+

WO2009025277A1 - 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法 - Google Patents

還元型補酵素ｑ10の製造方法、ならびに、その安定化方法 Download PDF

Info

Publication number
WO2009025277A1
WO2009025277A1 PCT/JP2008/064778 JP2008064778W WO2009025277A1 WO 2009025277 A1 WO2009025277 A1 WO 2009025277A1 JP 2008064778 W JP2008064778 W JP 2008064778W WO 2009025277 A1 WO2009025277 A1 WO 2009025277A1
Authority
WO
WIPO (PCT)
Prior art keywords
reduced coenzyme
coenzyme
food
stabilizing
same
Prior art date
Application number
PCT/JP2008/064778
Other languages
English (en)
French (fr)
Inventor
Takahiro Ueda
Yozo Nagira
Shiro Kitamura
Original Assignee
Kaneka Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corporation filed Critical Kaneka Corporation
Priority to JP2009529037A priority Critical patent/JP5364580B2/ja
Priority to EP08827632.4A priority patent/EP2186789B1/en
Priority to US12/674,604 priority patent/US20110123505A1/en
Publication of WO2009025277A1 publication Critical patent/WO2009025277A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/733—Compounds of undetermined constitution obtained from animals or plants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Emergency Medicine (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

　本発明は、食品、栄養機能食品、特定保健用食品、栄養補助剤、栄養剤、動物薬、飲料、飼料、化粧品、医薬品、治療薬、予防薬等として有用な還元型補酵素Ｑ10の安定化方法並びに安定化された組成物を提供すること。さらには、酸化型補酵素Ｑ10を原料とする簡便な還元型補酵素Ｑ10の製造方法を提供することを課題とする。本発明によって、甘草疎水性抽出物と還元型補酵素Ｑ10を共存させることにより、還元型補酵素Ｑ10の酸化を抑制させ、還元型補酵素Ｑ10を安定に保持することができる。また、酸化型補酵素Ｑ10と甘草疎水性抽出物を共存させることにより、還元型補酵素Ｑ10を製造することができる。                                                                               
PCT/JP2008/064778 2007-08-22 2008-08-20 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法 WO2009025277A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009529037A JP5364580B2 (ja) 2007-08-22 2008-08-20 還元型補酵素ｑ１０の製造方法、ならびに、その安定化方法
EP08827632.4A EP2186789B1 (en) 2007-08-22 2008-08-20 Method of producing reduced coenzyme q10 and method of stabilizing the same
US12/674,604 US20110123505A1 (en) 2007-08-22 2008-08-20 Method of producing reduced coenzyme q10 and method of stabilizing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-216001 2007-08-22
JP2007216001 2007-08-22

Publications (1)

Publication Number Publication Date
WO2009025277A1 true WO2009025277A1 (ja) 2009-02-26

Family

ID=40378178

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/064778 WO2009025277A1 (ja) 2007-08-22 2008-08-20 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法

Country Status (4)

