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WO2018171252A1 - 含有苯并异噻唑啉酮和噻苯隆的农药组合物 - Google Patents

含有苯并异噻唑啉酮和噻苯隆的农药组合物 Download PDF

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Publication number
WO2018171252A1
WO2018171252A1 PCT/CN2017/113936 CN2017113936W WO2018171252A1 WO 2018171252 A1 WO2018171252 A1 WO 2018171252A1 CN 2017113936 W CN2017113936 W CN 2017113936W WO 2018171252 A1 WO2018171252 A1 WO 2018171252A1
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Prior art keywords
composition according
pesticidal composition
active component
bit
mbit
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PCT/CN2017/113936
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English (en)
French (fr)
Inventor
仲汉根
季红进
花伟
季定根
韦建峰
王莹
王英
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江苏辉丰生物农业股份有限公司
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Publication of WO2018171252A1 publication Critical patent/WO2018171252A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof

Definitions

  • the invention belongs to the field of agricultural plant protection, and in particular relates to a pesticide composition with improved properties, in particular to a pesticide composition comprising benzisothiazolinone and thibenzo.
  • Benzoisothiazolinones are a new type of broad-spectrum fungicide mainly used for the prevention and treatment of various bacterial and fungal diseases such as cereal crops, vegetables and fruits.
  • the mechanism of bactericidal action mainly includes destroying the nuclear structure of the pathogen, causing it to lose the heart part and failing to death and interfering with the metabolism of the pathogenic cells, causing its physiological disorder and ultimately leading to death. It can effectively protect plants from pathogens in the early stage of disease occurrence. Increasing the dosage after disease occurrence can obviously control the spread of pathogens, thus achieving the dual functions of protection and eradication.
  • Common benzisothiazolinones include: 1,2-benzisothiazolin-3-one, 2-methyl-1,2-benzisothiazolin-3-one or 2-butyl- 1,2-Benzoisothiazolin-3-one.
  • Pyraclostrobin is a new type of high-efficiency plant growth regulator. When it is absorbed by plants, it can promote the separation of petioles and stems and form natural shedding. It can be widely used in pesticides and fertilizers. It has strong biological activity, and its ability to induce plant cell division and callus formation is many times higher than that of general cytokinins. Improve crop absorptive capacity and increase photosynthesis, so as to increase production and enhance the purpose. It can be used in various kinds of melons, fruits, vegetables, seedlings, flowers, food, tobacco and other crops, and can also be used for tissue culture, genetic engineering, etc. In production, it can significantly improve crop yield, improve quality and use less, has no pollution to the ecological environment, and is non-toxic to humans, animals, birds, bees and natural enemies.
  • Another object of the present invention is to provide a preparation method comprising the two active ingredients A and B pesticide compositions and Use in the agricultural field for disease prevention and disease resistance or for promoting plant growth.
  • the object of the invention can be achieved by the following measures:
  • a pesticidal composition comprising two active components A and B, wherein the active component A is a structural compound having the formula (I), wherein the active component B is thidiazuron,
  • R is selected from H or a C 1 - C 8 alkyl group.
  • the C 1 -C 8 alkyl group in the present invention means a linear or branched alkyl group having 1 to 8 carbon atoms, and includes a C 1 alkyl group (e.g., methyl group) and a C 2 alkyl group (e.g., ethyl group). , C 3 alkyl (such as n-propyl, isopropyl), C 4 alkyl (such as n-butyl, isobutyl, tert-butyl, sec-butyl), C 5 alkyl (such as n-pentyl, etc.) , C 6 alkyl, C 7 alkyl, C 8 alkyl. It includes, but is not limited to, C 1 -C 6 alkyl, C 1 -C 5 alkyl, C 1 -C 4 alkyl, and the like.
  • R is selected from H or a C 1 -C 4 alkyl group.
  • R is selected from the group consisting of H, -CH 3 or -C 4 H 9 .
  • A is 1,2-benzisothiazolin-3-one (abbreviated as BIT in the specification).
  • R is CH 3
  • A is 2-methyl-1,2-benzisothiazolin-3-one (abbreviated as MBIT in the specification).
  • R is C 4 H 9
  • A is 2-butyl-1,2-benzisothiazolin-3-one
  • the "butyl group” in the formula is preferably n-butyl (instruction Referred to as BBIT).
  • the weight ratio between the two components is 1: (0.01 to 1), and in order to further enhance the effect of the composition of the present invention, the weight ratio between the two components is further optimized to be 1: (0.0111 to 1).
  • the weight ratio between the two components of A and B can be arbitrarily adjusted within the range of the following ratios: 1:1, 2:1, 3:1, 4:1, 5:1 , 6:1, 7:1, 8:1, 9:1, 10:1, 11:1, 12:1, 13:1, 14:1, 15:1, 16:1, 17:1, 18 1, 19: 1, 20: 1, 21: 1, 22: 1, 23: 1, 24: 1, 25: 1, 26: 1, 27: 1, 28: 1, 29: 1, 30: 1 32:1, 33:1, 34:1, 35:1, 36:1, 37:1, 38:1, 39:1, 40:1, 41:1, 42:1, 43:1, 44 1, 45: 1, 46: 1, 47: 1, 48: 1, 49: 1, 50: 1, 51: 1, 52: 1, 53: 1, 54: 1, 55: 1, 56: 1 , 57:1, 58:1, 59:1, 60:1, 61:1, 62:1, 63:1, 64:1, 65:1, 66:1, 67:1, 68:1, 69 1, 70: 1, 71:1, 72: 1, 73
  • composition of the present invention is effective for controlling the true and bacterial diseases of crops, and more importantly, the combination of the two can better regulate the growth of crops, promote the health effects of crops, and improve crops. Production.
  • the present invention provides the use of a pesticide composition comprising component A (one of benzisothiazolinones) and component B (thiabendazole) in the field of disease prevention or disease promotion or promotion of crop growth in the agricultural field, in particular It is used for regulating crop growth and improving disease resistance in rice, corn or fruit trees.
