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TN2009000551A1 - Nouveaux composes chimiques - Google Patents

Nouveaux composes chimiques

Info

Publication number
TN2009000551A1
TN2009000551A1 TNP2009000551A TN2009000551A TN2009000551A1 TN 2009000551 A1 TN2009000551 A1 TN 2009000551A1 TN P2009000551 A TNP2009000551 A TN P2009000551A TN 2009000551 A TN2009000551 A TN 2009000551A TN 2009000551 A1 TN2009000551 A1 TN 2009000551A1
Authority
TN
Tunisia
Prior art keywords
chemical compounds
new chemical
compounds
drug
excessive
Prior art date
Application number
TNP2009000551A
Other languages
English (en)
Inventor
Ioannis Sapountzis
Peter Ettmayer
Christian Klein
Andrea Mantoulidis
Steffen Steurer
Irene Waizenegger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38792475&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2009000551(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TN2009000551A1 publication Critical patent/TN2009000551A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne des composés de formule générale (1), dans laquelle R1 à R3 et L sont définis dans la revendication 1, qui sont appropriés pour le traitement de maladies caractérisées par une prolifération cellulaire excessive ou anormale, et leur utilisation pour préparer un médicament possédant les propriétés mentionnées ci-dessus.
TNP2009000551A 2007-07-02 2009-12-31 Nouveaux composes chimiques TN2009000551A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07111566 2007-07-02
PCT/EP2008/058433 WO2009003999A2 (fr) 2007-07-02 2008-07-01 Nouveaux composés chimiques

Publications (1)

Publication Number Publication Date
TN2009000551A1 true TN2009000551A1 (fr) 2011-03-31

Family

ID=38792475

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000551A TN2009000551A1 (fr) 2007-07-02 2009-12-31 Nouveaux composes chimiques

Country Status (21)

Country Link
US (1) US8889665B2 (fr)
EP (1) EP2173734B1 (fr)
JP (1) JP5511658B2 (fr)
KR (1) KR20100039849A (fr)
CN (1) CN101796045A (fr)
AR (1) AR067397A1 (fr)
AU (1) AU2008270300A1 (fr)
BR (1) BRPI0814601A2 (fr)
CA (1) CA2692383A1 (fr)
CL (1) CL2008001943A1 (fr)
CO (1) CO6251316A2 (fr)
EA (1) EA201000105A1 (fr)
EC (1) ECSP099823A (fr)
IL (1) IL202625A0 (fr)
MA (1) MA32120B1 (fr)
MX (1) MX2009013935A (fr)
PE (1) PE20090837A1 (fr)
TN (1) TN2009000551A1 (fr)
TW (1) TW200911789A (fr)
UY (1) UY31198A1 (fr)
WO (1) WO2009003999A2 (fr)

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JP2010531850A (ja) * 2007-07-02 2010-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規化合物
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AR073501A1 (es) 2008-09-08 2010-11-10 Boehringer Ingelheim Int Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa
WO2010034838A2 (fr) 2008-09-29 2010-04-01 Boehringer Ingelheim International Gmbh Nouveaux composés chimiques
US8569316B2 (en) 2009-02-17 2013-10-29 Boehringer Ingelheim International Gmbh Pyrimido [5,4-D] pyrimidine derivatives for the inhibition of tyrosine kinases
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US10464896B2 (en) 2015-06-11 2019-11-05 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
KR101723881B1 (ko) * 2016-03-28 2017-04-07 이화여자대학교 산학협력단 신규한 트리아졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 오로라 키나제 관련 약학적 조성물
EP3817811B1 (fr) * 2018-07-04 2024-04-03 Boehringer Ingelheim International GmbH Dérivés de triazole benzamide en tant qu'agonistes de gpr142
CN115884965A (zh) * 2020-05-07 2023-03-31 拉姆巴姆医疗技术有限公司 用于治疗ApoL1相关疾病的组合物
CN116761801A (zh) * 2021-03-12 2023-09-15 四川科伦博泰生物医药股份有限公司 具有蛋白激酶抑制活性的杂环化合物、包含其的药物组合物及其制备方法和用途
IL316407A (en) * 2022-04-19 2024-12-01 Watershed Medical Inc A preparation for the treatment of urinary system disorders
CN114805334B (zh) * 2022-05-24 2023-06-09 深圳大学 一种QC和GSK-3β多靶向抑制剂及其制备方法与应用
WO2024149728A1 (fr) * 2023-01-10 2024-07-18 Astrazeneca Ab (hétéro)anilines substituées et leur utilisation
CN116068110B (zh) * 2023-01-19 2024-11-22 武汉大学 叠氮质谱探针的合成方法及应用

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WO2010034838A2 (fr) 2008-09-29 2010-04-01 Boehringer Ingelheim International Gmbh Nouveaux composés chimiques
US8569316B2 (en) 2009-02-17 2013-10-29 Boehringer Ingelheim International Gmbh Pyrimido [5,4-D] pyrimidine derivatives for the inhibition of tyrosine kinases
WO2011117382A1 (fr) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh Pyridyltriazoles
WO2011117381A1 (fr) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh Inhibiteurs de kinase b-raf
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
US20130023531A1 (en) 2011-01-27 2013-01-24 Boehringer Ingelheim International Gmbh Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors
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Also Published As

Publication number Publication date
JP5511658B2 (ja) 2014-06-04
ECSP099823A (es) 2010-01-29
US20110183952A1 (en) 2011-07-28
TW200911789A (en) 2009-03-16
PE20090837A1 (es) 2009-07-24
MA32120B1 (fr) 2011-03-01
CA2692383A1 (fr) 2009-01-08
BRPI0814601A2 (pt) 2019-09-24
JP2010531851A (ja) 2010-09-30
AR067397A1 (es) 2009-10-07
AU2008270300A1 (en) 2009-01-08
KR20100039849A (ko) 2010-04-16
EP2173734B1 (fr) 2016-03-23
CO6251316A2 (es) 2011-02-21
CL2008001943A1 (es) 2009-09-11
CN101796045A (zh) 2010-08-04
EA201000105A1 (ru) 2010-06-30
MX2009013935A (es) 2010-01-28
EP2173734A2 (fr) 2010-04-14
IL202625A0 (en) 2010-06-30
US8889665B2 (en) 2014-11-18
WO2009003999A2 (fr) 2009-01-08
UY31198A1 (es) 2009-01-30
WO2009003999A3 (fr) 2009-07-16

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