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WO2009122034A3 - Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation - Google Patents

Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation Download PDF

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Publication number
WO2009122034A3
WO2009122034A3 PCT/FR2009/000267 FR2009000267W WO2009122034A3 WO 2009122034 A3 WO2009122034 A3 WO 2009122034A3 FR 2009000267 W FR2009000267 W FR 2009000267W WO 2009122034 A3 WO2009122034 A3 WO 2009122034A3
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WO
WIPO (PCT)
Prior art keywords
alkyl
novel
dhsp90
inhibitory
compositions containing
Prior art date
Application number
PCT/FR2009/000267
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English (en)
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WO2009122034A2 (fr
WO2009122034A8 (fr
Inventor
Marcel Alasia
Luc Bertin
Victor Cerval
Frank Halley
Patrick Mailliet
Maria Mendez Perez
Hervé MINOUX
Jean-Marie Ruxer
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Sanofi-Aventis
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39930567&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009122034(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CN2009801174385A priority Critical patent/CN102026992A/zh
Priority to CA2718488A priority patent/CA2718488A1/fr
Priority to EP09728587A priority patent/EP2265598A2/fr
Priority to JP2010550234A priority patent/JP5674483B2/ja
Priority to EA201071078A priority patent/EA201071078A1/ru
Priority to MX2010010018A priority patent/MX2010010018A/es
Priority to AU2009232121A priority patent/AU2009232121A1/en
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Priority to BRPI0909731-7A priority patent/BRPI0909731A2/pt
Publication of WO2009122034A2 publication Critical patent/WO2009122034A2/fr
Publication of WO2009122034A3 publication Critical patent/WO2009122034A3/fr
Priority to TNP2010000351A priority patent/TN2010000351A1/fr
Publication of WO2009122034A8 publication Critical patent/WO2009122034A8/fr
Priority to IL208059A priority patent/IL208059A0/en
Priority to US12/881,414 priority patent/US8309721B2/en
Priority to MA33221A priority patent/MA32206B1/fr

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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Abstract

L'invention concerne les nouveaux produits de formule (I) : dans lesquels Het représente un hétérocycle éventuellement substitué par un ou plusieurs radicaux R1 ou R'1, R est choisi dans le groupe constitué par FORMULE(II) avec R1 et/ou R'1, choisis parmi H, halogène, CF3, nitro, cyano, alkyle, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, phénylalcoxy, alkylthio, carboxy libre ou estérifié par un radical alkyle, carboxamide, CO-NH(alkyl), CON(alkyl)2, NH-CO- alkyl, sulfonamide, NH-S02-alkyl, S(0)2-NHalkyl, S(O2)-N(alkyl)2; tous ces radicaux éventuellement substitués; W1, W2, W3 représentent indépendemment CH ou N, X représente O, S, NR2, C(O), S(O) ou S(0)2; Z représente H, HaI, -0-R2 ou -NH-R2 avec R2 représente H, alkyle, cycloalkyle ou hétérocycloalkyle éventuellement substitués; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments.
PCT/FR2009/000267 2008-03-14 2009-03-13 Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation WO2009122034A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
BRPI0909731-7A BRPI0909731A2 (pt) 2008-03-14 2009-03-13 derivados de carbazol inibidores de hsp90, composições que os contêm e a respectiva utilização
MX2010010018A MX2010010018A (es) 2008-03-14 2009-03-13 Nuevos derivados de carbazol inhibidores de hsp90, composiciones que los contienen y su uso.
CA2718488A CA2718488A1 (fr) 2008-03-14 2009-03-13 Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
EP09728587A EP2265598A2 (fr) 2008-03-14 2009-03-13 Nouveaux derives de carbazole inhibiteurs d' hsp90, compositions les contenant et utilisation
JP2010550234A JP5674483B2 (ja) 2008-03-14 2009-03-13 新規なｈｓｐ９０阻害性カルバゾール誘導体、同誘導体を含む組成物およびその使用
EA201071078A EA201071078A1 (ru) 2008-03-14 2009-03-13 Новые производные карбазола, являющиеся ингибиторами hsp90, содержащие их композиции и их применение
AU2009232121A AU2009232121A1 (en) 2008-03-14 2009-03-13 Novel HSP90 inhibitory carbazole derivatives, compositions containing same, and use thereof
CN2009801174385A CN102026992A (zh) 2008-03-14 2009-03-13 新的hsp90抑制性咔唑衍生物和含有该咔唑衍生物的组合物及其用途
TNP2010000351A TN2010000351A1 (en) 2009-03-13 2010-07-27 Novel hsp90 inhibitory carbazole derivatives compositions containing same and use thereof
IL208059A IL208059A0 (en) 2008-03-14 2010-09-07 Novel hsp90 inhibitory carbazole derivatives, compositions containing same and use thereof
US12/881,414 US8309721B2 (en) 2008-03-14 2010-09-14 HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof
MA33221A MA32206B1 (fr) 2008-03-14 2010-10-06 Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0801394A FR2928645A1 (fr) 2008-03-14 2008-03-14 Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
FR08/01394 2008-03-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/881,414 Continuation US8309721B2 (en) 2008-03-14 2010-09-14 HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof

Publications (3)

Publication Number Publication Date
WO2009122034A2 WO2009122034A2 (fr) 2009-10-08
WO2009122034A3 true WO2009122034A3 (fr) 2009-12-03
WO2009122034A8 WO2009122034A8 (fr) 2010-08-19

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PCT/FR2009/000267 WO2009122034A2 (fr) 2008-03-14 2009-03-13 Nouveaux derives de carbazole inhibiteurs d'ηsp90, compositions les contenant et utilisation

Country Status (24)

Country Link
US (1) US8309721B2 (fr)
EP (1) EP2265598A2 (fr)
JP (1) JP5674483B2 (fr)
KR (1) KR20100130603A (fr)
CN (1) CN102026992A (fr)
AR (1) AR070836A1 (fr)
AU (1) AU2009232121A1 (fr)
BR (1) BRPI0909731A2 (fr)
CA (1) CA2718488A1 (fr)
CL (1) CL2009000619A1 (fr)
CO (1) CO6251295A2 (fr)
CR (1) CR11653A (fr)
DO (1) DOP2010000272A (fr)
EA (1) EA201071078A1 (fr)
EC (1) ECSP10010473A (fr)
FR (1) FR2928645A1 (fr)
IL (1) IL208059A0 (fr)
MA (1) MA32206B1 (fr)
MX (1) MX2010010018A (fr)
NI (1) NI201000150A (fr)
PE (1) PE20091673A1 (fr)
TW (1) TW200938541A (fr)
UY (1) UY31711A (fr)
WO (1) WO2009122034A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011035416A1 (fr) * 2009-09-25 2011-03-31 Aegera Therapeutics Inc. Composés modulateurs de la hsp90, compositions, procédés et utilisations correspondants
MX2013007938A (es) 2011-01-07 2013-11-01 Taiho Pharmaceutical Co Ltd Compuesto biciclico novedoso o sal del mismo.
KR20140025326A (ko) 2011-01-07 2014-03-04 다이호야쿠힌고교 가부시키가이샤 신규 인돌, 인다졸 유도체 또는 그 염
JP5842630B2 (ja) 2011-03-16 2016-01-13 株式会社リコー カルバゾール誘導体、及び半導体ナノ結晶
JP2014075556A (ja) * 2012-10-05 2014-04-24 Idemitsu Kosan Co Ltd 有機エレクトロルミネッセンス素子用材料、及びそれを用いた有機エレクトロルミネッセンス素子
CA2895237C (fr) * 2013-01-10 2021-10-05 Merck Patent Gmbh Piperidinylcarbazole comme antipaludique
EP3670496A3 (fr) 2013-10-17 2020-09-30 Shionogi&Co., Ltd. Inhibiteurs de acc2
JP6345786B2 (ja) 2013-12-05 2018-06-20 ファーマサイクリックス エルエルシー ブルトン型チロシンキナーゼの阻害剤
US20170158636A1 (en) * 2014-07-16 2017-06-08 Novogen Ltd. Functionalised and substituted carbazoles as anti-cancer agents
RS58394B1 (sr) * 2014-10-01 2019-04-30 Janssen Pharmaceuticals Inc Mono- ili di-supstituisani indoli kao inhibitori replikacije denga virusa
PH12017501272B1 (en) * 2015-01-16 2023-01-11 Janssen Pharmaceuticals Inc Indole derivatives as dengue viral replication inhibitors
JP6673939B2 (ja) * 2015-04-29 2020-04-01 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｇｐｒ５２に関連する障害の治療または予防に有用なｇｐｒ５２のモジュレーターとしての１−ヘテロアリール−インドリン−４−カルボキサミド
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) * 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) * 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
DE102016122122B4 (de) * 2015-11-18 2021-02-11 Cynora Gmbh Organische Moleküle, insbesondere zur Verwendung in organischen optoelektronischen Vorrichtungen
US9966542B2 (en) * 2016-06-02 2018-05-08 E I Du Pont De Nemours And Company Electroactive materials
DE102017008073A1 (de) * 2017-08-28 2019-02-28 Henkel Ag & Co. Kgaa Neue anionische Tenside und Wasch- und Reinigungsmittel, welche diese enthalten
CN111217741B (zh) * 2019-03-01 2022-03-15 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 氟取代单咔唑类衍生物、其制备方法及应用
TW202400597A (zh) * 2022-04-28 2024-01-01 大陸商北京丹擎醫藥科技有限公司 三環雜環衍生物，其組合物和應用
WO2024199444A1 (fr) * 2023-03-31 2024-10-03 上海翊维康医药有限责任公司 Composé cyclique hétéroaromatique, son procédé de préparation et son utilisation
CN117159570B (zh) * 2023-11-01 2024-01-23 云南中医药大学 6-酰氧基甘露糖叠氮乙苷衍生物与氟康唑联合在制备抗耐药白念珠菌药物中的应用
CN117486782A (zh) * 2023-12-29 2024-02-02 中国医学科学院药用植物研究所 一种n-取代咔唑衍生物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036597A1 (fr) * 2000-11-03 2002-05-10 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Derives tricycliques de l'indole a activite anti-angiogenique
WO2006055760A1 (fr) * 2004-11-18 2006-05-26 Synta Pharmaceuticals Corp. Composes triazole modulant l'activite de hsp90

