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WO2016010139A1 - Agent d'enduisage cosmétique, procédé de production d'un produit de charge cosmétique à base d'hydrogène, et produit de charge cosmétique à base d'hydrogène - Google Patents

Agent d'enduisage cosmétique, procédé de production d'un produit de charge cosmétique à base d'hydrogène, et produit de charge cosmétique à base d'hydrogène Download PDF

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Publication number
WO2016010139A1
WO2016010139A1 PCT/JP2015/070534 JP2015070534W WO2016010139A1 WO 2016010139 A1 WO2016010139 A1 WO 2016010139A1 JP 2015070534 W JP2015070534 W JP 2015070534W WO 2016010139 A1 WO2016010139 A1 WO 2016010139A1
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Prior art keywords
agent
hydrogen
coating
cosmetic
water
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PCT/JP2015/070534
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English (en)
Japanese (ja)
Inventor
昇平 北
Original Assignee
株式会社ヴェルシーナ
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Application filed by 株式会社ヴェルシーナ filed Critical 株式会社ヴェルシーナ
Priority to JP2016534501A priority Critical patent/JPWO2016010139A1/ja
Publication of WO2016010139A1 publication Critical patent/WO2016010139A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients

Definitions

  • the present invention relates to a cosmetic coating agent (hereinafter also simply referred to as “coating agent”), a method for producing a cosmetic hydrogen filling (hereinafter also simply referred to as “manufacturing method” or “method for producing hydrogen filling”) and cosmetics.
  • the present invention relates to a hydrogen filling for use (hereinafter also simply referred to as “hydrogen filling”). More specifically, a cosmetic coating agent capable of bringing hydrogen directly into contact with the target surface when applied to any target surface of the human body, and a method for producing a cosmetic hydrogen filling using the cosmetic coating agent And a hydrogen filling for cosmetics produced using a cosmetic coating agent.
  • Hydrogen is known to be generated by reacting certain substances with water. For example, it is known that hydrogen is generated by reacting a metal such as magnesium with water. However, hydrogen volatilizes as soon as it is generated. Therefore, it has a technical problem of how to efficiently contact the generated hydrogen with the target surface.
  • Patent Document 1 discloses a hydrogen generating powder (hereinafter also referred to as Prior Art 1) containing a substance that generates hydrogen by reacting with water (hydrogen generating substance) and solid particles. Yes. It is described in Patent Document 1 that the conventional technique 1 generates hydrogen by reacting with moisture in an object when it contacts an object containing moisture. More specifically, the prior art 1 which is a cosmetic containing a substance that generates hydrogen and solid particles that are cosmetic ingredients is disclosed. Prior art 1 which is a cosmetic product generates hydrogen by reacting the substance that generates hydrogen with moisture in the skin.
  • the hydrogen-generating substance stays on the skin and reacts with moisture in the skin to continue to generate hydrogen. Therefore, it is described that hydrogen can be supplied to the skin for a long time.
  • the prior art 1 uses the moisture in the skin, the amount of moisture is limited, and the amount of hydrogen generated in a predetermined time is limited. Therefore, it is difficult for Conventional Technology 1 to bring a desired amount of hydrogen into contact with the skin within a predetermined time.
  • Patent Document 2 discloses an external preparation (hereinafter also referred to as Prior Art 2) in which a gel containing magnesium powder is a first agent and a gel containing citric acid or the like is a second agent (hereinafter also referred to as Prior Art 2).
  • the magnesium powder contained in the first agent has a passive film formed on the surface in advance so as not to generate hydrogen by reacting with moisture in the first agent.
  • the second agent contains citric acid in advance.
  • the passive film is first removed by citric acid contained in the second agent, and the magnesium powder and the second agent thus exposed are removed. It reacts with the contained water to generate hydrogen.
  • the application state applied to the skin is determined for a predetermined time (for example, several minutes to several tens of minutes). ) Can be maintained.
  • the gel contains a large amount of water and can be said to be a technique superior to the prior art 2 in that it is difficult to be limited by the amount of water for reacting with the magnesium powder.
  • the prior art 2 has the following problems. That is, in the prior art 2, it is difficult to uniformly mix the first agent that is gel and the second agent that is gel. In particular, when the user of the prior art 2 manually mixes the first agent and the second agent, there is a problem that it is very difficult to uniformly mix them.
  • bad mixture the mixture of the first agent and the second agent in the prior art 2 in an insufficiently mixed state (hereinafter also referred to as “bad mixture”) is applied to the application surface, the generated hydrogen efficiently contacts the application surface. It is difficult to make it.
  • the poor mixing of the first agent and the second agent means that magnesium is not uniformly dispersed in the defective mixture. Therefore, even if the defective mixture is applied to the application surface and hydrogen is generated on the application surface, the hydrogen is difficult to uniformly contact the application surface. That is, there is a possibility that the amount of generated hydrogen is partially biased due to a difference in the amount of magnesium present in the coated surface on which the defective mixture is coated, and as a result, the hydrogen contact with the coated surface may be biased.
