+

WO2013066839A3 - Composés et procédés - Google Patents

Composés et procédés Download PDF

Info

Publication number
WO2013066839A3
WO2013066839A3 PCT/US2012/062514 US2012062514W WO2013066839A3 WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3 US 2012062514 W US2012062514 W US 2012062514W WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
methods
hdac
enzymes
inhibition
Prior art date
Application number
PCT/US2012/062514
Other languages
English (en)
Other versions
WO2013066839A2 (fr
Inventor
Shomir Ghosh
Mercedes Lobera
Ryan Paul Trump
Cunyu Zhang
Original Assignee
Glaxosmithkline Llc
Tempero Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc, Tempero Pharmaceuticals, Inc. filed Critical Glaxosmithkline Llc
Publication of WO2013066839A2 publication Critical patent/WO2013066839A2/fr
Publication of WO2013066839A3 publication Critical patent/WO2013066839A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés ayant la formule : (I) et des sels de ceux-ci, formule dans laquelle A, B, m et n sont tels que définis selon l'invention, et des procédés de fabrication et d'utilisation de ces composés.
PCT/US2012/062514 2011-10-31 2012-10-30 Composés et procédés WO2013066839A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161553757P 2011-10-31 2011-10-31
US61/553,757 2011-10-31
US201261596269P 2012-02-08 2012-02-08
US61/596,269 2012-02-08

Publications (2)

Publication Number Publication Date
WO2013066839A2 WO2013066839A2 (fr) 2013-05-10
WO2013066839A3 true WO2013066839A3 (fr) 2015-06-25

Family

ID=48193011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/062514 WO2013066839A2 (fr) 2011-10-31 2012-10-30 Composés et procédés

Country Status (1)

Country Link
WO (1) WO2013066839A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108289449A (zh) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 用于防除植物病原性真菌的取代噁二唑
CN108368098B (zh) * 2015-12-18 2022-01-28 先正达参股股份有限公司 杀微生物的噁二唑衍生物

