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WO2009003999A3 - Nouveaux composés chimiques - Google Patents

Nouveaux composés chimiques Download PDF

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Publication number
WO2009003999A3
WO2009003999A3 PCT/EP2008/058433 EP2008058433W WO2009003999A3 WO 2009003999 A3 WO2009003999 A3 WO 2009003999A3 EP 2008058433 W EP2008058433 W EP 2008058433W WO 2009003999 A3 WO2009003999 A3 WO 2009003999A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical compounds
medicament
excessive
preparing
groups
Prior art date
Application number
PCT/EP2008/058433
Other languages
English (en)
Other versions
WO2009003999A2 (fr
Inventor
Ioannis Sapountzis
Peter Ettmayer
Christian Klein
Andreas Mantoulidis
Steffen Steurer
Irene Waizenegger
Original Assignee
Boehringer Ingelheim Int
Ioannis Sapountzis
Peter Ettmayer
Christian Klein
Andreas Mantoulidis
Steffen Steurer
Irene Waizenegger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38792475&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009003999(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA002692383A priority Critical patent/CA2692383A1/fr
Application filed by Boehringer Ingelheim Int, Ioannis Sapountzis, Peter Ettmayer, Christian Klein, Andreas Mantoulidis, Steffen Steurer, Irene Waizenegger filed Critical Boehringer Ingelheim Int
Priority to EA201000105A priority patent/EA201000105A1/ru
Priority to AU2008270300A priority patent/AU2008270300A1/en
Priority to BRPI0814601A priority patent/BRPI0814601A2/pt
Priority to MX2009013935A priority patent/MX2009013935A/es
Priority to JP2010513966A priority patent/JP5511658B2/ja
Priority to US12/665,769 priority patent/US8889665B2/en
Priority to CN200880105329A priority patent/CN101796045A/zh
Priority to EP08774579.0A priority patent/EP2173734B1/fr
Publication of WO2009003999A2 publication Critical patent/WO2009003999A2/fr
Publication of WO2009003999A3 publication Critical patent/WO2009003999A3/fr
Priority to IL202625A priority patent/IL202625A0/en
Priority to MA32465A priority patent/MA32120B1/fr
Priority to TNP2009000551A priority patent/TN2009000551A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés chimiques de formule générale (1), dans laquelle les groupes R1 à R3, L sont défini tel que dans la revendication 1. Ces composés conviennent au traitement de maladies caractérisées par une prolifération excessive ou anormale de cellules et sont utilisés dans la préparation d'un médicament possédant les propriétés susmentionnées.
PCT/EP2008/058433 2007-07-02 2008-07-01 Nouveaux composés chimiques WO2009003999A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US12/665,769 US8889665B2 (en) 2007-07-02 2008-07-01 Chemical compounds
JP2010513966A JP5511658B2 (ja) 2007-07-02 2008-07-01 新規化合物
EA201000105A EA201000105A1 (ru) 2007-07-02 2008-07-01 Химические соединения
AU2008270300A AU2008270300A1 (en) 2007-07-02 2008-07-01 Chemical compounds
BRPI0814601A BRPI0814601A2 (pt) 2007-07-02 2008-07-01 compostos químicos
MX2009013935A MX2009013935A (es) 2007-07-02 2008-07-01 Compuestos quimicos.
CN200880105329A CN101796045A (zh) 2007-07-02 2008-07-01 化合物
CA002692383A CA2692383A1 (fr) 2007-07-02 2008-07-01 Nouveaux composes chimiques
EP08774579.0A EP2173734B1 (fr) 2007-07-02 2008-07-01 Composés chimiques
IL202625A IL202625A0 (en) 2007-07-02 2009-12-09 New chemical compounds
MA32465A MA32120B1 (fr) 2007-07-02 2009-12-30 Nouveaux composes chimiques
TNP2009000551A TN2009000551A1 (fr) 2007-07-02 2009-12-31 Nouveaux composes chimiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07111566 2007-07-02
EP07111566.1 2007-07-02

Publications (2)

Publication Number Publication Date
WO2009003999A2 WO2009003999A2 (fr) 2009-01-08
WO2009003999A3 true WO2009003999A3 (fr) 2009-07-16

