+

WO2016039001A1 - Dispositif d'imagerie - Google Patents

Dispositif d'imagerie Download PDF

Info

Publication number
WO2016039001A1
WO2016039001A1 PCT/JP2015/069603 JP2015069603W WO2016039001A1 WO 2016039001 A1 WO2016039001 A1 WO 2016039001A1 JP 2015069603 W JP2015069603 W JP 2015069603W WO 2016039001 A1 WO2016039001 A1 WO 2016039001A1
Authority
WO
WIPO (PCT)
Prior art keywords
light source
camera
image
fluorescence
light
Prior art date
Application number
PCT/JP2015/069603
Other languages
English (en)
Japanese (ja)
Inventor
小田　一郎
紘之 妻鳥
Original Assignee
株式会社島津製作所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社島津製作所 filed Critical 株式会社島津製作所
Publication of WO2016039001A1 publication Critical patent/WO2016039001A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

Definitions

  • the present invention relates to an imaging apparatus for irradiating a fluorescent dye injected into a subject with excitation light and photographing fluorescence generated from the fluorescent dye.
  • near-infrared fluorescence imaging In recent years, a technique called near-infrared fluorescence imaging has been used for surgery.
  • indocyanine green (ICG) as a fluorescent dye is injected into the affected area.
  • ICG indocyanine green
  • the indocyanine green When the indocyanine green is irradiated with near-infrared light of about 600 to 850 nm (nanometer) as excitation light, the indocyanine green emits near-infrared fluorescence of about 750 to 900 nm.
  • This fluorescence is photographed by a camera capable of detecting near infrared light, and the image is displayed on a display unit such as a liquid crystal display panel.
  • a display unit such as a liquid crystal display panel.
  • Patent Document 1 discloses a near-infrared fluorescence intensity distribution image obtained by irradiating an indocyanine green excitation light to a living organ to which indocyanine green is administered, and indocyanine green administration. Compared with the cancer lesion distribution image obtained by applying X-rays, nuclear magnetic resonance or ultrasound to the previous test organ, it is detected by the intensity distribution image of near-infrared fluorescence, A data collection method is disclosed in which data of a region that is not detected in a cancer lesion distribution image is collected as cancer secondary lesion region data.
  • near infrared light having a wavelength of about 700 nm is not impossible to visually confirm, but near infrared light having a wavelength of about 800 nm cannot be visually confirmed.
  • a card-like or rod-like jig kneaded with indocyanine green has been prepared in the past. The operation of the camera is confirmed by irradiating the excitation light and photographing the jig irradiated with the excitation light with a camera. For this reason, not only a dedicated jig is required, but also a complicated operation of preparing the jig and executing a photographing operation is required.
  • the present invention has been made to solve the above-described problems, and an object of the present invention is to provide an imaging apparatus capable of very easily executing an operation check of a camera for photographing fluorescence.
  • the excitation light source that irradiates the subject with excitation light for exciting the fluorescent dye injected into the subject, and the fluorescence generated from the fluorescent dye when irradiated with the excitation light are photographed.
  • a second light source for irradiating light with a wavelength corresponding to the fluorescence is attached to the excitation light source.
  • the second light source irradiates light having a wavelength corresponding to the fluorescence and takes an image of an irradiation area with the camera to check whether the camera is operating normally. This is a light source for confirmation.
  • the excitation light source and the second light source are attached to the camera.
  • the excitation light and the fluorescence are near-infrared light.
  • an image processing unit for displaying a blood vessel image obtained by irradiating a subject with light having a wavelength corresponding to the fluorescence, on a display unit.
  • the present invention it is possible to very easily check the operation of a camera that captures fluorescence using light having a wavelength corresponding to the fluorescence from the second light source.
  • the third invention by turning on the second light source, it is always easy to check the operation of the camera that captures fluorescence regardless of the arrangement of the camera that captures fluorescence and the second light source. It becomes possible. In addition, it is possible to direct excitation light and fluorescence to the imaging region of the camera simply by moving the camera.
  • the fourth aspect of the present invention it is possible to check the operation of a camera that captures fluorescence with respect to near infrared rays that are difficult to visually recognize.
  • the fifth aspect it is possible to display a blood vessel image using a mechanism for confirming the operation of a camera that captures fluorescence.
  • FIG. 1 is a schematic diagram of an imaging apparatus according to the present invention.