  • component A one of benzisothiazolinones
  • component B thiabendazole
  • composition of the present invention can also be used in combination with other pesticides (such as fungicides, insecticides, herbicides, plant growth regulators), fertilizers, etc., and these are mixed with Commonly used pesticides or fertilizers disclosed in the art.
  • pesticides such as fungicides, insecticides, herbicides, plant growth regulators
  • fertilizers etc.
  • the active ingredient containing the pesticide composition of the present invention and a thiazole fungicide such as prochloraz or prochloraz copper salt, prochloraz, etc.
  • a thiazole fungicide such as prochloraz or prochloraz copper salt, prochloraz, etc.
  • triazole fungicide such as tebuconazole, prothioconazole
  • methoxy acrylates such as azoxystrobin, pyraclostrobin, picoxystrobin, ether oxystrobin, etc.
  • thiocarbamate fungicides such as mancozeb, desen Union, Daisen Zinc, etc.
  • composition of the present invention can be made into a pesticide-acceptable dosage form from the active ingredient and the pesticide adjuvant. Further, the composition comprises from 1.0001 to 85.0001% by weight of the active ingredient and from 98.9999 to 14.9999% by weight of the auxiliary agent in a pesticide-acceptable dosage form.
  • composition may specifically comprise an agrochemical adjuvant, such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, and a fertilizer, during application. It is possible to mix commonly used auxiliaries.
  • an agrochemical adjuvant such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, and a fertilizer, during application. It is possible to mix commonly used auxiliaries.
  • Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .
  • the active component A may be first dissolved in a basic substance to form a benzisothiazolin metal salt.
  • Suitable basic substances include: alkali metal carbonates, alkali metal hydroxides (such as hydroxides). Sodium, potassium hydroxide), alkali metal alkoxy carbonate, alkali metal alkoxide or magnesium methoxide.
  • the method of application of the compositions of the invention comprises the use of the compositions of the invention for aerial parts of plants, in particular leaves or foliage. You can choose to soak or apply to the surface of the control object.
  • the frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen.
  • the plant growth site such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).
  • compositions may be applied only with the active ingredient or may be mixed with an additive (agrochemical adjuvant). use.
  • composition of the present invention can be prepared into a pesticide-acceptable dosage form such as a wettable powder, a suspension, a water-dispersible granule, an aqueous emulsion or a microemulsion, an emulsifiable concentrate, a dispersible oil suspension, a suspoemulsion, an oil suspension or a micro Capsule type and the like.
  • a pesticide-acceptable dosage form such as a wettable powder, a suspension, a water-dispersible granule, an aqueous emulsion or a microemulsion, an emulsifiable concentrate, a dispersible oil suspension, a suspoemulsion, an oil suspension or a micro Capsule type and the like.
  • a pesticide-acceptable dosage form such as a wettable powder, a suspension, a water-dispersible granule, an aqueous emulsion or a microemulsion, an emul
  • composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and the auxiliary agent, such as a solvent, a solid carrier, and, if necessary, can be uniformly mixed and ground together with the surfactant to prepare a desired preparation. Dosage form.
  • the above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • aromatic hydrocarbons preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • Hexane or paraffin alcohol and ethylene glycol and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide, and vegetable or vegetable oils such as soybean oil.
  • the above solid carriers are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay.
  • a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand.
  • a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
  • Suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene poly
  • the two active ingredients in the compositions of the present invention exhibit synergistic effects, the activity of which is more pronounced than the expected sum of activity using a single compound, and the individual activity of a single compound.
  • the synergistic effect is manifested by allowing for a reduced application rate, a broader fungicidal control profile, quicker effect, longer lasting control effect, better control of plant harmful fungi by only one or a few applications, and broadening of possible application. Intervals. These properties are particularly desirable in the practice of plant fungi control.
  • the composition of the present invention is compounded with Significant synergistic effect; 2, because the chemical composition of the two single agents of the composition is very different, the mechanism of action is completely different, there is no cross-resistance, and the resistance problem caused by the separate use of the two single agents can be delayed;
  • the composition of the invention can well regulate crop growth, improve disease resistance and stress resistance, promote crop health and increase crop yield.
  • the active ingredient A and the B active ingredient are sufficiently mixed with various auxiliary agents and fillers, and are pulverized by an ultrafine pulverizer to obtain a wettable powder.
  • Active component A BIT
  • thidiam thidiam
  • Example 1 2.2% BIT ⁇ thiatoron WP
  • Active component A (MBIT) and thidiazuron to prepare wettable powder
  • Example 5 2.2% MBIT ⁇ thiazolon wettable powder
  • MBIT was 3%
  • thiablon 0.0999%
  • the remaining components were prepared in accordance with the method of Example 2.
  • Example 7 9.1503% MBIT ⁇ thiazolon wettable powder
  • Example 8 12.12% MBIT ⁇ thiazolon wettable powder
  • Active component A (BBIT) and thidiazuron to prepare wettable powder
  • BBIT was 3%
  • thiazole was 0.0999%
  • the remaining components were prepared in accordance with the method of Example 2.
  • Example 11 9.1503% BBIT ⁇ thiazolon wettable powder
  • Example 12 12.12% BBIT ⁇ thiazolon wettable powder
  • the active ingredient A and the active ingredient B, and the components such as a dispersing agent, a wetting agent, a thickener and water are uniformly mixed according to the formulation, and after being sanded and/or sheared at a high speed, a semi-finished product is obtained. After the analysis, the water is added and uniformly filtered to obtain the finished product.
  • Active component A BIT
  • Example 13 8% BIT ⁇ thiazolone suspension
  • Example 14 6.12% BIT ⁇ thiazolone suspension
  • Example 15 10.1429% BIT ⁇ thiazolone suspension
  • Active component A (MBIT) and thidiazuron preparation suspension
  • Example 17 8% MBIT ⁇ thiazolone suspension
  • MBIT was 6%
  • thiabendazole was 0.12%
  • the remaining components were prepared in accordance with the procedure of Example 14.