Family

ID=38792475

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/058433 WO2009003999A2 (fr) 2007-07-02 2008-07-01 Nouveaux composés chimiques

Country Status (21)

Country Link
US (1) US8889665B2 (fr)
EP (1) EP2173734B1 (fr)
JP (1) JP5511658B2 (fr)
KR (1) KR20100039849A (fr)
CN (1) CN101796045A (fr)
AR (1) AR067397A1 (fr)
AU (1) AU2008270300A1 (fr)
BR (1) BRPI0814601A2 (fr)
CA (1) CA2692383A1 (fr)
CL (1) CL2008001943A1 (fr)
CO (1) CO6251316A2 (fr)
EA (1) EA201000105A1 (fr)
EC (1) ECSP099823A (fr)
IL (1) IL202625A0 (fr)
MA (1) MA32120B1 (fr)
MX (1) MX2009013935A (fr)
PE (1) PE20090837A1 (fr)
TN (1) TN2009000551A1 (fr)
TW (1) TW200911789A (fr)
UY (1) UY31198A1 (fr)
WO (1) WO2009003999A2 (fr)

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AR073501A1 (es) 2008-09-08 2010-11-10 Boehringer Ingelheim Int Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa
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WO2015143654A1 (fr) 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. Inhibiteurs de la kinase trka, compositions et méthodes associées
WO2016161572A1 (fr) 2015-04-08 2016-10-13 Merck Sharp & Dohme Corp. Inhibiteurs de la kinase trka, compositions et procédés associés
US10464896B2 (en) 2015-06-11 2019-11-05 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
KR101723881B1 (ko) * 2016-03-28 2017-04-07 이화여자대학교 산학협력단 신규한 트리아졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 오로라 키나제 관련 약학적 조성물
EP3817811B1 (fr) * 2018-07-04 2024-04-03 Boehringer Ingelheim International GmbH Dérivés de triazole benzamide en tant qu'agonistes de gpr142
CN115884965A (zh) * 2020-05-07 2023-03-31 拉姆巴姆医疗技术有限公司 用于治疗ApoL1相关疾病的组合物
CN116761801A (zh) * 2021-03-12 2023-09-15 四川科伦博泰生物医药股份有限公司 具有蛋白激酶抑制活性的杂环化合物、包含其的药物组合物及其制备方法和用途
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CN114805334B (zh) * 2022-05-24 2023-06-09 深圳大学 一种QC和GSK-3β多靶向抑制剂及其制备方法与应用
WO2024149728A1 (fr) * 2023-01-10 2024-07-18 Astrazeneca Ab (hétéro)anilines substituées et leur utilisation
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WO2010034838A2 (fr) 2008-09-29 2010-04-01 Boehringer Ingelheim International Gmbh Nouveaux composés chimiques
US8569316B2 (en) 2009-02-17 2013-10-29 Boehringer Ingelheim International Gmbh Pyrimido [5,4-D] pyrimidine derivatives for the inhibition of tyrosine kinases
WO2011117382A1 (fr) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh Pyridyltriazoles
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US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
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ECSP099823A (es) 2010-01-29
US20110183952A1 (en) 2011-07-28
TW200911789A (en) 2009-03-16
PE20090837A1 (es) 2009-07-24
MA32120B1 (fr) 2011-03-01
CA2692383A1 (fr) 2009-01-08
BRPI0814601A2 (pt) 2019-09-24
JP2010531851A (ja) 2010-09-30
TN2009000551A1 (fr) 2011-03-31
AR067397A1 (es) 2009-10-07
AU2008270300A1 (en) 2009-01-08
KR20100039849A (ko) 2010-04-16
EP2173734B1 (fr) 2016-03-23
CO6251316A2 (es) 2011-02-21
CL2008001943A1 (es) 2009-09-11
CN101796045A (zh) 2010-08-04
EA201000105A1 (ru) 2010-06-30
MX2009013935A (es) 2010-01-28
EP2173734A2 (fr) 2010-04-14
IL202625A0 (en) 2010-06-30
US8889665B2 (en) 2014-11-18
WO2009003999A2 (fr) 2009-01-08
UY31198A1 (es) 2009-01-30

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