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WO2013121279A3 - Process to prepare ertapenem - Google Patents

Process to prepare ertapenem Download PDF

Info

Publication number
WO2013121279A3
WO2013121279A3 PCT/IB2013/000211 IB2013000211W WO2013121279A3 WO 2013121279 A3 WO2013121279 A3 WO 2013121279A3 IB 2013000211 W IB2013000211 W IB 2013000211W WO 2013121279 A3 WO2013121279 A3 WO 2013121279A3
Authority
WO
WIPO (PCT)
Prior art keywords
ertapenem
prepare
prepare ertapenem
lutidine
methylmorpholine
Prior art date
Application number
PCT/IB2013/000211
Other languages
French (fr)
Other versions
WO2013121279A2 (en
Inventor
Shankar Reddy Budidet
Mallikarjuna Reddy Karuru
Sivakumar KURIMISETTY
Rajasekhara Raju KONDURU
Sivakumaran Meenakshisunderam
Original Assignee
Aurobindo Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Limited filed Critical Aurobindo Pharma Limited
Publication of WO2013121279A2 publication Critical patent/WO2013121279A2/en
Publication of WO2013121279A3 publication Critical patent/WO2013121279A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention relates to a novel process for the preparation of Ertapenem of formula (I) or salt thereof, using hydrogenation catalyst in presence of N-methylmorpholine, 2,6-Lutidine or mixture thereof.
PCT/IB2013/000211 2012-02-14 2013-02-11 Process to prepare ertapenem WO2013121279A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN547CH2012 2012-02-14
IN547/CHE/2012 2012-02-14
IN3084/CHE/2012 2012-07-27
IN3084CH2012 2012-07-27

Publications (2)

Publication Number Publication Date
WO2013121279A2 WO2013121279A2 (en) 2013-08-22
WO2013121279A3 true WO2013121279A3 (en) 2014-09-12

Family

ID=47997590

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/000211 WO2013121279A2 (en) 2012-02-14 2013-02-11 Process to prepare ertapenem

Country Status (1)

Country Link
WO (1) WO2013121279A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104788453B (en) * 2014-01-16 2017-02-15 浙江九洲药业股份有限公司 One-pot preparation process of monosodium ertapenem
US10434089B2 (en) 2017-01-25 2019-10-08 The Johns Hopkins University Avibactam and carbapenems antibacterial agents
CN110698479A (en) * 2018-07-09 2020-01-17 武汉启瑞药业有限公司 Synthetic method of ertapenem monosodium salt
CN113880839A (en) * 2021-11-01 2022-01-04 石药集团中诺药业（石家庄）有限公司 Novel synthesis method of ertapenem sodium crude product
CN114105988B (en) * 2022-01-24 2022-04-29 深圳市海滨制药有限公司 Synthetic method of ertapenem sodium

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478820A (en) * 1992-02-04 1995-12-26 Zeneca Ltd. Antibiotic compounds
US7071330B2 (en) * 2001-01-16 2006-07-04 Williams John M Process for carbapenem synthesis
US20090312539A1 (en) * 2006-11-20 2009-12-17 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of carbapenem antibiotic
EP2141167A1 (en) * 2008-07-04 2010-01-06 ACS DOBFAR S.p.A. Process for synthesizing carbapenem using raney nickel
EP2388261A2 (en) * 2010-05-19 2011-11-23 Savior Lifetec Corporation Improved process for the preparation of carbapenem using carbapenem intermediates and recovery of carbapenem

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478820A (en) * 1992-02-04 1995-12-26 Zeneca Ltd. Antibiotic compounds
US7071330B2 (en) * 2001-01-16 2006-07-04 Williams John M Process for carbapenem synthesis
US20090312539A1 (en) * 2006-11-20 2009-12-17 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of carbapenem antibiotic
EP2141167A1 (en) * 2008-07-04 2010-01-06 ACS DOBFAR S.p.A. Process for synthesizing carbapenem using raney nickel
EP2388261A2 (en) * 2010-05-19 2011-11-23 Savior Lifetec Corporation Improved process for the preparation of carbapenem using carbapenem intermediates and recovery of carbapenem

Also Published As

Publication number Publication date
WO2013121279A2 (en) 2013-08-22

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