  • MBIT was 3%
  • thiabendazole was 0.0333%
  • the remaining components were prepared in the same manner as in Example 16.
  • Active component A (BBIT) and thidiazuron preparation suspension
  • BBIT was 6%
  • thiabendazole was 0.12%
  • the remaining components were prepared in the same manner as in Example 14.
  • BBIT was 3%
  • thiazole was 0.0333%
  • the remaining components were prepared in accordance with the procedure of Example 16.
  • the active ingredient A and the active ingredient B, and the auxiliary agent and the filler are uniformly mixed according to the formula, and are pulverized into a wettable powder by a jet stream, and then added with a certain amount of water to be mixed and squeezed, and sieved to obtain water dispersion. Granule products.
  • Active component A BIT
  • thidiazuron to prepare water-dispersible granules
  • Example 25 4.2% BIT ⁇ thiazolon water dispersible granules
  • Example 26 10.25% BIT ⁇ thiaphenon water dispersible granules
  • Example 27 15.1875% BIT ⁇ thiaphenon water dispersible granules
  • Active component A (MBIT) and thidiazuron to prepare water-dispersible granules
  • Example 28 4.2% M BIT ⁇ thiazolon water dispersible granules
  • Example 29 10.25% MBIT ⁇ thiaphenon water dispersible granules
  • Example 30 15.1875% MBIT ⁇ thiaphenon water dispersible granules
  • Active component A BBIT
  • thidiazuron to prepare water-dispersible granules
  • Example 31 4.2% B BIT ⁇ thiaphenon water dispersible granules
  • Example 32 10.25% BBIT ⁇ thiaphenon water dispersible granules
  • Example 33 15.1875% BBIT ⁇ thiazolon water dispersible granules
  • Dilute BIT and thiexone with acetone according to a certain concentration spray the stems and leaves on the crops, and measure the effects of various concentrations on the growth of the crops in the field, including the plant height, ear length, grain weight, disease resistance and yield. Wait for a comprehensive evaluation.
  • Plant height control rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
  • Ear length increase rate (plant ear length after treatment - clear water control plant ear length) / clear water control plant ear length * 100%
  • Grain 1000-grain weight increase rate (1000-grain weight of treated grain - 1000-grain weight of grain of clear water control) / Grain 1000-grain weight of clear water control *100%
  • BIT and thiabendazole have a good synergistic effect.
  • BIT and thidiazepine mixed in different ratios, relative to BIT, thidiazepine single agent, and water control, the growth regulation of oats The effect is obvious, mainly in 1.
  • composition of the present invention There is a significant increase in the unit yield of oats.
  • MBIT and thidiazepine were diluted with acetone according to a certain concentration, and sprayed twice after pear flowering and pear fruit setting, and the effects of each ratio on crop growth were measured in the field, including longitudinal diameter, transverse diameter, fruit setting rate, Comprehensive evaluation of disease resistance, fruit weight, and plant yield.
  • the fruit setting rate of the MBIT and the thiabendazole complex pear has a significant improvement effect; 2.
  • the yield is also improved due to the increase of the fruit setting rate; 3.
  • MBIT also has a certain regulating effect on the growth of grapes.
  • the leaves can make the leaves thicker, enhance photosynthesis, promote the inner nutrient transmission of pears, and increase the sugar and moisture of pears.
  • the weight of the fruit is correspondingly increased, thereby significantly increasing the unit yield of the pear; 4
  • the synergistic effect of thiampone and MBIT can have significant preventive and therapeutic effects on some major diseases of pear such as black spot disease.
  • BBIT and thiablon were diluted with acetone at a certain concentration, and the crops were sprayed with stems and leaves.
  • the effects of various concentrations on crop growth were measured in the field, including plant height, fruit length, fruit diameter, disease resistance and yield. Wait for a comprehensive evaluation.
  • Plant height control rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
  • Fruit length increase rate (fruit length after treatment - clear water control fruit length) / clear water control fruit length * 100%
  • Fruit diameter increase rate (fruit diameter after treatment - clear water control fruit diameter) / clear water control fruit diameter * 100%
  • the cucumber plant can be dwarfed, the cucumber can be controlled to control the length of the cucumber, which is good for pollination; 2.
  • the volume of the cucumber can be increased, and the yield can be increased; 3.
  • BBIT has a certain systemic effect on cucumber, and the gray mold of cucumber
  • the fungal diseases have certain protective effects, while the thiabendazole has certain resistance to disease and stress, and the two have a significant synergistic effect after mixing; 4.
  • the unit yield of the composition of the invention on cucumber Has a significant boost.
  • Spraying was carried out using the formulation examples of the present invention, three replicates, and the results were averaged.
  • the experimental data from Table 4 shows that the product of the present invention is applied during the development of soybeans, and can effectively regulate the healthy growth of soybeans.
  • Dwarf soybean plants can be effectively controlled to control the growth of soybeans and prevent soybeans from lodging.
  • BIT has a good systemic effect on soybeans and has a protective effect on soybean growth prevention of fungal diseases, while thiabendazole has soybeans. Growth has certain resistance to disease and stress, and the two have a synergistic effect after compounding; 3.
  • the composition of the invention has a significant effect on the unit yield of soybean.
  • Application period two sprays were carried out 10 days before flowering and 12 days after flowering.
  • Application period rice at the end of the Qisui period.
  • the number of panicles in rice (the number of grains per panicle was more than 5 grains per serving), the total number of grains per panicle, the number of grains per panicle, the seed setting rate, and the yield per mu were calculated. The yield was calculated and statistical analysis was performed.
  • the test results show that the application of the preparation product of the invention at the end of rice seeding can effectively regulate the healthy growth of rice.
  • Dwarf rice plants effectively control rice control and prevent rice from lodging; 2. It can increase the number of panicles in rice and increase the seed setting rate of rice; 4.
  • BBIT has certain systemicity to rice, and rice grain Fungal diseases such as blight have a certain protective effect, while thiabendazole has certain resistance to disease and stress, and it has significant synergistic effect after mixing; 5.