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103649074B (zh) * 2011-07-07 2016-05-11 默克专利股份公司 用于治疗癌症的取代的氮杂环
CN103764635B (zh) 2011-07-08 2016-01-20 诺华股份有限公司 新的三氟甲基-噁二唑衍生物及其在疾病治疗中的用途
SG11201609981RA (en) 2014-06-04 2016-12-29 Thomas Helledays Stiftelse För Medicinsk Forskning Mth1 inhibitors for treatment of inflammatory and autoimmune conditions
CA2949785A1 (fr) 2014-06-04 2015-12-10 Thomas Helledays Stiftelse For Medicinsk Forskning Inhibiteurs mth1 pour le traitement du cancer
JP6556146B2 (ja) * 2014-08-26 2019-08-07 武田薬品工業株式会社 複素環化合物
TW201713649A (zh) 2015-07-17 2017-04-16 武田藥品工業股份有限公司 雜環化合物
JPWO2017014170A1 (ja) 2015-07-17 2018-04-26 武田薬品工業株式会社 複素環化合物
JP6538266B2 (ja) 2015-07-27 2019-07-03 チョン クン ダン ファーマシューティカル コーポレーション ヒストン脱アセチル化酵素６阻害剤としての１，３，４−オキサジアゾールスルファミド誘導体化合物及びこれを含有する薬剤学的組成物（１，３，４−Ｏｘａｄｉａｚｏｌｅ Ｓｕｌｆａｍｉｄｅ Ｄｅｒｉｖａｔｉｖｅ Ｃｏｍｐｏｕｎｄｓ ａｓ Ｈｉｓｔｏｎｅ Ｄｅａｃｅｔｙｌａｓｅ ６ Ｉｎｈｉｂｉｔｏｒ， ａｎｄ ｔｈｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏｍｐｏｓｉｔｉｏｎ Ｃｏｍｐｒｉｓｉｎｇ ｔｈｅ ｓａｍｅ）
CA2993929C (fr) 2015-07-27 2020-10-20 Chong Kun Dang Pharmaceutical Corp. Composes derives de 1,3,4-oxadiazole sulfonamide servant d'inhibiteur de l'histone desacetylase 6, et composition pharmaceutique comprenant ceux-ci
CN108026056B (zh) 2015-07-27 2021-08-03 株式会社钟根堂 作为组蛋白脱乙酰酶6抑制剂的1,3,4-噁二唑酰胺衍生物化合物及其药物组合物
DK3331864T3 (da) * 2015-08-04 2021-12-13 Chong Kun Dang Pharmaceutical Corp 1,3,4-Oxadiazolderivat-forbindelser som histon-deacetylase-6-hæmmer, og den farmaceutiske sammensætning omfattende disse
EP3342772A4 (fr) 2015-08-25 2019-03-27 Takeda Pharmaceutical Company Limited Composé hétérocyclique
EP3356358B1 (fr) 2015-10-02 2020-05-06 Syngenta Participations AG Dérivés de oxadiazole microbiocides
WO2017055469A1 (fr) * 2015-10-02 2017-04-06 Syngenta Participations Ag Dérivés d'oxadiazole microbiocides
PL3362445T3 (pl) 2015-10-12 2023-08-07 Chong Kun Dang Pharmaceutical Corp. Związki będące pochodnymi oksadiazoloamin jako inhibitor deacetylazy histonowej 6 oraz kompozycja farmaceutyczna obejmujące takie związki
CN108347935A (zh) 2015-11-05 2018-07-31 巴斯夫欧洲公司 用于防治植物病原性真菌的取代噁二唑类
BR112018008413A2 (pt) 2015-11-19 2018-10-23 Basf Se compostos, mistura, composição agroquímica e método para combater fungos nocivos fitopatogênicos
MX2018006474A (es) 2015-12-02 2018-08-01 Syngenta Participations Ag Derivados de oxadiazol microbicidas.
JP2019507110A (ja) * 2015-12-17 2019-03-14 シンジェンタ パーティシペーションズ アーゲー 殺微生物性オキサジアゾール誘導体
UY37062A (es) 2016-01-08 2017-08-31 Syngenta Participations Ag Derivados de aryl oxadiazol fungicidas
JP2019514851A (ja) 2016-03-24 2019-06-06 シンジェンタ パーティシペーションズ アーゲー 殺微生物オキサジアゾール誘導体
AU2017250397A1 (en) 2016-04-11 2018-10-11 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
CN109071522B (zh) * 2016-04-12 2022-04-12 先正达参股股份有限公司 杀微生物的噁二唑衍生物
AU2017277354A1 (en) 2016-06-09 2018-12-06 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
US11066396B2 (en) 2016-06-23 2021-07-20 Merck Sharp & Dohme Corp. 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
CN106243083B (zh) * 2016-07-12 2018-10-30 浙江宏冠生物药业有限公司 一种伊马替尼制备方法
WO2018165520A1 (fr) 2017-03-10 2018-09-13 Vps-3, Inc. Composés inhibiteurs de métalloenzymes
WO2018177880A1 (fr) 2017-03-31 2018-10-04 Syngenta Participations Ag Compositions fongicides
WO2018177894A1 (fr) 2017-03-31 2018-10-04 Syngenta Participations Ag Compositions fongicides
EP3606913B1 (fr) 2017-04-03 2022-04-27 Syngenta Participations AG Dérivés d'oxadiazole microbiocides
BR112019020734B1 (pt) 2017-04-05 2023-12-05 Syngenta Participations Ag Compostos derivados de oxadiazol, composição agroquímica, método para controlar ou prevenir a infestação de plantas úteis por microrganismos fitopatogênicos e uso dos referidos compostos
BR112019020819B1 (pt) 2017-04-05 2023-12-05 Syngenta Participations Ag Composto de fórmula (i), composição agroquímica, método para controlar ou prevenir a infestação de plantas úteis por micro-organismos fitopatogênicos e uso de um composto de fórmula (i)
BR112019020735B1 (pt) 2017-04-05 2023-12-05 Syngenta Participations Ag Compostos derivados de oxadiazol microbiocidas e seu uso, composição agroquímica e método para controlar ou prevenir a infestação de plantas úteis por microrganismos fitopatogênicos
WO2018184985A1 (fr) 2017-04-05 2018-10-11 Syngenta Participations Ag Dérivés d'oxadiazole microbiocides
BR112019020756B1 (pt) 2017-04-05 2023-11-28 Syngenta Participations Ag Compostos derivados de oxadiazol microbicidas, composição agroquímica compreendendo os mesmos, método para controlar ou prevenir a infestação de plantas úteis por microrganismos fitopatogênicos e uso desses compostos
WO2018184987A1 (fr) 2017-04-05 2018-10-11 Syngenta Participations Ag Dérivés d'oxadiazole microbiocides
TWI829634B (zh) * 2017-04-06 2024-01-21 美商富曼西公司 殺真菌之噁二唑
CN111032651A (zh) 2017-07-31 2020-04-17 武田药品工业株式会社 杂环化合物
WO2019110663A1 (fr) * 2017-12-05 2019-06-13 Oryzon Genomics, S.A. Dérivés de 1,2,4-oxadiazole en tant qu'inhibiteurs de l'histone désacétylase 6
CN112020503A (zh) 2018-04-26 2020-12-01 先正达参股股份有限公司 杀微生物的噁二唑衍生物
KR102316234B1 (ko) 2018-07-26 2021-10-22 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
CN111285861B (zh) * 2018-12-10 2021-08-17 浙江省化工研究院有限公司 一种含三氟甲基噁二唑取代的嘧啶胺类化合物、其制备方法及应用
AR118673A1 (es) 2019-04-18 2021-10-20 Syngenta Crop Protection Ag Procedimiento para la preparación de derivados de oxadiazol microbiocidas
AU2020284606B2 (en) 2019-05-31 2023-01-19 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
WO2020254494A1 (fr) * 2019-06-21 2020-12-24 Bayer Aktiengesellschaft Oxadiazoles fongicides
CN114846012B (zh) 2019-09-27 2024-01-26 武田药品工业株式会社 可用作hdac6抑制剂的2-异吲哚-1,3,4-噁二唑衍生物
KR20240133645A (ko) 2023-02-28 2024-09-04 주식회사 종근당 옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
WO2025031913A1 (fr) 2023-08-04 2025-02-13 Syngenta Crop Protection Ag Procédés de lutte contre l'infestation de plantes par le micro-organisme phytopathogène corynespora cassiicola ou de prévention de celle-ci