  • the present inventor has improved the mixing and homogenization of the first agent and the second agent through the above-described investigation, and makes hydrogen contact uniformly with the coating surface, whereby the redox action (antioxidation action) by the hydrogen. Has been recognized that it can be exhibited evenly on the coated surface.
  • an object of the first aspect of the present invention is to provide a coating agent capable of bringing a desired amount of hydrogen into contact with the coating surface without deviation for a predetermined time.
  • the second aspect of the present invention provides a method for producing a semi-fluid hydrogen filling material filled with hydrogen by mixing the first agent and the second agent with improved mixing and homogenization. Let it be an issue.
  • the third aspect of the present invention is to provide a hydrogen filling material in which hydrogen is filled in a semi-fluid material by mixing the first agent and the second agent with improved mixing and homogenization. To do.
  • the cosmetic coating agent of the present invention is a semi-fluid containing a first agent, which is a powder containing a hydrogen generating material capable of generating hydrogen by contact with water, and mixed with the first agent. And a second agent which is a product.
  • the first agent and the second agent are mixed, the hydrogen generating material contained in the first agent is brought into contact with moisture contained in the second agent, and hydrogen is added.
  • hydrogen is added.
  • the cosmetic hydrogen filling material of the present invention is characterized in that hydrogen generated by mixing the first agent and the second agent is filled in a semi-fluid material constituting the second agent.
  • the coating agent according to the first aspect of the present invention since the first agent is a powder and the second agent is a semi-fluid material, the mixing and homogenization of both is improved. Therefore, the coating agent of this invention can disperse
  • the third aspect of the present invention can provide a hydrogen-filled material in which hydrogen is filled in a state that is equal to or nearly equal to a semi-fluid material.
  • FIG. 2A and FIG. 2B are explanatory diagrams for explaining a process of generating hydrogen using the coating agent according to the first embodiment
  • FIG. 2A shows the first agent and the second agent added to the mixing container
  • FIG. 2B shows a state before the first agent and the second agent are mixed in the mixing container
  • FIG. 2C shows a state where the first agent and the second agent are mixed.
  • FIG. 3A is an enlarged schematic diagram showing one aspect of the coated product in the first embodiment
  • FIG. 3B is an enlarged schematic diagram showing another aspect of the coated product in the first embodiment. It is a schematic diagram which shows the storage container with which the hydrogen filling concerning 2nd embodiment was filled.
  • FIG. 1 is a front view of a sealed container 112 filled with the first agent 10 and a sealed container 114 filled with the second agent 20 in the first embodiment.
  • FIG. 2A shows a state before mixing the first agent 10 and the second agent 20 added to the mixing container 120.
  • FIG. 2B shows a state in which the first agent 10 and the second agent 20 are mixed in the mixing container 120.
  • FIG. 2C shows a state in which the hydrogen filling 200 obtained by mixing the first agent 10 and the second agent 20 is applied to the vertical surface 142 of the test plate 140.
  • FIG. 3A is an enlarged schematic view showing a coating product 50 which is one aspect in the first embodiment
  • FIG. 3B is an enlarged schematic view showing a metal complex coating product 50A which is another aspect in the first embodiment.
  • the “application surface” refers to the surface of a human body, and the application agent of the first invention is applied to skin (including the scalp), hair, or nails. It means a place (or a place where the hydrogen filling material of the third invention is applied).
  • Applying the coating agent of the first aspect of the present invention to the coating surface means that the first agent and the second agent are mixed in advance to form a mixture, and hydrogen is generated before or is generated in the mixture. In a state, it includes applying to an application surface. For the above application, the first agent and the second agent are applied to the application surface, and then the first agent and the second agent are mixed on the application surface to form a mixture. Generating hydrogen.
  • the coating agent or hydrogen filling material of the present invention can be applied to the face as a cosmetic pack (or a hydrogen filling material is applied).
  • the cosmetic pack includes a type that is applied to the face and washed away after maintaining the application state for a predetermined time, and a cream type that does not require washing after application.
  • the application location of the coating agent and hydrogen filling material of the present invention is not limited to the face.
  • the coating agent and hydrogen filling material of the present invention are applied as cosmetics to the coated surface.
  • cosmetic means an application for cosmetic purposes.
  • the coating agent and hydrogen filling material of the present invention are used for cosmetic purposes on the skin such as the face, neck, arms, feet, scalp, nails, or hair. Beauty as used herein refers to expecting the body surface that has been damaged by active oxygen to be beautifully prepared or to be repaired, or to recover or recover the damage, except for medical purposes. including.
  • the coating agent 100 according to the present embodiment is mixed with the first agent 10, which is a powder containing the hydrogen generating material 12 that can generate hydrogen by contact with water, and contains moisture.
