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WO2008129980A1 - 還元型補酵素ｑ１０含有粒子状組成物及びその製造方法 - Google Patents

還元型補酵素ｑ１０含有粒子状組成物及びその製造方法 Download PDF

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Publication number
WO2008129980A1
WO2008129980A1 PCT/JP2008/057333 JP2008057333W WO2008129980A1 WO 2008129980 A1 WO2008129980 A1 WO 2008129980A1 JP 2008057333 W JP2008057333 W JP 2008057333W WO 2008129980 A1 WO2008129980 A1 WO 2008129980A1
Authority
WO
WIPO (PCT)
Prior art keywords
particulate composition
reduced coenzyme
food
disclosed
production
Prior art date
Application number
PCT/JP2008/057333
Other languages
English (en)
French (fr)
Inventor
Shinsuke Akao
Takashi Ueda
Takahiro Ueda
Yozo Nagira
Hideyuki Kishida
Original Assignee
Kaneka Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corporation filed Critical Kaneka Corporation
Priority to JP2009510841A priority Critical patent/JP5244790B2/ja
Publication of WO2008129980A1 publication Critical patent/WO2008129980A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

　本発明は、食品、栄養機能食品、特定保健用食品、栄養補助剤、栄養剤、動物薬、飲料、飼料、化粧品、医薬品、治療薬、予防薬等の分野において、高い酸化安定性と高い生体吸収性を兼ね備えた還元型補酵素Ｑ１０を含有する粒子状組成物、その製造方法、及びその安定化方法を提案することを課題とする。本発明者らは、上記課題を解決すべく鋭意研究した結果、水溶性賦形剤を主成分とし、水溶性アスコルビン酸類を含有するマトリックス中に、還元型補酵素Ｑ１０を含有する油性成分がドメインを形成して多分散している、還元型補酵素Ｑ１０を含有する粒子状組成物が、高い酸素安定性と高い生体吸収性を兼ね備えた組成物であることを見出し、本発明を完成させた。
PCT/JP2008/057333 2007-04-16 2008-04-15 還元型補酵素ｑ１０含有粒子状組成物及びその製造方法 WO2008129980A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009510841A JP5244790B2 (ja) 2007-04-16 2008-04-15 還元型補酵素ｑ１０含有粒子状組成物及びその製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-107202 2007-04-16
JP2007107202 2007-04-16
JP2007330191 2007-12-21
JP2007-330191 2007-12-21

Publications (1)

Publication Number Publication Date
WO2008129980A1 true WO2008129980A1 (ja) 2008-10-30

Family

ID=39875508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057333 WO2008129980A1 (ja) 2007-04-16 2008-04-15 還元型補酵素ｑ１０含有粒子状組成物及びその製造方法

Country Status (2)