Country Link
US (1) US20110123505A1 (ja)
EP (1) EP2186789B1 (ja)
JP (2) JP5364580B2 (ja)
WO (1) WO2009025277A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011001348A (ja) * 2009-05-18 2011-01-06 Kaneka Corp 酒酔い又は二日酔い防止・軽減用組成物
JPWO2009044852A1 (ja) * 2007-10-05 2011-02-10 株式会社カネカ 還元型補酵素ｑ１０の製造方法
JP2011057674A (ja) * 2009-09-11 2011-03-24 Omnica Gmbh コエンザイムｑ−１０と抗酸化剤とを含む組成物
WO2011045934A1 (ja) * 2009-10-16 2011-04-21 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
WO2011132718A1 (ja) * 2010-04-20 2011-10-27 株式会社カネカ 還元型補酵素ｑ１０含有組成物とその製造方法及び安定化方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2535928C1 (ru) * 2013-05-31 2014-12-20 Закрытое акционерное общество "Научно-производственное объединение "ДОМ ФАРМАЦИИ" Экспрессный способ получения восстановленной формы коэнзима q10 на основе катализаторов для использования в фармацевтических и пищевых композициях
JP2020536537A (ja) * 2017-10-06 2020-12-17 カーギル インコーポレイテッド 易溶解性ステビオールグリコシド組成物
MY205266A (en) 2019-04-06 2024-10-10 Cargill Inc Methods for making botanical extract composition
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10109933A (ja) 1996-08-16 1998-04-28 Kanegafuchi Chem Ind Co Ltd 医薬組成物
WO2001052822A1 (en) 2000-01-20 2001-07-26 Chopra Raj K Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications
WO2002047699A1 (fr) 2000-12-12 2002-06-20 Kaneka Corporation Compositions de prévention ou d'amélioration de syndromes multifactoriels
WO2003037316A1 (fr) 2001-10-11 2003-05-08 Kaneka Corporation Ligands de recepteurs actives par le proliferateur de peroxisome et procede de fabrication correspondant
WO2003062182A1 (en) 2002-01-18 2003-07-31 Kaneka Corporation Method for stabilizing reduced coenzyme q10 and composition therefor
WO2003084556A1 (fr) * 2002-04-04 2003-10-16 Kaneka Corporation Procede de fabrication de composition lipidique contenant des composants hydrophobes de glycyrrhiza
WO2005110400A1 (ja) 2004-05-13 2005-11-24 Kaneka Corporation リパーゼ阻害剤、コレステロールエステラーゼ阻害剤、中性脂肪吸収抑制剤、コレステロール吸収抑制剤及びコレステロールエステル吸収抑制剤
JP2006070016A (ja) * 2004-08-02 2006-03-16 Kaneka Corp 還元型補酵素ｑを含有する美白用組成物
WO2006085562A1 (ja) 2005-02-09 2006-08-17 Kaneka Corporation メタボリックシンドローム及びインスリン抵抗性症候群の予防及び／又は処置用組成物
JP2006328024A (ja) * 2005-05-30 2006-12-07 Seiren Co Ltd 皮膚用外用剤
WO2007052802A1 (ja) 2005-11-07 2007-05-10 Kaneka Corporation 酸化に対して安定な還元型補酵素ｑ10含有組成物、及び還元型補酵素ｑ10を安定化する方法
WO2007060992A1 (ja) 2005-11-25 2007-05-31 Kaneka Corporation メタボリックシンドロームもしくはインスリン抵抗性症候群の予防または改善剤
WO2007097412A1 (ja) * 2006-02-24 2007-08-30 Kaneka Corporation 甘草ポリフェノール含有水中油型乳化組成物
WO2007123044A1 (ja) * 2006-04-17 2007-11-01 Kaneka Corporation 甘草ポリフェノール製剤
WO2008084828A1 (ja) * 2007-01-11 2008-07-17 Kaneka Corporation 補酵素ｑ10粒子の製造方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
DE3224619A1 (de) * 1981-07-14 1983-05-19 Freund Industrial Co., Ltd., Tokyo Orale pharmazeutische zusammensetzung
CH655005A5 (it) * 1983-02-16 1986-03-27 Sigma Tau Ind Farmaceuti Composizione farmaceutica ad azione metabolica ed energetica utilizzabile in terapia cardiaca e vascolare.
CZ283428B6 (cs) * 1992-04-30 1998-04-15 Schering Corporation Stabilní hydratovaný suchý práškový cefalosporin vhodný pro orální aplikaci ve formě suspenze
US5744187A (en) * 1996-12-16 1998-04-28 Gaynor; Mitchel L. Nutritional powder composition
JP3549197B2 (ja) * 2001-08-10 2004-08-04 日清ファルマ株式会社 ユビキノン含有製剤
TWI329510B (en) * 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
TWI305547B (en) * 2001-12-27 2009-01-21 Kaneka Corp Processes for producing coenzyme q10
TW200302055A (en) * 2002-01-18 2003-08-01 Kaneka Corp Ubiquinol-enriched fat-containing foods
DE10205362A1 (de) * 2002-02-08 2003-08-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung wasserdispergierbarer Trockenpulver von in Wasser schwer löslichen Verbindungen
AU2004206144B2 (en) * 2003-01-17 2007-10-11 Taiyo Kagaku Co., Ltd. Compositions containing coenzyme Q10
TW200513194A (en) * 2003-07-31 2005-04-16 Kaneka Corp Fat and oil processed composition for prevention and/or amelioration of life-style related disease
JP4842824B2 (ja) * 2004-08-24 2011-12-21 日清ファルマ株式会社 コエンザイムｑ１０含有組成物
US20060147542A1 (en) * 2004-12-24 2006-07-06 Tadao Ono Solid preparation containing reduced coenzyme Q10 and method for producing the same
US8067217B2 (en) * 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
WO2007040591A2 (en) * 2005-03-01 2007-04-12 Jarrow Formulas, Inc. A ubiquinone composition and a container for its convenient transport and storage
CA2666688C (en) * 2006-06-22 2016-01-19 Kaneka Corporation Reduced coenzyme q10-containing composition and method for producing the same
US20080102131A1 (en) * 2006-10-31 2008-05-01 Kaneka Corporation Particulate composition comprising bioactive substance and method of producing the same
JP2010030901A (ja) * 2006-11-17 2010-02-12 Kaneka Corp ストレス症状の緩和または予防剤
WO2009001787A1 (ja) * 2007-06-22 2008-12-31 Kaneka Corporation 補酵素ｑ１０含有組成物
WO2009001786A1 (ja) * 2007-06-22 2008-12-31 Kaneka Corporation 生理活性物質含有組成物

