde in vitro til differentiering af en human pluripotent stamcellepopulation i en kardiomyocytcellepopulation
EP4001402A1 (en) 2015-09-08 2022-05-25 FUJIFILM Cellular Dynamics, Inc. Macs-based purification of stem cell-derived retinal pigment epithelium
WO2017044483A1 (en) 2015-09-08 2017-03-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells
ES2897974T3 (es) 2015-09-11 2022-03-03 Astellas Pharma Inc Método para producir células progenitoras renales
CA2998287A1 (en) 2015-09-24 2017-04-20 Crispr Therapeutics Ag Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
JP6691756B2 (ja) 2015-09-29 2020-05-13 東亞合成株式会社 合成ペプチドを用いた神経幹細胞の生産方法
EP3356520B1 (en) 2015-10-02 2022-03-23 The U.S.A. as represented by the Secretary, Department of Health and Human Services Lentiviral protein delivery system for rna-guided genome editing
WO2017062401A1 (en) 2015-10-05 2017-04-13 ORIG3N Inc. Diagnosis and treatment of parkinson's disease based on identification and amelioration of liver dysfunction
JP7263005B2 (ja) 2015-10-16 2023-04-24 フェイト セラピューティクス，インコーポレイテッド 基底状態の多能性の誘導及び維持に関するプラットフォーム
JP6976939B2 (ja) 2015-10-20 2021-12-08 フジフィルム セルラー ダイナミクス，インコーポレイテッド 遺伝的プログラミングによる多系統造血前駆細胞の作製
JP2016011317A (ja) * 2015-10-21 2016-01-21 加治佐　功 ゲノム編集用クリスパーキャス９による老化遺伝子切り取り若返り経口不老不死薬７
SG11201804197RA (en) 2015-11-18 2018-06-28 Orbis Health Solutions Llc T7 alpha viral vector system
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
GB201601503D0 (en) 2016-01-27 2016-03-09 Isis Innovation Dendritic cells
US20190249172A1 (en) 2016-02-18 2019-08-15 The Regents Of The University Of California Methods and compositions for gene editing in stem cells
EP3431584B1 (en) 2016-03-18 2023-06-28 Kyoto University Methods for freezing an aggregate of pluripotent stem cell-derived cardiomyocytes
WO2017164746A1 (en) 2016-03-25 2017-09-28 Pluriomics B.V. In vivo method for differentiating human pluripotent stem cells into atrial cardiomyocytes
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
PL3444334T3 (pl) 2016-04-15 2022-01-10 Kyoto University Sposób indukowania limfocytów t cd8-dodatnich swoistych wobec antygenu
KR102312123B1 (ko) 2016-04-22 2021-10-13 고쿠리츠 다이가쿠 호진 교토 다이가쿠 도파민 생산 신경전구세포의 제조방법
EP3459553A4 (en) 2016-05-16 2020-01-15 National University Corporation Nagoya University MITIGATION AND TREATMENT OF PERINATAL BRAIN INJURY WITH PLURIPOTENT STEM CELLS
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
WO2017216771A2 (en) 2016-06-17 2017-12-21 Genesis Technologies Limited Crispr-cas system, materials and methods
CA3029582A1 (en) 2016-07-01 2018-01-04 Research Development Foundation Elimination of proliferating cells from stem cell-derived grafts
EP3491134B1 (en) 2016-08-01 2023-10-11 University of Pittsburgh - of The Commonwealth System of Higher Education Human induced pluripotent stem cells for high efficiency genetic engineering
SG11201900983TA (en) 2016-08-03 2019-03-28 Univ Nagoya Nat Univ Corp Amelioration and treatment of chronic lung disease using pluripotent stem cells
CA3032925A1 (en) 2016-08-03 2018-02-08 Life Science Institute, Inc. Alleviation and treatment of ischemia reperfusion-induced lung injury using pluripotent stem cells
US11259520B2 (en) 2016-08-04 2022-03-01 Fanuc Corporation Stem cell manufacturing system, stem cell information management system, cell transport apparatus, and stem cell frozen storage apparatus
US10354218B2 (en) 2016-08-04 2019-07-16 Fanuc Corporation System and method for iPS cell bank using internet technology
US10373109B2 (en) 2016-08-04 2019-08-06 Fanuc Corporation System and method for iPS cell bank using media
US10576167B2 (en) 2016-08-17 2020-03-03 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
US11473057B2 (en) 2016-09-02 2022-10-18 Takara Bio Inc. Method for obtaining microglia from pluripotent stem cells
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
AU2017340634B2 (en) 2016-10-05 2022-06-02 FUJIFILM Cellular Dynamics, Inc. Generating mature lineages from induced pluripotent stem cells with MECP2 disruption
CA3039774A1 (en) 2016-10-10 2018-04-19 The National Institute for Biotechnology in the Negev Ltd. Non-cytotoxic modified cells and use thereof
EP3533867A4 (en) 2016-10-31 2020-07-22 National University Corporation Tottori University NON-HUMAN ANIMAL PRODUCING HUMAN ANTIBODIES AND PROCESS FOR THE PREPARATION OF HUMAN ANTIBODIES USING IT
AU2017359330B2 (en) 2016-11-09 2022-03-10 The United States Of America, As Represented By The Secretary Department Of Health And Human Services 3D vascularized human ocular tissue for cell therapy and drug discovery
CN110114470A (zh) 2016-12-27 2019-08-09 住友化学株式会社 诱导的多能性干细胞的评价方法及选择方法、以及诱导的多能性干细胞的制备方法
WO2018135646A1 (ja) 2017-01-20 2018-07-26 国立大学法人京都大学 ＣＤ８α＋β＋細胞傷害性Ｔ細胞の製造方法
EP3575392A4 (en) 2017-01-26 2020-08-26 Osaka University MEDIUM INTENDED TO INDUCE DIFFERENTIATION OF STEM CELLS INTO MESODERMAL CELLS AND PROCESS INTENDED TO PRODUCE MESODERMAL CELLS
KR102448428B1 (ko) 2017-01-27 2022-09-30 가부시키가이샤 가네카 내배엽계 세포 집단, 및 다능성 세포로부터 3배엽 중 어느 하나의 세포 집단을 제조하는 방법
US11603519B2 (en) 2017-02-06 2023-03-14 National Cancer Center Japan T-cell receptor
EP3583201B1 (en) 2017-02-14 2024-01-17 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods of engineering human induced pluripotent stem cells to produce liver tissue
US10828330B2 (en) 2017-02-22 2020-11-10 IO Bioscience, Inc. Nucleic acid constructs comprising gene editing multi-sites and uses thereof
EP3587556A4 (en) 2017-02-24 2021-04-14 Koji Tanabe CELL TREATMENT DEVICE, SUSPENSION CULTURE VESSEL AND STEM CELL INDUCTION METHOD
US20190382706A1 (en) 2017-02-27 2019-12-19 Koji Tanabe Somatic cell production system
CA3054272C (en) 2017-02-27 2023-01-24 I Peace, Inc. Cell processing system and cell processing apparatus
EP3591040A4 (en) 2017-03-03 2020-11-11 Kyoto University METHOD OF PRODUCTION OF PANCREATIC PROGENITOR CELLS
JP7171055B2 (ja) 2017-03-14 2022-11-15 国立大学法人京都大学 多能性幹細胞からヘルパーｔ細胞を製造する方法