  • the composition of the present invention is applied to rice Unit yield has a significant boost.

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Abstract

本发明公开了一种农药组合物，其有效成分包含A和B，其中活性组分A为具有式(I)的结构化合物，活性组分B为噻苯隆，两组分之间的重量比为1∶(0.01～1)，本发明还提供了该组合物的制备方法及用途。试验结果表明，本发明的组合物可很好的调节作物生长，提高抗病抗逆性，促进作物健康作用，提高作物产量。

Description

含有苯并异噻唑啉酮和噻苯隆的农药组合物 技术领域
本发明属于农业植物保护领域，特别是涉及一种具有改进性能的农药组合物，具体地说是涉及一种包含苯并异噻唑啉酮和噻苯隆的农药组合物。
背景技术
苯并异噻唑啉酮类化合物是一种新型、广谱杀菌剂，主要用于防治和治疗禾谷类作物、蔬菜、水果等多种细菌、真菌性病害。其杀菌作用机理，主要包括破坏病菌细胞核结构，使其失去心脏部位而衰竭死亡和干扰病菌细胞的新陈代谢，使其生理紊乱，最终导致死亡两个方面。在病害发生初期使用可有效保护植株不受病原物侵染，病害发生后酌情增加用药量可明显控制病菌的蔓延，从而达到保护和铲除的双重作用。常见的苯并异噻唑啉酮类化合物包括：1，2-苯并异噻唑啉-3-酮、2-甲基-1，2-苯并异噻唑啉-3-酮或2-丁基-1，2-苯并异噻唑啉-3-酮。
噻苯隆(pyraclostrobin)是新型高效植物生长调节剂，噻苯隆被植物吸收后，可促进叶柄与茎之间的分离组织，形成自然脱落，在农药、肥料中可被广泛应用。它具有极强的生物活性，其诱导植物细胞分裂、愈伤组织形成的能力比一般细胞分裂素高许多倍。提高作物吸收能力，增加光合作用，从而达到增产、增优目的。可用于各类瓜、果、蔬菜、苗木、花卉、粮食、烟草等作物，还可用于组织培养、基因工程等。在生产上能显著提高作物产量、改善品质且有用量少、对生态环境无污染，对人、畜、鸟、蜜蜂、天敌无毒等特点。
实际的农药经验已经表明，重复且专一施用一种活性化合物来防治有害菌种在很多情况下将导致菌种菌株的快速选择性，为降低抗性菌种菌株选择性的危险性，目前通常使用不同活性化合物的混合物来防治有害菌种。通过将具有不同作用机理的活性化合物进行组合，可延缓抗性产生，降低施用量，减少防治成本。
发明内容
本发明的目的是提供一种具有增效作用的农药组合物，以提高杀菌防治效果，延缓抗性产生，同时能够调剂作物生长，提高作物产量。
11.本发明的另一个目的是提供包含两种有效成分A和B农药组合物的制备方法及在 农业领域防病抗病或促进植物生长中的用途。
本发明的目的可以通过以下措施达到：
一种农药组合物，所述的组合物包含A和B两种活性组分，其中活性组分A为具有式(I)的结构化合物，其中活性组分B为噻苯隆，
Figure PCTCN2017113936-appb-000001
式(I)中，R选自H或C1～C8烷基。
本发明中的C1～C8烷基是指含有1至8个碳原子的直链或支链烷基，它包括C1烷基(如甲基)、C2烷基(如乙基)、C3烷基(如正丙基、异丙基)、C4烷基(如正丁基、异丁基、叔丁基、仲丁基)、C5烷基(如正戊基等)、C6烷基、C7烷基、C8烷基。它包括但不限于C1～C6烷基、C1～C5烷基、C1～C4烷基等。
在一种优选方案中，R选自H或C1～C4烷基。
在一种更优选的方案中，R选自H、-CH3或-C4H9。
式(I)中，当R为H时，A为1，2-苯并异噻唑啉-3-酮(说明书中简称BIT)。
式(I)中，当R为CH3时，A为2-甲基-1，2-苯并异噻唑啉-3-酮(说明书中简称MBIT)。
式(I)中，当R为C4H9时，A为2-丁基-1，2-苯并异噻唑啉-3-酮，该式中的“丁基”优选正丁基(说明书中简称BBIT)。
两组分之间的重量比为1∶(0.01～1)，为使本发明的组合物效果更进一步提升，两组分之间的重量比进一步优化为1∶(0.0111～1)。
一种优选的方案中，A和B两组分之间的重量比可以任意地在下述配比的范围内进行调整：1∶1、2∶1、3∶1、4∶1、5∶1、6∶1、7∶1、8∶1、9∶1、10∶1、11∶1、12∶1、13∶1、14∶1、15∶1、16∶1、17∶1、18∶1、19∶1、20∶1、21∶1、22∶1、23∶1、24∶1、25∶1、26∶1、27∶1、28∶1、29∶1、30∶1、32∶1、33∶1、34∶1、35∶1、36∶1、37∶1、38∶1、39∶1、40∶1、41∶1、42∶1、43∶1、44∶1、45∶1、46∶1、47∶1、48∶1、49∶1、50∶1、51∶1、52∶1、53∶1、54∶1、55∶1、56∶1、57∶1、58∶1、59∶1、60∶1、61∶1、62∶1、63∶1、64∶1、65∶1、66∶1、67∶1、68∶1、69∶1、70∶1、71∶1、72∶1、73∶1、74∶1、75∶1、76∶1、77∶1、78∶1、79∶1、80∶1、81∶1、82∶1、83∶1、84∶1、85∶1、86∶1、87∶1、88∶1、89∶1、90∶1、91∶1、92∶1、93∶1、94∶1、95∶1、96∶1、97∶1、98∶1、99∶1、 100∶1，也可以在以上任意两个配比所组成的范围内进行选择，这些比例可以理解为重量比，也可以包括摩尔比。