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137212A1 (en) * 2002-03-01 2005-06-23 Rodolfo Cadilla Hppars activators
US20080227834A1 (en) * 2005-09-29 2008-09-18 Sanofi-Aventis Derivatives of 2-aminothiazoles and 2-amino-oxazoles, processes for their preparation and their use as pharmaceutical compositions
US20090062252A1 (en) * 2007-08-27 2009-03-05 Helicon Therapeutics, Inc. Therapeutic isoxazole compounds
WO2011088192A1 (fr) * 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Composés et procédés

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137212A1 (en) * 2002-03-01 2005-06-23 Rodolfo Cadilla Hppars activators
US20080227834A1 (en) * 2005-09-29 2008-09-18 Sanofi-Aventis Derivatives of 2-aminothiazoles and 2-amino-oxazoles, processes for their preparation and their use as pharmaceutical compositions
US20090062252A1 (en) * 2007-08-27 2009-03-05 Helicon Therapeutics, Inc. Therapeutic isoxazole compounds
WO2011088192A1 (fr) * 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Composés et procédés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHERMETEV ET AL.: "Synthesis of secondary and tertiary aminofurazans.", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 53, no. 3, March 2004 (2004-03-01), pages 596 - 614 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108289449A (zh) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 用于防除植物病原性真菌的取代噁二唑
CN108368098B (zh) * 2015-12-18 2022-01-28 先正达参股股份有限公司 杀微生物的噁二唑衍生物

Also Published As

Publication number Publication date
WO2013066839A2 (fr) 2013-05-10

Similar Documents

Publication Publication Date Title
WO2013066839A3 (fr) Composés et procédés
WO2013066835A3 (fr) Composés et procédés
EA201290191A1 (ru) N1-ПИРАЗОЛОСПИРОКЕТОНОВЫЕ ИНГИБИТОРЫ АЦЕТИЛ-KoA-КАРБОКСИЛАЗЫ
MD20150043A2 (ro) Inhibitori ai histon-demetilazelor
PH12013500145B1 (en) Agonists of gpr40
EA201391315A1 (ru) Гуанидиновое соединение
WO2011084991A3 (fr) Inhibiteurs fluorés de hdac et leurs utilisations
PH12015502425A1 (en) Novel compounds for selective histone deacetylase inhibitors, and pharmeceutical composition comprising the same
PH12013501240A1 (en) Neprilysin inhibitors
WO2014047427A3 (fr) Inhibiteurs de la mcl-1 à base de benzofurane, de benzothiophène et d'indole substitués
UA110943C2 (uk) N-ацилсульфонамідні промотори апоптозу
SG191175A1 (en) Neprilysin inhibitors
PH12014501967A1 (en) Benzodioxanes in combination with other actives for inhibiting leukotriene production
WO2013061004A8 (fr) Nouveaux composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines
MX2014007969A (es) Hidroxiamidas de ácido cinámico como inhibidores de la histona desacetilasa 8.
MY167898A (en) Co-crystals and salts of ccr3-inhibitors
MX2014013851A (es) Composiciones farmaceuticas topicas que comprenden terbinafina y urea.
EA201301114A1 (ru) Ингибитор фосфоинозитид-3-киназы, содержащий цинксвязывающий фрагмент
WO2014036502A8 (fr) Composés de tétracyclines
WO2011159124A3 (fr) Nouveau dérivé de benzoxazole présentant une activité inhibitrice contre l'interleukine 6, procédé pour le préparer, et composition pharmaceutique le contenant
ZA201500362B (en) Novel compound having ability to inhibit 11b-hsd1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient
WO2011088160A3 (fr) Nouveaux inhibiteurs de cyp17
WO2014035846A3 (fr) Composés azaindole substitué, leurs sels, leurs compositions pharmaceutiques et leurs procédés d'utilisation
WO2013033602A3 (fr) Amides d'acide gras, compositions et procédés d'utilisation
WO2012122450A3 (fr) Inhibiteurs de la peptide déformylase

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12844814

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 27/08/2014)

122 Ep: pct application non-entry in european phase

Ref document number: 12844814

Country of ref document: EP

Kind code of ref document: A2

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载