DK0577847T3 - Morphinanderivat og medicinsk anvendelse deraf - Google Patents
Morphinanderivat og medicinsk anvendelse derafInfo
- Publication number
- DK0577847T3 DK0577847T3 DK93902520T DK93902520T DK0577847T3 DK 0577847 T3 DK0577847 T3 DK 0577847T3 DK 93902520 T DK93902520 T DK 93902520T DK 93902520 T DK93902520 T DK 93902520T DK 0577847 T3 DK0577847 T3 DK 0577847T3
- Authority
- DK
- Denmark
- Prior art keywords
- medical use
- nch3
- morphine derivative
- xso2
- alkylene
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1011592 | 1992-01-23 | ||
| JP29430892 | 1992-11-02 | ||
| PCT/JP1993/000080 WO1993015081A1 (en) | 1992-01-23 | 1993-01-22 | Morphinan derivative and medicinal use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0577847T3 true DK0577847T3 (da) | 1999-06-23 |
Family
ID=26345314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93902520T DK0577847T3 (da) | 1992-01-23 | 1993-01-22 | Morphinanderivat og medicinsk anvendelse deraf |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6323212B1 (da) |
| EP (2) | EP0577847B1 (da) |
| JP (1) | JP2525552B2 (da) |
| KR (1) | KR970011390B1 (da) |
| AT (1) | ATE172201T1 (da) |
| AU (2) | AU666702B2 (da) |
| CA (1) | CA2105072C (da) |
| DE (1) | DE69321525T2 (da) |
| DK (1) | DK0577847T3 (da) |
| ES (1) | ES2121988T3 (da) |
| FI (1) | FI106126B (da) |
| NO (1) | NO302755B1 (da) |
| NZ (1) | NZ246687A (da) |
| TW (1) | TW332814B (da) |
| WO (1) | WO1993015081A1 (da) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ246687A (en) * | 1992-01-23 | 1996-12-20 | Toray Industries | Morphinan derivative and pharmaceutical compositions thereof |
| AU683664B2 (en) * | 1993-06-30 | 1997-11-20 | Toray Industries, Inc. | Antitussive |
| JP3948026B2 (ja) * | 1993-07-19 | 2007-07-25 | 東レ株式会社 | 脳細胞保護剤 |
| DE69424853T2 (de) * | 1993-07-23 | 2000-10-05 | Toray Industries, Inc. | Morphinan-derivate und ihre medizinische verwendung |
| SE9401727D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds I |
| DE19602959A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| EP0829481A1 (en) * | 1996-09-16 | 1998-03-18 | Pfizer Inc. | Morphinan hydroxamic acid compounds |
| ES2236630T3 (es) * | 1996-11-25 | 2005-07-16 | Toray Industries, Inc. | Agente antipruritico. |
| ATE377602T1 (de) | 1997-03-27 | 2007-11-15 | Toray Industries | Morphinanderivate und ihre medizinische anwendung |
| PT948965E (pt) * | 1997-07-11 | 2004-08-31 | Toray Industries | Composicoes medicinais estaveis contendo um derivado de 4,5-epoximorfinano |
| JP2003526594A (ja) * | 1997-07-14 | 2003-09-09 | アドラー コーポレーション | カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法 |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| WO1999005146A1 (fr) * | 1997-07-25 | 1999-02-04 | Toray Industries, Inc. | Remedes contre l'hyponatremie |
| WO1999011289A1 (fr) * | 1997-09-02 | 1999-03-11 | Toray Industries, Inc. | Remedes contre la toxicomanie |
| US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| DE60039444D1 (de) * | 1999-08-24 | 2008-08-21 | Toray Industries | Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes |
| NZ519897A (en) * | 1999-12-03 | 2004-02-27 | Iouri Malov | Electroretinogram (ERG) using image segments which stimulate output signals with very little cross-correlation |
| WO2001074819A1 (fr) * | 2000-04-03 | 2001-10-11 | Toray Industries, Inc. | Agents analgesiques contenant des derives de n-oxyde de morphinane en tant que principe actif |
| DE60231388D1 (de) * | 2001-03-30 | 2009-04-16 | Toray Industries | Mittel zur behandlung des syndroms der unruhigen beine |
| WO2002080918A1 (fr) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| MXPA04011327A (es) | 2002-05-17 | 2005-08-15 | Jenken Biosciences Inc | Opioides y compuestos similares a opioides y usos de los mismos. |