  • the first agent 10 is a powder material
  • the second agent 20 is a semi-fluid material 22. Therefore, compared with the mixing of gel and gel in the prior art 2, the coating agent 100 can easily mix both (that is, the first agent 10 and the second agent 20) uniformly, thereby achieving uniform mixing. It has been. Therefore, the mixture 30 (refer FIG. 2B) obtained by mixing the 1st agent 10 and the 2nd agent 20 contains the hydrogen generating material 12 disperse
  • the well-dispersed hydrogen 40 is present inside the mixture 30, and the hydrogen 40 can be uniformly brought into contact with the coating surface 144 (see FIG. 2C).
  • produced inside the mixture 30 is also called the hydrogen filling 200 suitably.
  • the application surface 144 of the test plate 140 is schematically shown as the body surface to which the application agent 100 is applied.
  • the coating agent 100 quickly surrounds the powder material with moisture by mixing the second agent 20 containing water and the first agent 10. be able to. Therefore, even if the powder 30 that is the first agent 10 is locally biased in the mixture 30, the hydrogen generating material 12 contained in the powder and the surrounding first The water of the two agents 20 can be reacted quickly to initiate a hydrogen generation reaction. That is, the coating agent 100 avoids the delay of the start of the hydrogen generation reaction based on the nonuniform mixing as in the prior art 2.
  • the second agent 20 is a semi-fluid material 22 and can control the properties of the mixture 30 obtained by mixing the first agent 10 and the second agent 20 to the semi-fluidity. Since the mixture 30 is semi-fluid, it is possible to maintain a state where it adheres to the coating surface 144 for a predetermined time. Therefore, according to the coating agent 100, the mixture 30 containing the water derived from the second agent 20 is adhered to the coating surface 144 for a predetermined time, so that a desired amount of hydrogen 40 is brought into contact with the coating surface 144 without any bias for a predetermined time. be able to.
  • the mixture 30 is semi-fluid even when applied to the application surface 144 for a predetermined time, so that the water contained therein is difficult to evaporate. Therefore, the mixture 30 has sufficient hydrogen 40 to react with the hydrogen generating material 12 while being applied to the skin. For example, if it is applied to any skin surface such as the face with moisture in a non-woven sheet, it will be affected by the influence of outside air temperature or body temperature during About 15% to 35% of the water is evaporated with respect to the water contained in the sheet. Compared to such a sheet, the moisture retention of the mixture 30 is significantly superior.
  • the first agent 10 and the second agent 20 are hermetically sealed in a sealed container 112 and a sealed container 114, respectively, for example, as shown in FIG.
  • the term “sealed” means that the contents are enclosed in an impermeable container.
  • the sealed container 112 is filled with the first agent 10 from an opening (not shown), and the opening is closed and sealed by a sealed clasp 116.
  • the bag-like sealed container 112 and the sealed container 114 are illustrated in FIG. 1, the form of the container that encloses the first agent 10 and the second agent 20 is not limited thereto. Details of the coating agent 100 of the present invention will be described below.
  • the first agent 10 is a powder containing a hydrogen generating material 12 capable of generating hydrogen 40 by contact with water.
  • the powder material means an aggregate made up of a large number of powders.
  • a large number of powders constituting the powder material include cases in which aggregates are formed in various forms such as powder, granule, and powder.
  • the size of the powder is not particularly limited.
  • the particle size (longest diameter) is in the range of 0.01 mm to 3 mm, preferably 0.05 mm to 1 mm, more preferably 0.00.
  • the range is 1 mm or more and 0.5 mm or less.
  • the size of the powder is not less than the above lower limit, it is preferable in terms of easy handling of the first agent 10.
  • the size of the powder is not more than the above upper limit in that the total contact area between the powder and moisture can be increased, and prompt dissolution of the powder or prompt generation of hydrogen can be promoted.
  • the particle size of the powder is measured according to JIS Z 8815: 1994 “General Rules for Screening Test Method”.
  • the hydrogen generating material 12 is, for example, a metal such as magnesium, calcium, calcined calcium, uncalcined calcium or aluminum; a hydrogenated metal such as magnesium hydride, calcium hydride, silicon hydride or barium hydride; a semimetal such as germanium; Examples of silicic acid, silicic acid anhydride, aluminum silicate, silicic acid-based hydrogen such as silica-absorbed hydrogen in which hydrogen is embedded in silicon dioxide or silicon oxide; minerals such as germanium, or combinations of two or more selected from these However, the present invention is not limited to this.
  • the hydrogen generating material 12 includes not only a material that quickly generates hydrogen when it comes into contact with water, but also a material that generates hydrogen due to the presence of an acid, a base, or a catalyst together with water.
  • a metal or a metal hydride can be preferably selected as the hydrogen generating material 12 in the present embodiment.
  • magnesium can be preferably selected as the metal that is the hydrogen generating material 12.
  • magnesium hydride can be preferably selected as the metal hydride that is the hydrogen generating material 12. This is because magnesium can be taken as a mineral component and has no adverse effects on the human body, so it is excellent in safety when applied to the skin.
  • the first agent 10 in the present embodiment may include a coating product 50 in which the hydrogen generating material 12 is coated with the water-soluble film 52.