CN110494559B (zh) 2017-03-28 2023-10-31 味之素株式会社 不分化地维持用培养基添加剂
ES2912383T3 (es) 2017-04-18 2022-05-25 Fujifilm Cellular Dynamics Inc Células efectoras inmunitarias específicas de antígeno
AU2018255346B2 (en) 2017-04-19 2024-05-02 Capricor, Inc. Methods and compositions for treating skeletal muscular dystrophy
WO2018199662A1 (ko) * 2017-04-26 2018-11-01 주식회사 툴젠 sRAGE를 분비하는 줄기세포를 포함하는 알츠하이머병의 예방 또는 치료용 약학 조성물
US20200147146A1 (en) 2017-05-02 2020-05-14 Koji Tanabe Pharmaceutical composition and cosmetic composition
EP3621434A4 (en) 2017-05-10 2021-03-31 University of Rochester TREATMENT METHODS FOR NEUROPSYCHIATRIC DISORDERS
US11821007B2 (en) 2017-05-25 2023-11-21 Kyoto University Method for inducing differentiation of intermediate mesodermal cell to renal progenitor cell, and method for inducing differentiation of pluripotent stem cell to renal progenitor cell
EP3406712A1 (en) 2017-05-26 2018-11-28 Fundación Centro Nacional De Investigaciones Oncológicas Carlos III Method for expanding stemness and differentiation potential of pluripotent cells
GB201708554D0 (en) * 2017-05-30 2017-07-12 Queens Univ Of Belfast A method for the generation of induced pluirpotent stem cells
JP7008294B2 (ja) 2017-06-13 2022-02-10 大日本印刷株式会社 腸オルガノイド及びその作製方法
WO2018230588A1 (ja) 2017-06-14 2018-12-20 武田薬品工業株式会社 細胞封入デバイス
JP6758631B2 (ja) 2017-06-19 2020-09-23 国立大学法人大阪大学 角膜内皮細胞マーカー及びその利用
JP6736772B2 (ja) 2017-06-19 2020-08-05 公益財団法人神戸医療産業都市推進機構 多能性幹細胞の分化能の予測方法及びそのための試薬
JP7255805B2 (ja) 2017-06-20 2023-04-11 国立大学法人東海国立大学機構 多能性幹細胞による胎児発育不全に伴う脳障害の改善及び治療
US10660523B2 (en) 2017-07-07 2020-05-26 Hideo Ando Light-source unit, measurement apparatus, near-infrared microscopic apparatus, optical detection method, imaging method, calculation method, functional bio-related substance, state management method, and manufacturing method
WO2019078262A1 (ja) 2017-10-17 2019-04-25 国立大学法人広島大学 骨軟骨修復を誘導する多能性幹細胞
US20210363496A1 (en) 2017-10-17 2021-11-25 Kyoto University Method for obtaining artificial neuromuscular junction from pluripotent stem cells
US20200332315A1 (en) 2017-11-02 2020-10-22 National University Corporation Tottori University Method for high production of protein using mammalian artificial chromosome vector
WO2019092505A1 (en) 2017-11-09 2019-05-16 Casebia Therapeutics Llp Self-inactivating (sin) crispr/cas or crispr/cpf1 systems and uses thereof
CN111630155B (zh) 2017-11-15 2024-05-03 沃泰克斯药物股份有限公司 胰岛细胞制备性组合物和使用方法
CN111492052A (zh) 2017-11-30 2020-08-04 国立大学法人京都大学 细胞的培养方法
JP7401432B2 (ja) 2017-12-01 2023-12-19 エンコーデッド セラピューティクス， インコーポレイテッド 操作されたｄｎａ結合タンパク質
WO2019118935A1 (en) 2017-12-14 2019-06-20 Casebia Therapeutics Limited Liability Partnership Novel rna-programmable endonuclease systems and their use in genome editing and other applications
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
US11624049B2 (en) 2017-12-22 2023-04-11 Orizuru Therapeutics, Inc. Cell culturing apparatus, culture solution aspirator, and cell culturing method
WO2019152549A1 (en) 2018-02-05 2019-08-08 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and y-rnas
CN112352054A (zh) 2018-03-16 2021-02-09 国立大学法人鸟取大学 小鼠人工染色体载体及其用途
JP7550648B2 (ja) 2018-03-19 2024-09-13 クリスパー セラピューティクス アーゲー 新規ｒｎａプログラム可能エンドヌクレアーゼ系およびその使用
TW201945536A (zh) 2018-03-19 2019-12-01 國立大學法人京都大學 水凝膠膠囊
WO2019180247A1 (en) 2018-03-22 2019-09-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for reprogramming somatic cells
KR102708268B1 (ko) 2018-03-30 2024-09-20 오리즈루 세라퓨틱스 가부시키가이샤 헤테로시클릭 화합물
US20210054406A1 (en) 2018-03-30 2021-02-25 Kyoto University Cell production method
US12018281B2 (en) 2018-03-30 2024-06-25 Kyoto University Cardiomyocyte maturation promoter
JPWO2019189758A1 (ja) 2018-03-30 2021-04-01 味の素株式会社 ポリリジン類縁体を含む、細胞増殖促進用組成物
US11268070B2 (en) 2018-04-16 2022-03-08 Cellular Engineering Technologies, Inc. Methods for creating integration-free, virus-free, exogenous oncogene-free IPS cells and compositions for use in such methods
KR20210005111A (ko) 2018-04-20 2021-01-13 후지필름 셀룰러 다이내믹스, 인코포레이티드 안구 세포의 분화를 위한 방법 및 이의 용도
WO2019208505A1 (ja) 2018-04-23 2019-10-31 国立大学法人京都大学 増殖抑制剤
WO2019208788A1 (ja) 2018-04-27 2019-10-31 株式会社カネカ 膵臓β細胞の製造方法
US20210254006A1 (en) 2018-06-06 2021-08-19 Ideaya Biosciences, Inc. Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds
US20210260002A1 (en) 2018-06-18 2021-08-26 University Of Rochester Methods of treating schizophrenia and other neuropsychiatric disorders
EP3810184A2 (en) 2018-06-21 2021-04-28 University of Rochester Methods of treating or inhibiting onset of huntington's disease
MX2021000459A (es) 2018-07-13 2021-06-23 Univ Kyoto Metodo para producir celulas t gamma y delta.
US20210299331A1 (en) 2018-07-19 2021-09-30 Kyoto University Pluripotent stem cell-derived plate-shaped cartilage and method for producing the same
EP3828262A4 (en) 2018-07-23 2022-03-30 Kyoto University Novel renal progenitor cell marker and method for concentrating renal progenitor cells using same
AU2019313964A1 (en) 2018-08-03 2021-03-18 Kyoto University Cell production method
AU2019320072A1 (en) 2018-08-10 2021-02-25 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
CN112639111B (zh) 2018-08-10 2023-07-21 国立大学法人京都大学 使用阳离子性脂质的转染心肌细胞的方法
TW202434719A (zh) 2018-08-10 2024-09-01 國立大學法人京都大學 Ｃｄ３陽性細胞的製造方法
EP3838279B1 (en) 2018-08-14 2025-03-05 National Center for Global Health and Medicine Supernatant of brown adipocytes, method for preparing same and utilization thereof
CN112601813A (zh) 2018-08-20 2021-04-02 田边刚士 细胞的培养或诱导方法
US11898130B2 (en) 2018-08-20 2024-02-13 Peace, Inc. Cell culture equipment
US20210198624A1 (en) 2018-08-22 2021-07-01 Kyoto University Method for producing enteric neural precursors
EA202190624A1 (ru) 2018-08-31 2021-06-09 Нойл-Иммьюн Байотек, Инк. Car-экспрессирующие т-клетки и car-экспрессирующий вектор
MX2021003147A (es) 2018-09-19 2021-05-14 Takeda Pharmaceuticals Co Celulas productoras de insulina.