发明人通过试验发现，本发明的组合物是用于防治农作物真、细菌性病害增效明显，更重要的是两者复配可以更好的调节作物的生长，促进作物的健康作用，提高作物的产量。
本发明提供了包含组分A(苯并异噻唑啉酮类中的一种)和组分B(噻苯隆)的农药组合物在农业领域防病抗病或促进作物生长中的用途，特别是在水稻、玉米或果树方面调节作物生长提高抗病效果等方面的用途。
为充分发挥本发明的优势效果，本发明的组合物还可以与其他农药(如杀菌剂、杀虫剂、除草剂、植物生长调节剂)、肥料等混合使用，这些与之混用的均为现有技术公开的常用的农药或肥料。比如含有本发明农药组合物的有效成分与噻唑类杀菌剂(如咪鲜胺或咪鲜胺铜盐、咪鲜胺锰盐等)、三唑类杀菌剂(如戊唑醇、丙硫菌唑等)、甲氧基丙烯酸酯类(如嘧菌酯、吡唑醚菌酯、啶氧菌酯、醚菌酯等)，或硫代氨基甲酸酯类杀菌剂(如代森锰锌、代森联、代森锌等)。
本发明的组合物可以由活性成分和农药助剂制成农药上允许的剂型。进一步的，该组合物由1.0001～85.0001％重量份的活性组分与98.9999～14.9999％重量份的助剂组成农药上允许的剂型。
上述组合物具体可包含农药助剂，例如载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂和肥料中的一种或几种，在施用的过程中可以混合常用的助剂。
合适的助剂可以是固体或液体，它们通常是剂型加工过程中常用的物质，例如天然的或再生的矿物质，溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂或肥料。
在制备液体剂型时，可以先将活性组分A溶于碱性物质，形成苯并异噻唑啉金属盐，合适的碱性物质包括：碱金属碳酸盐、碱金属氢氧化物(如氢氧化钠、氢氧化钾)、碱金属烷氧基碳酸盐、碱金属醇盐或甲醇镁。
本发明组合物的施用方法包括将本发明的组合物用于植物生长的地上部分，特别是叶部或叶面。可以选择浸种或涂抹于防治对象表面。施用的频率和施用量取决于病原体的生物学和气候生存条件。可以将植物的生长场所，如稻田，用组合物的液体制剂浸湿，或者将组合物以固体形式施用于土壤中，如以颗粒形式(土壤施用)，组合物可以由土壤经植物根部进入植物体内(内吸作用)。
这些组合物可以仅仅包含活性成分进行施用，也可以与添加剂(农药助剂)一起混合 使用。
本发明的组合物可以制备成农药上可接受的剂型，例如可湿性粉剂、悬浮剂、水分散粒剂、水乳剂或微乳剂、乳油、可分散油悬浮剂、悬乳剂、油悬浮剂或微囊剂型等。根据这些组合物的性质以及施用组合物所要达到的目的和环境情况，可以选择将组合物以喷雾、弥雾、喷粉、撒播或泼浇等之类的方法施用。
可用已知的方法可以将本发明的组合物制备成各种剂型，可以将有效成分与助剂，如溶剂、固体载体，需要时可以与表面活性剂一起均匀混合、研磨，制备成所需要的剂型。
上述的溶剂可选自芳香烃，优选含8-12个碳原子，如二甲苯混合物或取代的苯，酞酸酯类，如酞酸二丁酯或酞酸二辛酸，脂肪烃类，如环己烷或石蜡，醇和乙二醇和它们的醚和酯，如乙醇，乙二醇，乙二醇单甲基；酮类，如环己酮，强极性的溶剂，如N-甲基-2-吡咯烷酮，二甲基亚砜或二甲基甲酰胺，和植物油或植物油，如大豆油。
上述的固体载体，如用于可湿性粉剂和可分散剂的通常是天然矿物填料，例如滑石、高岭土，蒙脱石或活性白土。为了管理组合物的物理性能，也可以加入高分散性硅酸或高分散性吸附聚合物载体，例如粒状吸附载体或非吸附载体，合适的粒状吸附载体是多孔型的，如浮石、皂土或膨润土；合适的非吸附载体如方解石或砂。另外，可以使用大量的无机性质或有机性质的预制成粒状的材料作为载体，特别是白云石。
根据本发明的组合物中的有效成分的化学性质，合适的表面活性剂为木质素磺酸、萘磺酸、苯酚磺酸、碱土金属盐或胺盐，烷基芳基磺酸盐，烷基硫酸盐，烷基磺酸盐，脂肪醇硫酸盐，脂肪酸和硫酸化脂肪醇乙二醇醚，还有磺化萘和萘衍生物与甲醛的缩合物，萘或萘磺酸与苯酚和甲醛的缩合物，聚氧乙烯辛基苯基醚，乙氧基化异辛基酚，辛基酚，壬基酚，烷基芳基聚乙二醇醚，三丁基苯聚乙二醇醚，三硬脂基苯基聚乙二醇醚，烷基芳基聚醚醇，乙氧基化蓖麻油，聚氧乙烯烷基醚，氧化乙烯缩合物、乙氧基化聚氧丙烯，月桂酸聚乙二醇醚缩醛，山梨醇酯，木质素亚硫酸盐废液和甲基纤维素。
本发明的组合物中两种有效成分表现为增效效果，该组合物的活性比使用单个化合物的活性预期总和，以及单个化合物的单独活性更为显著。增效效果表现为允许施用量减少、更宽的杀真菌控制谱、见效快、更持久的防治效果、通过仅仅一次或少数几次施用更好的控制植物有害真菌、以及加宽了可能的施用间隔时间。这些特性是植物真菌控制实践过程中特别需要的。
本发明的农药组合物的表现出的其它特点主要表现为：1、本发明的组合物混配具有 明显的增效作用；2、由于本组合物的两个单剂化学结构差异很大，作用机理完全不同，不存在交互抗性，可延缓两单剂单独使用所产生的抗性问题；3、本发明的组合物可很好的调节作物生长，提高抗病抗逆性，促进作物健康作用，提高作物产量。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限定本发明，凡在本发明的精神和原则之内所做的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