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008003202A (es) * 2005-09-16 2008-03-25 Serenex Inc Derivados de carbazol.
US8405508B2 (en) 2006-08-09 2013-03-26 Emd Millipore Corporation Use of gamma hardened RFID tags in pharmaceutical devices

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036597A1 (fr) * 2000-11-03 2002-05-10 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Derives tricycliques de l'indole a activite anti-angiogenique
WO2006055760A1 (fr) * 2004-11-18 2006-05-26 Synta Pharmaceuticals Corp. Composes triazole modulant l'activite de hsp90

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FR2928645A1 (fr) 2009-09-18
EA201071078A1 (ru) 2011-04-29
US20110166169A1 (en) 2011-07-07
WO2009122034A2 (fr) 2009-10-08
EP2265598A2 (fr) 2010-12-29
IL208059A0 (en) 2010-12-30
US8309721B2 (en) 2012-11-13
CO6251295A2 (es) 2011-02-21
BRPI0909731A2 (pt) 2019-03-06
ECSP10010473A (es) 2010-10-30
KR20100130603A (ko) 2010-12-13
WO2009122034A8 (fr) 2010-08-19
CR11653A (es) 2010-11-22
PE20091673A1 (es) 2009-11-14
DOP2010000272A (es) 2010-10-15
JP2011513473A (ja) 2011-04-28
CA2718488A1 (fr) 2009-10-08
NI201000150A (es) 2011-03-29
CN102026992A (zh) 2011-04-20
JP5674483B2 (ja) 2015-02-25
UY31711A (es) 2009-11-10
CL2009000619A1 (es) 2011-02-18
TW200938541A (en) 2009-09-16
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