EP3800250A4 (en) 2018-10-10 2022-03-30 National University Corporation Tottori University Method for producing animal cell containing dna of interest using micronucleate cell fusion method
JP7079946B2 (ja) 2018-10-10 2022-06-03 国立大学法人鳥取大学 外来染色体を含むヒト人工多能性幹細胞の製造方法
AU2019356165A1 (en) 2018-10-12 2021-05-27 Vivet Therapeutics Codon-optimized transgene for the treatment of progressive familiar intrahepatic cholestasis type 3 (PFIC3)
JP7553918B2 (ja) 2018-10-15 2024-09-19 公立大学法人横浜市立大学 栄養組成物
EP3875578A4 (en) 2018-10-31 2022-08-10 Kyoto University METHOD FOR GENERATING PLURIPOTENT STEM CELLS WITH RELEASED DIFFERENTIATION RESISTANCE TO MESENDODERM
CN119139353A (zh) 2018-11-07 2024-12-17 爱平世股份有限公司 医药品组合物以及化妆品组合物
BR112021008434A2 (pt) 2018-11-07 2021-09-28 Vivet Therapeutics Transgene abcb11 otimizado por códon para o tratamento de colestase intra-hepática familiar progressiva tipo 2 (pfic2)
CN113302290A (zh) 2018-11-16 2021-08-24 编码治疗公司 治疗威尔逊氏病的组合物和方法
CA3119041A1 (en) 2018-11-19 2020-05-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biodegradable tissue replacement implant and its use
CN113710799B (zh) 2018-11-28 2024-11-12 克里斯珀医疗股份公司 用于在LNP中使用的编码CAS9的优化mRNA
BR112021010297A2 (pt) 2018-11-28 2021-08-24 Board Of Regents, The University Of Texas System Edição de genomas multiplexadores de células imunes para aumentar a funcionalidade e resistência ao ambiente supressivo
WO2020116606A1 (ja) 2018-12-06 2020-06-11 キリンホールディングス株式会社 Ｔ細胞又はｎｋ細胞の製造方法、ｔ細胞又はｎｋ細胞の培養用培地、ｔ細胞又はｎｋ細胞の培養方法、未分化ｔ細胞の未分化状態を維持する方法及びｔ細胞又はｎｋ細胞の増殖促進剤
AU2019396450B2 (en) 2018-12-11 2025-08-28 University Of Rochester Methods of treating schizophrenia and other neuropsychiatric disorders
EP3900787A4 (en) 2018-12-21 2022-02-23 Kyoto University Lubricin-localized cartilage-like tissue, method for producing same and composition comprising same for treating articular cartilage damage
US20220062341A1 (en) 2018-12-26 2022-03-03 Kirin Holdings Kabushiki Kaisha Modified tcr and production method therefor
AU2019411973B2 (en) 2018-12-27 2024-09-05 Kyoto University T-cell receptor modified object
EP3919124A4 (en) 2019-02-01 2022-11-23 Kyoto University CELL DETECTION METHOD
WO2020167822A2 (en) 2019-02-13 2020-08-20 University Of Rochester Gene networks that mediate remyelination of the human brain
CN113728093A (zh) 2019-02-26 2021-11-30 国立大学法人东北大学 使用iPS细胞生产成骨细胞构建体的方法
JP7531170B2 (ja) 2019-03-05 2024-08-09 ファナック株式会社 細胞製造システム
EP4219700A1 (en) 2019-03-07 2023-08-02 The Regents of the University of California Crispr-cas effector polypeptides and methods of use thereof
WO2020209959A1 (en) 2019-03-08 2020-10-15 Crispr Therapeutics Ag Nucleobase-editing fusion protein systems, compositions, and uses thereof
US20220145274A1 (en) 2019-03-12 2022-05-12 Crispr Therapeutics Ag Novel high fidelity rna-programmable endonuclease systems and uses thereof
JP7489377B2 (ja) 2019-03-29 2024-05-23 株式会社カネカ 多能性幹細胞を含む細胞集団及びその製造方法
EP3950953A4 (en) 2019-03-29 2023-04-19 Public University Corporation Yokohama City University SCREENING METHOD AND TOXICITY ASSESSMENT METHOD
US12268715B2 (en) 2019-04-10 2025-04-08 Orizuru Therapeutics, Inc. Method for producing biological tissue-like structure
EP3957722A4 (en) 2019-04-17 2023-01-18 Keio University METHOD FOR PRODUCTION AND KIT OF INDUCED PLURIPOTENT STEM CELLS
US20210047649A1 (en) 2019-05-08 2021-02-18 Vertex Pharmaceuticals Incorporated Crispr/cas all-in-two vector systems for treatment of dmd
IL287808B2 (en) 2019-05-14 2024-07-01 Aleph Farms Ltd Pluripotent cell aggregates and use thereof
EP3970795A4 (en) 2019-05-15 2023-06-14 Ajinomoto Co., Inc. Method for purifying neural crest cells or corneal epithelial cells
CA3141455A1 (en) 2019-05-20 2020-11-26 Ajinomoto Co., Inc. Expansion culture method for cartilage or bone precursor cells
WO2020236696A1 (en) 2019-05-23 2020-11-26 Dignity Health Inhibitory interneuron treatment methods, uses and compositions for diabetes
EP3976798A4 (en) 2019-05-29 2023-07-12 Encoded Therapeutics, Inc. Compositions and methods for selective gene regulation
EP3981870A4 (en) 2019-06-10 2023-11-01 I Peace, Inc. ERYTHROCYTE REMOVAL DEVICE, MONONUCLEAR CELL COLLECTOR, CELL CULTURE DEVICE, CELL CULTURE SYSTEM, CELL CULTURE METHOD, AND MONONUCLEAR CELL COLLECTION METHOD
JP7133822B2 (ja) 2019-06-10 2022-09-09 アイ ピース，インコーポレイテッド 赤血球除去装置、単核球回収器、細胞培養装置、細胞培養システム、細胞培養方法、及び単核球の回収方法
TW202113062A (zh) 2019-06-11 2021-04-01 國立大學法人京都大學 腎間質細胞的製造方法
WO2020264072A1 (en) 2019-06-25 2020-12-30 Semma Therapeutics, Inc. Enhanced differentiation of beta cells
EP3992274A4 (en) 2019-06-28 2023-08-09 I Peace, Inc. CELL GROUPS DIVIDER, METHOD FOR MAKING CELL GROUPS DIVIDER AND METHOD FOR DIVIDING CELL GROUPS
WO2020262354A1 (ja) 2019-06-28 2020-12-30 アイ ピース， インコーポレイテッド 細胞培養器及び細胞培養装置
KR20220039719A (ko) 2019-07-03 2022-03-29 팩터 바이오사이언스 인크. 양이온성 지질 및 이의 용도
WO2021014515A1 (ja) 2019-07-19 2021-01-28 東京エレクトロン株式会社 細胞の分化状態の評価方法
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
WO2021030424A1 (en) 2019-08-13 2021-02-18 Semma Therapeutics, Inc. Pancreatic differentiation
CN114269900B (zh) 2019-08-20 2025-01-14 千纸鹤治疗公司 心肌细胞的富集方法
WO2021038997A1 (ja) 2019-08-29 2021-03-04 ファナック株式会社 細胞製造装置
US20230037137A1 (en) 2019-08-29 2023-02-02 Fanuc Corporation Cell production device and system therefor
JP7391339B2 (ja) 2019-08-29 2023-12-05 ファナック株式会社 細胞製造装置及びその製造方法
CN114630898B (zh) 2019-10-01 2024-08-02 国立大学法人京都大学 输尿管芽顶端部细胞的分离方法
TW202130805A (zh) 2019-10-21 2021-08-16 日商武田藥品工業股份有限公司 增生抑制劑
EP4052718A1 (en) 2019-10-31 2022-09-07 Life Science Institute, Inc. Therapy for interstitial cystitis by pluripotent stem cells
WO2021085576A1 (ja) 2019-11-01 2021-05-06 国立大学法人京都大学 Ｔ細胞の製造方法
EP4056673A4 (en) 2019-11-06 2024-04-03 I Peace, Inc. CELL CULTURE DEVICE
WO2021095811A1 (ja) 2019-11-12 2021-05-20 学校法人順天堂 体細胞の直接分化転換方法
WO2021106832A1 (ja) 2019-11-25 2021-06-03 国立大学法人京都大学 Ｔ細胞マスターセルバンク
JP7058431B2 (ja) 2019-12-12 2022-04-22 国立大学法人千葉大学 巨核球および血小板を含む凍結乾燥製剤
FR3105260A1 (fr) 2019-12-20 2021-06-25 Centre National De La Recherche Scientifique (Cnrs) Modèle organoïde cardiaque vascularisé apres incorporation de cardiomyocytes dérivés de cellules souches pluripotentes induites humaines
AU2021225952A1 (en) 2020-02-28 2022-10-20 Takeda Pharmaceutical Company Limited Method for producing natural killer cells from pluripotent stem cells
EP4118188A1 (en) 2020-03-11 2023-01-18 Bit Bio Limited Method of generating hepatic cells
BR112022018101A2 (pt) 2020-03-13 2022-11-22 Goliver Therapeutics Células hepáticas tipo tronco para tratamento e/ou prevenção de distúrbios hepáticos fulminantes
JP7418759B2 (ja) 2020-03-18 2024-01-22 ファナック株式会社 顕微鏡観察システム
TWI888509B (zh) 2020-03-19 2025-07-01 日商千紙鶴治療公司 心肌細胞的精製方法
EP4123016A4 (en) 2020-03-19 2024-06-19 Orizuru Therapeutics, Inc. METHOD FOR THE PURIFICATION OF CARDIOMYOCYTES
JPWO2021193360A1 (pt) 2020-03-24 2021-09-30
EP4130253A4 (en) 2020-03-31 2024-05-29 Kyoto University METHOD FOR PRODUCING T-LYMPHOCYTE PROGENITORS
AU2021250052A1 (en) 2020-03-31 2022-11-03 Sky Pharma Co.,Ltd. Method for screening for, method for producing, and method for designing drug active ingredients
CN115551998A (zh) 2020-05-26 2022-12-30 希里欧斯株式会社 低免疫原性细胞
CN115803426A (zh) 2020-05-28 2023-03-14 千纸鹤治疗公司 均一尺寸的细胞聚集体的大量制造方法
