WO2013171098A3 - Method for producing l-cysteine using a benzoic acid-containing culture medium - Google Patents
Method for producing l-cysteine using a benzoic acid-containing culture medium Download PDFInfo
- Publication number
- WO2013171098A3 WO2013171098A3 PCT/EP2013/059477 EP2013059477W WO2013171098A3 WO 2013171098 A3 WO2013171098 A3 WO 2013171098A3 EP 2013059477 W EP2013059477 W EP 2013059477W WO 2013171098 A3 WO2013171098 A3 WO 2013171098A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cysteine
- producing
- benzoic acid
- culture medium
- containing culture
- Prior art date
Links
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 title abstract 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title abstract 4
- 239000005711 Benzoic acid Substances 0.000 title abstract 2
- 235000010233 benzoic acid Nutrition 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000001963 growth medium Substances 0.000 title 1
- 235000013878 L-cysteine Nutrition 0.000 abstract 2
- 239000004201 L-cysteine Substances 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 150000003548 thiazolidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention relates to a method for producing L-cysteine and the L-cysteine and thiazolidine derivatives thereof by fermenting a micro-organism strain in a fermentation medium to which benzoic acid is added in a concentration range of 1-500 mg/L.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012208359.6 | 2012-05-18 | ||
| DE102012208359A DE102012208359A1 (en) | 2012-05-18 | 2012-05-18 | Process for the fermentative production of L-cysteine and derivatives of this amino acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2013171098A2 WO2013171098A2 (en) | 2013-11-21 |
| WO2013171098A3 true WO2013171098A3 (en) | 2014-01-09 |
Family
ID=48430738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2013/059477 WO2013171098A2 (en) | 2012-05-18 | 2013-05-07 | Method for the fermentative production of l-cystein and derivates of said amino acid |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE102012208359A1 (en) |
| WO (1) | WO2013171098A2 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1442263A1 (en) * | 1964-08-24 | 1969-10-09 | Kyowa Hakko Kogyo Kk | Process for the production of α-ketolglutaric acid and L-glutamic acid |
| EP0885962A1 (en) * | 1997-06-19 | 1998-12-23 | Consortium für elektrochemische Industrie GmbH | Microorganisms and process for the fermentative production of L-Cystein, L-Cystin, N-Acetyl-Serin or thiazolidin-derivates |
| EP1496111A2 (en) * | 2003-07-10 | 2005-01-12 | Consortium für elektrochemische Industrie GmbH | Variants of 3-Phosphoglycerate dehydrogenase with reduced inhibition by L-serine and genes encoding the same |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8601582D0 (en) | 1986-01-23 | 1986-02-26 | Electricity Council | Production of l-cysteine |
| TW313589B (en) | 1991-12-12 | 1997-08-21 | Wacker Chemie Gmbh | |
| DE19539952A1 (en) | 1995-10-26 | 1997-04-30 | Consortium Elektrochem Ind | Process for the preparation of O-acetylserine, L-cysteine and L-cysteine-related products |
| DE19949579C1 (en) | 1999-10-14 | 2000-11-16 | Consortium Elektrochem Ind | Microorganism with deregulated cysteine metabolism, useful for high-level production of cysteine and its derivatives, has increased activity of the CysB transcription regulator |
| DE10232930A1 (en) | 2002-07-19 | 2004-02-05 | Consortium für elektrochemische Industrie GmbH | Process for the fermentative production of amino acids and amino acid derivatives of the phosphoglycerate family |
| WO2004113373A1 (en) | 2003-06-21 | 2004-12-29 | University Of Sheffield | Overexpression of the cyddc transporter |
| JP4479283B2 (en) | 2004-03-04 | 2010-06-09 | 味の素株式会社 | L-cysteine producing bacterium and method for producing L-cysteine |
| JP4604537B2 (en) | 2004-03-31 | 2011-01-05 | 味の素株式会社 | L-cysteine producing bacterium and method for producing L-cysteine |
| DE102004035052A1 (en) | 2004-07-20 | 2006-02-16 | Basf Ag | Microorganisms for the production of sulfur-containing compounds |
| DE602009000714D1 (en) | 2008-03-06 | 2011-03-24 | Ajinomoto Kk | L-cysteine-producing bacterium and process for producing L-cysteine |
| DE102011075656A1 (en) | 2011-05-11 | 2012-03-29 | Wacker Chemie Ag | Producing L-cystine useful as food additive, preferably in baking industry, as ingredient in cosmetics and as starting material for producing active pharmaceutical ingredient, comprises fermenting microorganism strain in fermentation medium |
-
2012
- 2012-05-18 DE DE102012208359A patent/DE102012208359A1/en not_active Withdrawn
-
2013
- 2013-05-07 WO PCT/EP2013/059477 patent/WO2013171098A2/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1442263A1 (en) * | 1964-08-24 | 1969-10-09 | Kyowa Hakko Kogyo Kk | Process for the production of α-ketolglutaric acid and L-glutamic acid |
| EP0885962A1 (en) * | 1997-06-19 | 1998-12-23 | Consortium für elektrochemische Industrie GmbH | Microorganisms and process for the fermentative production of L-Cystein, L-Cystin, N-Acetyl-Serin or thiazolidin-derivates |
| EP1496111A2 (en) * | 2003-07-10 | 2005-01-12 | Consortium für elektrochemische Industrie GmbH | Variants of 3-Phosphoglycerate dehydrogenase with reduced inhibition by L-serine and genes encoding the same |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013171098A2 (en) | 2013-11-21 |
| DE102012208359A1 (en) | 2013-11-21 |
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