以下实施例所有配方中百分比均为重量百分比。本发明组合物各种制剂的加工工艺均为现有技术，根据不同情况可以有所变化。
一、剂型制备实施例
(一)可湿性粉剂的加工及实施例
将活性成分A与B活性成分与各种助剂及填料等按比例充分混合，经超细粉碎机粉碎后制得可湿性粉剂。
1、活性组分A(BIT)和噻苯隆制备可湿性粉剂
实施例1：2.2％BIT·噻苯隆可湿性粉剂
BIT 2％，噻苯隆0.2％，萘磺酸钠盐3.57％，硫酸铵5.17％，皂角粉3.33％，高岭土补足至100％。
实施例2：3.0999％BIT·噻苯隆可湿性粉剂
BIT 3％，噻苯隆0.0999％，脂肪酰胺N-甲基牛磺酸钠盐4.15％，十二烷基硫酸钠5.07％，硫酸铵3.21％，凹凸棒土补足至100％。
实施例3：9.1503％BIT·噻苯隆可湿性粉剂
BIT 9％，噻苯隆0.1503％，苯磺酸钠盐4.63％，硅酸镁铝3.07％，烷基酚聚氧乙烯醚硫酸盐6.36％，白炭黑补足至100％。
实施例4：12.12％BIT·噻苯隆可湿性粉剂
BIT 12％，噻苯隆0.12％，烷基酚聚氧乙烯醚6.43％，拉开粉BX 5.28％，膨润土8.47％，硅藻土补足至100％。
2、活性组分A(MBIT)和噻苯隆制备可湿性粉剂
实施例5：2.2％MBIT·噻苯隆可湿性粉剂
MBIT 2％，噻苯隆0.2％，其余组分按照实施例1的方法制备。
实施例6：3.0999％MBIT·噻苯隆可湿性粉剂
MBIT 3％，噻苯隆0.0999％，其余组分按照实施例2的方法制备。
实施例7：9.1503％MBIT·噻苯隆可湿性粉剂
MBIT 9％，噻苯隆0.1503％，其余组分按照实施例3的方法制备。
实施例8：12.12％MBIT·噻苯隆可湿性粉剂
MBIT 12％，噻苯隆0.12％，其余组分按照实施例4的方法制备。
3、活性组分A(BBIT)和噻苯隆制备可湿性粉剂
实施例9：2.2％BBIT·噻苯隆可湿性粉剂
BBIT 2％，噻苯隆0.2％，其余组分按照实施例1的方法制备。
实施例10：3.0999％BBIT·噻苯隆可湿性粉剂
BBIT 3％，噻苯隆0.0999％，其余组分按照实施例2的方法制备。
实施例11：9.1503％BBIT·噻苯隆可湿性粉剂
BBIT 9％，噻苯隆0.1503％，其余组分按照实施例3的方法制备。
实施例12：12.12％BBIT·噻苯隆可湿性粉剂
BBIT 12％，噻苯隆0.12％，其余组分按照实施例4的方法制备。
(二)悬浮剂的加工及实施例
将活性成分活性组分A与活性组分B，与分散剂、润湿剂、增稠剂和水等各组分按配方的比例混合均匀，经砂磨和/或高速剪切后，得到半成品，分析后补加水混合均匀过滤即得成品。
1、活性组分A(BIT)和噻苯隆制备悬浮剂
实施例13：8％BIT·噻苯隆悬浮剂
BIT 4％，噻苯隆4％，木质素磺酸钠盐4.75％，烷基苯磺酸钠盐7.32％，硫酸铵3.67％，黄原胶3.72％，乙二醇6％，硅油0.03％，水补足至100％。
实施例14：6.12％BIT·噻苯隆悬浮剂
BIT 6％，噻苯隆0.12％，硫酸铵4.23％，脂肪醇聚氧乙烯醚8.57％，皂角粉5.73％，乙二醇4％，硅酸镁铝3.11％，硅油0.02％，水补足至100％。
实施例15：10.1429％BIT·噻苯隆悬浮剂
BIT 10％，噻苯隆0.1429％，膨润土5.36％，丙三醇7％，十二烷基硫酸钠5.47％，硅 酸镁铝4.22％烷基芳基聚乙二醇醚6.32％，硅油0.03％，水补足至100％。
实施例16：3.0333％BIT·噻苯隆悬浮剂
BIT 3％，噻苯隆0.0333％，碳酸氢钠3.26％，乙二醇5％，烷基磺酸钠6.32％，黄原胶3.07％，甲基戊醇4％，硅油0.01％，水补足至100％。
2、活性组分A(MBIT)和噻苯隆制备悬浮剂
实施例17：8％MBIT·噻苯隆悬浮剂
MBIT 4％，噻苯隆4％，其余组分按照实施例13的方法制备。
实施例18：6.12％MBIT·噻苯隆悬浮剂
MBIT 6％，噻苯隆0.12％，其余组分按照实施例14的方法制备。
实施例19：10.1429％MBIT·噻苯隆悬浮剂
MBIT 10％，噻苯隆0.1429％，其余组分按照实施例15的方法制备。
实施例20：3.0333％MBIT·噻苯隆悬浮剂
MBIT 3％，噻苯隆0.0333％，其余组分按照实施例16的方法制备。
3、活性组分A(BBIT)和噻苯隆制备悬浮剂
实施例21：8％BBIT·噻苯隆悬浮剂
BBIT 4％，噻苯隆4％，其余组分按照实施例13的方法制备。
实施例22：6.12％BBIT·噻苯隆悬浮剂
BBIT 6％，噻苯隆0.12％，其余组分按照实施例14的方法制备。
实施例23：10.1429％BBIT·噻苯隆悬浮剂
BBIT 10％，噻苯隆0.1429％，其余组分按照实施例15的方法制备。
实施例24：3.0333％BBIT·噻苯隆悬浮剂
BBIT 3％，噻苯隆0.0333％，其余组分按照实施例16的方法制备。
(三)水分散粒剂的加工及实施例
将活性成分A与活性成分B，与助剂和填料按配方的比例混合均匀，经气流粉碎成可湿性粉剂，再加入一定量的水混合挤压造粒，经干燥筛分后制得水分散粒剂产品。
1、活性组分A(BIT)和噻苯隆制备水分散粒剂