Country Link
JP (1) JP5244790B2 (ja)
WO (1) WO2008129980A1 (ja)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2489652A4 (en) * 2009-10-16 2014-05-07 Kaneka Corp PROCESS FOR PREPARING REDUCED COENZYME Q10, METHOD FOR ITS STABILIZATION AND COMPOSITION THEREWITH
JP2016520037A (ja) * 2013-04-25 2016-07-11 ジャージャン メディスン カンパニー リミテッド シンチョン ファーマシューティカル ファクトリー 還元型コエンザイムｑ１０粉末、その組成物及び製造方法
JP2016160199A (ja) * 2015-02-27 2016-09-05 株式会社東洋新薬 コエンザイムｑ１０含有固形組成物
JP2017521368A (ja) * 2014-06-11 2017-08-03 マリンクロッド エルエルシー 異なる溶解プロファイルを有する噴霧乾燥組成物及びその調製方法
JP2018145148A (ja) * 2017-03-07 2018-09-20 富士フイルム株式会社 ソフトカプセル剤
WO2023120555A1 (ja) 2021-12-24 2023-06-29 株式会社カネカ 還元型補酵素ｑ１０の保存方法
WO2023120558A1 (ja) 2021-12-24 2023-06-29 株式会社カネカ 還元型補酵素ｑ１０の保存方法
WO2023120552A1 (ja) * 2021-12-24 2023-06-29 株式会社カネカ 還元型補酵素ｑ１０の梱包体及び保存方法
WO2023176878A1 (ja) * 2022-03-17 2023-09-21 株式会社カネカ 還元型補酵素Ｑ１０のＦｏｒｍＩＩ型結晶を含有する固体組成物の保存方法及び前記固体組成物を含有する梱包体
WO2023176875A1 (ja) * 2022-03-17 2023-09-21 株式会社カネカ 還元型補酵素Ｑ１０のＦｏｒｍＩＩ型結晶を含有する固体組成物の保存方法及び前記固体組成物を含有する梱包体
WO2023176871A1 (ja) 2022-03-17 2023-09-21 株式会社カネカ 還元型補酵素Ｑ１０のＦｏｒｍＩＩ型結晶を含有する固体組成物
WO2025057734A1 (ja) * 2023-09-13 2025-03-20 株式会社カネカ 還元型補酵素ｑ１０の共結晶を含有する固体組成物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117243933B (zh) * 2023-11-20 2024-02-13 上海交通大学医学院附属上海儿童医学中心 一种含辅酶q10的心脏停搏液组合物及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003119127A (ja) * 2001-10-10 2003-04-23 Kanegafuchi Chem Ind Co Ltd 安定な還元型補酵素ｑ製剤
WO2003032967A1 (en) * 2001-10-10 2003-04-24 Kaneka Corporation Method of stabilizing reduced coenzyme q10
WO2005041945A1 (ja) * 2003-10-31 2005-05-12 Kaneka Corporation 還元型補酵素ｑ含有組成物
US20050147598A1 (en) * 2002-01-18 2005-07-07 Yasuyoshi Ueda Method for stabilizing reduced coenzyme q10 and composition therefor
JP2006206583A (ja) * 2004-12-28 2006-08-10 Kaneka Corp 還元型補酵素ｑ１０の保存方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003119127A (ja) * 2001-10-10 2003-04-23 Kanegafuchi Chem Ind Co Ltd 安定な還元型補酵素ｑ製剤
WO2003032967A1 (en) * 2001-10-10 2003-04-24 Kaneka Corporation Method of stabilizing reduced coenzyme q10
US20050147598A1 (en) * 2002-01-18 2005-07-07 Yasuyoshi Ueda Method for stabilizing reduced coenzyme q10 and composition therefor
WO2005041945A1 (ja) * 2003-10-31 2005-05-12 Kaneka Corporation 還元型補酵素ｑ含有組成物
JP2006206583A (ja) * 2004-12-28 2006-08-10 Kaneka Corp 還元型補酵素ｑ１０の保存方法

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2489652A4 (en) * 2009-10-16 2014-05-07 Kaneka Corp PROCESS FOR PREPARING REDUCED COENZYME Q10, METHOD FOR ITS STABILIZATION AND COMPOSITION THEREWITH
JP2016520037A (ja) * 2013-04-25 2016-07-11 ジャージャン メディスン カンパニー リミテッド シンチョン ファーマシューティカル ファクトリー 還元型コエンザイムｑ１０粉末、その組成物及び製造方法
JP2017521368A (ja) * 2014-06-11 2017-08-03 マリンクロッド エルエルシー 異なる溶解プロファイルを有する噴霧乾燥組成物及びその調製方法
JP2016160199A (ja) * 2015-02-27 2016-09-05 株式会社東洋新薬 コエンザイムｑ１０含有固形組成物
JP2018145148A (ja) * 2017-03-07 2018-09-20 富士フイルム株式会社 ソフトカプセル剤
WO2023120555A1 (ja) 2021-12-24 2023-06-29 株式会社カネカ 還元型補酵素ｑ１０の保存方法
WO2023120558A1 (ja) 2021-12-24 2023-06-29 株式会社カネカ 還元型補酵素ｑ１０の保存方法
WO2023120552A1 (ja) * 2021-12-24 2023-06-29 株式会社カネカ 還元型補酵素ｑ１０の梱包体及び保存方法
WO2023176878A1 (ja) * 2022-03-17 2023-09-21 株式会社カネカ 還元型補酵素Ｑ１０のＦｏｒｍＩＩ型結晶を含有する固体組成物の保存方法及び前記固体組成物を含有する梱包体
WO2023176875A1 (ja) * 2022-03-17 2023-09-21 株式会社カネカ 還元型補酵素Ｑ１０のＦｏｒｍＩＩ型結晶を含有する固体組成物の保存方法及び前記固体組成物を含有する梱包体
WO2023176871A1 (ja) 2022-03-17 2023-09-21 株式会社カネカ 還元型補酵素Ｑ１０のＦｏｒｍＩＩ型結晶を含有する固体組成物
WO2025057734A1 (ja) * 2023-09-13 2025-03-20 株式会社カネカ 還元型補酵素ｑ１０の共結晶を含有する固体組成物

Also Published As

Publication number Publication date
JP5244790B2 (ja) 2013-07-24
JPWO2008129980A1 (ja) 2010-07-22

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