  • 2 is a perspective view of an illumination / photographing unit 12.
  • FIG. FIG. 3 is a schematic front view of the illumination / photographing unit 12. It is a block diagram which shows the main control systems of the imaging device which concerns on this invention. It is a schematic diagram which shows the state which displays the image of the blood vessel 101 in the hand 100 of the patient 17 with the imaging device which concerns on this invention.
  • FIG. 1 is a schematic diagram of an imaging apparatus according to the present invention.
  • the imaging apparatus includes an input unit 11 such as a touch panel, and includes a main body 10 including a control unit 30 and the like described later, an illumination / photographing unit 12 supported movably by an arm 13, a liquid crystal display panel, and the like. And a treatment table 16 on which a patient 17 is placed.
  • the illumination / imaging unit 12 is not limited to the one supported by the arm 13, and may be one carried by the operator or fixed to an existing facility.
  • FIG. 2 is a perspective view of the illumination / photographing unit 12 described above.
  • FIG. 3 is a schematic front view of the illumination / photographing unit 12.
  • the illumination / photographing unit 12 includes a camera 21 capable of detecting near-infrared light and visible light, a visible light source 22 including one or more LEDs disposed on the outer periphery of the camera 21, and an outer periphery of the visible light source 22.
  • An excitation light source 23 composed of one or more LEDs disposed in the section, and a confirmation light source 24 composed of one or more LEDs disposed in the LEDs constituting the visible light source 22 (corresponding to a second light source) .
  • positioning is not limited to this.
  • the visible light source 22 emits visible light.
  • the excitation light source 23 irradiates near infrared light having a wavelength of 760 nm, which is excitation light for exciting indocyanine green.
  • the confirmation light source 24 emits near-infrared light having a wavelength of 810 nm, which approximates the wavelength of fluorescence generated from indocyanine green.
  • the wavelength of the excitation light source 23 is not limited to 760 nm, and may be any wavelength that can excite indocyanine green.
  • the wavelength of the light source 24 for confirmation is not limited to 810 nm, and may be longer than the wavelength emitted by indocyanine green.
  • FIG. 4 is a block diagram showing a main control system of the imaging apparatus according to the present invention.
  • This imaging apparatus is composed of a CPU that performs logical operations, a ROM that stores operation programs necessary for controlling the apparatus, a RAM that temporarily stores data during control, and the like, and a control unit that controls the entire apparatus 30.
  • the control unit 30 includes an image processing unit 31 that executes various image processing described later.
  • the control unit 30 is connected to the input unit 11 and the display unit 14 described above.
  • the control unit 30 is connected to an illumination / photographing unit 12 including a camera 21, a visible light source 22, an excitation light source 23, and a confirmation light source 24. Further, the control unit 30 may be connected to an image storage unit 33 that stores an image captured by the camera 21.
  • the image storage unit 33 includes a near-infrared image storage unit 34 that stores a near-infrared image and a visible image storage unit 35 that stores a visible image.
  • a composite image storage unit that stores an image obtained by combining the visible image and the near-infrared image may be provided.
  • the confirmation light source 24 When performing an operation for breast cancer using the imaging apparatus according to the present invention, first, the confirmation light source 24 is turned on and an image at that time is taken by the camera 21.
  • the confirmation light source 24 emits near-infrared light having a wavelength of 810 nm that approximates the wavelength of fluorescence generated from indocyanine green. This near infrared light cannot be confirmed by human eyes.
  • near-infrared light having a wavelength of 810 nm is emitted from the light source for confirmation 24 and an image of this irradiation region is taken by the camera 21, when the camera 21 is operating normally, near-infrared light is emitted.
  • An image of a region irradiated with is taken by the camera 21, and the image is displayed on the display unit 14. This makes it possible to easily check the operation of the camera 21.
  • indocyanine green is injected into the breast of the patient 17 who is supine on the treatment table 16 by injection. Then, near infrared rays are emitted from the excitation light source 23 toward the subject including the affected part, and visible light is emitted from the visible light source 22. As the near infrared light emitted from the excitation light source 23, as described above, 760 nm near infrared light acting as excitation light for indocyanine green to emit fluorescence is employed. Thereby, indocyanine green generates fluorescence in the near infrared region having a peak at about 800 nm.