实施例25：4.2％BIT·噻苯隆水分散粒剂
BIT 4％，噻苯隆0.2％，木质素磺酸钠盐5.32％，十二烷基硫酸钠4.52％，膨润土6％，硅酸镁铝3.42％，高岭土补足至100％。
实施例26：10.25％BIT·噻苯隆水分散粒剂
BIT 10％，噻苯隆0.25％，脂肪酰胺N-甲基牛磺酸钠盐6.87％，磺酸钠盐5.36％，硫酸铵8％，黄原胶4.56％，凹凸棒土补足至100％。
实施例27：15.1875％BIT·噻苯隆水分散粒剂
BIT 15％，噻苯隆0.1875％，十二烷基硫酸钠7.46％，皂角粉5.32％，尿素7％，硅酸镁铝4.86％，高岭土补足至100％。
2、活性组分A(MBIT)和噻苯隆制备水分散粒剂
实施例28：4.2％M BIT·噻苯隆水分散粒剂
MBIT 4％，噻苯隆0.2％，其余组分按照实施例25的方法制备。
实施例29：10.25％MBIT·噻苯隆水分散粒剂
MBIT 10％，噻苯隆0.25％，其余组分按照实施例26的方法制备。
实施例30：15.1875％MBIT·噻苯隆水分散粒剂
MBIT 15％，噻苯隆0.1875％，其余组分按照实施例27的方法制备。
3、活性组分A(BBIT)和噻苯隆制备水分散粒剂
实施例31：4.2％B BIT·噻苯隆水分散粒剂
BBIT 4％，噻苯隆0.2％，其余组分按照实施例25的方法制备。
实施例32：10.25％BBIT·噻苯隆水分散粒剂
BBIT 10％，噻苯隆0.25％，其余组分按照实施例26的方法制备。
实施例33：15.1875％BBIT·噻苯隆水分散粒剂
BBIT 15％，噻苯隆0.1875％，其余组分按照实施例27的方法制备。
二、药效验证试验
(一)生物测定实施例
1、BIT与噻苯隆复配对燕麦生长调节综合测定试验
将BIT与噻苯隆用丙酮按照一定浓度稀释，对作物进行茎叶喷雾，在田间测定各个浓度对作物生长的影响，包括对作物的株高、穗长、籽粒千粒重、抗病情况以及产量情况等进行综合评价。
株高控制率＝(清水对照株高-处理后的株高)/清水对照株高*100％
穗长提高率＝(处理后的植株穗长-清水对照植株穗长)/清水对照植株穗长*100％
预防效果＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
籽粒千粒重提高率＝(处理后的籽粒千粒重-清水对照的籽粒千粒重)/清水对照的籽粒千粒重*100％
亩产提高率＝(处理后的亩产量-清水对照的亩产量)/清水对照的亩产量*100％
表1.BIT与噻苯隆复配对燕麦生长调节综合测定汇总表
Figure PCTCN2017113936-appb-000002
注：表格中“噻”为“噻苯隆”缩写(下同)。
通过实验发明人发现，BIT与噻苯隆之间具有很好协同提升作用，BIT与噻苯隆混配在不同配比下，相对BIT、噻苯隆单剂，以及清水对照，对燕麦的生长调节作用明显，主要表现在1、可以矮化燕麦植株，有效控制燕麦控旺徒长，防止燕麦倒伏；2、可以提升燕麦的穗长，提高穗粒数；3、可显著提高燕麦籽粒的重量；4、BIT对燕麦生长预防真菌病害具有一定的保护作用，而噻苯隆对燕麦生长具有一定的抗病抗逆能力，两者混配后具有一定的协同增效作用；5、本发明的组合物对燕麦的单位产量具有显著的提升作用。
2、MBIT与噻苯隆复配对梨生长调节综合测定试验
将MBIT与噻苯隆用丙酮按照一定浓度稀释，分别在梨开花期和梨坐果后进行两次喷雾，在田间测定各个配比对作物生长的影响，包括对纵径、横径、坐果率、抗病情况、果实粒重，以及株产量情况等进行综合评价。
纵径提高率＝(药剂处理后果粒纵径-清水对照果粒纵径)/清水对照果粒纵径*100％
横径提高率＝(药剂处理后果粒横径-清水对照果粒横径)/清水对照果粒横径*100％
座果率＝坐果数/花蕾数*100％
果实重量率＝(药剂处理的单粒重量-清水对照单粒重量)/清水对照单粒重量*100％
病害预防控制率＝(清水对照发病指数-处理后发病指数)/清水对照的发病指数*100％
增产量＝(药剂处理的每株重量-清水对照的每株重量)/清水对照的每株重量*100％
表2 MBIT与噻苯隆复配对梨生长调节综合测定汇总表
Figure PCTCN2017113936-appb-000003
据分析表明，1、MBIT与噻苯隆复配对梨的座果率有显著的提升作用；2、由于座果率的提升，产量也有相应的提升作用；3、由于噻苯隆属于植物内在激素，而MBIT对葡萄的生长也具有一定的调节作用，两者混配后可以使梨叶片更厚实，增强光合作用，促进梨内在营养的传导作用，提高梨的糖分和水分，因此对梨的果实有显著的提升作用，果实重量相应提高，从而显著提高梨的单位产量；4、噻苯隆与MBIT的协同作用，可对梨一些主要病害如黑星病有显著的预防治疗作用。
3、BBIT与噻苯隆复配对黄瓜生长调节综合测定试验
将BBIT与噻苯隆用丙酮按照一定浓度稀释，对作物进行茎叶喷雾，在田间测定各个浓度对作物生长的影响，包括对作物的株高、果长、果径、抗病情况以及产量情况等进行综合评价。
株高控制率＝(清水对照株高-处理后的株高)/清水对照株高*100％
果长提高率＝(处理后的果长-清水对照果长)/清水对照果长*100％
果径提高率＝(处理后的果径-清水对照果径)/清水对照果径*100％
预防效果＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
