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WO2013021398A3 - A process for preparation of mivacurium chloride - Google Patents

A process for preparation of mivacurium chloride Download PDF

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Publication number
WO2013021398A3
WO2013021398A3 PCT/IN2012/000540 IN2012000540W WO2013021398A3 WO 2013021398 A3 WO2013021398 A3 WO 2013021398A3 IN 2012000540 W IN2012000540 W IN 2012000540W WO 2013021398 A3 WO2013021398 A3 WO 2013021398A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
octene
bis
methyl
chloride
Prior art date
Application number
PCT/IN2012/000540
Other languages
French (fr)
Other versions
WO2013021398A2 (en
Inventor
Mahalinga Manjathuru
Anil Narayan MAYEKAR
Yogeesh Derambala
Pejakala Kakrannaya Vasudeva
Thangavel Arulmoli
Gautam Kumar Das
Original Assignee
Sequent Scientific Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequent Scientific Limited filed Critical Sequent Scientific Limited
Publication of WO2013021398A2 publication Critical patent/WO2013021398A2/en
Publication of WO2013021398A3 publication Critical patent/WO2013021398A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention discloses a novel, cost-effective process for preparation of [R-[R*,R*-(E)]]-2,2'-(l,8-dioxo-4-octene-l,8-diyl) bis(oxy- 3, 1-propanediyl) bis(l,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-l-[(3,4,5- trimethoxyphenyl)- methyl] isoquinolinium) dichloride, commonly known as mivacurium chloride, which avoids the conversion of (E)-4-octene-l,8-dioic acid to its acid chloride and use of non-ionic polymeric adsorbent resin to get a highly pure product.
PCT/IN2012/000540 2011-08-05 2012-08-03 A process for preparation of mivacurium chloride WO2013021398A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2693/CHE/2011 2011-08-05
IN2693CH2011 2011-08-05

Publications (2)

Publication Number Publication Date
WO2013021398A2 WO2013021398A2 (en) 2013-02-14
WO2013021398A3 true WO2013021398A3 (en) 2013-03-14

Family

ID=47669030

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000540 WO2013021398A2 (en) 2011-08-05 2012-08-03 A process for preparation of mivacurium chloride

Country Status (1)

Country Link
WO (1) WO2013021398A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103373959A (en) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 Preparation method of cis-benzyl isoquinoline compound and application thereof
CN108375644B (en) * 2016-12-07 2021-11-30 四川科瑞德制药股份有限公司 Analysis method of neuromuscular blocker intermediate
CN108929269B (en) * 2017-05-26 2024-01-23 四川科瑞德制药股份有限公司 Benzisoquinoline non-depolarizing muscle relaxant and preparation method and application thereof
CN110698398B (en) * 2019-10-31 2021-08-03 武汉嘉诺康医药技术有限公司 Purification method of mikui ammonium chloride
CN111471013B (en) * 2020-05-26 2021-04-30 朗天药业(湖北)有限公司 Mickura ammonium chloride and preparation method of injection thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4761418A (en) * 1984-07-18 1988-08-02 Burroughs Wellcome Co. Novel compounds
US20070293534A1 (en) * 2006-06-20 2007-12-20 Farmabios S.P.A. Process for the preparation of mivacurium chloride

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4761418A (en) * 1984-07-18 1988-08-02 Burroughs Wellcome Co. Novel compounds
US20070293534A1 (en) * 2006-06-20 2007-12-20 Farmabios S.P.A. Process for the preparation of mivacurium chloride

Also Published As

Publication number Publication date
WO2013021398A2 (en) 2013-02-14

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