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10109933A (ja) 1996-08-16 1998-04-28 Kanegafuchi Chem Ind Co Ltd 医薬組成物
WO2001052822A1 (en) 2000-01-20 2001-07-26 Chopra Raj K Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications
WO2002047699A1 (fr) 2000-12-12 2002-06-20 Kaneka Corporation Compositions de prévention ou d'amélioration de syndromes multifactoriels
WO2003037316A1 (fr) 2001-10-11 2003-05-08 Kaneka Corporation Ligands de recepteurs actives par le proliferateur de peroxisome et procede de fabrication correspondant
WO2003062182A1 (en) 2002-01-18 2003-07-31 Kaneka Corporation Method for stabilizing reduced coenzyme q10 and composition therefor
WO2003084556A1 (fr) * 2002-04-04 2003-10-16 Kaneka Corporation Procede de fabrication de composition lipidique contenant des composants hydrophobes de glycyrrhiza
WO2005110400A1 (ja) 2004-05-13 2005-11-24 Kaneka Corporation リパーゼ阻害剤、コレステロールエステラーゼ阻害剤、中性脂肪吸収抑制剤、コレステロール吸収抑制剤及びコレステロールエステル吸収抑制剤
JP2006070016A (ja) * 2004-08-02 2006-03-16 Kaneka Corp 還元型補酵素ｑを含有する美白用組成物
WO2006085562A1 (ja) 2005-02-09 2006-08-17 Kaneka Corporation メタボリックシンドローム及びインスリン抵抗性症候群の予防及び／又は処置用組成物
JP2006328024A (ja) * 2005-05-30 2006-12-07 Seiren Co Ltd 皮膚用外用剤
WO2007052802A1 (ja) 2005-11-07 2007-05-10 Kaneka Corporation 酸化に対して安定な還元型補酵素ｑ10含有組成物、及び還元型補酵素ｑ10を安定化する方法
WO2007060992A1 (ja) 2005-11-25 2007-05-31 Kaneka Corporation メタボリックシンドロームもしくはインスリン抵抗性症候群の予防または改善剤
WO2007097412A1 (ja) * 2006-02-24 2007-08-30 Kaneka Corporation 甘草ポリフェノール含有水中油型乳化組成物
WO2007123044A1 (ja) * 2006-04-17 2007-11-01 Kaneka Corporation 甘草ポリフェノール製剤
WO2008084828A1 (ja) * 2007-01-11 2008-07-17 Kaneka Corporation 補酵素ｑ10粒子の製造方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NUTRITION RESEARCH, vol. 13, 1993, pages 667 - 676
PROGRESS IN THE CHEMISTRY OF ORGANIC NATURAL PRODUCTS, vol. 73, 1998
See also references of EP2186789A4
THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, vol. 13, 2007, pages 103 - 109