CN116033912A (zh) 2020-05-29 2023-04-28 富士胶片细胞动力公司 视网膜色素上皮和感光器双细胞聚集物及其使用方法
CN116323677A (zh) 2020-05-29 2023-06-23 富士胶片细胞动力公司 视网膜色素上皮和光感受器双层及其用途
US20230235319A1 (en) 2020-06-12 2023-07-27 Bayer Aktiengesellschaft Crispr-cas12a directed random mutagenesis agents and methods
CN115885038A (zh) 2020-06-17 2023-03-31 国立大学法人京都大学 表达嵌合抗原受体的免疫活性细胞
JP7429294B2 (ja) 2020-07-13 2024-02-07 国立大学法人京都大学 骨格筋前駆細胞及びその精製方法、筋原性疾患を治療するための組成物、並びに骨格筋前駆細胞を含む細胞群の製造方法
EP4180514A4 (en) 2020-07-20 2024-09-04 Aichi Medical University COMPOSITION FOR UNDIFFERENTIATED MAINTENANCE CULTURE OF PLURIPOTENT CELLS, MEDIUM FOR UNDIFFERENTIATED MAINTENANCE CULTURE OF PLURIPOTENT CELLS, METHOD FOR MAINTENANCE CULTURE IN UNDIFFERENTIATED STATE OF PLURIPOTENT CELLS, AND METHOD FOR PRODUCING PLURIPOTENT CELLS
US20230265456A1 (en) 2020-08-10 2023-08-24 Fundacion Para La Investigacion Medica Aplicada Gene therapy vector expressing cyp27a1 for the treatment of cerebrotendinous xanthomatosis
EP4202041A4 (en) 2020-08-18 2024-10-16 Kyoto University Method for maintaining and amplifying human primordial germ cells / human primordial germ cell-like cells
JPWO2022050419A1 (pt) 2020-09-04 2022-03-10
WO2022069598A1 (en) 2020-09-29 2022-04-07 Genethon Enhancing utrophin expression in cell by inducing mutations within utrophin regulatory elements and therapeutic use thereof
US20240034981A1 (en) 2020-10-22 2024-02-01 The Regents Of The University Of California Devices and Methods for Evaluating the Viability of Embryos
US20230051406A1 (en) 2020-11-13 2023-02-16 Catamaran Bio, Inc. Genetically modified natural killer cells and methods of use thereof
TW202237818A (zh) 2020-11-20 2022-10-01 日商千紙鶴治療公司 成熟化劑
WO2022115611A1 (en) 2020-11-25 2022-06-02 Catamaran Bio, Inc. Cellular therapeutics engineered with signal modulators and methods of use thereof
US20250269057A1 (en) 2020-12-16 2025-08-28 Universitat Pompeu Fabra Therapeutic lama2 payload for treatment of congenital muscular dystrophy
JP2022099262A (ja) 2020-12-22 2022-07-04 アイ ピース，インコーポレイテッド 細胞の培養器及び細胞の培養方法
US20240091382A1 (en) 2020-12-23 2024-03-21 Vivet Therapeutics Minimal bile acid inducible promoters for gene therapy
CN116583595A (zh) 2020-12-23 2023-08-11 三井化学株式会社 培养构件及其用途
EP4269571A4 (en) 2020-12-25 2025-01-01 Kyoto University METHOD FOR PRODUCING NAIVE HUMAN PLURIPOTENT STEM CELLS FROM SOMATIC CELLS
JP7536245B2 (ja) * 2021-01-26 2024-08-20 アイ ピース，インコーポレイテッド オリゴデンドロサイトの作製方法
JPWO2022172960A1 (pt) 2021-02-09 2022-08-18
EP4306633A4 (en) 2021-03-09 2025-03-19 National University Corporation Tokyo Medical and Dental University METHOD FOR PRODUCING CELL CLUSTERS
JPWO2022196714A1 (pt) 2021-03-17 2022-09-22
EP4308132A1 (en) 2021-03-19 2024-01-24 Technische Universität Dresden Human macrophages resistant to tumor-induced repolarization
EP4060026A1 (en) 2021-03-19 2022-09-21 Technische Universität Dresden Ex-vivo proliferation of human phagocytic cells
EP4134086A1 (en) 2021-08-12 2023-02-15 Technische Universität Dresden Human macrophages resistant to tumor-induced repolarization
US20240279612A1 (en) 2021-04-01 2024-08-22 Institut National de la Santé et de la Recherche Médicale Liver organoid manufacturing methods, liver organoids obtained with the same, and uses thereof
US20240191192A1 (en) 2021-04-08 2024-06-13 Takeda Pharmaceutical Company Limited Method for activating t-cells
WO2022230919A1 (ja) 2021-04-28 2022-11-03 国立大学法人 東京医科歯科大学 細胞の製造方法
JPWO2022230977A1 (pt) 2021-04-30 2022-11-03
WO2022236187A1 (en) 2021-05-07 2022-11-10 Children's Hospital Los Angeles Methods for making stem cell-derived enteric neural crest cells and their use in enteric neuropathy treatment
US20220389436A1 (en) 2021-05-26 2022-12-08 FUJIFILM Cellular Dynamics, Inc. Methods to prevent rapid silencing of genes in pluripotent stem cells
JP2024520423A (ja) 2021-05-28 2024-05-24 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 弱接着細胞を収容するための二次マトリックスを有する生分解性組織スキャフォールド
AU2022280062A1 (en) 2021-05-28 2023-11-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods to generate macular, central and peripheral retinal pigment epithelial cells
EP4352205A1 (en) 2021-06-07 2024-04-17 Institut National de la Santé et de la Recherche Médicale (INSERM) Method for generating highly functional hepatocytes by differentiating hepatoblasts
EP4353243A4 (en) 2021-06-10 2025-06-25 Ajinomoto Co., Inc. METHOD FOR PRODUCING MESENCHYMAL STEM CELLS
EP4101928A1 (en) 2021-06-11 2022-12-14 Bayer AG Type v rna programmable endonuclease systems
WO2022258753A1 (en) 2021-06-11 2022-12-15 Bayer Aktiengesellschaft Type v rna programmable endonuclease systems
BR112023026141A2 (pt) 2021-06-15 2024-03-05 Takeda Pharmaceuticals Co Métodos para produzir uma população de células enriquecida em células nk, para produzir células nk derivadas de células-tronco pluripotentes induzidas, para tratar um sujeito em necessidade de terapia de células e para produzir uma população de células compreendendo células progenitoras hematopoiéticas cd34+, e, populações de células nk e de células não classificadas
CN117561328A (zh) 2021-06-29 2024-02-13 国立大学法人佐贺大学 iPS细胞来源的软骨细胞结构体的制造方法
JPWO2023286834A1 (pt) 2021-07-15 2023-01-19
EP4372079A4 (en) 2021-07-15 2025-07-30 Astellas Pharma Inc PERICYTE-LIKE CELLS EXPRESSING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AT A HIGH LEVEL
WO2023003025A1 (ja) 2021-07-21 2023-01-26 国立大学法人京都大学 網膜組織の製造方法
US20240318142A1 (en) 2021-08-11 2024-09-26 Kyoto University Method for producing renal interstitial progenitor cells, erythropoietin-producing cells, and method for producing renin-producing cells
EP4144841A1 (en) 2021-09-07 2023-03-08 Bayer AG Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof
KR20240056604A (ko) 2021-09-13 2024-04-30 후지필름 셀룰러 다이내믹스, 인코포레이티드 수임 심장 전구세포의 제조 방법
CA3234008A1 (en) 2021-09-27 2023-03-30 Kyoto University Method for producing t cell
WO2023053220A1 (ja) 2021-09-28 2023-04-06 公益財団法人京都大学ｉＰＳ細胞研究財団 多能性幹細胞の製造方法
EP4419655A1 (en) 2021-10-20 2024-08-28 University of Rochester Humanized chimeras for the prospective assessment of cell addition and replacement therapies
WO2023069987A1 (en) 2021-10-20 2023-04-27 University Of Rochester Rejuvenation treatment of age-related white matter loss cross reference to related application
EP4419654A1 (en) 2021-10-20 2024-08-28 University of Rochester Method for rejuvenating glial progenitor cells and rejuvenated glial progenitor cells per se
AU2022371442A1 (en) 2021-10-21 2024-04-18 Vertex Pharmaceuticals Incorporated Hypoimmune cells
EP4426814A2 (en) 2021-11-01 2024-09-11 Vertex Pharmaceuticals Incorporated Stem cell derived pancreatic islet differentiation
CA3236365A1 (en) 2021-11-02 2023-05-11 University Of Rochester Tcf7l2 mediated remyelination in the brain
KR20240099452A (ko) 2021-11-11 2024-06-28 가부시키가이샤 헤리오스 유전자-변형 다능성 줄기 세포, 이로부터 유래하는 면역담당 세포, 상기 세포의 제조방법 및 이의 용도
WO2023085433A1 (ja) 2021-11-15 2023-05-19 国立大学法人鳥取大学 ヒト細胞内でヒト人工染色体ベクターを作製する方法
JPWO2023090372A1 (pt) 2021-11-16 2023-05-25
JP7748680B2 (ja) 2021-11-16 2025-10-03 国立大学法人鳥取大学 改変ｄ領域を含むヒト免疫グロブリン重鎖遺伝子座を有する哺乳動物人工染色体ベクター、及びそのベクターを保持する細胞又は非ヒト動物
US20250084391A1 (en) 2021-12-23 2025-03-13 Bayer Aktiengesellschaft Novel small type v rna programmable endonuclease systems