  • the camera 21 captures the vicinity of the affected part of the patient 17.
  • the camera 21 can detect near infrared light and visible light.
  • the near-infrared image and visible image captured by the camera 21 are sent to the image processing unit 31 shown in FIG.
  • the image processing unit 31 converts the near-infrared image and the visible image into image data that can be displayed on the display unit 14.
  • the near-infrared image data is stored in the near-infrared image storage unit 34 in the image storage unit 33.
  • the visible image data is stored in the visible image storage unit 35 of the image storage unit 33.
  • the image processing unit 31 uses the near-infrared image data and the visible image data to create a composite image obtained by fusing the visible image and the near-infrared image. Then, the image processing unit 31 displays the near-infrared image, the visible image, and the composite image on the display unit 14 at the same time or selectively in divided regions.
  • FIG. 5 is a schematic diagram showing a state in which an image of the blood vessel 101 in the hand 100 of the patient 17 is displayed by the imaging apparatus according to the present invention.
  • near-infrared light having a wavelength of 810 nm is irradiated from the light source 24 for confirmation.
  • near-infrared light having a wavelength of 810 nm blood vessels can be visualized, and in particular, an artery in the blood vessel 101 can be clearly visualized.
  • the vein since the vein is close to the body surface, the vein can be visualized with near-infrared light of 810 nm.
  • the hand 100 of the patient 17 is irradiated with near-infrared light having a wavelength of 810 nm from the confirmation light source 24 and photographed with the camera 21, as shown in FIG.
  • the blood vessel 101 in the hand 100 of the patient 17 can be displayed on the display unit 14. For this reason, the image of the blood vessel 101 can be visualized using the confirmation light source 24 for confirming the operation of the camera 21.
  • the excitation light source 23 and the confirmation light source 24 are attached to the camera 21, near-infrared light having a wavelength of 810 nm and a wavelength of 760 are associated with the movement of the camera 21.
  • the irradiation region of near infrared light can also be moved.
  • the confirmation light source 24 since the confirmation light source 24 always faces the imaging region of the camera 21, it is extremely easy to confirm the operation of photographing a near-infrared image having a wavelength of 810 nm by the camera 21 regardless of the orientation of the camera 21 and the confirmation light source 24. Can be executed.
  • the camera 21, the visible light source 22, the excitation light source 23, and the confirmation light source 24 may be arranged separately. Even in this case, it is possible to shoot and display a necessary image by matching the imaging region of the camera 21 with the light irradiation region of the visible light source 22, the excitation light source 23, and the confirmation light source 24. .
  • the confirmation light source 24 is installed in another place such as the main body 10, it is necessary to point the camera 21 in that direction in order to confirm the operation state of the camera 21. At this time, as described above, near-infrared light having a wavelength of 810 nm cannot be visually confirmed, so that the operation confirmation operation of the camera 21 becomes complicated.
  • the excitation light source 23 that emits near-infrared light having a wavelength of 760 nm is used.
  • indocyanine green is excited to emit light. What can irradiate near infrared light of about 700 nm to 900 nm can be used.
  • the confirmation light source 24 that emits near-infrared light having a wavelength of 810 nm is used.
  • the confirmation light source 24 has a light emission wavelength of indocyanine green of 750 nm to 900 nm. Any device can be used as long as it can irradiate nearby near infrared rays.
  • indocyanine green is used as a material containing a fluorescent dye, and the indocyanine green is irradiated with near-infrared light of 760 nm as excitation light, thereby approximately 800 nm from indocyanine green.
  • near-infrared light 760 nm as excitation light
  • near-infrared light 760 nm
  • light other than near-infrared light may be used.
  • 5-ALA (5-aminolevulinic acid / 5-aminolevulinic acid) can be used as a fluorescent dye.
  • 5-ALA When 5-ALA is used, 5-ALA that has entered the body of the patient 17 changes to a protoporphyrin IX / PpIX that is a fluorescent substance.
  • visible light of about 400 nm When visible light of about 400 nm is irradiated toward the protoporphyrin, red visible light is irradiated as fluorescence from the protoporphyrin. Therefore, when 5-ALA is used, an excitation light source that emits visible light having a wavelength of about 400 nm may be used, and a light source for confirmation emits fluorescence from protoporphyrin. What irradiates red visible light to be used may be used.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

