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WO2013066839A3 - Compounds and methods - Google Patents

Compounds and methods Download PDF

Info

Publication number
WO2013066839A3
WO2013066839A3 PCT/US2012/062514 US2012062514W WO2013066839A3 WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3 US 2012062514 W US2012062514 W US 2012062514W WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
methods
hdac
enzymes
inhibition
Prior art date
Application number
PCT/US2012/062514
Other languages
French (fr)
Other versions
WO2013066839A2 (en
Inventor
Shomir Ghosh
Mercedes Lobera
Ryan Paul Trump
Cunyu Zhang
Original Assignee
Glaxosmithkline Llc
Tempero Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc, Tempero Pharmaceuticals, Inc. filed Critical Glaxosmithkline Llc
Publication of WO2013066839A2 publication Critical patent/WO2013066839A2/en
Publication of WO2013066839A3 publication Critical patent/WO2013066839A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to compounds that inhibit histone deacetylase (HDAC) enzymes, the preparation of these compounds or salts of said compound, the use of these compounds in the treatment of neurodegenerative diseases or conditions ameliorated by inhibition of HDAC activity and pharmaceutical compositions that are comprised of these compounds.
PCT/US2012/062514 2011-10-31 2012-10-30 Compounds and methods WO2013066839A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161553757P 2011-10-31 2011-10-31
US61/553,757 2011-10-31
US201261596269P 2012-02-08 2012-02-08
US61/596,269 2012-02-08

Publications (2)

Publication Number Publication Date
WO2013066839A2 WO2013066839A2 (en) 2013-05-10
WO2013066839A3 true WO2013066839A3 (en) 2015-06-25

Family

ID=48193011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/062514 WO2013066839A2 (en) 2011-10-31 2012-10-30 Compounds and methods

Country Status (1)

Country Link
WO (1) WO2013066839A2 (en)

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CN108289449A (en) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 Qu Dai oxadiazoles for preventing and kill off plant pathogenic fungi