EP4472648A1 (en) 2022-02-01 2024-12-11 University of Rochester Methods of generating a population of neurons from human glial progenitor cells and genetic constructs for carrying out such methods
EP4474476A1 (en) 2022-02-04 2024-12-11 Kyoto University T cell production method
WO2023153464A1 (ja) 2022-02-09 2023-08-17 住友ファーマ株式会社 多能性幹細胞から中脳底板領域の神経系細胞への分化における、培養液中の細胞の分化能を判定する方法
WO2023157727A1 (ja) 2022-02-15 2023-08-24 国立大学法人神戸大学 ヒト多能性幹細胞由来ライディッヒ様細胞の作製方法及びヒト多能性幹細胞由来ライディッヒ様細胞集団
JP7315184B2 (ja) 2022-02-16 2023-07-26 株式会社コーセー 多能性幹細胞から表皮角化細胞への分化誘導方法
KR20240155220A (ko) 2022-03-02 2024-10-28 리니지 셀 테라퓨틱스, 인크. 청력 상실을 치료하기 위한 방법 및 조성물
WO2023172514A1 (en) 2022-03-07 2023-09-14 Catamaran Bio, Inc. Engineered immune cell therapeutics targeted to her2 and methods of use thereof
CN118871119A (zh) 2022-03-11 2024-10-29 学校法人庆应义塾 脊髓损伤治疗剂
WO2023182328A1 (ja) 2022-03-23 2023-09-28 国立大学法人京都大学 制御性ｔ細胞の製造方法
KR20250006874A (ko) 2022-04-25 2025-01-13 오리즈루 세라퓨틱스 가부시키가이샤 Alk5 저해 활성과 cdk8/19 저해 활성을 갖는 성숙화제
AU2023260469A1 (en) 2022-04-25 2024-11-14 Cell Cure Neurosciences, Ltd. Methods and compositions for treating vision loss
WO2023210713A1 (ja) 2022-04-27 2023-11-02 国立大学法人京都大学 心外膜細胞再生促進剤および心外膜細胞の再生促進方法
WO2023215455A1 (en) 2022-05-05 2023-11-09 University Of Rochester Dual macroglial-microglial approach towards therapeutic cell replacement in neurodegenerative and neuropsychiatric disease
JPWO2023228908A1 (pt) 2022-05-23 2023-11-30
WO2023238932A1 (ja) 2022-06-10 2023-12-14 国立大学法人京都大学 未分化多能性幹細胞の検出方法および検出試薬
JP2025523400A (ja) 2022-06-10 2025-07-23 バイエル・アクチエンゲゼルシヤフト 新規の小型ｖ型ｒｎａプログラム可能エンドヌクレアーゼ系
EP4541882A4 (en) 2022-06-17 2025-10-15 Univ Kyoto METHOD FOR PRODUCING THYMIC EPITHELIAL CELLS
EP4544025A1 (en) 2022-06-21 2025-04-30 Institut National de la Santé et de la Recherche Médicale A method for producing a bioengineered mammal induced pluripotent stem cell-derived cardiac organoid
KR20250038661A (ko) 2022-06-29 2025-03-19 후지필름 홀딩스 아메리카 코포레이션 Ipsc-유래된 성상 세포 및 이의 사용 방법
JPWO2024010085A1 (pt) 2022-07-07 2024-01-11
AU2023307842A1 (en) 2022-07-14 2025-02-06 Orizuru Therapeutics, Inc. Fibrin gel sheet for cell transplantation
JPWO2024024742A1 (pt) 2022-07-25 2024-02-01
CN119744302A (zh) 2022-07-26 2025-04-01 国立大学法人京都大学 具有脱落结构的人工受体
JPWO2024029617A1 (pt) 2022-08-05 2024-02-08
CN119698463A (zh) 2022-08-08 2025-03-25 希里欧斯株式会社 细胞团块的制造方法
WO2024053684A1 (ja) 2022-09-06 2024-03-14 大日本印刷株式会社 フィーダー細胞、細胞シートおよびそれらの製造方法、ならびにフィーダー細胞を用いた細胞の維持または増殖方法
EP4585225A1 (en) 2022-09-08 2025-07-16 Keio University Spinal cord injury therapeutic targeting from acute phase to subacute phase
JPWO2024058234A1 (pt) 2022-09-13 2024-03-21
EP4338745A1 (en) 2022-09-14 2024-03-20 Technische Universität Dresden Allogeneic human macrophages for cell therapy
CN120112629A (zh) 2022-09-26 2025-06-06 国立大学法人京都大学 T细胞产生方法
WO2024070494A1 (ja) 2022-09-26 2024-04-04 国立大学法人京都大学 膵内胚葉細胞の製造方法
EP4596672A1 (en) 2022-09-28 2025-08-06 Saga University Three-dimensional tissue body and method for producing same
CN120359301A (zh) 2022-09-29 2025-07-22 国立大学法人京都大学 用于评价肾毒性的方法
US20240139256A1 (en) 2022-09-30 2024-05-02 FUJIFILM Cellular Dynamics, Inc. Methods for the production of cardiac fibroblasts
EP4620480A1 (en) 2022-11-16 2025-09-24 Kansai Medical University Educational Corporation Implantation facilitator, and screening system therefor
WO2024129743A2 (en) 2022-12-13 2024-06-20 Bluerock Therapeutics Lp Engineered type v rna programmable endonucleases and their uses
WO2024163747A2 (en) 2023-02-02 2024-08-08 University Of Rochester Competitive replacement of glial cells
AU2024218970A1 (en) 2023-02-06 2025-07-31 Bluerock Therapeutics Lp Degron fusion proteins and methods of production and use thereof
WO2024192329A1 (en) 2023-03-16 2024-09-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for producing stable human chondroctyes and their use for promoting cartillage growth and repair
WO2024256530A1 (en) 2023-06-13 2024-12-19 Universiteit Maastricht Improved method for generating kidney organoids
WO2025008763A1 (en) 2023-07-06 2025-01-09 Astrazeneca Ab Modified cell
WO2025038494A1 (en) 2023-08-11 2025-02-20 Tune Therapeutics, Inc. Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
WO2025059073A1 (en) 2023-09-11 2025-03-20 Tune Therapeutics, Inc. Epigenetic editing methods and systems for differentiating stem cells
WO2025076291A1 (en) 2023-10-06 2025-04-10 Bluerock Therapeutics Lp Engineered type v rna programmable endonucleases and their uses
WO2025117331A1 (en) 2023-12-01 2025-06-05 Eli Lilly And Company Methods of making stem cell-derived islet-like cells, as well as populations and compositions including the same
WO2025114599A1 (en) 2023-12-01 2025-06-05 Academisch Ziekenhuis Maastricht Improved kidney organoid culture method by modulating pka
WO2025126208A1 (en) 2023-12-12 2025-06-19 Accellta Ltd. Media for maintaining, differentiating, or both, pluripotent stem cells
WO2025166063A1 (en) 2024-01-31 2025-08-07 Bluerock Therapeutics Lp Igfbp2 in cell culture
WO2025168691A1 (en) 2024-02-07 2025-08-14 Astrazeneca Ab Engineered cells expressing modified hla-e polypeptide
WO2025207481A1 (en) 2024-03-25 2025-10-02 Bluerock Therapeutics Lp Measuring viability in cell aggregates
CN118497110A (zh) * 2024-06-11 2024-08-16 广东横琴联合生命科学有限责任公司 一种诱导衰老皮肤成纤维细胞分化为胚胎干细胞的方法及其应用

Family Cites Families (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US70292A (en) * 1867-10-29 Petess
US4650761A (en) * 1981-11-27 1987-03-17 Eli Lilly And Company Method for stabilizing and selecting recombinant DNA containing host cell
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
US4861719A (en) * 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US4937190A (en) * 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
US5192553A (en) * 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US6140111A (en) * 1987-12-11 2000-10-31 Whitehead Institute For Biomedical Research Retroviral gene therapy vectors and therapeutic methods based thereon
US7070994B2 (en) * 1988-03-21 2006-07-04 Oxford Biomedica (Uk) Ltd. Packaging cells
US5591624A (en) * 1988-03-21 1997-01-07 Chiron Viagene, Inc. Retroviral packaging cell lines
JP2886547B2 (ja) 1988-07-26 1999-04-26 協和醗酵工業株式会社 ノイラミニダーゼの製造法
JP3082204B2 (ja) * 1988-09-01 2000-08-28 ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ 両栄養性および環境栄養性宿主域を持つ組換え体レトロウイルス
JP3051411B2 (ja) * 1989-03-14 2000-06-12 持田製薬株式会社 新規ｄｎａならびにそれを含有する発現プラスミド
US5266491A (en) * 1989-03-14 1993-11-30 Mochida Pharmaceutical Co., Ltd. DNA fragment and expression plasmid containing the DNA fragment
JP2897295B2 (ja) * 1989-12-14 1999-05-31 味の素株式会社 レトロウィルス高生産用ｄｎａ構築物及びレトロウィルス高生産用細胞株
US5674980A (en) * 1989-12-21 1997-10-07 Biogen Inc Fusion protein comprising tat-derived transport moiety
US5817491A (en) * 1990-09-21 1998-10-06 The Regents Of The University Of California VSV G pseusdotyped retroviral vectors
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5834256A (en) * 1993-06-11 1998-11-10 Cell Genesys, Inc. Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
FR2707091B1 (fr) 1993-06-30 1997-04-04 Cohen Haguenauer Odile Vecteur rétroviral pour le transfert et l'expression de gènes dans des cellules eucaryotes.