| EP1555266B1 (en) | 2002-10-09 | 2014-05-21 | Toray Industries, Inc. | Remedies or preventives for urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| WO2004108084A2 (en) * | 2003-06-04 | 2004-12-16 | Alkermes Controlled Therapeutics, Ii | Polymorphic forms of naltrexone |
| WO2005117589A1 (en) * | 2004-05-28 | 2005-12-15 | Human Biomolecular Research Institute | Synthesis of metabolically stable analgesics, pain medications and other agents |
| PE20060723A1 (es) * | 2004-11-04 | 2006-08-29 | Toray Industries | Derivados de morfina como agentes analgesicos |
| HUE029202T2 (en) | 2005-04-06 | 2017-02-28 | Toray Industries | Crystals and procedure for the preparation of morphinane derivatives |
| ES2307352B1 (es) * | 2005-04-12 | 2009-09-18 | Bti, I+D, S.L. | Implante dental y piezas destinadas a ser conectadas a un implante dental, y la conexion interna entre el implante dental y cada pieza. |
| EP2010539B1 (en) | 2006-04-21 | 2017-06-14 | Nektar Therapeutics | Stereoselective reduction of a morphinone |
| ES2418104T3 (es) | 2007-04-24 | 2013-08-12 | Toray Industries, Inc. | Agente terapéutico o profiláctico para la discinesia |
| ES2381056T3 (es) | 2007-04-26 | 2012-05-22 | Toray Industries, Inc. | Preparación sólida estable que contiene un derivado de 4,5-epoximorfinano |
| ES2555785T3 (es) * | 2007-06-22 | 2016-01-08 | Toray Industries, Inc. | Remedio o preventivo para esquizofrenia |
| JP5613417B2 (ja) | 2007-10-05 | 2014-10-22 | 東レ株式会社 | モルヒナン誘導体またはその薬理学的に許容される酸付加塩を有効成分とする皮膚性状改善治療薬 |
| EP2252150B1 (en) * | 2008-02-14 | 2018-04-11 | Alkermes, Inc. | Selective opioid compounds |
| US8609682B2 (en) | 2008-07-11 | 2013-12-17 | Regents Of The University Of Minnesota | Analgesic agents |
| HUE036876T2 (hu) | 2008-10-24 | 2018-08-28 | Toray Industries | 4,5-Epoximorfinán származékot tartalmazó stabil tabletta |
| US8563727B2 (en) * | 2009-02-23 | 2013-10-22 | Mallinckrodt Llc | (+)-morphinanium N-oxides and processes for their production |
| JP2012518652A (ja) * | 2009-02-23 | 2012-08-16 | マリンクロッド インコーポレイテッド | （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体 |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| US8436174B2 (en) * | 2009-02-23 | 2013-05-07 | Mallinckrodt Llc | (+)-morphinanium quaternary salts and processes for their production |
| WO2010144641A1 (en) * | 2009-06-11 | 2010-12-16 | Mallinckrodt Inc. | Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer |
| CA2764884C (en) * | 2009-06-11 | 2017-04-04 | Mallinckrodt Llc | Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| WO2011009020A2 (en) | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| CN102711759B (zh) | 2010-01-29 | 2015-05-13 | 东丽株式会社 | 胆道疾病的治疗或预防药 |
| EP2995614B8 (en) | 2010-06-11 | 2018-03-28 | Rhodes Technologies Inc. | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| ES2728701T3 (es) | 2010-07-16 | 2019-10-28 | Mallinckrodt Llc | (+)-Morfinanos como antagonistas del receptor 9 de tipo Toll y aplicaciones terapéuticas de los mismos |
| ES2632932T3 (es) | 2010-10-19 | 2017-09-18 | Memorial Sloan-Kettering Cancer Center | Derivados 6-amido de 4,5a-epoximorfinanos para el tratamiento del dolor |
| ES2586655T3 (es) | 2011-01-31 | 2016-10-18 | Toray Industries, Inc. | (-)-17-(ciclopropilmetil)-3,14beta-dihidroxi-4,5alfa-epoxi-6beta-[N-metil-trans-3-(3-furil)acrilamido]morfinano para su utilización en el tratamiento o prevención de la caquexia por cáncer |
| US9296699B2 (en) | 2011-06-09 | 2016-03-29 | Mallinckrodt Llc | Reductive amination of 6-keto morphinans by catalytic hydrogen transfer |