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009044852A1 (ja) * 2007-10-05 2011-02-10 株式会社カネカ 還元型補酵素ｑ１０の製造方法
JP5558823B2 (ja) * 2007-10-05 2014-07-23 株式会社カネカ 還元型補酵素ｑ１０の製造方法
JP2011001348A (ja) * 2009-05-18 2011-01-06 Kaneka Corp 酒酔い又は二日酔い防止・軽減用組成物
JP2011057674A (ja) * 2009-09-11 2011-03-24 Omnica Gmbh コエンザイムｑ−１０と抗酸化剤とを含む組成物
WO2011045934A1 (ja) * 2009-10-16 2011-04-21 株式会社カネカ 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
WO2011132718A1 (ja) * 2010-04-20 2011-10-27 株式会社カネカ 還元型補酵素ｑ１０含有組成物とその製造方法及び安定化方法
US20130142767A1 (en) * 2010-04-20 2013-06-06 Keneka Corporation Composition containing reduced coenzyme q10, and manufacturing and stabilising methods therefor
JPWO2011132718A1 (ja) * 2010-04-20 2013-07-18 株式会社カネカ 還元型補酵素ｑ１０含有組成物とその製造方法及び安定化方法
JP5810079B2 (ja) * 2010-04-20 2015-11-11 株式会社カネカ 還元型補酵素ｑ１０含有組成物とその製造方法及び安定化方法

Also Published As

Publication number Publication date
JP2014012000A (ja) 2014-01-23
EP2186789A4 (en) 2012-03-14
EP2186789B1 (en) 2013-12-25
JP5364580B2 (ja) 2013-12-11
JPWO2009025277A1 (ja) 2010-11-25
EP2186789A1 (en) 2010-05-19
US20110123505A1 (en) 2011-05-26

Similar Documents

Publication Publication Date Title
WO2009025277A1 (ja) 還元型補酵素ｑ10の製造方法、ならびに、その安定化方法
EP1475363A4 (en) PROCESS FOR STABILIZING REDUCED COENZYME Q 10 AND COMPOSITION THEREOF
WO2010147751A3 (en) Compositions and methods for producing stable negative oxidation reduction potential in consumable materials
WO2006112998A8 (en) Liquid nutritional product to supplement human milk
WO2008006890A3 (en) Synthetic biocompatible material having an improved oxidation resistance, process for preparing the same and prosthetic articles obtained therefrom
WO2006068697A3 (en) Compositions including iron
WO2008129980A1 (ja) 還元型補酵素ｑ１０含有粒子状組成物及びその製造方法
PT2111126E (pt) Estabilidade melhorada em suplementos vitamínicos e minerais
WO2007082693A3 (en) Improved enzyme formulations for animal feed
WO2009057611A1 (ja) 含水有機溶媒を用いる還元型補酵素ｑ１０の製造方法
WO2008105113A1 (ja) 口腔内用殺菌剤、及び該殺菌剤を含有する食品添加剤
MX382322B (es) Producto fermentado que contiene un microorganismo productor de equol, por el cual se mantiene la capacidad productiva de equol, y procedimiento para la producción del mismo.
WO2008008544A3 (en) Equine whole food supplements
MX2012001318A (es) Bebida carbonatada que comprende harina de soya o leche de soya.
WO2011116220A3 (en) Oral supplement
ZA201102286B (en) Photosynthetic microorganisms enriched in selenium using selenohydroxy acid compounds, uses thereof in nutrition, cosmetics and oharmacy
WO2011150395A3 (en) Nutrient compositions
WO2011019875A3 (en) Antioxidant dietary supplement compositions
DE602005008918D1 (de) Trog für Ferkel
WO2009041699A1 (ja) 防風通聖散配合製剤
WO2007028222A3 (en) Soy processing method using specific enzyme, processed soy powderand processed soy liquid
TW200509884A (en) Method of purifying reduced coenzyme Q10
WO2007146559A3 (en) Nutritional composition and method of making the same
WO2008120542A1 (ja) ミチヤナギを有効成分とする固形製剤形態を有する食品組成物
WO2004092334A3 (en) Methods of producing edible fungi containing activated folates and nutritional supplements containing activated folates

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08827632

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009529037

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008827632

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12674604

Country of ref document: US

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载