US5534423A (en) 1993-10-08 1996-07-09 Regents Of The University Of Michigan Methods of increasing rates of infection by directing motion of vectors
US5519134A (en) * 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US6013517A (en) * 1994-05-09 2000-01-11 Chiron Corporation Crossless retroviral vectors
US5525735A (en) * 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) * 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
WO1996013597A2 (en) * 1994-10-28 1996-05-09 The Trustees Of The University Of Pennsylvania Improved adenovirus and methods of use thereof
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5637456A (en) * 1995-02-17 1997-06-10 The University Of Texas, Board Of Regents Rapid test for determining the amount of functionally inactive gene in a gene therapy vector preparation
US5707618A (en) * 1995-03-24 1998-01-13 Genzyme Corporation Adenovirus vectors for gene therapy
US5830725A (en) * 1995-04-28 1998-11-03 The Board Of Trustees For The Leland Stanford Junior University Rapid, stable high-titre production of recombing retrovirus
US5744320A (en) * 1995-06-07 1998-04-28 Promega Corporation Quenching reagents and assays for enzyme-mediated luminescence
DE69637147T2 (de) * 1995-07-28 2008-03-06 Marie Curie Cancer Care Transportproteine und deren verwendungen
CA2232506A1 (en) * 1995-09-22 1997-03-27 Medical Research Council Improvements in or relating to mutagenesis of nucleic acids
US5910434A (en) * 1995-12-15 1999-06-08 Systemix, Inc. Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
FR2751345B1 (fr) * 1996-07-16 1998-09-18 Univ Paris Curie Lignees d'encapsidation hautement productrices
US6025192A (en) * 1996-09-20 2000-02-15 Cold Spring Harbor Laboratory Modified retroviral vectors
US6255071B1 (en) * 1996-09-20 2001-07-03 Cold Spring Harbor Laboratory Mammalian viral vectors and their uses
US6017735A (en) * 1997-01-23 2000-01-25 Marie Curie Cancer Care Materials and methods for intracellular transport and their uses
US6416959B1 (en) * 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening
WO1999010536A1 (en) * 1997-08-22 1999-03-04 Yale University A process to study changes in gene expression in granulocytic cells
JPH11115328A (ja) * 1997-10-16 1999-04-27 Dainippon Printing Co Ltd 熱転写受像シート及びその製造方法
US6835567B1 (en) * 1998-04-14 2004-12-28 Signal Pharmaceuticals, Inc. PNS cell lines and methods of use therefor
US20020174013A1 (en) 1998-04-17 2002-11-21 Viztec Inc., A Florida Corporation Chip card advertising method and system
US6146874A (en) * 1998-05-27 2000-11-14 University Of Florida Method of preparing recombinant adeno-associated virus compositions
KR20000006334A (ko) * 1998-06-26 2000-01-25 이선경 바이러스코딩염기서열이전혀없는고효율레트로바이러스벡터
US6485959B1 (en) 1998-10-07 2002-11-26 Cedars Sinai Medical Center Cell preconditioning and cryopresevation medium
AU6339399A (en) 1998-10-16 2000-05-08 Novartis Ag Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6875607B1 (en) 1998-11-09 2005-04-05 Es Cell International Pte Ltd Embryonic stem cells
US6376246B1 (en) * 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6153432A (en) * 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
US6312949B1 (en) 1999-03-26 2001-11-06 The Salk Institute For Biological Studies Regulation of tyrosine hydroxylase expression
US6773920B1 (en) * 1999-03-31 2004-08-10 Invitrogen Corporation Delivery of functional protein sequences by translocating polypeptides
WO2000073423A1 (fr) 1999-06-01 2000-12-07 Chugai Seiyaku Kabushiki Kaisha Cellule de conditionnement
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US6881825B1 (en) * 1999-09-01 2005-04-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Identication of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and virues
US20030161817A1 (en) * 2001-03-28 2003-08-28 Young Henry E. Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
EP1218489B1 (en) 1999-09-24 2009-03-18 Cybios LLC Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
US6280718B1 (en) 1999-11-08 2001-08-28 Wisconsin Alumni Reasearch Foundation Hematopoietic differentiation of human pluripotent embryonic stem cells
US7544509B2 (en) * 2000-01-24 2009-06-09 Mcgill University Method for preparing stem cell preparations
US6395546B1 (en) 2000-02-01 2002-05-28 Neurogeneration, Inc. Generation of dopaminergic neurons from human nervous system stem cells
US7439064B2 (en) * 2000-03-09 2008-10-21 Wicell Research Institute, Inc. Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
AU6319901A (en) 2000-05-17 2001-11-26 Geron Corp Neural progenitor cell populations
US20020090722A1 (en) * 2000-06-15 2002-07-11 Tanja Dominko Pluripotent mammalian cells
DE10031179A1 (de) 2000-06-27 2002-01-31 Amaxa Gmbh Verfahren zur Einbringung von Nukleinsäuren und anderen biologisch aktiven Molekülen in den Kern höherer eukaryontischer Zellen mit Hilfe elektrischen Stroms
WO2002010201A2 (en) * 2000-07-31 2002-02-07 Active Motif Peptide-mediated delivery of molecules into cells
JP2002065261A (ja) 2000-08-30 2002-03-05 Mitsubishi Kasei Institute Of Life Sciences 生殖細胞の取得方法
EP1313642B1 (de) * 2000-08-31 2006-04-26 Edwin Lundgren Steuervorrichtung für einen lenkdrachen an einem boot
EP1379624A2 (en) 2000-11-27 2004-01-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Transfection of human embryonic stem cells
US20080268054A1 (en) 2000-12-04 2008-10-30 Eugene Bell Dermal derived human stem cells and compositions and methods thereof
CN101310010A (zh) 2001-01-02 2008-11-19 斯坦姆荣公司 一种生产具有预先选择的免疫型和/或基因型的纯合干细胞群的方法,适于从其衍生的移植物的细胞,和使用它们的材料及方法
CZ20032082A3 (cs) * 2001-01-31 2003-11-12 Interface Biotech A/S Zlepšený způsob kultivace savčích buněk in vitro pro autologní způsoby implantace a transplantace
JP2003009854A (ja) 2001-04-09 2003-01-14 Kyowa Hakko Kogyo Co Ltd エンブリオイドボディ形成方法及びその用途
DE10119901A1 (de) 2001-04-23 2002-10-24 Amaxa Gmbh Schaltungsanordnung zur Einbringung von Nukleinsäuren und anderen biologisch aktiven Molekülen in den Kern höherer eukaryontischer Zellen mit Hilfe elektrischen Stroms
ATE278796T1 (de) 2001-04-23 2004-10-15 Amaxa Gmbh Pufferlössung für die elektroporation und verfahren umfassend die verwendung derselben
WO2002097090A1 (en) * 2001-05-31 2002-12-05 Sumitomo Pharmaceuticals Co., Ltd. Genes with es cell-specific expression
WO2003018780A1 (en) 2001-08-27 2003-03-06 Advanced Cell Technology, Inc. De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
KR20040039382A (ko) * 2001-09-20 2004-05-10 교와 핫꼬 고교 가부시끼가이샤 골격근 간질 유래 다분화능 줄기세포
JP2004248505A (ja) * 2001-09-21 2004-09-09 Norio Nakatsuji 移植抗原の一部または全てを欠除したｅｓ細胞由来の未分化な体細胞融合細胞およびその製造
EP1437403A4 (en) 2001-09-21 2004-10-27 Japan Science & Tech Corp METHOD FOR PATTERNING REPROGRAMMING FACTOR, METHOD OF PATTERNED REPROGRAMMING FACTOR, METHOD FOR USE OF REPROGRAMMING FACTOR, METHOD FOR DIFFERENTIATING AND SIFE-INGENATING FAN
US7588937B2 (en) * 2001-10-03 2009-09-15 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
DE10162080A1 (de) * 2001-12-10 2003-06-26 Albrecht Mueller Verfahren zur Herstellung von Stammzellen mit erhöhtem Entwicklungspotential
US7625752B2 (en) * 2001-12-21 2009-12-01 Mount Sinai Hospital Cellular compositions and methods of making and using them
WO2003064634A1 (en) * 2002-01-31 2003-08-07 Asahi Techno Glass Corporation Liquid for frozen storage of primate embryo stem cells and frozen storage method
WO2003068937A2 (en) * 2002-02-13 2003-08-21 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells
ES2198216B1 (es) * 2002-07-02 2005-04-16 Juan Carlos Instituto Cientifico Y Tecnologico De Navarra, S.A.(67%). Medio de cultivo de celulas madre-progenitoras autologas humanas y sus aplicaciones.
