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WO2009008000A3 - Procédé de préparation de 6-hydroxy-2-(4-hydroxyphényl)-3-[4-(2-pipéridinoéthoxy)benzoyl]benzo[b]thiophène - Google Patents

Procédé de préparation de 6-hydroxy-2-(4-hydroxyphényl)-3-[4-(2-pipéridinoéthoxy)benzoyl]benzo[b]thiophène Download PDF

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Publication number
WO2009008000A3
WO2009008000A3 PCT/IN2008/000273 IN2008000273W WO2009008000A3 WO 2009008000 A3 WO2009008000 A3 WO 2009008000A3 IN 2008000273 W IN2008000273 W IN 2008000273W WO 2009008000 A3 WO2009008000 A3 WO 2009008000A3
Authority
WO
WIPO (PCT)
Prior art keywords
thiophene
benzo
hydroxyphenyl
benzoyl
hydroxy
Prior art date
Application number
PCT/IN2008/000273
Other languages
English (en)
Other versions
WO2009008000A2 (fr
Inventor
Rajamannar Thennati
Srinivasu Kilaru
Nileshkumar Sureshbhai Patel
Yesha Vijaykumar Patel
Original Assignee
Sun Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Ltd. filed Critical Sun Pharmaceutical Industries Ltd.
Publication of WO2009008000A2 publication Critical patent/WO2009008000A2/fr
Publication of WO2009008000A3 publication Critical patent/WO2009008000A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un procédé de préparation de 6-hydroxy-2-(4-hydroxyphényl)-3-[4-(2-pipéridinoéthoxy)benzoyl]benzo[b]thiophène, un composé de formule (I), ledit procédé comprenant la déprotection d'un composé de formule (II) avec une base dans du diméthylsulfoxyde pour donner un composé de formule (I) essentiellement pur avec une pureté par HPLC de 99 % ou plus par surface et la conversion facultative en son sel pharmaceutiquement acceptable.
PCT/IN2008/000273 2007-04-12 2008-04-15 Procédé de préparation de 6-hydroxy-2-(4-hydroxyphényl)-3-[4-(2-pipéridinoéthoxy)benzoyl]benzo[b]thiophène WO2009008000A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN723MU2007 2007-04-12
IN723/MUM/2007 2007-04-12

Publications (2)

Publication Number Publication Date
WO2009008000A2 WO2009008000A2 (fr) 2009-01-15
WO2009008000A3 true WO2009008000A3 (fr) 2011-08-11

Family

ID=40229220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000273 WO2009008000A2 (fr) 2007-04-12 2008-04-15 Procédé de préparation de 6-hydroxy-2-(4-hydroxyphényl)-3-[4-(2-pipéridinoéthoxy)benzoyl]benzo[b]thiophène

Country Status (1)

Country Link
WO (1) WO2009008000A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011029088A2 (fr) * 2009-09-07 2011-03-10 Dr. Reddy's Laboratories Ltd. Préparation de raloxifène et de ses sels
IT1403083B1 (it) * 2010-10-25 2013-10-04 Fidia Farmaceutici Nuova forma polimorfa di raloxifene cloridrato

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes

Also Published As

Publication number Publication date
WO2009008000A2 (fr) 2009-01-15

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