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WO2008136519A1 - Ｅｐ４アゴニストを含有してなる細胞傷害性ｔ細胞の活性化剤 - Google Patents

Ｅｐ４アゴニストを含有してなる細胞傷害性ｔ細胞の活性化剤 Download PDF

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Publication number
WO2008136519A1
WO2008136519A1 PCT/JP2008/058464 JP2008058464W WO2008136519A1 WO 2008136519 A1 WO2008136519 A1 WO 2008136519A1 JP 2008058464 W JP2008058464 W JP 2008058464W WO 2008136519 A1 WO2008136519 A1 WO 2008136519A1
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WIPO (PCT)
Prior art keywords
cytotoxic
agonist
cell activator
microorganism
infectious disease
Prior art date
Application number
PCT/JP2008/058464
Other languages
English (en)
French (fr)
Inventor
Masahiro Takigawa
Naohiro Seo
Kenji Kabashima
Takayuki Maruyama
Toshiya Kanaji
Original Assignee
National University Corporation, Hamamatsu University School Of Medicine
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation, Hamamatsu University School Of Medicine, Ono Pharmaceutical Co., Ltd. filed Critical National University Corporation, Hamamatsu University School Of Medicine
Priority to US12/599,194 priority Critical patent/US8507545B2/en
Priority to BRPI0811306 priority patent/BRPI0811306A2/pt
Priority to AU2008246579A priority patent/AU2008246579A1/en
Priority to CN200880023882A priority patent/CN101686985A/zh
Priority to CA 2684922 priority patent/CA2684922A1/en
Priority to JP2009513028A priority patent/JP5479092B2/ja
Priority to EP20080764261 priority patent/EP2147672A4/en
Priority to MX2009012043A priority patent/MX2009012043A/es
Publication of WO2008136519A1 publication Critical patent/WO2008136519A1/ja
Priority to IL201918A priority patent/IL201918A0/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C—CHEMISTRY; METALLURGY
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

　低分子で、より適用の簡便な癌および／または微生物感染症に対する免疫増強作用を有する薬剤を提供することを本発明の課題とする。 　ＥＰ４アゴニストは、細胞傷害性Ｔ細胞の活性化作用を介した免疫増強作用を有するので、癌、微生物感染症の予防および／または治療に有用である。
PCT/JP2008/058464 2007-05-08 2008-05-07 Ｅｐ４アゴニストを含有してなる細胞傷害性ｔ細胞の活性化剤 WO2008136519A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US12/599,194 US8507545B2 (en) 2007-05-08 2008-05-07 Cytotoxic T cell activator comprising EP4 agonist
BRPI0811306 BRPI0811306A2 (pt) 2007-05-08 2008-05-07 Ativador de célula t citotóxica compreendendo agonista ep4
AU2008246579A AU2008246579A1 (en) 2007-05-08 2008-05-07 Cytotoxic T cell activator comprising EP4 agonist
CN200880023882A CN101686985A (zh) 2007-05-08 2008-05-07 含有ep4激动剂的细胞毒性t细胞的活化剂
CA 2684922 CA2684922A1 (en) 2007-05-08 2008-05-07 Cytotoxic t cell activator comprising ep4 agonist
JP2009513028A JP5479092B2 (ja) 2007-05-08 2008-05-07 Ｅｐ４アゴニストを含有してなる細胞傷害性ｔ細胞の活性化剤
EP20080764261 EP2147672A4 (en) 2007-05-08 2008-05-07 CYTOTOXIC T CELL ACTIVATOR WITH AN EP4 AGONIST
MX2009012043A MX2009012043A (es) 2007-05-08 2008-05-07 Activador de celulas t citotoxicas que comprende agonista ep4.
IL201918A IL201918A0 (en) 2007-05-08 2009-11-04 Cytotoxic t cell activator comprising ep4 agonist

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-123119 2007-05-08
JP2007123119 2007-05-08

Publications (1)

Publication Number Publication Date
WO2008136519A1 true WO2008136519A1 (ja) 2008-11-13

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ID=39943622

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PCT/JP2008/058464 WO2008136519A1 (ja) 2007-05-08 2008-05-07 Ｅｐ４アゴニストを含有してなる細胞傷害性ｔ細胞の活性化剤

Country Status (13)

Country Link
US (1) US8507545B2 (ja)
EP (1) EP2147672A4 (ja)
JP (2) JP5479092B2 (ja)
KR (1) KR20100016299A (ja)
CN (1) CN101686985A (ja)
AU (1) AU2008246579A1 (ja)
BR (1) BRPI0811306A2 (ja)
CA (1) CA2684922A1 (ja)
IL (1) IL201918A0 (ja)
MX (1) MX2009012043A (ja)
RU (1) RU2009145280A (ja)
WO (1) WO2008136519A1 (ja)
ZA (1) ZA200907760B (ja)

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WO2013004291A1 (en) 2011-07-04 2013-01-10 Rottapharm S.P.A. Cyclic amine derivatives as ep4 receptor agonists
JP2013536183A (ja) * 2010-07-30 2013-09-19 アラーガン インコーポレイテッド 皮膚修復のための化合物及び方法

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WO2012112757A2 (en) 2011-02-17 2012-08-23 Allergan, Inc. Compositions and improved soft tissue replacement methods
WO2013105997A2 (en) 2011-02-23 2013-07-18 Allergan, Inc. Compositions and improved soft tissue replacement methods
US20150004175A1 (en) * 2011-12-13 2015-01-01 Yale University Compositions and Methods for Reducing CTL Exhaustion
EP2814482A1 (en) 2012-02-16 2014-12-24 Allergan, Inc. Compositions and improved soft tissue replacement methods
EP2814526B1 (en) 2012-02-16 2016-11-02 Allergan, Inc. Compositions and improved soft tissue replacement methods
WO2013123275A1 (en) 2012-02-16 2013-08-22 Allergan, Inc. Compositions and improved soft tissue replacement methods
EP2814510A1 (en) 2012-02-16 2014-12-24 Allergan, Inc. Compositions and improved soft tissue replacement methods
AU2013292357C1 (en) 2012-07-19 2017-05-25 Cayman Chemical Company, Inc. Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated disease and conditions
WO2014144610A1 (en) 2013-03-15 2014-09-18 Cayman Chemical Company, Inc. Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
BR112015023080A2 (pt) 2013-03-15 2017-07-18 Cayman Chemical Co Inc composto, composição farmacêutica, e, método para tratamento de doenças
AU2014290512A1 (en) 2013-07-19 2015-11-12 Cayman Chemical Company, Inc. Methods, systems, and compositions for promoting bone growth
EP3030252B1 (en) 2013-08-09 2018-11-07 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2015109112A1 (en) * 2014-01-16 2015-07-23 Gemmus Pharma Inc. Combination treatment of antibiotic and gpcr agonist for viral/bacterial co-infections
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport
CA3167058A1 (en) 2020-02-12 2021-08-19 Cytoagents, Inc. Compositions and methods for treating coronavirus infections

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