US7422736B2 (en) 2002-07-26 2008-09-09 Food Industry Research And Development Institute Somatic pluripotent cells
US20040048297A1 (en) * 2002-07-30 2004-03-11 Gene Logic, Inc. Nucleic acid detection assay control genes
JP3736517B2 (ja) * 2002-11-13 2006-01-18 学校法人近畿大学 体細胞核初期化因子
AU2003901099A0 (en) 2003-03-11 2003-03-27 Es Cell International Pte Ltd. Methods of inducing differentiation of stem cells
US20070104679A1 (en) * 2003-03-25 2007-05-10 Masuo Obinata Induction of differentiation of stem cells, and control of differentiation potency of stem cells
US9567591B2 (en) 2003-05-15 2017-02-14 Mello Biotechnology, Inc. Generation of human embryonic stem-like cells using intronic RNA
JPWO2004101775A1 (ja) * 2003-05-16 2006-07-13 協和醗酵工業株式会社 新規な成体組織由来の幹細胞およびその用途
US20050019801A1 (en) * 2003-06-04 2005-01-27 Curis, Inc. Stem cell-based methods for identifying and characterizing agents
FR2859219B1 (fr) * 2003-09-02 2005-10-14 Alain Privat Procede de production de neurones a partir de cellules d'une lignee cellulaire
JP2005095027A (ja) 2003-09-22 2005-04-14 Reprocell Inc 細胞の未分化状態マーカープロモーターおよびその利用
WO2005035741A1 (ja) 2003-10-09 2005-04-21 Kyowa Hakko Kogyo Co., Ltd. ゲノムが改変された細胞
EP1682150B1 (en) 2003-11-10 2012-12-26 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation
US7682828B2 (en) * 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
AU2004294835B2 (en) 2003-12-01 2010-04-29 Technion Research & Development Foundation Ltd. Methods of generating stem cells and embryonic bodies carrying disease-causing mutations and methods of using same for studying genetic disorders
US20050233446A1 (en) * 2003-12-31 2005-10-20 Parsons Xuejun H Defined media for stem cell culture
JP4901471B2 (ja) * 2004-02-19 2012-03-21 国立大学法人京都大学 体細胞核初期化物質のスクリーニング方法
RU2375448C2 (ru) * 2004-03-23 2009-12-10 Асубио Фарма Ко., Лтд. Способ выращивания плюрипотентных стволовых клеток
AU2004318461B9 (en) * 2004-03-30 2009-02-26 Kyoto University Process for producing multipotential stem cell originating in testoid cell
US8012747B2 (en) * 2004-06-01 2011-09-06 San Diego State University Foundation Expression system
WO2006006692A1 (ja) * 2004-07-08 2006-01-19 Japan Science And Technology Agency 低血清培養で選択的に増殖する動物組織遍在性の分化多能性細胞
WO2006084229A2 (en) 2004-07-15 2006-08-10 Primegen Biotech, Llc Use of nuclear material to therapeutically reprogram differentiated cells
US20060088599A1 (en) * 2004-08-02 2006-04-27 Prasad Paras N Amino functionalized ORMOSIL nanoparticles as delivery vehicles
JPWO2006035741A1 (ja) 2004-09-29 2008-05-15 伸弥 山中 Ｅｓ細胞特異的発現遺伝子及びその利用
US20060095319A1 (en) * 2004-10-29 2006-05-04 Cardwell Carlzo B Marketing and compensation method
WO2006088867A2 (en) 2005-02-15 2006-08-24 Medistem Laboratories, Incorporated Method for expansion of stem cells
JPWO2006093172A1 (ja) * 2005-02-28 2008-08-07 財団法人先端医療振興財団 成体幹細胞の体外増幅方法
US20070033061A1 (en) * 2005-04-05 2007-02-08 Achaogen, Inc. Business methods for commercializing antimicrobial and cytotoxic compounds
WO2007026255A2 (en) 2005-06-22 2007-03-08 Universitetet I Oslo Dedifferentiated cells and methods of making and using dedifferentiated cells
JP4395193B2 (ja) * 2005-08-01 2010-01-06 ニューポテンシャル，インコーポレイテッド 回復能を有する再プログラムされた細胞の作製
GB2445706A (en) 2005-11-11 2008-07-16 Univ Edinburgh Reprogramming and genetic modification of cells
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
PT1970446E (pt) 2005-12-13 2011-09-01 Univ Kyoto Factor de reprogramação nuclear
US20090227032A1 (en) * 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8129187B2 (en) * 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
EP1987148A4 (en) 2006-02-27 2009-08-05 Imgen Co Ltd DEDIFFERENTIATION OF ASTROCYTES IN NEURONAL STEM CELLS USING THE BMI-1 GENE
US20090252711A1 (en) 2006-05-11 2009-10-08 Andrew Craig Boquest Stem Cells And Methods Of Making And Using Stem Cells
US20090028835A1 (en) 2006-09-08 2009-01-29 Michigan State University Human transcriptome corresponding to human oocytes and use of said genes or the corresponding polypeptides to trans-differentiate somatic cells
JP2008099662A (ja) 2006-09-22 2008-05-01 Institute Of Physical & Chemical Research 幹細胞の培養方法
US20080132803A1 (en) * 2006-11-30 2008-06-05 Hyman Friedlander Method and system for doing business by mining the placental-chord complex
GB2458863B (en) 2007-01-17 2011-10-12 Wisconsin Alumni Res Found Improved culture of stem cells
EP2132225A4 (en) 2007-02-27 2010-06-09 Procell Therapeutics Inc COMBINED USE OF NANOG AND OCT4 PERMEABLE TO CELLS TO INCREASE SELF-RENEWAL AND DELETE DIFFERENTIATION OF STEM CELLS
WO2008105566A1 (en) 2007-02-27 2008-09-04 Korea Stem Cell Bank System for providing stem cell services using internet and method thereof
EP3399025B1 (en) 2007-03-23 2025-05-07 Wisconsin Alumni Research Foundation Somatic cell reprogramming
MX348010B (es) 2007-04-07 2017-05-23 Whitehead Inst Biomedical Res Reprogramacion de celulas somaticas.