  • the coating 50 is formed by coating the metal 14 as the hydrogen generating material 12 with a water-soluble film 52. That is, the first agent 10 includes a coating 50 having a water-soluble film 52 and the hydrogen generating material 12 disposed inside the water-soluble film 52.
  • “arranged inside the water-soluble film 52” means a state where the water-soluble film 52 is covered.
  • the first agent 10 may be substantially composed of only one or a plurality of coating materials 50, and includes both the hydrogen generating material 12 and the coating material 50 that are not covered with the water-soluble film 52 and whose surface is exposed. It may be comprised.
  • the hydrogen generating material 12 is covered with the water-soluble coating 52.
  • the aspect in which one or more granular hydrogen generating materials 12 are effectively included in the water-soluble coating 52 a plurality of This includes a mode in which the granular hydrogen generating material 12 is bound by the water-soluble film 52 and granulated. A part of the outer peripheral surface of the granulated product granulated as described above may be covered with the water-soluble film 52, or the entire outer periphery may be covered with the water-soluble film 52.
  • the coating 50 includes the water-soluble film 52, the coating 50 has good affinity for the water-containing semi-flowable material 22, and when the aggregate of the coating 50 is mixed with the second agent 20, the coating 50 is condensed. It prevents the collection (so-called “dama”). Therefore, the coating 50 is excellent in dispersibility in the second agent 20. From this point of view, it is preferable that all of the hydrogen generating material 12 contained in the first agent 10 is contained in the coating 50. This is because the dispersibility of the hydrogen generating material 12 in the second agent 20 is particularly improved.
  • the hydrogen generating material 12 contained in the coating 50 is coated with the water-soluble film 52, it is prevented or suppressed from absorbing hydrogen in the atmosphere and generating hydrogen in the storage state. Therefore, unlike the prior art 2, it is not necessary to form a passive film on the metal material in advance and to make it contained in the gel. From the viewpoint of avoiding that the hydrogen generating material 12 reacts with moisture in the outside air to generate hydrogen, the hydrogen generating material 12 is completely enclosed by the water-soluble film 52 so as to be shielded from the outside air. Is preferred.
  • the water-soluble film 52 is formed of, for example, a water-soluble compound such as polyethylene glycol (PEG), polyvinyl pyrrolidone (PVP), hydroxypropyl cellulose (HPC) or sugar; a water-soluble excipient such as lactose, starch or corn starch, or these Although a mixture can be illustrated, it is not limited to this. Further, the water-soluble film 52 may be composed of only the water-soluble compound or water-soluble excipient as described above, or may contain any material in addition to the water-soluble compound or water-soluble excipient. Good.
  • the mass of the water-soluble film 52 in the coating 50 is not particularly limited.
  • the mass of the water-soluble film 52 is preferably 0.5% by mass or more and 20% by mass or less with respect to the mass of the coating product 50 (100% by mass). It is more preferable that it is 10% by mass or more.
  • the coating 50 formed by coating the hydrogen generating material 12 and the like with a small amount of the water-soluble film 52 when the first agent 10 and the second agent 20 are mixed, the moisture contained in the second agent 20 Thus, the water-soluble film 52 can be quickly dissolved.
  • the hydrogen generating material 12 such as magnesium is quickly exposed to the second agent 20 and the hydrogen generating reaction starts.
  • the water-soluble film 52 in the present embodiment preferably contains PEG in the range of 70% by mass or more and 100% by mass or less.
  • the coating material 50 may be composed of only the water-soluble film 52 and the hydrogen generating material 12, but may include an optional material 18, which is another component, together with the hydrogen generating material 12 as shown in FIG. 3A.
  • the coating 50 in this embodiment has the acid substance 16 covered with the water-soluble film 52 together with the hydrogen generating material 12 (see FIG. 3A). That is, the coating 50 has the acid substance 16 together with the hydrogen generating material 12, and both the hydrogen generating material 12 and the acid substance 16 are disposed inside the water-soluble film 52. In other words, the hydrogen generating material 12 and the acid substance 16 are included in the water-soluble film 52 in one coating 50.
  • the hydrogen generating material 12 and the acid substance 16 can be reacted efficiently. That is, since the second agent 20 is a semi-fluid substance 22, the particles mixed in the second agent 20 have a characteristic that it is difficult to diffuse compared to the liquid solvent. Accordingly, the first agent 10 and the second agent 20 containing the coating product 50 are mixed to dissolve the water-soluble film 52, and then the hydrogen generating material 12 and the acid substance 16 that are included in the coating product 50 are brought close to each other. It is possible to start the hydrogen generation reaction in the maintained state. By mixing the coating material 50 with the second agent 20 which is a semi-fluid material 22, compared with the case where the coating material 50 is mixed with a liquid solvent, a very advantageous effect can be obtained in terms of utilization of the acid substance 16. Demonstrate.
  • the first purpose is as follows. It is known that when a metal material such as magnesium or magnesium hydride reacts with water, a metal salt is generated and the reaction system is biased toward the alkaline side. Therefore, it is desirable to neutralize the skin so that the coating agent 100 is not excessively stimulated.