| CN103917543A (zh) | 2011-09-08 | 2014-07-09 | 马林克罗特有限公司 | 在不分离中间体的情况下制备生物碱 |
| ES2750640T3 (es) * | 2012-08-16 | 2020-03-26 | Scripps Research Inst | Ligandos opioides kappa novedosos |
| TWI449704B (zh) * | 2013-04-26 | 2014-08-21 | Everlight Chem Ind Corp | 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物 |
| WO2015082932A1 (en) | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
| JP2015166331A (ja) * | 2014-05-14 | 2015-09-24 | 遼東化学工業株式会社 | ナルフラフィンの結晶およびその製造方法 |
| WO2016152953A1 (ja) * | 2015-03-24 | 2016-09-29 | 東レ株式会社 | モルヒナン誘導体及びその医薬用途 |
| CA3241654A1 (en) | 2015-04-30 | 2016-11-03 | Memorial Sloan-Kettering Cancer Center | Mitragynine analogs and uses thereof |
| EP3369736A4 (en) | 2015-10-29 | 2019-04-24 | University of Tsukuba | MORPHINANE DERIVATIVE AND MEDICAL USE THEREOF |
| US11529340B2 (en) | 2016-03-22 | 2022-12-20 | Regents Of The University Of Minnesota | Combination for treating pain |
| US10988481B2 (en) * | 2016-05-19 | 2021-04-27 | Virginia Commonwealth University | Potent and selective mu opioid receptor modulators |
| JP6814470B2 (ja) | 2017-02-10 | 2021-01-20 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| AU2019228497B2 (en) * | 2018-02-27 | 2025-01-16 | Delpor, Inc. | Compositions for small molecule therapeutic agent compounds |
| EP3761982B1 (en) | 2018-03-08 | 2024-10-09 | Victoria Link Ltd | Use of nalfurafine for the treatment of demyelinating diseases |
| US11214577B2 (en) | 2019-03-29 | 2022-01-04 | Humanwell Pharmaceutical US | Morphinans useful for treating medical disorders |
| EP3997092A4 (en) * | 2019-07-08 | 2023-09-06 | University of Health Sciences & Pharmacy in St. Louis | G-PROTEIN INFLUENCED OPIOID RECEPTOR AGONIST/ANALGESICS WITH REDUCED ARRESTIN RECRUITMENT |
| EP4039331A4 (en) | 2019-09-30 | 2024-01-17 | Nippon Chemiphar Co., Ltd. | Azepan derivative |
| KR20220087427A (ko) | 2019-10-24 | 2022-06-24 | 도레이 카부시키가이샤 | 악액질의 치료제 또는 예방제 |
| US20230255955A1 (en) | 2020-06-30 | 2023-08-17 | Toray Industries, Inc. | Ameliorating agent or prophylactic agent for muscle weakness symptom in disease or syndrome associated with metabolic disorder |
| CN115181109B (zh) * | 2021-04-02 | 2024-06-04 | 南京正大天晴制药有限公司 | 吗啡喃衍生物的晶体及其制备方法 |
| CA3216667A1 (en) | 2021-04-23 | 2022-10-27 | Toray Industries, Inc. | Therapeutic or prophylactic agent for cachexia accompanied by ghrelin resistance |
| CR20230576A (es) | 2021-06-14 | 2024-04-05 | Scorpion Therapeutics Inc | Derivados de la urea que pueden ser utilizados para tratar el cáncer |
| JPWO2023190665A1 (da) * | 2022-03-29 | 2023-10-05 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3236851A (en) * | 1966-02-22 | Unsaturated morphinan derivatives | ||
| NL290054A (da) | ||||
| DE622231C (de) * | 1934-03-09 | 1935-11-23 | Hermann Fischer Dr | Verfahren zur Herstellung von Diacetylmorphin |
| GB864107A (en) | 1958-09-10 | 1961-03-29 | Albert Boehringer | Morphine derivatives |
| GB919311A (en) | 1958-10-29 | 1963-02-20 | T & H Smith Ltd | Derivatives of 14-hydroxycodeine and their preparation |
| DE2254298A1 (de) | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| GB1593191A (en) | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| GB1587831A (en) * | 1977-03-23 | 1981-04-08 | Reckitt & Colmann Prod Ltd | Morphine derivatives |
| US4362870A (en) | 1980-01-16 | 1982-12-07 | Regents Of The University Of Minnesota | Selective opioid receptor alkylating agents |
| JPS574991A (en) | 1980-06-10 | 1982-01-11 | Sankyo Co Ltd | Cyclopropylmethylnormorphine-6-sulfuric ester |
| US4401672A (en) | 1981-10-13 | 1983-08-30 | Regents Of The University Of Minnesota | Non-addictive narcotic antitussive preparation |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| US4767718A (en) * | 1984-06-18 | 1988-08-30 | Southern Illinois University Foundation | Fluorescent opioid reagents and methods of use thereof in the detection of opioid receptors |