JP2010528613A (ja) 2007-05-29 2010-08-26 クリストファー ビー． リード， 多能細胞集団を産生する方法およびその使用
EP2164951A2 (en) * 2007-05-30 2010-03-24 The General Hospital Corporation Methods of generating pluripotent cells from somatic cells
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US20120282229A1 (en) 2007-08-01 2012-11-08 Christian Kannemeier Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
EP2190976A4 (en) 2007-08-10 2010-10-20 Univ Dayton METHOD FOR PRODUCING PLURIPOTENTAL STEM CELL LENGTH CELLS
CA2698091C (en) 2007-08-31 2018-07-03 Brett Chevalier Wnt pathway stimulation in reprogramming somatic cells
WO2009057831A1 (ja) 2007-10-31 2009-05-07 Kyoto University 核初期化方法
WO2009061442A1 (en) 2007-11-06 2009-05-14 Children's Medical Center Corporation Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells
US9005966B2 (en) 2007-11-19 2015-04-14 The Regents Of The University Of California Generation of pluripotent cells from fibroblasts
JP5558097B2 (ja) * 2007-12-10 2014-07-23 国立大学法人京都大学 効率的な核初期化方法
US9683232B2 (en) * 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
US20090191171A1 (en) * 2008-01-18 2009-07-30 Yupo Ma Reprogramming of Differentiated Progenitor or Somatic Cells Using Homologous Recombination
KR101481164B1 (ko) 2008-01-30 2015-01-09 주식회사 미래셀바이오 체세포 유래 다능성 줄기세포의 제조 방법
WO2009102983A2 (en) 2008-02-15 2009-08-20 President And Fellows Of Harvard College Efficient induction of pluripotent stem cells using small molecule compounds
US20110061118A1 (en) 2008-03-17 2011-03-10 Helmholtz Zentrum Munchen Vectors and methods for generating vector-free induced pluripotent stem (ips) cells using site-specific recombination
SG10201808863UA (en) * 2008-03-17 2018-11-29 Scripps Research Inst Combined chemical and genetic approaches for generation of induced pluripotent stem cells
CN101250502A (zh) 2008-04-01 2008-08-27 中国科学院上海生命科学研究院 一种诱导的多潜能干细胞的制备方法
CN101550406B (zh) * 2008-04-03 2016-02-10 北京大学 制备多潜能干细胞的方法,试剂盒及用途
US20100021437A1 (en) * 2008-04-07 2010-01-28 The McLean Hospital Corporation Whitehead Institute for Biomedical Research Neural stem cells derived from induced pluripotent stem cells
ES2722198T3 (es) 2008-05-02 2019-08-08 Univ Kyoto Método de reprogramación nuclear
EP2128245A1 (en) 2008-05-27 2009-12-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Generation of induced pluripotent stem (iPS) cells
KR101648019B1 (ko) * 2008-06-04 2016-08-16 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 비-바이러스 접근법을 사용한 ｉＰＳ 세포의 생산 방법
CA2732401C (en) 2008-07-31 2014-08-05 Gifu University Efficient method for establishing induced pluripotent stem cells
US20100062534A1 (en) * 2008-09-09 2010-03-11 The General Hospital Corporation Inducible lentiviral vectors for reprogramming somatic cells
CN102239249A (zh) * 2008-10-24 2011-11-09 威斯康星校友研究基金会 通过非病毒重编程获得的多潜能干细胞

Also Published As

Publication number Publication date
JP2014000083A (ja) 2014-01-09
EP4223769A2 (en) 2023-08-09
EA014166B1 (ru) 2010-10-29
JP4183742B1 (ja) 2008-11-19
EP3418297B1 (en) 2023-04-05
JP4411362B2 (ja) 2010-02-10
KR101420740B1 (ko) 2014-07-17
BRPI0619794B1 (pt) 2020-09-15
CN101356270A (zh) 2009-01-28
MX352337B (es) 2017-11-21
JP5603282B2 (ja) 2014-10-08
CA2632142C (en) 2013-08-06
JP2009165481A (ja) 2009-07-30
US8048999B2 (en) 2011-11-01
EA201000858A1 (ru) 2011-02-28
HK1125131A1 (en) 2009-07-31
EP2208786B1 (en) 2018-08-01
CN103113463B (zh) 2015-02-18
EP2206724A1 (en) 2010-07-14
CN101864392A (zh) 2010-10-20
HK1125967A1 (en) 2009-08-21
JP2011188860A (ja) 2011-09-29
JP2009165479A (ja) 2009-07-30
WO2007069666A1 (ja) 2007-06-21
NZ569530A (en) 2011-07-29
JPWO2007069666A1 (ja) 2009-05-21
EP1970446A4 (en) 2009-04-08
IL191903A0 (en) 2008-12-29
US20090068742A1 (en) 2009-03-12
CN103113463A (zh) 2013-05-22
BRPI0619794A2 (pt) 2011-10-18
CN101356270B (zh) 2014-02-12
CN101864392B (zh) 2016-03-23
EP2206778B1 (en) 2018-08-01
DK1970446T3 (da) 2011-10-24
JP2009165478A (ja) 2009-07-30
JP5943324B2 (ja) 2016-07-05
IL191903A (en) 2011-11-30
CN103773804A (zh) 2014-05-07
EP1970446B1 (en) 2011-08-03
EP2206778A1 (en) 2010-07-14
JP4411363B2 (ja) 2010-02-10
BRPI0619794B8 (pt) 2022-06-14
KR20080095852A (ko) 2008-10-29
JP5098028B2 (ja) 2012-12-12
EA018039B1 (ru) 2013-05-30
AU2006325975B2 (en) 2011-12-08
ZA200804673B (en) 2009-11-25
EA200870046A1 (ru) 2009-12-30
EP3418297A1 (en) 2018-12-26
MX2008007654A (es) 2008-09-26
JP5467223B2 (ja) 2014-04-09
JP5248371B2 (ja) 2013-07-31
EP4223769A3 (en) 2023-11-01
EP2208786A1 (en) 2010-07-21
AU2006325975A1 (en) 2007-06-21
EP1970446A1 (en) 2008-09-17
ES2367525T3 (es) 2011-11-04
JP2008283972A (ja) 2008-11-27
CA2632142A1 (en) 2007-06-21
JP2009165480A (ja) 2009-07-30

Similar Documents

Publication Publication Date Title
PT1970446E (pt) Factor de reprogramação nuclear
EP2896690A3 (en) Use of RNA for reprogramming somatic cells
EP1812556A4 (en) NEURONAL PRECURSORS OF FEEDER-FREE HUMAN EMBRYONIC STEM CELL CULTURE
IL283597A (en) A pluripotent stem cell growth medium containing human serum and without a nutrient layer
WO2006070370A3 (en) Stem cells culture systems
GB2449772A (en) Large scale production of stem cells
SI1572984T1 (sl) Kulturni sistem brez hranilnih celic, brez kseno-komponent, za humane embrionalne matične celice
WO2010120785A3 (en) Methods and compositions for stem cell cultures
ZA201606403B (en) Pluripotent stem cell culture on micro-carriers
WO2010129294A3 (en) Small molecules supporting pluripotent cell growth and methods thereof
EP2046946B8 (en) Pluripotent stem cell culture
WO2008151058A3 (en) Methods of generating pluripotent cells from somatic cells
WO2007098150A3 (en) Photobioreactor and uses therefor
IL178232A0 (en) Methods for growing pluripotent stem cells
GB0716313D0 (en) Methods for embryonic stem cell culture
MX2010000348A (es) Cultivo de celulas madre pluripotentes individuales.
EP1987148A4 (en) DEDIFFERENTIATION OF ASTROCYTES IN NEURONAL STEM CELLS USING THE BMI-1 GENE
WO2011062963A3 (en) Induced puripotent stem cells and related methods
WO2009093022A3 (en) Cell re-programming
WO2009073523A3 (en) De-differentiation of human cells
PH12015500619A1 (en) Plant regulatory elements and uses thereof
GB2462569A (en) Primate stem cells produced by somatic cell nuclear transfer
CR8547A (es) Composiciones y metodos relacionados con el cultivo de celulas madre neurales con celulas estromales de medula osea
WO2007022348A3 (en) Amplification of cell polulations from embryonic stem cells
GB2450599A (en) Automated culture of stem cells
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载