La présente invention concerne une source de lumière pour vérification (24) qui est allumée, et une image photographiée à cet instant avec une caméra (21). Une lumière dans l'infrarouge proche présentant une longueur d'onde de 810 nm est projetée à partir de la source lumineuse de vérification (24), se rapprochant de la longueur d'onde de la lumière fluorescente qui est émise depuis le vert d'indocyanine. Lorsque la caméra (21) fonctionne normalement, une image d'une région dans laquelle la lumière dans l'infrarouge proche est projetée est photographiée par la caméra (21), et son image est affichée dans une unité d'affichage (14). Il est ainsi possible d'exécuter facilement une vérification de fonctionnement de la caméra (21).
PCT/JP2015/069603 2014-09-08 2015-07-08 Dispositif d'imagerie WO2016039001A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014182534 2014-09-08
JP2014-182534 2014-09-08

Publications (1)

Publication Number Publication Date
WO2016039001A1 true WO2016039001A1 (fr) 2016-03-17

Family

ID=55458763

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2015/069603 WO2016039001A1 (fr) 2014-09-08 2015-07-08 Dispositif d'imagerie

Country Status (1)

Country Link
WO (1) WO2016039001A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019180712A (ja) * 2018-04-09 2019-10-24 株式会社島津製作所 治療支援装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012050633A (ja) * 2010-08-31 2012-03-15 Fujifilm Corp 画像撮像装置

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012050633A (ja) * 2010-08-31 2012-03-15 Fujifilm Corp 画像撮像装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019180712A (ja) * 2018-04-09 2019-10-24 株式会社島津製作所 治療支援装置
JP7043947B2 (ja) 2018-04-09 2022-03-30 株式会社島津製作所 治療支援装置

Similar Documents

Publication Publication Date Title
JP6319448B2 (ja) イメージング装置
JP6299770B2 (ja) 赤外光イメージング装置
JP6319449B2 (ja) イメージング装置
JP5074044B2 (ja) 蛍光観察装置および蛍光観察装置の作動方法
JPH0924053A (ja) 外科手術支援システム
CN108882896A (zh) 用于评定组织的治愈的方法和系统
US9522240B2 (en) Visualization apparatus for vein
US10413619B2 (en) Imaging device
JP6184086B2 (ja) 光治療装置
KR20130133969A (ko) 영상분석을 통해 자동으로 시술영역 및 조사강도가 조절되는 레이저 시술장치
JP6485275B2 (ja) イメージング装置
US20190239749A1 (en) Imaging apparatus
WO2018003169A1 (fr) Dispositif d'imagerie
JP6512320B2 (ja) イメージング装置
WO2016039001A1 (fr) Dispositif d'imagerie
JP2019066398A (ja) イメージング装置
JP6295915B2 (ja) イメージング装置
JP2021186417A (ja) 治療支援装置および関心領域の設定方法
US20060264761A1 (en) Portable fluorescence scanner for molecular signatures
JP2015188559A (ja) 医療用イメージング装置
JP2017104147A (ja) 手術具に付ける蛍光体マーカー付設具、これを使用した手術具の体内残置検出方法、及び手術具の体内残置検出装置
US12114961B2 (en) Image processing apparatus and image processing method and non-transitory computer-readable medium
JP6432533B2 (ja) イメージング装置
JP2016112220A (ja) イメージング装置
JP2016112219A (ja) イメージング装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15839259

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15839259

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载