  • the acid substance 16 can act as an acid required for such neutralization.
  • the neutrality is not strictly limited to pH 7, but means around pH 7, which is a range that does not adversely affect the skin.
  • the second purpose is as follows. In studying the present invention, a new finding has been obtained that an acid contributes to promote a reaction for generating hydrogen 40 from a metal material and water.
  • the purpose of causing the coating material 100 to contain the acid substance 16 in this embodiment is not limited to the first purpose described above, but also aims to promote the hydrogen generation reaction.
  • the mode in which the acid substance 16 is included in the coating 50 has been described.
  • the acid substance 16 contained in the coating agent 100 is not limited to this, and may be contained in the first agent 10 as a powder different from the coating product 50, or may be described later in addition to the first agent 10.
  • the second agent 20 may be included.
  • the hydrogen generating reaction starts in a state where the hydrogen generating material 12 and the acid substance 16 both encapsulated in the coating 50 are close to each other in the second agent 20. Is very favorable.
  • the aspect of dissolving the water-soluble film 52 containing the hydrogen generating material 12 and the acid substance 16 inside the second agent 20 that is the semi-fluid material 22 is sufficient to achieve the second object. This is a very preferred embodiment.
  • a metal complex 60 in which a metal material (metal simple substance or metal hydride) as the hydrogen generating material 12 is coordinated to an acid substance 16 such as citric acid is used as the first agent 10. It is mentioned to make it contain.
  • a metal complex 60 in which the acid substance 16 is coordinated to a metal material capable of generating hydrogen 40 by contact with water can be used as the hydrogen generating material 12 in the coating agent 100.
  • the coating 50 in this embodiment may be a metal complex coating 50A in which a metal complex 60 is coated with a water-soluble film 52 as shown in FIG. 3B. That is, the coating 50 may be a metal complex coating 50 ⁇ / b> A having a water-soluble film 52 and a metal complex 60 disposed inside the water-soluble film 52.
  • the metal complex 60 is configured by the acid substance 16 being coordinated to the metal 14 or the hydrogenated metal that is the hydrogen generating material 12.
  • the metal complex 60 is covered with the water-soluble film 52 when the first agent 10 and the second agent 20 are mixed. The coordination structure is prevented from collapsing. After the water-soluble film 52 is dissolved, the hydrogen generation reaction can be started in a state where the metal material that is the hydrogen generating material 12 and the acid substance 16 are in very close positions. Therefore, in particular, the second object can be suitably realized.
  • the hydrogen generation reaction when the first agent 10 and the second agent 20 are mixed is promoted, and the amount of hydrogen generated increases.
  • the stimulation given to the coated surface also increases. For this reason, when the application surface is a portion that is relatively weak to irritation such as a face, there is a case where it is desired to reduce irritation caused by hydrogen generation.
  • the stimulation caused by the hydrogen generation described above can be reduced by containing a cationized polysaccharide (cationized polysaccharide) in the second agent 20.
  • a cationized polysaccharide cationized polysaccharide
  • the mechanism for reducing the irritation is not clear, when the second agent 20 containing the cationized polysaccharide and the first agent 10 containing the metal complex 60 are mixed and applied to the application surface, a large amount Hydrogen can be brought into contact with the application surface and can be unstimulated or hypostimulated.
  • the cationized polysaccharide in the second agent 20 it is possible to reduce the irritation that the hydrogen generated by mixing with the first agent 10 gives to the skin, and a sufficient amount for the skin under a good feeling of use. Of hydrogen can be contacted.
  • the cationized polysaccharide means a polysaccharide in which a part of hydroxyl groups contained in the polysaccharide is cationized.
  • the polysaccharide include, but are not limited to, xanthan gum, guar gum, cellulose, cellulose derivative, and hyaluronic acid.
  • cationized xanthan gum is preferable because it has a remarkable effect of reducing the irritation caused by the generation of hydrogen described above.
  • examples of the cationized xanthan gum include, but are not limited to, xanthan hydroxypropyltrimonium (xanthan hydroxypropyltrimethylammonium) and the like.
  • the total amount of the acid substance 16 contained in the first agent 10 and the second agent 20 in the coating agent 100 is as follows. It can be as follows. That is, when the metal 14 or metal hydride contained in the first agent 10 as the hydrogen generating material 12 is all converted to a metal salt, an amount exceeding the amount of the acid substance 16 required to neutralize the metal salt without excess or deficiency. Is preferably contained in one of the first agent 10 and the second agent 20 or distributed to the first agent 10 and the second agent 20.
  • the coating agent 100 is an m-valent salt (molar equivalent (X / m)) in which the metal salt generated by the reaction of the metal 14 or the metal hydride 12 as the hydrogen generating material 12 with moisture is the molar mass X.
