WO1992000740A3 - Bis-dioxopiperazines and their use as protection agents - Google Patents
Bis-dioxopiperazines and their use as protection agents Download PDFInfo
- Publication number
- WO1992000740A3 WO1992000740A3 PCT/GB1991/001156 GB9101156W WO9200740A3 WO 1992000740 A3 WO1992000740 A3 WO 1992000740A3 GB 9101156 W GB9101156 W GB 9101156W WO 9200740 A3 WO9200740 A3 WO 9200740A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- hydrogen
- maximum
- carbon atoms
- aliphatic hydrocarbon
- Prior art date
Links
- 239000011814 protection agent Substances 0.000 title 1
- 125000002015 acyclic group Chemical group 0.000 abstract 3
- 125000001931 aliphatic group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940045200 cardioprotective agent Drugs 0.000 abstract 1
- 239000012659 cardioprotective agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Chemical group C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- -1 trimethylene, tetramethylene Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of formula (II), wherein n is 0, 1 or 2, R1, R2, R3 and R4 are each separately selected from hydrogen, unsubstituted acyclic aliphatic hydrocarbon groups having a maximum of six carbon atoms and C1-6 alkyl groups substituted by a hydroxy group or by a C1-6 alkoxy group, or one of R1 and R2 and one of R3 and R4 is hydrogen and the others together form a trimethylene, tetramethylene or pentamethylene bridging group, R5 is hydrogen or an unsubstituted acyclic aliphatic hydrocarbon group having a maximum of six carbon atoms, and R6 is an acyclic aliphatic hydrocarbon group having a maximum of six carbon atoms or a group CH2R7 in which R7 is a C1-5 alkyl group substituted by a hydroxy group or by a C1-6 alkoxy group, or a salt thereof formed with a physiologically acceptable inorganic or organic acid, are of use in therapy, particularly as cardioprotective agents.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9015435.2 | 1990-07-13 | ||
| GB909015435A GB9015435D0 (en) | 1990-07-13 | 1990-07-13 | Pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1992000740A2 WO1992000740A2 (en) | 1992-01-23 |
| WO1992000740A3 true WO1992000740A3 (en) | 1992-03-19 |
Family
ID=10679046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB1991/001156 WO1992000740A2 (en) | 1990-07-13 | 1991-07-12 | Bis-dioxopiperazines and their use as protection agents |
Country Status (2)
| Country | Link |
|---|---|
| GB (2) | GB9015435D0 (en) |
| WO (1) | WO1992000740A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9115596D0 (en) * | 1991-07-12 | 1991-09-04 | Creighton Andrew M | Pharmaceutical compositions |
| CZ309069B6 (en) | 2020-01-16 | 2022-01-12 | Univerzita Karlova V Praze | Use of ICRF-193 derivatives to prevent chronic cumulative cardiotoxicity due to anthracycline anticancer therapy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1240700B (en) * | 1960-10-31 | 1967-05-18 | Eastman Kodak Co | Jet fuels |
| NL273690A (en) * | 1961-01-19 | 1900-01-01 | ||
| GB8916072D0 (en) * | 1989-07-13 | 1989-08-31 | Creighton Andrew M | Pharmaceutical compositions |
-
1990
- 1990-07-13 GB GB909015435A patent/GB9015435D0/en active Pending
-
1991
- 1991-07-12 WO PCT/GB1991/001156 patent/WO1992000740A2/en active Application Filing
- 1991-07-12 GB GB9115156A patent/GB2245832A/en not_active Withdrawn
Non-Patent Citations (6)
| Title |
|---|
| Advances in Pharmacology and Chemotherapy, volume 19, 1982, Academic Press, Inc.; E.H. Herman et al.: "Biological properties of ICRF-159 and related bis(dioxopiperazine) compounds", pages 249-290, see pages 255-256,263,278-286 (cited in the application) * |
| Cancer Chemother. Pharmacol., volume 16, 1986, Springer-Verlag; R.H. Herman et al.: "Pretreatment with ICRF-187 provides long-lasting protection against chronic daunorubicin cardiotoxicity in rabbits", pages 102-106, see the whole article * |
| Cancer Chemother. Pharmacol., volume 19, 1987, Springer-Verlag; E.H. Herman et al.: "Reduction of chronic doxorubicin cardiotoxicity in beagle dogs by bis-morpholinomethyl derivative of razoxane (ICRF-159)", pages 277-281, see the whole article * |
| Int. J. Clin. Pharm. Res., volume VI, no. 2, 1986, S.A. Mortensen et al.: "Clinical and non-invasive assessment of anthracycline cardiotoxicity: perspctives on myocardial protection", pages 137-150, see the whole article * |
| New Eng. J. Med., volume 319, no. 12, 1988, J.L. Speyer et al.: "Protective effects of the bispiperazinedone ICR5-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer", pages 745-752, see the whole article * |
| Research Communications in Chemical Pathology and Pharmacology, volume 48, no. 1, April 1985, E.H. Herman et al.: "Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in syrian golden hamsters", pages 39-55, see abstract; figure 1; table 1 (cited in the application) * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9015435D0 (en) | 1990-08-29 |
| GB9115156D0 (en) | 1991-08-28 |
| WO1992000740A2 (en) | 1992-01-23 |
| GB2245832A (en) | 1992-01-15 |
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