| IN163125B (da) | 1985-01-08 | 1988-08-13 | Alkaloida Vegyeszeti Gyar | |
| DE3617182A1 (de) | 1985-05-23 | 1986-11-27 | Sandoz-Patent-GmbH, 79539 Lörrach | Morphinan-derivate |
| HU196376B (en) * | 1985-05-23 | 1988-11-28 | Sandoz Ag | Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds |
| US4806556A (en) | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4730048A (en) | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| JPH01149788A (ja) | 1987-12-08 | 1989-06-12 | Chugai Pharmaceut Co Ltd | 新規なモルヒネ誘導体 |
| FR2636330B1 (fr) | 1988-09-13 | 1990-11-30 | Sanofi Sa | Procede de preparation de derives de morphinane |
| CA2006311A1 (en) | 1988-12-21 | 1990-06-21 | Ken Kanematsu | Morphine derivative |
| US5219861A (en) * | 1988-12-21 | 1993-06-15 | Chugai Seiyaku Kabushiki Kaisha | 6 β-Thiomorphine derivatives |
| US5258386A (en) * | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| NZ246687A (en) * | 1992-01-23 | 1996-12-20 | Toray Industries | Morphinan derivative and pharmaceutical compositions thereof |
| AU683664B2 (en) * | 1993-06-30 | 1997-11-20 | Toray Industries, Inc. | Antitussive |
-
1993
- 1993-01-22 NZ NZ246687A patent/NZ246687A/en not_active IP Right Cessation
- 1993-01-22 JP JP5509616A patent/JP2525552B2/ja not_active Expired - Lifetime
- 1993-01-22 KR KR1019930702860A patent/KR970011390B1/ko not_active Expired - Lifetime
- 1993-01-22 ES ES93902520T patent/ES2121988T3/es not_active Expired - Lifetime
- 1993-01-22 DK DK93902520T patent/DK0577847T3/da active
- 1993-01-22 AU AU33671/93A patent/AU666702B2/en not_active Expired
- 1993-01-22 AT AT93902520T patent/ATE172201T1/de active
- 1993-01-22 US US08/108,643 patent/US6323212B1/en not_active Expired - Lifetime
- 1993-01-22 EP EP93902520A patent/EP0577847B1/en not_active Expired - Lifetime
- 1993-01-22 DE DE69321525T patent/DE69321525T2/de not_active Expired - Lifetime
- 1993-01-22 EP EP98100805A patent/EP0846694A1/en not_active Withdrawn
- 1993-01-22 CA CA002105072A patent/CA2105072C/en not_active Expired - Lifetime
- 1993-01-22 WO PCT/JP1993/000080 patent/WO1993015081A1/ja active IP Right Grant
- 1993-01-30 TW TW082100590A patent/TW332814B/zh not_active IP Right Cessation
- 1993-09-22 NO NO933376A patent/NO302755B1/no not_active IP Right Cessation
- 1993-09-22 FI FI934144A patent/FI106126B/fi not_active IP Right Cessation
-
1995
- 1995-12-22 AU AU40671/95A patent/AU686483B2/en not_active Expired
-
2000
- 2000-03-31 US US09/541,793 patent/US6277859B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993015081A1 (en) | 1993-08-05 |
| AU3367193A (en) | 1993-09-01 |
| NO933376D0 (no) | 1993-09-22 |
| DE69321525T2 (de) | 1999-03-04 |
| EP0577847B1 (en) | 1998-10-14 |
| NO302755B1 (no) | 1998-04-20 |
| EP0846694A1 (en) | 1998-06-10 |
| TW332814B (en) | 1998-06-01 |
| CA2105072C (en) | 1998-07-28 |
| ES2121988T3 (es) | 1998-12-16 |
| ATE172201T1 (de) | 1998-10-15 |
| US6323212B1 (en) | 2001-11-27 |
| US6277859B1 (en) | 2001-08-21 |
| KR970011390B1 (ko) | 1997-07-10 |
| EP0577847A4 (en) | 1994-12-07 |
| AU686483B2 (en) | 1998-02-05 |
| JP2525552B2 (ja) | 1996-08-21 |
| NZ246687A (en) | 1996-12-20 |
| EP0577847A1 (en) | 1994-01-12 |
| AU666702B2 (en) | 1996-02-22 |
| DE69321525D1 (de) | 1998-11-19 |
| NO933376L (no) | 1993-09-23 |
| FI106126B (fi) | 2000-11-30 |
| FI934144L (fi) | 1993-09-22 |
| JPH08502275A (ja) | 1996-03-12 |
| AU4067195A (en) | 1996-03-07 |
| FI934144A0 (fi) | 1993-09-22 |
| CA2105072A1 (en) | 1993-07-24 |
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