  • the acid substance 16 contained in the coating agent 100 is an n-valent acid (molar equivalent (Y / n)) having a molar mass Y, it is preferable to satisfy the following formula 3. Molar equivalent of acid (Y / n)> Mole equivalent of salt (X / m) (Formula 3)
  • the coating agent 100 showing such a relationship can be realized for both the first purpose and the second purpose.
  • Examples of the acid substance 16 that can be included in the coating agent 100 include citric acid, aconitic acid, malic acid, acetic acid, fumaric acid, maleic acid, adipic acid, malonic acid, succinic acid, succinic anhydride, oxalic acid, and tartaric acid. Any or a combination of organic acids is exemplified. However, the acid substance 16 is not limited to these as long as the first object and / or the second object can be realized. These acid substances 16 are contained in the first agent 10 and / or the second agent 20.
  • the molar equivalent of the acid is described, but when two or more kinds of acids are contained in the first agent 10 and / or the second agent 20, it is calculated for each of the two or more kinds of acids contained.
  • the total molar equivalents in the first agent 10 or the second agent 20 may be applied to the above formula 3. The same applies to the molar equivalent of the salt.
  • the coating material 50 used in the present embodiment may appropriately contain a metal 14 (or a hydrogenated metal) that is the hydrogen generating material 12 and an optional material 18 other than the acid substance 16. .
  • an optional material 18 other than the metal complex 60 may be appropriately contained in the metal complex coating 50A as shown in FIG. 3B.
  • the optional material 18 can be determined as appropriate without departing from the spirit of the present invention.
  • a material containing a component that can suitably act on the skin or the body is suitable as the optional material 18.
  • the optional material 18 is not limited to one type, and two or more different components may be selected as the optional material 18.
  • a fragrance, a preservative, a color material, or the like may be selected as the optional material 18.
  • the optional material 18 includes, for example, ascorbic acid or a derivative thereof, carotenoid, polyphenol, or an antioxidant such as coenzyme Q10; collagen peptide N-acetylglucosamine and the like can be mentioned.
  • Ascorbic acid derivatives include ascorbic acid sodium salt, ascorbic acid potassium salt, ascorbic acid magnesium salt, dehydroascorbic acid, and ascorbic acid glucoside.
  • polyphenols include flavonoids such as anthocyanins, quercetin, rutin, or isoflavones, or catechins.
  • the coating agent 100 by applying the coating agent 100 to the skin, the hydrogen 40 generated is brought into contact with the skin to exert an antioxidant effect, and any one or two or more antioxidant substances described above are selected as the optional material 18. Therefore, a higher antioxidant action can be exhibited, which is preferable.
  • the second agent 20 is an agent that is planned to be used in combination with the first agent 10, and contains moisture for reacting with the hydrogen generating material 12 contained in the first agent 10 to generate hydrogen 40.
  • This is a semi-fluid material 22.
  • the semi-fluid material 22 means a material having a fluid property between a liquid and a solid.
  • the semi-fluid material 22 preferably has a fluidity that does not easily flow due to the action of gravity in the outside air at room temperature.
  • the semi-fluid substance 22 here contains the solid substance which becomes semi-fluid easily by simple mixing.
  • the semi-fluid material 22 is a non-fluid material having a fixed shape such as agar or jelly, but includes a material that can be easily formed into an irregular shape and a semi-fluid by a simple mixing operation. .
  • the second agent 20 is previously adjusted to a preferable viscosity so that a mixture 30 obtained by mixing the first agent 10 and the second agent 20 also becomes a semi-fluid material 22 suitable for application.
  • the coating agent 100 does not easily flow down from the coating surface due to gravity.
  • the area of the virtual drooping surface 146 that indicates the virtual drooping surface of the hydrogen filling 200 is zero or slightly after a predetermined time has elapsed with respect to the coating surface 144 just after the hydrogen filling 200 is applied. It is preferable that From this point of view, the fluidity of the semi-fluid material 22 is preferably adjusted to the following range, for example.
  • the hydrogen filling 200 is applied to the vertical surface 142 of the test plate 140 in the range of the application area S1, and after being left for 10 minutes, the application area S2 of the hydrogen filling 200 after a predetermined time (application surface 144 + virtual drooping surface) 146).
  • the ratio of the coating area S2 after the lapse of a predetermined time when the coating area S1 is 100% is preferably 100% or more and 120% or less, and preferably 100% or more and 115% or less with respect to the coating area S1. More preferably, it is 100% or more and 110% or less.
  • the ratio of the coating area S2 being 100% means that drooping of the hydrogen filling material 200 did not substantially occur after a predetermined time.
  • the test for confirming the change in the coating areas S1 and S2 described above may be performed at room temperature (about 23 ° C. ⁇ 2 ° C.).
  • the vertical surface 142 of the test plate 140 is a smooth surface made of, for example, a resin.
  • the thickness of the hydrogen filling material 200 applied to the vertical surface 142 is preferably in the range of 0.5 mm or more and 5 mm or less, and the minimum value may be selected from the thicknesses at which the hydrogen filling material 200 can be applied as uniformly as possible.