亩产提高率＝(处理后的亩产量-清水对照的亩产量)/清水对照的亩产量*100％
表3 BBIT与噻苯隆复配对黄瓜生长调节综合测定汇总表
Figure PCTCN2017113936-appb-000004
据分析表明，1、可以矮化黄瓜植株，有效控制黄瓜控旺徒长，利于授粉；2、可以提升黄瓜的体积，增加产量；3、BBIT对黄瓜具有一定的内吸性，对黄瓜灰霉病等真菌病害具有一定的保护作用，而噻苯隆对黄瓜生长具有一定的抗病抗逆能力，两者混配后具有显著的协同增效作用；4、本发明的组合物对黄瓜的单位产量具有显著的提升作用。
(二)田间药效验证试验
(1)BIT与噻苯隆混配对大豆作物调节生长及抗病增产的田间综合试验
施药时期：大豆发育期。
施药次数：2～3次。利用本发明的制剂实施例进行喷施，三个重复，结果取平均值。
表4 BIT与噻苯隆混配对大豆调节生长的田间综合实验
Figure PCTCN2017113936-appb-000005
从表4实验数据显示，本发明的产品在大豆发育期施用，可以有效调节大豆的健康生长。1、可以矮化大豆植株，有效控制大豆控旺徒长，防止大豆倒伏；2、BIT对大豆具有较好的内吸性，对大豆生长预防真菌病害具有一定的保护作用，而噻苯隆对大豆生长具有一定的抗病抗逆能力，两者混配后具有一定的协同增效作用；3、本发明的组合物对大豆的单位产量具有显著的提升作用。
(2)MBIT与噻苯隆对葡萄作物调节生长及抗病增产的田间综合试验
施药时期：分别在葡萄开花前10天和葡萄盛花后12天进行两次喷雾。
施药次数：2次。利用本发明的制剂实施例进行喷施，三个重复，结果取平均值。
表5 MBIT与噻苯隆混配对葡萄调节生长的田间综合实验
Figure PCTCN2017113936-appb-000006
Figure PCTCN2017113936-appb-000007
从上表实验数据分析表明，1、MBIT与噻苯隆复配对葡萄的座果率有显著的提升作用；2、由于座果率的提升，葡萄后期生长的穗粒数也有相应的提升作用；3、由于噻苯隆属于植物内在激素，而MBIT对葡萄的生长也具有一定的调节作用，两者混配后可以使葡萄叶片更厚实，增强光合作用，促进葡萄内在营养的传导作用，提高葡萄的糖分和水分，因此对葡萄的籽粒有显著的提升作用，籽粒重量相应提高，从而显著提高葡萄的单位产量；4、MBIT与噻苯隆的协同作用，可对葡萄一些主要病害如霜霉病有显著的预防治疗作用。
(3)BBIT与噻苯隆对水稻作物调节生长及抗病增产的田间综合试验
施药时期：水稻齐穗末期。调查水稻成穗数(每穗有5粒以上实粒数为有效穗)、每穗总粒数、每穗实粒数、结实率、单位亩产量，计算增产率，进行统计分析。
表6 BBIT与噻苯隆混配对水稻调节生长的田间综合实验
Figure PCTCN2017113936-appb-000008
Figure PCTCN2017113936-appb-000009
试验结果表明，在水稻齐穗末期施用本发明的制剂产品，可以有效调节水稻的健康生长。1、可以矮化水稻植株，有效控制水稻控旺徒长，防止水稻倒伏；2、可以提升水稻的成穗数，提高水稻的结实率；4、BBIT对水稻具有一定的内吸性，对水稻纹枯病等真菌病害具有一定的保护作用，而噻苯隆对水稻生长具有一定的抗病抗逆能力，两者混配后具有显著的协同增效作用；5、本发明的组合物对水稻的单位产量具有显著的提升作用。

Claims (10)

  1. 一种农药组合物，其特征在于所述的组合物包含A和B两种活性组分，其中活性组分A为具有式(I)的结构化合物，活性组分B为噻苯隆，两组分之间的重量比为1∶(0.01～1)
    Figure PCTCN2017113936-appb-100001
    式(I)中，R选自H或C1～C8烷基。
  2. 根据权利要求1所述的农药组合物，其特征在于式(I)中，R选自H或C1～C4烷基。
  3. 根据权利要求1所述的农药组合物，其特征在于式(I)中，R优先选自H、-CH3或-C4H9，对应的活性组分A分别为1，2-苯并异噻唑啉-3-酮、2-甲基-1，2-苯并异噻唑啉-3-酮或2-丁基-1，2-苯并异噻唑啉-3-酮。
  4. 根据权利要求1所述的农药组合物，其特征在于活性组分A和活性组分B的重量比为1∶0.0111～1。
  5. 根据权利要求1～4中任一所述的农药组合物，其特征在于该组合物由活性成分和助剂制成农药上允许的剂型。
  6. 根据权利要求5所述的农药组合物，其特征在于该农药组合物由1.0001～85.0001％重量份的活性组分与98.9999～14.9999％重量份的助剂组成农药上允许的剂型。
  7. 根据权利要求5所述的农药组合物，其特征在于所述的剂型为水分散粒剂、悬浮剂或可湿性粉剂。
  8. 根据权利要求5或6述的农药组合物，其特征在于所述农药助剂选自载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂或肥料中的一种或几种。
  9. 权利要求1～8中任一所述的农药组合物在农业领域防病抗病或促进作物生长中的用途。
  10. 根据权利要求9所述的用途，其特征在于所述的作物为水稻、玉米或果树。
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