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WO2013008162A1 (en) 2011-07-08 2013-01-17 Novartis Ag Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
US10179790B2 (en) 2014-06-04 2019-01-15 Thomas Helledays Stiftelse For Medicinsk Forskning MTH1 inhibitors for treatment of cancer
SG11201609981RA (en) 2014-06-04 2016-12-29 Thomas Helledays Stiftelse För Medicinsk Forskning Mth1 inhibitors for treatment of inflammatory and autoimmune conditions
JP6556146B2 (en) * 2014-08-26 2019-08-07 武田薬品工業株式会社 Heterocyclic compounds
JPWO2017014170A1 (en) 2015-07-17 2018-04-26 武田薬品工業株式会社 Heterocyclic compounds
AU2016297362B2 (en) 2015-07-17 2020-04-16 Takeda Pharmaceutical Company Limited Oxadiazole derivatives useful as HDAC inhibitors
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CA2993918C (en) 2015-07-27 2020-09-29 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
EP3328843B1 (en) 2015-07-27 2022-10-26 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
PT3331864T (en) 2015-08-04 2022-01-18 Chong Kun Dang Pharmaceutical Corp 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
JPWO2017033946A1 (en) 2015-08-25 2018-06-07 武田薬品工業株式会社 Heterocyclic compounds
BR112018006623B1 (en) 2015-10-02 2022-04-26 Syngenta Participations Ag Compound derived from oxadiazole, its use, agrochemical composition and method of controlling or preventing the infestation of useful plants by phytopathogenic microorganisms
BR112018006630B8 (en) * 2015-10-02 2022-07-12 Syngenta Participations Ag COMPOUND DERIVED FROM OXADIAZOLE MICROBIOCIDES, AGROCHEMICAL COMPOSITION COMPRISING SUCH COMPOUND, METHOD OF CONTROL OR PREVENTION OF INFESTATION OF USEFUL PLANTS BY PHYTOPATOGENIC MICROORGANISMS AND USE OF A COMPOUND
JP6697074B2 (en) * 2015-10-12 2020-05-20 チョン クン ダン ファーマシューティカル コーポレーション Oxadiazole amine derivative compound as histone deacetylase 6 inhibitor and pharmaceutical composition containing the same
US10555526B2 (en) 2015-11-05 2020-02-11 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
US10499644B2 (en) 2015-11-19 2019-12-10 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
MX2018006474A (en) 2015-12-02 2018-08-01 Syngenta Participations Ag Microbiocidal oxadiazole derivatives.
CN108430997B (en) * 2015-12-17 2021-06-04 先正达参股股份有限公司 Microbicidal oxadiazole derivatives
EP3390398A1 (en) * 2015-12-18 2018-10-24 Syngenta Participations AG Microbiocidal oxadiazole derivatives
UY37062A (en) 2016-01-08 2017-08-31 Syngenta Participations Ag DERIVATIVES OF ARYL OXADIAZOL FUNGICIDAS
CN109071520B (en) 2016-03-24 2022-06-14 先正达参股股份有限公司 Microbicidal oxadiazole derivatives
US10986839B2 (en) 2016-04-11 2021-04-27 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
BR112018070785B1 (en) * 2016-04-12 2023-01-10 Syngenta Participations Ag MICROBIOCIDENT OXADIAZOLE DERIVATIVE COMPOUNDS, AGROCHEMICAL COMPOSITION, METHOD OF CONTROL OR PREVENTION OF INFESTATION OF USEFUL PLANTS BY PHYTOPATHOGENIC MICRO-ORGANISMS AND USE OF THE SAID COMPOUNDS
AU2017277354A1 (en) 2016-06-09 2018-12-06 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
US11066396B2 (en) 2016-06-23 2021-07-20 Merck Sharp & Dohme Corp. 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
CN106243083B (en) * 2016-07-12 2018-10-30 浙江宏冠生物药业有限公司 A kind of Imatinib preparation method
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
BR112019020134B1 (en) 2017-03-31 2023-05-09 Syngenta Participations Ag FUNGICIDAL COMPOSITIONS
CN113979962A (en) 2017-03-31 2022-01-28 先正达参股股份有限公司 Fungicidal compositions
EP3606913B1 (en) 2017-04-03 2022-04-27 Syngenta Participations AG Microbiocidal oxadiazole derivatives
BR112019020734B1 (en) 2017-04-05 2023-12-05 Syngenta Participations Ag Compounds derived from oxadiazole, agrochemical composition, method for controlling or preventing infestation of useful plants by phytopathogenic microorganisms and use of said compounds
WO2018184982A1 (en) 2017-04-05 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018184987A1 (en) 2017-04-05 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
BR112019020819B1 (en) 2017-04-05 2023-12-05 Syngenta Participations Ag COMPOUND OF FORMULA (I), AGROCHEMICAL COMPOSITION, METHOD FOR CONTROLLING OR PREVENTING INFESTATION OF USEFUL PLANTS BY PHYTOPATHOGENIC MICROORGANISMS AND USE OF A COMPOUND OF FORMULA (I)
BR112019020739B1 (en) 2017-04-05 2023-12-19 Syngenta Participations Ag COMPOUNDS DERIVED FROM OXADIAZOLE MICROBIOCIDES AND THEIR USE, AGROCHEMICAL COMPOSITION, METHOD TO CONTROL OR PREVENT INFESTATION OF USEFUL PLANTS BY PHYTOPATHOGENIC MICROORGANISMS
WO2018184984A1 (en) 2017-04-05 2018-10-11 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
TW202417417A (en) 2017-04-06 2024-05-01 美商富曼西公司 Fungicidal oxadiazoles
CA3071825A1 (en) 2017-07-31 2019-02-07 Takeda Pharmaceutical Company Limited Heterocyclic compound
SG11202005254RA (en) * 2017-12-05 2020-07-29 Oryzon Genomics Sa 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors
WO2019207062A1 (en) 2018-04-26 2019-10-31 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
KR102316234B1 (en) 2018-07-26 2021-10-22 주식회사 종근당 1,3,4-Oxadiazole Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same
CN111285861B (en) * 2018-12-10 2021-08-17 浙江省化工研究院有限公司 A kind of pyrimidine amine compound containing trifluoromethyl oxadiazole substitution, its preparation method and application
AR118673A1 (en) 2019-04-18 2021-10-20 Syngenta Crop Protection Ag PROCEDURE FOR THE PREPARATION OF OXADIAZOLE DERIVATIVES MICROBIOCIDES
US20230079386A1 (en) 2019-05-31 2023-03-16 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
BR112021025300A2 (en) * 2019-06-21 2022-02-01 Bayer Ag fungicidal oxadiazoles
CN114846012B (en) 2019-09-27 2024-01-26 武田药品工业株式会社 2-isoindole-1,3,4-oxadiazole derivatives useful as HDAC6 inhibitors
KR20240133645A (en) 2023-02-28 2024-09-04 주식회사 종근당 Oxadiazole Derivative Compounds, and the Pharmaceutical Composition Comprising the same
WO2025031913A1 (en) 2023-08-04 2025-02-13 Syngenta Crop Protection Ag Methods of controlling or preventing infestation of plants by the phytopathogenic microorganism corynespora cassiicola

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Patent Citations (4)

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US20080227834A1 (en) * 2005-09-29 2008-09-18 Sanofi-Aventis Derivatives of 2-aminothiazoles and 2-amino-oxazoles, processes for their preparation and their use as pharmaceutical compositions
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Non-Patent Citations (1)

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SHERMETEV ET AL.: "Synthesis of secondary and tertiary aminofurazans.", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 53, no. 3, March 2004 (2004-03-01), pages 596 - 614 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108289449A (en) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 Qu Dai oxadiazoles for preventing and kill off plant pathogenic fungi

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