  • the second agent 20 in the present embodiment can be in the form of a gel, cream, paste, or mousse, for example. Any of these can provide preferable properties as the semi-fluid material 22, and good coating properties to the skin are expected.
  • gel is a highly viscous and fluid amorphous state, and is solid and non-fluid, such as agar-like, jelly-like, etc. Includes those that can be amorphous and semi-fluid.
  • the cream form and paste form refer to an indeterminate state having high viscosity and fluidity.
  • Examples of the component contained in the second agent 20 for causing semi-fluidity include cellulose derivatives such as methylcellulose, carboxymethylcellulose, hydroxyethylcellulose, and hydroxypropylcellulose; polysaccharides such as xanthan gum and guar gum; glycerin; agar It can be selected from gelatin and the like.
  • cellulose derivatives such as methylcellulose, carboxymethylcellulose, hydroxyethylcellulose, and hydroxypropylcellulose
  • polysaccharides such as xanthan gum and guar gum
  • glycerin glycerin
  • agar It can be selected from gelatin and the like.
  • One or more of these components are contained in the semi-fluid 22.
  • the 2nd agent 20 may contain either or both of a clay (viscosity) component or the thickening component mentioned later. .
  • the thickening component refers to a material that swells when added to water or an aqueous solvent and can impart thickening to the water or aqueous solvent.
  • the thickening component include inorganic components derived from minerals, but are not limited thereto. Specifically, for example, one or a combination of two or more selected from aluminum magnesium silicate, magnesium magnesium silicate, montmorillonite, beidellite, hectorite, saponite, and stevensite can be mentioned, but not limited thereto. .
  • Water or an aqueous solvent to which a thickening component is added has low fluidity within an appropriate range. Therefore, the second agent 20 containing a thickening component has a high viscosity.
  • the fluidity as used herein is not particularly specified by a strict numerical value, but includes from a degree that the user feels thicker than purified water to a gel-like degree having a lower fluidity.
  • the second agent 20 which is a semi-fluid material 22 contains moisture.
  • the moisture reacts with the hydrogen generating material 12 in the first agent 10 to generate hydrogen 40.
  • the water content in the second agent 20 is preferably 65% or more and 90% or less, and more preferably 70% or more and 85% or less with respect to 100% by mass of the total amount of the second agent 20.
  • the semi-flowable material 22 as the second agent 20 includes a member for increasing moisture and viscosity (or clay), and a fragrance, a mineral component, a preservative, a moisturizing agent and the like without departing from the spirit of the present invention.
  • Optional ingredients may be added.
  • the production method of the present invention can also be understood as one usage mode of the coating agent 100 according to the first present invention.
  • the coating material 100 can provide the hydrogen filling material 200 by using it according to the method for producing a hydrogen filling material according to the second aspect of the present invention.
  • the production method of the present invention does not limit the method of using the coating agent 100.
  • the first agent 10 and the second agent 20 described above are mixed, and the hydrogen generating material 12 contained in the first agent 10 is changed to the second agent 20. Hydrogen 40 is generated in contact with the contained moisture. Thereby, the semi-fluid hydrogen filling 200 filled with the hydrogen 40 can be manufactured. According to the production method of the present invention, it is possible to easily provide the semi-fluid hydrogen filling 200 in which the hydrogen 40 is well dispersed and the hydrogen 40 is filled.
  • the 1st agent 10 and the 2nd agent 20 are prepared, and as shown to FIG. 2A, these are added to the mixing container 120 of an upper opening by appropriate amounts.
  • the order of addition is not particularly limited, for example, it is preferable to first add the second agent 20 to the mixing container 120 and add the first agent 10 as evenly as possible.
  • the first agent 10 and the second agent 20 are mixed in the mixing container 120 using a suitable stirring tool (for example, a spoon 130) to form a mixture 30.
  • a suitable stirring tool for example, a spoon 130
  • hydrogen 40 is generated by the contact between the hydrogen generating material 12 contained in the first agent 10 and the moisture contained in the second agent 20, whereby the hydrogen filling 200 is obtained.
  • the mixture 30 or the hydrogen filling 200 obtained thereby can be applied to a predetermined region of the human body, and the hydrogen 40 can be brought into contact with the skin in the region.
  • a coating agent 100 in which the first agent 10 and the second agent 20 are sealed in a sealed container 112 and a sealed container 114, respectively. It is preferable to provide 1). Thereby, the user can easily carry out the production method of the present invention without obtaining a predetermined amount of the first agent 10 and the second agent 20 and obtain the hydrogen filling 200.
  • FIG. 4 is a schematic diagram showing the storage container 150 filled with the hydrogen filling 200 according to the second embodiment.
  • the hydrogen filling material 200 is configured by filling the semi-fluid material 22 constituting the second agent 20 with the hydrogen 40 generated by mixing the first agent 10 and the second agent 20 described above. That is, the hydrogen filling material 200 includes the first agent 10 or the reaction product of the first agent 10, the second agent 20, and the hydrogen 40.
  • the reaction product of the first agent 10 means a by-product generated when the first agent 10 reacts with the second agent 20 to generate hydrogen 40.
  • the reactant is magnesium hydroxide.
  • the hydrogen filling material 200 has a characteristic that the hydrogen 40 is difficult to volatilize because the semi-fluid material 22 is filled with the hydrogen 40. That is, the hydrogen filling material 200 can maintain the filling state of the hydrogen 40 for a long time.
  • the hydrogen filling material 200 in this embodiment is stored in a storage container 150 including a container main body 152 and a lid 154.
  • a storage container 150 including a container main body 152 and a lid 154 By storing the hydrogen filling 200 in the storage container 150 including the lid 154 that can be opened and closed, the hydrogen filling 200 can be applied in a desired amount at the time of use.
  • the hydrogen filling 200 may be packaged in appropriate amounts. By sealing the hydrogen filling material 200 inside the packaging container, it is possible to further prevent the hydrogen 40 filled in the hydrogen filling material 200 from volatilizing.
  • the hydrogen filling material 200 in the present embodiment includes both an aspect in which the hydrogen generating material 12 included in the first agent 10 does not remain and an aspect in which the hydrogen generating material 12 remains.
  • FIG. 4 shows a mode in which the hydrogen generating material 12 remains in the hydrogen filling 200.
  • the first agent 10 and the second agent 20 are mixed to form the mixture 30, and before the entire amount of the hydrogen generating material 12 is used for the reaction of hydrogen generation, the hydrogen filling 200 is sealed in a sealable container. You may store, maintaining the state applied.
  • the term “before the total amount of the hydrogen generating material 12 is used for the reaction of hydrogen generation” refers to a state where the hydrogen 40 and the hydrogen generating material 12 are mixed in the hydrogen filling 200.
  • applying an internal pressure in a storage container means adjusting the pressure inside a storage container so that it may become higher than an external pressure. As a result, further hydrogen generation reaction can be suppressed inside the container, and the hydrogen generating material 12 can be left in the hydrogen filling 200. After the sealable storage container is opened, the hydrogen generating material 12 remaining in the hydrogen filling 200 reacts with moisture contained in the hydrogen filling 200 to generate hydrogen 40.
  • the above embodiment includes the following technical idea.
  • a first agent that is a powder containing a hydrogen generating material capable of generating hydrogen by contact with water
  • a second agent which is a semi-fluid material containing water and mixed with the first agent
  • a cosmetic coating agent comprising: (2) The cosmetic coating agent according to (1), wherein the hydrogen generating material is a metal or a metal hydride.
  • the first agent includes a coating obtained by coating the hydrogen generating material with a water-soluble film.
  • the coating includes a metal complex coating in which a metal complex is coated on the water-soluble film, The said metal complex is a cosmetic coating agent as described in said (6) formed by the said acid substance coordinating to the metal or hydrogenation metal which is the said hydrogen generating material.

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Abstract

　L'invention concerne un agent d'enduisage grâce auquel il est possible d'amener une quantité souhaitée d'hydrogène en contact uniforme avec une surface d'enduisage pour un temps déterminé. L'agent d'enduisage (100) contient un premier agent (10) qui est une poudre contenant un matériau générant de l'hydrogène, apte à générer de l'hydrogène au contact de l'eau, et un second agent (20) qui est un semi-fluide (22) contenant de l'eau, et qui est mélangé avec le premier agent (10) pour utilisation.
PCT/JP2015/070534 2014-07-18 2015-07-17 Agent d'enduisage cosmétique, procédé de production d'un produit de charge cosmétique à base d'hydrogène, et produit de charge cosmétique à base d'hydrogène WO2016010139A1 (fr)

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KR101840943B1 (ko) 2016-11-03 2018-03-21 김현수 수소 발생제 조성물
CN110225890A (zh) * 2015-12-04 2019-09-10 小林光 含氢溶液、含氢溶液的制造方法、含氢溶液的制造装置、及活体用氢生成材料
US10617712B2 (en) 2016-01-29 2020-04-14 Kit Co. Ltd. Solid preparation, method for producing solid reparation, and method for generating hydrogen
US11707063B2 (en) 2016-08-23 2023-07-25 Bosquet Silicon Corp. Compound, production method therefor, and hydrogen supply method
DE102022127153A1 (de) 2022-10-17 2024-04-18 Viawa Gmbh Wasserstoffgas enthaltender schaum

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CN110225890A (zh) * 2015-12-04 2019-09-10 小林光 含氢溶液、含氢溶液的制造方法、含氢溶液的制造装置、及活体用氢生成材料
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CN110191699A (zh) * 2016-08-23 2019-08-30 小林光 氢供给材料与其制造方法、及氢供给方法
KR101840943B1 (ko) 2016-11-03 2018-03-21 김현수 수소 발생제 조성물
DE102022127153A1 (de) 2022-10-17 2024-04-18 Viawa Gmbh Wasserstoffgas enthaltender schaum
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